Liver failure is a clinical critical illness,and its complications have various clinical manifestations,often resulting in local or systemic invasive fungal disease( IFD). The damage of other organs may occur secondary to IFD in liver failure patients,thus worsening liver injury. This will ultimately lead to multiple organ failure with extremely high fatality,so it is very difficult to manage. To investigate the causes,symptoms,diagnosis,treatment,prognosis,and prevention of IFD in liver failure,this article reviews the consensus and controversy over IFD in liver failure in recent years and describes the significance and prospect of its research,with the purpose of improving the clinical diagnosis and treatment of IFD in liver failure.