2015 No. 4

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Editorial

Pursue excellence of clinical research on chronic hepatitis B in China

Jia JiDong

2015, 31(4): 481-482. DOI: 10.3969/j.issn.1001-5256.2015.04.001

Abstract(1996)

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Abstract:

In China universal vaccination program against hepatitis B virus( HBV) in newborns has led to a dramatic decline in HBs Ag prevalence from 9. 75% in 1992 to 7. 18% in 2006. However,it is estimated that there are still around 90 million patients with chronic HBV infection,including 20- 30 million wit...

Therapeutic guidelines

American Gastroenterological Association Institute guideline on the prevention and treatment of hepatitis B virus reactivation during immunosuppressive drug therapy

Tang ShanHong, Zeng WeiZheng, Jiang MingDe

2015, 31(4): 483-485. DOI: 10.3969/j.issn.1001-5256.2015.04.002

Abstract(324)

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An update on the management of chronic hepatitis C: 2015 consensus guidelines from the Canadian Association for the Study of the Liver

Zhang Ning, Luo ShengQiang

2015, 31(4): 486-489. DOI: 10.3969/j.issn.1001-5256.2015.04.003

Abstract(315)

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Recommendations for the use of transient elastography in chronic viral hepatitis: introduction to the Australian Liver Association expert consensus in 2014

Yu yueCheng, Hou JinLin

2015, 31(4): 490-494. DOI: 10.3969/j.issn.1001-5256.2015.04.004

Abstract(264)

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Abstract:

Discussions by experts

Combination therapy and sequential therapy with interferons and nucleos( t) ide analogues against HBV

Li Qiang, Zhuo QiBin, Huang YuXian, Li XinYan, Chen Liang

2015, 31(4): 495-499. DOI: 10.3969/j.issn.1001-5256.2015.04.005

Abstract(2855)

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Abstract:
Currently,there are two categories of antiviral drugs used for chronic hepatitis B( CHB) : interferons( IFNs) and nucleos( t) ide analogues( NAs). IFNs showed lower efficacy and more adverse effects,although they achieved some anti- HBV results. NAs showed stronger antiviral activity and a lower inc...

Prevention of mother-to-child transmission of hepatitis B virus: controversies and focuses of current strategies

Shen Yao, Zhang XiaoHui, Chen Yu

2015, 31(4): 500-504. DOI: 10.3969/j.issn.1001-5256.2015.04.006

Abstract(2822)

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Abstract:
Mother- to- child transmission( MTCT) is an important way of hepatitis B virus( HBV) transmission. Blocking the HBV MTCT has a great significance for the prevention and treatment of hepatitis B. This article reviews the current blocking strategies implemented in the antepartum,peripartum,and postpar...

Predictive and prognostic evaluation of hepatitis B virus-induced liver failure

Han Tao, Zhang YuLing

2015, 31(4): 505-509. DOI: 10.3969/j.issn.1001-5256.2015.04.007

Abstract(2523)

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Abstract:
Hepatitis B virus( HBV)- induced liver failure is a severe clinical syndrome with complicated manifestations resulting in high mortality. The prognosis largely depends on early diagnosis and timely intervention. This article reviews the predictive and prognostic evaluation system for the development...

Significance of changes in hepatic histology from patients with HBe Ag( + ) or HBe Ag(-) chronic hepatitis B and normal or mildly elevated alanine aminotransferase

Lan Lin, Kong Yin, Zhang LingYi

2015, 31(4): 510-513. DOI: 10.3969/j.issn.1001-5256.2015.04.008

Abstract(2754)

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Abstract:
Alanine aminotransferase( ALT) abnormality is an indicator of the degree of liver inflammation caused by immune activation in patients with chronic hepatitis B( CHB). However,approximately half of the CHB patients with normal or mildly elevated ALT levels have concealed significant changes in hepati...

Next-generation sequencing in study of hepatitis B virus variation

Zhang XinXin, Wang MingJie

2015, 31(4): 514-519. DOI: 10.3969/j.issn.1001-5256.2015.04.009

Abstract(3378)

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Abstract:
The high mutation rate during hepatitis B virus( HBV) replication leads to HBV quasispecies. The study of HBV quasispecies has an important significance for the hepatitis B pathogenesis,prognosis,and outcome prediction. Recently,the next- generation sequencing( NGS) is extensively used in many biolo...

Original articles_Viral hepatitis

Clinical significance of testing serum proteins related to liver functions in chronic HBV carriers

Zhang JiWang, Tang ZhiGui, Yuan YongQiang

2015, 31(4): 520-522. DOI: 10.3969/j.issn.1001-5256.2015.04.010

Abstract(1769)

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Abstract:
Objective To investigate the serum levels of liver function- related proteins( cholinesterase,Ch E; album,Alb,prealbumin,PA; transferrin,TRF; ferritin,FRT; C- reactive protein,CRP; and ceruloplasmin,CER) and assess their clinical diagnostic significance for chronic hepatitis B virus( HBV) carriers. ...

Efficacy of entecavir treatment for patients with chronic hepatitis B

Xia ShuLin, He XiaoFeng

2015, 31(4): 523-525. DOI: 10.3969/j.issn.1001-5256.2015.04.011

Abstract(1828)

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Abstract:
Objective To evaluate the efficacy of entecavir treatment up to 96 weeks for patients with chronic hepatitis B( CHB). Methods The study recruited 62 CHB patients who were admitted to or hospitalized at the Taixing People' s Hospital from July 2011 to July 2014.The patients were treated with entecavi...

Clinical efficacy of telbivudine and interferon in treatment of HBe Ag-positive chronic hepatitis B: a comparative study

Li HuoYan, Yang ZhaoHui, Ma LiLi, Ma Long

2015, 31(4): 526-529. DOI: 10.3969/j.issn.1001-5256.2015.04.012

Abstract(1648)

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Abstract:
Objective To evaluate the clinical efficacy and safety of telbivudine( TLD) and interferon( IFN) α in the treatment of HBe Ag-positive chronic hepatitis B( CHB). Methods A total of 84 CHB patients who were admitted to Xiamen Municipal Third Hospital Affiliated to Fujian University of Traditional Chi...

A clinical study of autologous cytokine-induced killer cells in treatment of patients with chronic hepatitis B

Wang ShaoYang, Lin TaoFa, Liu HaiZhou, Ma WeiMin, Xie ZhiHong

2015, 31(4): 530-533. DOI: 10.3969/j.issn.1001-5256.2015.04.013

Abstract(1771)

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Abstract:
Objective To evaluate the safety and efficacy of autologous cytokine- induced killer( CIK) cells in the treatment of patients with chronic hepatitis B( CHB),and to investigate a new therapeutic strategy for CHB. Methods Peripheral blood mononuclear cells were isolated from 84 patients with CHB,and t...

Relationship between e system of hepatitis B and HBV DNA quantification

Wang Fei, Xu AiLing, Xin XiaXia, Yuan Hong, Xiong JingJing, Zhang Qi, Wang Chen

2015, 31(4): 534-536. DOI: 10.3969/j.issn.1001-5256.2015.04.014

Abstract(2092)

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Abstract:
Objective To analyze and compare the viral replication in patients with hepatitis B virus( HBV) when serum markers HBe Ag and HBe Ab are both positive,or HBe Ag alone is positive,or HBe Ab alone is positive,or both are negative. Methods Electrochemiluminescence method was used to detect serum marker...

Analysis of correlations of age with liver pathological change and HBV DNA level in chronic HBV infection patients with normal ALT and mild ALT elevation

Li Jing, Liu ZhiQuan, Lu YuFeng, Li YuXiao, Li BingShun

2015, 31(4): 537-540. DOI: 10.3969/j.issn.1001-5256.2015.04.015

Abstract(367)

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Abstract:
Objective To investigate the liver pathological changes and features of hepatitis B virus( HBV) DNA in chronic HBV infection patients with normal alanine transaminase( ALT) and mild ALT elevation. Methods A total of 1123 chronic HBV infection patients with normal ALT and mild ALT elevation who were ...

Correlation analysis of percentages of T lymphocyte subsets and CD4~+CD25~+ regulatory T cells and HBV DNA level in peripheral blood of chronic hepatitis B patients

Li CaiDong, Chen XiLian, Tian PengFei, Li HuiJun, Wu Bin

2015, 31(4): 541-545. DOI: 10.3969/j.issn.1001-5256.2015.04.016

Abstract(2559)

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Abstract:
Objective To investigate the correlation between the percentages of T lymphocyte subsets( CD3+T,CD4+T,CD8+T,and CD4+/ CD8+T) and CD4+CD25+regulatory T cells( Treg cells) and hepatitis B virus( HBV) DNA level in the peripheral blood of chronic hepatitis B( CHB) patients. Methods We chose 175 patients...

Analysis of hepatic CD4~+,CD8~+,CD20~+,and CD57~+ T lymphocytes in chronic hepatitis B patients with different HBe Ag status

Xian YongChao, Cheng ShuQuan, Ni Hui, Huang ChengJun

2015, 31(4): 546-550. DOI: 10.3969/j.issn.1001-5256.2015.04.017

Abstract(393)

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Abstract:
Objective To investigate the relationship of hepatic immune cells( CD4+,CD8+,CD20+,and CD57+T lymphocytes) with liver pathology and clinical relevance in chronic hepatitis B( CHB) patients with different HBe Ag status. Methods A total of 70 CHB patients admitted to our hospital from January 2008 to ...

Measurement of peripheral blood Treg,Tr1,and Th17 cells in patients with chronic hepatitis B and its clinical significance

Huang JinFa, Xu Tao, Pan XingNan, Lai XiaoHuan, Zheng LianQiu, Huang ZhiJie

2015, 31(4): 551-555. DOI: 10.3969/j.issn.1001-5256.2015.04.018

Abstract(2332)

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Abstract:
Objective To investigate the expression characteristics of Treg,Tr1,and Th17 cells in the peripheral blood of patients with chronic hepatitis B( CHB) and their correlations with the state of CHB. Methods A total of 40 patients with mild- to- moderate CHB and40 patients with severe CHB who were admit...

Study on p-p38 expression and its significance in liver tissues of mice with acute liver failure and patients with HBV-related acute-on-chronic liver failure

Chen Jing, Liu XiaoYan, Yang HaoZhen, Huang Kun, Hu JinHua, Xin ShaoJie

2015, 31(4): 556-559. DOI: 10.3969/j.issn.1001-5256.2015.04.019

Abstract(2420)

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Abstract:
Objective To investigate the expression and significance of phosphorylated p38mitogen- activated protein kinase( p- p38MAPK)in mice with acute liver failure induced by D- galactosamine( D- Gal N) / lipopolysaccharide( LPS) and patients with HBV- related acute-on- chronic liver failure( HBV- ACLF). M...

Relevance between relapse and course of treatment in genotype 1 chronic hepatitis C patients with slow virologic response

Sun JianMin, Hu QingJun

2015, 31(4): 560-563. DOI: 10.3969/j.issn.1001-5256.2015.04.020

Abstract(2390)

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Abstract:
Objective To investigate the relevance between relapse and course of treatment in genotype 1 chronic hepatitis C( CHC) patients with slow virologic response. Methods Totally 157 genotype 1 CHC inpatients or outpatients were selected from the Third People' s Hospital of Jiaozuo and the People's Hospi...

Original articles_Liver neoplasms

Clinical research on treatment of advanced primary liver cancer with combination of thymosin α1 and arsenic trioxide

Gao ChengGuang, Chen RiXia

2015, 31(4): 564-568. DOI: 10.3969/j.issn.1001-5256.2015.04.021

Abstract(2452)

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Abstract:
Objective To evaluate the efficacy of thymosin ɑ1 combined with arsenic trioxide in the treatment of advanced primary liver cancer( PLC). Methods A total of 59 patients with advanced PLC who were admitted to Jiangyan Hospital of Traditional Chinese Medicine from July 2011 to July 2014 were divided i...

Efficacy of nutritional intervention in patients with primary hepatocellular carcinoma treated by transcatheter arterial chemoembolization

Hu CaiXia, Zheng JiaSheng, Cui ShiChang, Qian ZhiLing

2015, 31(4): 569-572. DOI: 10.3969/j.issn.1001-5256.2015.04.022

Abstract(2274)

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Abstract:
Objective To investigate the efficacy of short- term nutritional intervention in patients with primary hepatocellular carcinoma treated by transcatheter arterial chemoembolization. Methods Sixty patients with primary hepatocellular carcinoma who were admitted to Beijing Youan Hospital to receive tra...

Clinical study of ultrasound-guided percutaneous radiofrequency ablation for primary hepatic carcinoma adjacent to the diaphragm

Li Meng, Li ZhiYan, Tian JiangKe, Dong XiaoYu, Liu Yang, Li Chen, Yuan MingXing, Zhao HongWei

2015, 31(4): 573-577. DOI: 10.3969/j.issn.1001-5256.2015.04.023

Abstract(2274)

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Abstract:
Objective To investigate the safety and efficacy of ultrasound( US)- guided percutaneous radiofrequency ablation( RFA) for primary hepatic carcinoma adjacent to the diaphragm. Methods This study included 277 patients with 362 lesions of primary hepatic carcinoma managed with US- guided percutaneous ...

Original articles_Others

Effects of artificial liver plasma exchange on cytokines in patients with liver failure

Zhang LiangJie, Chen HuiJuan, Zhao ShouSong

2015, 31(4): 578-581. DOI: 10.3969/j.issn.1001-5256.2015.04.024

Abstract(2245)

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Abstract:

Objective To observe the effect of plasma exchange( PE) therapy for removing serum interleukin- 6( IL- 6),tumor necrosis factor alpha( TNFα),and interferon gamma( IFNγ) in patients with liver failure,and to assess the value of artificial liver support system in the treatment of liver failure. Method...

Relationship between zonula occludens-1 and blood-brain barrier permeability in rats with hepatic encephalopathy

Hu LiHua, Chen Peng, Wang XiaoLi, Zhang JiYe, Su LianMing, Zhang PeiYi

2015, 31(4): 582-584. DOI: 10.3969/j.issn.1001-5256.2015.04.025

Abstract(2206)

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Abstract:

Objective To investigate the relationship between zonula occludens- 1( ZO- 1) level and blood- brain barrier permeability in rats with hepatic encephalopathy( HE). Methods One hundred and eighty Sprague- Dawley rats were equally and randomly divided into control and HE( 4,8,and 12 h) groups of 45 an...

Brief reports

Impact of HCV 5′NCR genetic mutation on standard program of anti-HCV therapy

Mao WeiWu, Du Peng, Zhang WenJie, Li Jing, Qu Yan, Shi HuaiYuan, Wang YanXia

2015, 31(4): 585-587. DOI: 10.3969/j.issn.1001-5256.2015.04.026

Abstract(276)

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Case reports

Thrombolysis through superior mesenteric artery catheter combined with systemic anticoagulant therapy for treating acute extensive portal vein thrombosis: a report of two cases

Qi LingXia, Wen XiaoYu, Bai Yang, Peng ShanShan, Cui YuanYuan, Li Bo, Hua Rui, Pan Yu, Jin QingLong, Li JiaRui, Niu JunQi, Tang XiaoBin

2015, 31(4): 588-590. DOI: 10.3969/j.issn.1001-5256.2015.04.027

Abstract(2519)

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Undifferentiated pleomorphic sarcoma of the spleen: a report of one case

Fu Yu, Wang YingChao, Tan LuDong, Jin Zhe, Jia BaoXing, Liu YaHui

2015, 31(4): 591-592. DOI: 10.3969/j.issn.1001-5256.2015.04.028

Abstract(2513)

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Reviews

Research advances in predictors of treatment responses to pegylated interferon alpha in patients with chronic hepatitis B

Gao AiHua, Zhang YuGuo, Nan YueMin

2015, 31(4): 594-598. DOI: 10.3969/j.issn.1001-5256.2015.04.029

Abstract(1742)

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Abstract:
The treatment responses to pegylated interferon alpha( PEG- IFNα) in patients with chronic hepatitis B( CHB) are associated with the genetic polymorphisms,immune status,hepatitis B virus genotype,and viral load of the host. This article reviews the recent studies on influential factors for the respo...

Latest progress in treatment of chronic hepatitis B with tenofovir disoproxil fumarate

Zhang Yue, Lu: Yang, Li Xu, Gao PuJun

2015, 31(4): 599-602. DOI: 10.3969/j.issn.1001-5256.2015.04.030

Abstract(2309)

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Abstract:
There are 400 million individuals infected with chronic hepatitis B virus( HBV) all over the world. The management of chronic hepatitis B( CHB) has been improved markedly over the last decade,primarily due to the availability of oral nucleoside analogue( NA)therapy. Among the numerous NAs,tenofovir ...

Research progress in Treg/Th17 imbalance in persistent HBV infection

Cheng Ping, Xue BoYu

2015, 31(4): 603-606. DOI: 10.3969/j.issn.1001-5256.2015.04.031

Abstract(1648)

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Abstract:
Persistent infection with hepatitis B virus( HBV) is associated with host immune response. CD4+T cells play an important role in HBV- specific immune response. The restoration of HBV- specific T- cell response after antiviral therapy using nucleoside and nucleotide analogues is also associated with ...

Research advances in receptor and inhibitors of hepatitis B virus entry

Li Qiang, Zhuo QiBin, Huang YuXian, Chen Liang

2015, 31(4): 607-610. DOI: 10.3969/j.issn.1001-5256.2015.04.032

Abstract(2346)

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Abstract:
Sodium taurocholate cotransporting polypeptide( NTCP) was identified as the receptor for hepatitis B virus( HBV) infection in2012. The finding of HBV receptor has provided a new target for the development of new anti- HBV drugs. This article describes the bottleneck of research on HBV infection,as w...

Research advances in drug resistance to nucleos( t) ide analogues in treatment of chronic hepatitis B

Fan Xiu, Lin XiaoDong, Cen XiaoHong, Hou YuXiang

2015, 31(4): 611-613. DOI: 10.3969/j.issn.1001-5256.2015.04.033

Abstract(2005)

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Abstract:
Antiviral treatment is the key in the treatment of chronic hepatitis B. The long- term antiviral therapy with nucleos( t) ide analogues may lead to the viral gene mutations and drug resistance,and then the sensitivity of virus to the drug is decreased. In this study,the point mutations associated wi...

Research progress in dynamic evolution characteristics of nucleos( t) ide analogue-resistant mutants

Wang Yang, Liu Shuang, Zhou Li, Zheng SuJun, Duan ZhongPing

2015, 31(4): 614-617. DOI: 10.3969/j.issn.1001-5256.2015.04.034

Abstract(1824)

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Abstract:
Long- term antiviral therapy with nucleos( t) ide analogues against hepatitis B virus may lead to the occurrence of drug- resistant viral mutations. As a challenging topic in antiviral research,the problem of drug- resistant mutations may be associated with the aggregation of chronic hepatitis B and...

Role of interleukin-10 in prognosis of hepatitis B virus infection

Wu ZhangHui, Wei Jia

2015, 31(4): 618-621. DOI: 10.3969/j.issn.1001-5256.2015.04.035

Abstract(1687)

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Abstract:
Multiple etiological factors are integrally involved in the development of hepatitis B virus( HBV) infection. Interleukin- 10( IL-10) is an essential cytokine of immune regulation,and IL- 10 gene promoter polymorphism affects its mRNA transcription and serum level.IL- 10 is related to the prognosis ...

Research progress in interleukin 28B polymorphisms in infection and treatment of chronic hepatitis B virus

Zhang Can, Wan Hui, Chen Hong, Zhang Kai

2015, 31(4): 622-625. DOI: 10.3969/j.issn.1001-5256.2015.04.036

Abstract(2379)

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Abstract:
The infection / clearance and antiviral therapy of hepatitis B virus( HBV) are affected by various factors,such as the host,virus,and environment. Recent studies have proven that interleukin 28B( IL- 28B) polymorphisms are highly associated with the clearance and antiviral therapy of hepatitis C vir...

Research progress in antiviral therapy for chronic hepatitis C

Yu GuoYing, Huang Qun, Ma YuXiu

2015, 31(4): 626-629. DOI: 10.3969/j.issn.1001-5256.2015.04.037

Abstract(2584)

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Abstract:
Antiviral therapy is the most important treatment for chronic hepatitis C. This paper reviews the progress in antiviral treatment over recent years,including the combination therapy with polyethylene glycol- Interferon( PEG- IFN) and ribavirin( RBV),specific target therapy,and gene therapy. The pape...

Research progress in relationship between TLR4 and nonalcoholic fatty liver disease

Shen Min, Fan HuaiYan, Wei Jia

2015, 31(4): 630-634. DOI: 10.3969/j.issn.1001-5256.2015.04.038

Abstract(2624)

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Nonalcoholic fatty liver disease( NAFLD) is prevalent in patients with characteristics of metabolic syndrome. The main clinicopathological manifestations of NAFLD are fatty degeneration of liver parenchyma cells and fat storage,which can progress to liver cirrhosis and eventually lead to liver failu...

Roles of epithelial cell adhesion molecule in diagnosis and treatment of hepatocellular carcinoma

Zhang MinNa, Yang YongPing, Mao PanYong

2015, 31(4): 635-638. DOI: 10.3969/j.issn.1001-5256.2015.04.039

Abstract(2765)

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Epithelial cellular adhesion molecule( Ep CAM) is a transmembrane glycoprotein expressed in epithelial tissues and most epithelial- derived malignant tumors. Ep CAM is associated with cell adhesion,migration,proliferation,and differentiation,as well as tumor development and progression. In recent ye...

Advances in multidisciplinary individualized treatment of refractory hepatic alveolar echinococcosis

Abuduaini Abulizi, Wen Hao

2015, 31(4): 639-641. DOI: 10.3969/j.issn.1001-5256.2015.04.040

Abstract(2711)

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Hepatic alveolar echinococcosis( HAE) is a zoonotic parasitic disease that seriously threatens the population in western China and compromises patients' quality of life. With the continuous improvement in radical resection rate in recent years,late- stage HAE patients that were incurable in the past...

A review of relationship between gut microecology and liver diseases

Wang XiaoTong, Han Tao

2015, 31(4): 642-645. DOI: 10.3969/j.issn.1001-5256.2015.04.041

Abstract(2673)

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Abstract:
In recent years,gut microecology has attracted increasing attention because of its close relationship with the development and progression of various liver diseases and associated complications. The impairment of liver function can disturb gut microecology,whereas the imbalance in gut microecology i...