Epithelial cellular adhesion molecule( Ep CAM) is a transmembrane glycoprotein expressed in epithelial tissues and most epithelial- derived malignant tumors. Ep CAM is associated with cell adhesion,migration,proliferation,and differentiation,as well as tumor development and progression. In recent years,Ep CAM has been identified as a stem cell marker of hepatocellular carcinoma( HCC). This paper elucidates the roles of Ep CAM in the diagnosis,treatment,and prognosis of HCC,which shed light on the potential molecular targeted therapy in future.
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