Liver failure is a complex process involving many factors. The molecular therapy targeting the cytokines and receptors associated with liver failure has become the research hotspots in recent years. Immunotherapy for liver failure includes promoting the regeneration of hepatocytes and immunoregulati...

Liver failure is a threat to human health. The survival of patients has been increased with the improvement in both diagnosis and treatment. Several major advances in the diagnosis and treatment of liver failure have been made in recent years,as follows: the EASL-defined diagnostic criteria for acut...

Liver failure is a clinical critical illness,and its complications have various clinical manifestations,often resulting in local or systemic invasive fungal disease( IFD). The damage of other organs may occur secondary to IFD in liver failure patients,thus worsening liver injury. This will ultimatel...

Acute-on-chronic liver failure( ACLF) is the most complicated form of liver failure among various types of liver failure. There are certain differences in the conception,etiology,and pathogenesis of ACLF between different regions. In recent years,ACLF has attracted attention of hepatologists all ove...

Liver failure is a common clinical syndrome of serious liver disease with high fatality. Artificial liver support system is one of the effective methods in the treatment of liver failure,which is widely used by clinicians as a common treatment method for liver failure. This article reviews the princ...

Liver failure is a common pathophysiological process of various hepatic diseases developing into the end stage. Because of its intricate pathogenesis and lack of specific and impactful treatment,the incidence and mortality of hepatic failure remains high and life-threatening. Currently,the principle...

Bacterial infection is a common complication in patients with liver cirrhosis,and acute-on-chronic liver failure due to bacterial infection has become a serious clinical problem. There are still many problems in the research on the pathogenesis and management of bacterial infection in liver cirrhosi...

Objective To investigate the predictive values of four scoring systems,the Model for End-Stage Liver Disease( MELD),the MELD with incorporation of serum sodium( MELD-Na),the integrated MELD( i MELD),and the MELD to serum sodium ratio( MESO),in the short-term prognosis of patients with hepatitis B-as...

Objective To learn the clinical characteristics of concurrent acute-on-chronic liver failure( ACLF) and hepatorenal syndrome( HRS),and to investigate the predictive factors for HRS in patients with ACLF. Methods A total of 806 patients with ACLF who were admitted to our hospital from January 2012 to...

Objective To explore the methods for prevention and treatment of endotoxemia and multiple organ failure in patients with severe hepatitis. Methods A total of 61 patients with severe hepatitis and toxic enteroparalysis were randomly assigned to three groups. The first group was treated with plasmaphe...

Objective To study the clinical features and liver pathology in chronic hepatitis B( HBV)-infected patients with normal liver function,and to explore the influencing factors. Methods A total of 316 chronic HBV-infected patients with normal liver function who were admitted to our hospital from August...

Objective To study the causes and influential factors for relapse after drug withdrawal in patients with chronic hepatitis C( CHC). Methods One hundred and one cases of CHC,including 36 males and 65 females,who were outpatients or inpatients in our hospital,were enrolled as subjects. Twenty-six pati...

Objective To study the relationship between Helicobacter pylori( H. pylori) infection and common lethal factors for hepatitis B virus-related cirrhosis( HBC). Methods A total of 235 patients with HBC who were admitted to our hospitals from October 2008 to October 2014 were retrospectively analyzed. ...

Objective To investigate the effects of Monsel's solution on bleeding in endoscopic sclerotherapy for esophageal varices. Methods One hundred and sixteen patients with cirrhosis and esophageal variceal bleeding who were admitted to our hospital from February 2013 to February 2015 were enrolled as su...

Objective To investigate the immunological improvement effects of different doses of ursodeoxycholic acid( UDCA) on patients with different stages of primary biliary cirrhosis( PBC) and enhance the understanding of the roles of the immune system in the disease,and to provide evidence for the standar...

Objective To analyze the expression levels of γ-glutamyl transpeptidase( GGT) and alpha-fetoprotein( AFP) and their correlation in patients with hepatocellular carcinoma( HCC) and to evaluate their diagnostic values for HCC. Methods A total of 160 patients consisting of 84 cases of HCC and 76 cases ...

Objective To explore the prognostic factors for patients treated by radical resection of the liver metastases from colorectal cancer and to analyze the significance of these factors. Methods The clinical and pathological data concerning 182 patients with liver metastases from colorectal cancer,who w...

Objective To study the changes in biological characteristics of a liver cancer cell line PLC / RAF /5 after repeated exposure to a chemotherapy drug,5-fluorouraci( 5-FU),and to investigate the relationship between drug-resistant liver cancer cells and liver cancer stem cells. Methods A low concentra...

Objective To systematically evaluate the clinical efficacy of somatostatin and its analogues combined with proton pump inhibitor in the prevention of pancreatitis after endoscopic retrograde cholangiopancreatography( ERCP) by an evidence-based medicine approach.Methods Articles were searched manuall...

Objective To determine the Golgi protein-73( GP73) level and platelet( PLT) count in the peripheral blood of patients with hepatitis B virus( HBV)-related liver diseases and to investigate their values in diagnosing different stages of HBV-related liver diseases.Methods Peripheral blood samples were...

Objective To investigate the main clinical characteristics of patients with autoimmune hepatitis( AIH). Methods An analysis was performed on the data of 194 AIH patients who visited Guanggu Branch of Hubei Provincial Hospital of Traditional Chinese Medicine from December 2010 to December 2014 and 19...

Objective To study the effect of high altitude( HA) of 4300 m on the hepatic gluconeogenesis in rats and its underlying mechanism. Methods Thirty-six healthy adult male Sprague-Dawley( SD) rats were randomly assigned to group H1( HA exposure for 1 day,n = 6),group H3( HA exposure for 3 days,n = 6),g...

Acute-on-chronic liver failure( ACLF),a severe hepatic syndrome,is the most common type of hepatic failure in China,which has no specific treatment until now. Traditional therapies mainly include comprehensive medical treatment,artificial liver support system( ALSS),and liver transplantation. In rec...

Acute-on-chronic liver failure( ACLF) is a severe liver disease with high mortality in China. Early diagnosis could reduce complications and improve the survival rate. In the present review,the definition,etiology,and pathogenesis related to inflammatory response,reactive oxygen species,and metaboli...

Liver diseases are common in China. When the diseases progress to the end stage,liver transplantation has been considered as the most effective means of treatment. Whereas,due to the causes such as lack of donors,the treatment of acute-on-chronic liver failure has been restricted. While stem cells,e...

A high proportion of the causes of liver failure remain unknown. This paper reviews the progress in the epidemiology,etiology,treatment,and prognosis of liver failure of unknown etiology. The possible causes of liver failure of unknown etiology may include occult hepatitis B virus infection,herpesvi...

Current antiviral treatment strategy for chronic hepatitis B( CHB) includes pegylated interferon( PEG-IFN) and nucleos( t) ide analogues( NAs). Whether combination therapy with PEG-IFN and NAs improve therapeutic efficacy has become the key question regarding the antiviral therapy for CHB. This arti...

Chronic infection with hepatitis B virus( HBV) often leads to the development of liver cirrhosis and liver cancer,creating immense sociological,clinical,and economic burdens worldwide. Although current anti-HBV drugs can control the disease progression,they often fail to eliminate the virus because ...

Hepatitis B virus( HBV) infection is the main cause of liver fibrosis,cirrhosis,and hepatocellular carcinoma,and it is also a major health problem around the world. How to establish an efficient,reliable,and standardized animal model of chronic HBV infection is essential to the study of the pathogen...

Spontaneous portosystemic shunt( SPSS) has not yet drawn enough attention. The incidence of SPSS in cirrhotic patients is 38%-40%,and 46%-70% of cirrhotic patients with refractory encephalopathy show SPSS. Embolization of SPSS may be a safe and effective method for the treatment of refractory enceph...

Liver fibrosis is the common pathological consequence of all chronic liver diseases with various etiologies. The mechanism of liver fibrosis is associated with the activation and proliferation of hepatic stellate cells( HSCs). The interaction between immune cells and HSCs can regulate the production...

Recent studies have found that endoplasmic reticulum stress( ERS) is a common feature of the pathogenesis of organ fibrosis.However,the functional alteration of ERS and its potential role in the process of liver fibrosis is still unclear. This review summarizes the potential function of ERS and ERS-...

In the past,liver cirrhosis was thought to be irreversible. However,theoretically,the process of liver cirrhosis could be slowed down by inhibiting extracellular matrix( ECM) production and by promoting its degradation. Wnt signaling pathway has been involved in many physiological and pathological p...

Abnormal liver function is biochemical and pathological changes in the liver caused by damages from pathogens,which can be found in viral hepatitis,fatty liver,alcoholic liver diseases,autoimmune liver diseases,and some non-liver diseases. Due to the diversity in etiology,it is difficult to make a d...

The hepatic nodular lesions in the progression of various chronic liver diseases are hot topics all the time. There is a close relationship between hepatic nodular lesions and hepatocellular carcinoma( HCC),and the former is the precancerous lesions of the latter. This paper summarizes the pathologi...

Liver resection is the main method of treatment of hepatic space-occupying lesion,and pleural effusion is one of the common complications. With the technological development in recent years,this paper analyzes the pleural effusion after liver resection from the aspects of hypoproteinemia,diaphragm d...

The renin-angiotensin system( RAS) is a classical circulating enzyme pathway that plays an important role in regulation of pancreatic function. In recent years,with deepening understanding of RAS,researchers found that RAS not only includes the classical ACE-Ang II-AT1 axis,but also includes the new...