Alanine aminotransferase( ALT) abnormality is an indicator of the degree of liver inflammation caused by immune activation in patients with chronic hepatitis B( CHB). However,approximately half of the CHB patients with normal or mildly elevated ALT levels have concealed significant changes in hepatic histology. CHB patients with normal or mildly elevated ALT levels may have significant histopathological changes in hepatic tissues,and those changes vary between HBe Ag( +) and HBe Ag(-) CHB patients. Attention and investigation on the clinical management of CHB patients with normal or mildly elevated ALT levels may have great significance in grasping the right treatment opportunity and reducing the risk of liver cirrhosis.
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