It has been confirmed that the body's response to hepatitis C virus( HCV) is not only associated with virus,but also associated with some cytokines and their gene polymorphisms. In this paper,the current research on some cytokines associated with HCV and their gene polymorphisms is reviewed. And it is shown that interleukin- 28 B is closely associated with the course and prognosis of chronic hepatitis C( CHC). Therefore,it is of great significance for the clinical diagnosis and treatment of CHC to investigate host cytokines and their gene polymorphisms.
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