Diffusion-weighted magnetic resonance imaging for evaluation of micro-angiogenesis in residual tumor after treatment with percutaneous ethanol injection in a rabbit VX2 liver tumor model

Chen Juan; Yin HuaBin; Zhang HuanHuan; Wei ChunXiao; Wang Li; Qian Ting

doi:10.3969/j.issn.1001-5256.2016.01.018

Volume 32 Issue 1

Jan. 2016

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Article Navigation > Journal of Clinical Hepatology > 2016 > 32(1): 101-105

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Diffusion-weighted magnetic resonance imaging for evaluation of micro-angiogenesis in residual tumor after treatment with percutaneous ethanol injection in a rabbit VX2 liver tumor model

DOI: 10.3969/j.issn.1001-5256.2016.01.018

Department of Radiology,Shanghai Fifth People's Hospital Affiliated to Fudan University

Research funding:

Received Date: 2015-08-24
Published Date: 2016-01-20

Abstract

Abstract

Objective To investigate the application of diffusion- weighted magnetic resonance imaging( DW- MRI) for the evaluation of the therapeutic effect of percutaneous ethanol injection( PEI) and its effect on micro- angiogenesis in residual tumor in a rabbit VX2 liver tumor model. Methods A total of 26 rabbits with VX2 liver tumor were randomly divided into experimental group and control group,with13 rabbits in each group. CT- guided PEI was performed for the experimental group,and no treatment was performed for the control group.DW- MRI was performed at 1 week after operation. Apparent diffusion coefficient( ADC) ADCtotalin the active tumor areas and necrosis areas were compared within the experimental group,ADCperfand microvascular density( MVD) count in the active tumor areas were compared between the two groups,and the correlation between ADCperfand MVD count was analyzed. The Shapiro- Wilk test was applied for normality analysis,the Wilcoxon rank sum test was applied for comparison of continuous data between the two groups,and the correlation between ADCperfand MVD count was analyzed by the Pearson correlation coefficient. Results In the experimental group,ADCtotalshowed a significant difference between the necrosis areas and the active tumor areas( [1. 674( 1. 340- 2. 571) ] × 10- 3mm2/ s vs [1. 296( 1. 120-1. 972) ]× 10- 3mm2/ s; Z = 2. 052,P = 0. 040). ADCperfand MDV count in the active tumor areas showed no significant differences between the experimental group and the control group [0. 568( 0. 381- 1. 873) ]× 10- 3mm2/ s vs [0. 947( 0. 518- 1. 476) ]× 10- 3mm2/ s,Z =0. 487,P = 0. 626; 23. 641 ± 6. 138 vs 23. 487 ± 3. 466; Z =- 0. 128,P = 0. 898). In both groups,ADCperfin the active tumor areas was positively correlated with MDV count( r = 0. 583 and 0. 593,P = 0. 037 and 0. 033). Conclusion DW- MRI can accurately assess the therapeutic effect of PEI and reflect the condition of micro- angiogenesis in a rabbit VX2 liver tumor model. At 1 week after PEI,PEI has no obvious effect on micro- angiogenesis in residual tumor.
- liver neoplasms,
- diffusion magnetic resonance imaging,
- catheter ablation,
- models,animal

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References

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Diffusion-weighted magnetic resonance imaging for evaluation of micro-angiogenesis in residual tumor after treatment with percutaneous ethanol injection in a rabbit VX2 liver tumor model

DOI: 10.3969/j.issn.1001-5256.2016.01.018