Cholestatic hepatopathy is one of the most common diseases in infants including the newborn and it is one of the most significant reasons for infantile death and disability. There are a large number of causes and a large variance in prognosis of this disease. This paper introduces approaches to the diagnosis of biliary atresia and cholestatic hepatopathy and presents a synopsis of therapies for cholestatic hepatopathy in infants nowadays. This paper points out that in future,cooperation across disciplines should be enhanced; new technologies should be developed; academic communication should be held regularly; the early diagnosis and personalized medication of cholestatic hepatopathy in infants should be improved.