With the improvement in health economics and wide application of vaccines,the incidence of viral hepatitis decreases dramatically; however,the proportion of non- infectious liver diseases,such as nonalcoholic fatty liver disease,hereditary liver disease,and autoimmune hepatitis,climbs up rapidly. Th...

For children with chronic hepatitis B( CHB),the antiviral therapy should be started in the immune active phase. There are two categories of antiviral drugs used for CHB: interferons( IFNs) and nucleos( t) ide analogues( NAs). In this paper,the current status of antiviral therapy of CHB in children i...

In recent years,the incidence of idiosyncratic drug- induced liver injury( IDILI) has been increasing,posing a threat to human health. This article reviews the incidence,pathogenesis,and the principles of clinical diagnosis and treatment of IDILI. Because there is limited literature on IDILI in chil...

Cholestatic hepatopathy is one of the most common diseases in infants including the newborn and it is one of the most significant reasons for infantile death and disability. There are a large number of causes and a large variance in prognosis of this disease. This paper introduces approaches to the ...

Intestinal microecology is an important and complex biological system essential to human health. Intestinal microecology and the liver are closely related in anatomical structure and function. Infantile cholestatic liver disease lead to abnormal bile secretion,abnormal excretion,and reduced bile rel...

Biliary atresia is an important reason for neonatal jaundice,and it is also the primary cause of liver transplantation in children.Porto- jejunal anastomosis( Kasai procedure) is an effective method for treating biliary atresia. In this article,the complications after Kasai procedure and long- term ...

Elevation of aminotransferase could be seen in children with various diseases. Early diagnosis and etiological treatment could improve the prognosis of some diseases and reduce liver injury,so early diagnosis plays a crucial role for treatment. In this paper,diagnosis and differential diagnosis of t...

Objective To analyze the correlation between malnutrition and prognosis in Uyghur pediatric patients with hepatitis A in Hetian of Xinjiang Uyghur Autonomous Region,China. Methods The clinical data of 342 children with hepatitis A admitted to the Infectious Disease Hospital of Hetian from January 20...

Objective To study the blocking effects of different concentrations of hepatitis B vaccine( Hep B) combined with hepatitis B immune globulin( HBIG) on mother- to- infant transmission of hepatitis B virus( HBV) and the influencing factors for mother- to- infant transmission of HBV. Methods A total of...

Objective To investigate the clinical characteristics and outcomes of drug- induced liver injury( DILI) in children,and to improve the understanding of DILI in children. Methods One hundred and eighty- four children with DILI who were under 16 years and hospitalized in our hospital from January 2004...

Objective To provide a scientific basis for the prevention and early intervention of obesity and nonalcoholic fatty liver disease( NAFLD) in adolescents. Methods Anthropometric measurements,liver function test,and abdominal ultrasonography were performed in adolescents who received physical examinat...

Objective To investigate the significances of clinical diagnostic approaches to biliary atresia( BA) and intrahepatic cholestasis( IHC) in children,and to improve clinicians' understanding of BA and reduce the rates of missed diagnosis and false diagnosis. Methods A total of 133 children diagnosed w...

Objective To investigate the value of tandem mass spectrometry( MS / MS) in the etiological diagnosis of cholestasis in infants.Methods A total of 153 infants with cholestasis who visited the Department of Pediatrics,Shengjing Hospital,China Medical University,from January 2013 to March 2015 were st...

Objective To observe the clinical efficacy of artificial extracorporeal liver support therapy in the treatment of pediatric acute liver failure( PALF) and to analyze the associated prognostic factors. Methods The clinical records of 23 patients with PALF treated from January 2012 to February 2015 in...

Objective To explore the influencing factors for chronic hepatitis C( CHC) with thyroid dysfunction( TD) in untreated Chinese patients and provide evidence for clinical individualized treatment. Methods One thousand and twelve untreated CHC patients were collected nationwide in China. Thyroid functi...

Objective To preliminarily investigate the relationship between the chronic hepatitis C virus( HCV) genotypes,2a and 1b,and thyroid hormone levels and autoantibodies. Methods In patients who were admitted to our hospital and diagnosed with chronic hepatitis C from October 2013 to December 2014,rever...

Objective To assess the accuracy of indirect enzyme- linked immunosorbent assay( ELISA) for hepatitis C virus( HCV) antibody as a routine test in the blood center,discuss how to optimize the reporting process for HCV antibody,and protect donors' enthusiasm and precious blood resources. Methods A tot...

Objective To explore the serological characteristics of viral hepatitis patients with positive anti- mitochondrial antibody( AMA)- M2 and its clinical implications. Methods Serum was collected from viral hepatitis patients who were admitted to Beijing You'an Hospital,Capital Medical University,from ...

Objective To analyze the efficacy of endoscopic histoacryl injection in the treatment of gastric variceal bleeding caused by regional portal hypertension. Methods The endoscopic features and efficacy of endoscopic histoacryl injection were examined and compared in two groups of patients admitted to ...

Objective To explore the efficacy of terlipressin therapy for refractory ascites in cirrhosis and type- 2 hepatorenal syndrome( HRS- 2). Methods Forty patients with refractory ascites in cirrhosis and HRS- 2 who were admitted to our hospital from June 2009 to June 2014 were randomly divided into tre...

Objective To assess the clinical efficacy of percutaneous transhepatic cholecystostomy in elderly patients with severe calculous cholecystitis. Methods The clinical data of 60 elderly patients with severe calculous cholecystitis were analyzed. All of the patients were divided into observation group ...

Objective To explore the clinical efficacy of endoscopic biliary metallic stent drainage( EBMSD) in the treatment of malignant obstructive jaundice( MOJ). Methods A total of 48 patients with MOJ who underwent EBMSD in the General Hospital of Beijing Military Command from January 2012 to April 2014 w...

Objective To investigate the expression and significance of Bax,cyclooxygenase- 2( COX2),and inhibitor of differentiation 1( ID1) in gallbladder adenocarcinoma tissues. Methods A total of 70 patients confirmed with gallbladder adenocarcinoma by pathological examination in the Department of Pathology...

Objective To analyze the clinical characteristics of drug- induced liver injury( DILI) accompanied by autoimmune phenomena and to provide evidence for clinical practice. Methods An analysis was performed on the clinical data of 51 patients who were admitted to Beijing You'an Hospital from 2011 to 20...

Objective To summarize the imaging characteristics of solitary necrotic nodule of the liver( SNNL) on contrast- enhanced ultrasonography( CEUS) and to investigate the role CEUS plays in the diagnosis and differential diagnosis of SNNL. Methods Twenty- five lesions of 23 cases diagnosed with SNNL by ...

Objective To investigate the effect of plasma exchange with non- bioartificial liver support system on serum manganese levels in patients with hepatic encephalopathy and its clinical significance. Methods A total of 22 inpatients with hepatic encephalopathy who were admitted to our hospital from Oct...

Objective To summarize the survival outcomes of 34 cases of liver transplantation,and analyze the influencing factors for the long- term survival outcomes after liver transplantation. Methods Thirty- four patients who underwent liver transplantation in our hospital from September 2002 to August 2014...

Objective To perform preoperative planning,virtual resection,and risk assessment for patients to be treated by hepatectomy using the liver hepatic image analysis system( IQQA- Liver) and to evaluate the effect and feasibility of three- dimensional( 3D) image reconstruction in assisting liver surgery...

Since age at hepatitis B virus( HBV) infection is a major risk factor associated with the chronicity of HBV,it is of great importance to evaluate the effect of immunoprophylaxis as early as possible in the mother- to- child transmission. This review focuses on HBV serologic and virologic markers in ...

Congenital biliary atresia is considered a neonatal rare disease with multiple causes and phenotypes,whose pathogenesis remains unclear. At present,the etiological study of congenital biliary atresia mainly focuses on viral infection,immune disorder,and dysplasia.This paper summarizes the main etiol...

It has been confirmed that the body's response to hepatitis C virus( HCV) is not only associated with virus,but also associated with some cytokines and their gene polymorphisms. In this paper,the current research on some cytokines associated with HCV and their gene polymorphisms is reviewed. And it ...

It has been found in recent years that adipose tissue is not only the organ for storing energy,but can also secrete many adipokines including leptin,adiponectin,and resistin. Leptin and adiponectin play important roles in the formation and treatment of non- alcoholic fatty liver disease( NAFLD) due ...

It is vital for reducing the occurrence of complications,such as liver cirrhosis and hepatic carcinoma,to early diagnose liver fibrosis in chronic hepatitis B and intervene in time with antiviral therapy. Although liver biopsy is the " golden standard" for the diagnosis of fibrosis,it has certain di...

Liver cirrhosis is the final outcome of various chronic liver diseases. In recent years,along with the rapid development of molecular biology and cell biological engineering technology,liver regeneration based on stem cell transplantation technique has become a new research hotspot for treatment of ...

Primary biliary cirrhosis( PBC) is an autoimmune liver disease characterized by chronic and progressive cholestasis,which has a tendency to develop cirrhosis. The pathogenesis of PBC is complicated and still unclear. This paper reviews the latest research progress in immunological mechanisms and the...