Intrahepatic cholestasis is a manifestation of liver damage commonly seen in clinical practice,with a complex etiology and involvement of a wide range of diseases. Its pathogenesis is related to hepatocellular damage and bile capillary cell damage,bile acid transport disorder,and abnormal bile flow. The treatment of intrahepatic cholestasis mainly includes drug therapy,and major drugs include ursodeoxycholic acid,obeticholic acid,S- adenosyl methionine,and traditional Chinese medicine preparations. The pathogenesis and treatment of intrahepatic cholestasis are reviewed in this article.
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