The renin-angiotensin system( RAS) is a classical circulating enzyme pathway that plays an important role in regulation of pancreatic function. In recent years,with deepening understanding of RAS,researchers found that RAS not only includes the classical ACE-Ang II-AT1 axis,but also includes the new ACE2-Ang( 1-7)-Mas axis. Extensive studies have confirmed that the ACE2-Ang( 1-7)-Mas axis can antagonize the effect of the ACE-Ang II-AT1 axis. This paper reviews the composition and function of both axes of the RAS in the local pancreas,and also presents the comparison between the two axes.
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