Intrahepatic cholestasis is a manifestation of liver damage commonly seen in clinical practice,with a complex etiology and involvement of a wide range of diseases. Its pathogenesis is related to hepatocellular damage and bile capillary cell damage,bile acid transport disorder,and abnormal bile flow....

Progressive familial intrahepatic cholestasis( PFIC) refers to a heterogeneous group of autosomal- recessive disorders. The estimated incidence varies between 1 /50,000 and 1 /100,000 births. Three types of PFIC have been identified and related to mutations in hepatocellular transport system genes i...

Primary biliary cirrhosis( PBC) is a chronic autoimmune cholestatic liver disease. The paper introduces the progress in etiology,pathogenesis,clinical characteristics,and treatment of PBC,which has great significance for early diagnosis,disease surveillance,guiding standardized treatment,and improvi...

The incidence of iatrogenic bile duct injuries has been increased along with the application of laparoscopic surgery,although surgical lesions have been reduced and postoperative recovery has been accelerated. Once bile duct injury occurs,the short- term and long-term adverse effects are very severe...

Hepatolithiasis is one of the most prevalent benign biliary tract diseases in Southwest China,and surgery is the optimal treatment for this disease. However,hepatolithiasis has insidious onset and complicated course,as well as high rate of residual stones and recurrence and high incidence of cholang...

Objective To explore the clinical efficacy of several medications for acute biliary colic. Methods Two hundred and forty patients with acute biliary colic admitted to Beijing Anzhen Hospital from January 2012 to January 2014 were selected for retrospective analysis and randomly divided into four gro...

Objective To analyze the clinical efficacy of glucocorticoid therapy in addition to conventional treatment for patients with drug-induced cholestatic liver disease. Methods A total of 115 patients with drug- induced cholestatic liver disease who were admitted to Affiliated Hospital of Inner Mongolia...

Objective To investigate the prevalence of cholelithiasis in the employees of Kailuan Corporation and to provide a reference for effective preventive measures. Methods A total of 101 510 in- service or retired employees of Kailuan Corporation were recruited. All of them completed checkups organized ...

Objective To systematically evaluate the association between smoking and the risk of primary biliary cirrhosis( PBC) from the perspective of evidence- based medicine. Methods A literature search was performed in Pub Med,EMBASE,CBM,CNKI,Wanfang Data,and VIP database to collect the case- control studi...

Objective To assess the efficacy of adjuvant therapy with fenofibrate for primary biliary cirrhosis( PBC). Methods CNKI,Wanfang Data,China Biology Medicine,Pub Med,Embase,and Cochrane library were searched for the pertinent literature of randomized controlled trials( RCTs) of adjuvant therapy with f...

Objective To evaluate the clinical effect of holmium laser lithotripsy combined with fiber choledochoscope in the treatment of intra- and extra- hepatolithiasis. Methods Sixty- four patients who were diagnosed with intra- and extra- hepatolithiasis in our hospital from January 2012 to July 2014 were...

Objective To evaluate the safety and efficacy of therapeutic endoscopic retrograde cholangiopancreatography( ERCP) in very elderly patients( 85 years or older) with common bile duct stones. Methods A retrospective study was conducted on 150 patients with common bile duct stones who underwent ERCP in...

Objective To investigate the efficacy of endoscopic retrograde cholangiopancreatography( ERCP) in the treatment of acute obstructive suppurative cholangitis( AOSC),and to examine the results of bile bacterial culture and drug susceptibility test. Methods A retrospective analysis was performed on 150...

Objective To analyze the clinical characteristics of patients treated with multiple therapeutic endoscopic retrograde cholangiopancreatography( ERCP) procedures and to evaluate the causes,safety,and efficacy of repeated ERCP. Methods Analyses of therapeutic results,complications,and postoperative ou...

Objective To compare the efficacy of precise and traditional liver resection in the treatment of intrahepatic bile duct stones.Methods One hundred and twenty- seven patients with intrahepatic bile duct stones who were treated with surgery in our hospital from December 2008 to December 2014 were sele...

Objective To explore the clinical application of preoperative biliary drainage in the treatment of patients with malignant obstructive jaundice( MOJ) with acute cholangitis( AC). Methods A retrospective study was performed on the clinical data of 74 patients with MOJ and AC who were treated with pre...

Objective To observe the effects of different suture techniques on complications after choledochojejunostomy. Methods A retrospective analysis was performed on the clinical data of 162 patients who underwent choledochojejunostomy from January 2005 to December2014 in our hospital. The patients were d...

Objective To systematically review the efficacy and safety of fast- track surgery( FTS) in perioperative nursing for biliary calculi surgery. Methods Online databases of Pub Med,Cochrane Library,CBM,CNKI,VIP,and Wanfang Data were comprehensively searched for relevant randomized controlled trials( RC...

Objective To systematically evaluate the advantages and disadvantages of choledochoscopic gallbladder- preserving cholelithotomy( CGPC) and laparoscopic cholecystectomy( LC) in the treatment of gallstones. Methods The databases of CBM,CNKI,VIP,Wanfang Data,Pub Med,EMBASE,the Cochrane Library,and Web...

Objective To analyze the influencing factors for conversion of laparoscopic cholecystectomy to open surgery,and to provide a clinical reference for developing surgical procedures. Methods A total of 278 patients receiving laparoscopic cholecystectomy in our hospital from January 2009 to December 201...

Objective To investigate the identification and treatment of variation of extrahepatic bile duct in laparoscopic cholecystectomy( LC),and to reduce the occurrence of bile duct injury. Methods This study included 60 patients who received LC in the People's Hospital of Caidian District in Wuhan and ha...

Objective To evaluate the clinical efficacy of transumbilical single- port laparoscopic cholecystectomy in patients with acute cholecystitis and the effect of this surgical procedure on the postoperative recovery of gastrointestinal function. Methods This study enrolled74 patients who were diagnosed...

Objective To investigate the risk factors for the complications of transumbilical single- port laparoscopic cholecystectomy( TUSPLC) and to explore the prophylactic methods. Methods The clinical data of 120 patients undergoing TUSPLC in our hospital from January 2012 to December 2014 were retrospect...

Objective To explore the feasibility and efficacy of percutaneous transhepatic approach in the treatment of intrahepatic and extrahepatic bile duct stones. Methods Nineteen patients with bile duct stones who were treated in our hospital from January 2000 to October2014 were enrolled as subjects. In ...

Objective To investigate the factors influencing the liver histological features in chronic hepatitis B virus( HBV) infection patients with low alanine transaminase( ALT) levels by analyzing the relationship of serum hepatitis B surface antigen( HBs Ag) level with liver inflammation grade and fibros...

Objective To investigate the HBs Ag seroprevalence in the young generation in Qidong of Jiangsu Province,China. Methods A total of 15 534 students for college entrance examination from 2006 to 2014 were randomly selected from three secondary schools in Qidong as student group. Some of them had hepat...

Objective To study the quality of life( Qo L) and its influential factors among outpatients with chronic hepatitis B or C. Methods Patients diagnosed with chronic hepatitis B or C between March 2012 and March 2014 were included in the hepatitis group,whereas volunteers presenting with neither signif...

Objective To investigate the impacts of mannan- binding lectin( MBL) on the phenotype and function of CD11c- positive human peripheral blood myeloid dendritic cells( CD11c+m DC). Methods CD11c+m DC and CD4+T lymphocytes from healthy human volunteers were isolated by magnetic bead sorting and were st...

Although there are many surgical methods for intrahepatic bile duct stones,one single treatment cannot achieve the satisfactory therapeutic effect. The article introduces the progress in the etiology,pathological features,and therapeutic methods for intrahepatic bile duct stones. It is reckoned that...

Post- cholecystectomy syndrome( PCS) is a common digestive disease. The incidence of PCS is increasing with the popularization of laparoscopic technique. This article introduces the etiology,diagnosis,and treatment of PCS,and discusses the controversy over whether the gallbladder should be resected,...

In order to achieve the sustained suppression of hepatitis B virus replication,the long- term and even life- long antiviral therapy is needed for patients with chronic hepatitis B( CHB). So the adherence to antiviral therapy is one of the critical factors for achieving effective therapy. In this art...

HBV is a major health problem faced by human beings. The study of the mechanism of HBV infection has been a key point in this field. To carry out the related research on HBV,establishment of simple and available in vivo and in vitro infection models is the trend. Due to the close relationship betwee...

Intravoxel incoherent motion diffusion- weighted imaging( IVIM- DWI) can not only obtain various parameters,but also provide diffusion and perfusion information without contrast agents. IVIM- DWI could make up for the deficiency of traditional DWI and contrast enhancement methods. This paper introdu...