A high proportion of the causes of liver failure remain unknown. This paper reviews the progress in the epidemiology,etiology,treatment,and prognosis of liver failure of unknown etiology. The possible causes of liver failure of unknown etiology may include occult hepatitis B virus infection,herpesvirus infection,transfusion-transmitted virus infection,hepatitis G virus infection,human parvovirus Bl9 infection,autoimmune and hepatitis. Aciclovir can be considered in the empirical treatment for patients with liver failure of unknown etiology.The mortality in patients with liver failure of unknown etiology is high. The research on the etiology and treatments should be strengthened.
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