Antiviral therapy is the most important treatment for chronic hepatitis C. This paper reviews the progress in antiviral treatment over recent years,including the combination therapy with polyethylene glycol- Interferon( PEG- IFN) and ribavirin( RBV),specific target therapy,and gene therapy. The paper believes that the anti- hepatitis C virus treatment needs more effective drug combination therapies,shorter courses,less side effect,higher drug resistance threshold,etc.