Bacterial infection is a common complication in patients with liver cirrhosis,and acute-on-chronic liver failure due to bacterial infection has become a serious clinical problem. There are still many problems in the research on the pathogenesis and management of bacterial infection in liver cirrhosis,such as insidious onset,difficult early diagnosis,and increased multi-drug resistant bacteria. This article reviews the research progress in the causes and management of bacterial infection in liver cirrhosis. More effective strategies for the prevention,early diagnosis,and reasonable treatment of bacterial infection in liver cirrhosis should be developed to reduce the mortality of severe patients.