Liver failure is a common clinical syndrome of serious liver disease with high fatality. Artificial liver support system is one of the effective methods in the treatment of liver failure,which is widely used by clinicians as a common treatment method for liver failure. This article reviews the principle and classification of artificial liver support system and summarizes the latest progress in the study and treatment of non-bioartificial liver support system in recent years. The research hotspots of bioartificial liver are also reviewed. Finally,the prospect of Li's artificial liver support system is discussed.