2016 No. 1

2016 Vol. 32, No. 1

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Editorial

Interventional treatment for hepatocellular carcinoma: a review of current status and perspectives

Cheng HongYan

2016, 32(1): 3-8. DOI: 10.3969/j.issn.1001-5256.2016.01.001

Abstract(3377)

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Abstract:
Interventional treatment has become the first- line therapeutic method for intermediate- stage hepatocellular carcinoma( HCC).With the development of related techniques,drug- loaded microparticles and radioactive microspheres have been applied in clinical practice,with good therapeutic effect achiev...

Therapeutic guidelines

Consensus on the diagnosis and management of autoimmune hepatitis(2015)

Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association

2016, 32(1): 9-22. DOI: 10.3969/j.issn.1001-5256.2016.01.002

Abstract(6235)

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Abstract:

Consensus on the diagnosis and management of primary sclerosing cholangitis(2015)

Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Gastroenterology, Chinese Medical Association; Chinese Society of Infectious Diseases, Chinese Medical Association

2016, 32(1): 23-31. DOI: 10.3969/j.issn.1001-5256.2016.01.003

Abstract(440)

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Abstract:

Expert consensus on clinical application of entecavir: an update in 2015

Expert Committee for Clinical Application of Entecavir

2016, 32(1): 32-39. DOI: 10.3969/j.issn.1001-5256.2016.01.004

Abstract(895)

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Abstract:

An excerpt of 2015 EASL clinical practical guidelines: vascular diseases of the liver

Gao Fan, Hu FengRong, Qi XingShun

2016, 32(1): 40-43. DOI: 10.3969/j.issn.1001-5256.2016.01.005

Abstract(281)

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Abstract:

Discussions by experts

Current status and confusion in comprehensive interventional therapy for hepatocellular carcinoma

Liang HongYuan, Lu ZaiMing

2016, 32(1): 44-48. DOI: 10.3969/j.issn.1001-5256.2016.01.006

Abstract(3042)

PDF (1494KB)(604)

Abstract:
In recent years,hepatocellular carcinoma( HCC) has become the second leading cause of cancer- related death worldwide. Due to the insidious onset of this disease,only 20%- 30% of the patients with HCC have the opportunity for surgical resection or liver transplantation. At present,interventional the...

Current status of transcatheter arterial chemoembolization combined with radiofrequency ablation in treatment of primary liver cancer

Lu: TianShi, Zou YingHua, Wang Jian, Song Li

2016, 32(1): 49-55. DOI: 10.3969/j.issn.1001-5256.2016.01.007

Abstract(2650)

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Abstract:
In recent years,more and more therapeutic methods have been applied for the treatment of primary liver cancer; however,since most lesions develop from progressive liver disease or liver cirrhosis,primary liver cancer is still a refractory malignant tumor. Although surgical resection and liver transp...

Application of local ablative therapies for hepatocellular carcinoma

Zhu XiaoLi, Shen Jian

2016, 32(1): 56-61. DOI: 10.3969/j.issn.1001-5256.2016.01.008

Abstract(3152)

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Abstract:
Hepatocellular carcinoma( HCC) is a common malignant tumor in the world,and surgical resection and liver transplantation are two radical treatment modalities,but only 10%- 20% of all patients can receive such treatments. In recent years,local therapies including radiofrequency ablation,microwave abl...

Radiological evaluation after treatment of hepatocellular carcinoma: criteria and application

Wang WenJun, Zhao Yan, Han GuoHong

2016, 32(1): 62-67. DOI: 10.3969/j.issn.1001-5256.2016.01.009

Abstract(3145)

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Abstract:
An early and accurate response evaluation is essential for clinicians to decide whether to continue the treatment with current therapeutic regimen or to make necessary changes. This article briefly introduces the development of response evaluation criteria for tumors,elaborates on the application of...

The interventional treatment for hepatocellular carcinoma originating from the caudate lobe

Wang HuaMing

2016, 32(1): 68-71. DOI: 10.3969/j.issn.1001-5256.2016.01.010

Abstract(2827)

PDF (1709KB)(467)

Abstract:
Hepatocellular carcinoma( HCC) originating from the caudate lobe is a special- site HCC,which is rare and difficult to treat.The major therapeutic method in the past was surgical resection. In recent years,interventional treatment for HCC originating from the caudate lobe has achieved significant pr...

Original articles_Interventional treatment of liver cancer

Severe complications after ultrasound-guided percutaneous microwave coagulation therapy for primary hepatic carcinoma

Li XinHui, Feng ZhiQiang, Zhang HongYi, Wu Di, Zhao Gang, Wang Xin, Liu Yang

2016, 32(1): 72-75. DOI: 10.3969/j.issn.1001-5256.2016.01.011

Abstract(2065)

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Abstract:

Objective To investigate the severe complications after ultrasound- guided percutaneous microwave coagulation therapy( PMCT) for primary hepatic carcinoma( PHC) and measures for prevention and treatment. Methods A total of 652 patients with PHC who were admitted to department of hepatobiliary surger...

Effect of transcatheter arterial chemoembolization combined with interferon adjuvant therapy in treatment of advanced primary liver cancer: a meta-analysis

Weng NingNa, Li Xiao

2016, 32(1): 76-79. DOI: 10.3969/j.issn.1001-5256.2016.01.012

Abstract(1763)

PDF (1646KB)(418)

Abstract:

Objective To investigate the effect of transcatheter arterial chemoembolization( TACE) combined with interferon( IFN) adjuvant therapy in the treatment of advanced primary liver cancer,and to provide new ideas for adjuvant therapies after TACE. Methods The databases including Cochrane Library,Pub Me...

Prognostic factors for transcatheter arterial chemoembolization in patients with hepatocellular carcinoma

Ma ShiJie, Zou ShaoJing, Luo XiaoLing, Li QianJun, Huang JiaSheng

2016, 32(1): 80-83. DOI: 10.3969/j.issn.1001-5256.2016.01.013

Abstract(2657)

PDF (1618KB)(447)

Abstract:

Objective To investigate the prognostic factors for transcatheter arterial chemoembolization( TACE) in patients with advanced primary hepatocellular carcinoma( HCC). Methods The clinical data of 124 patients with advanced HCC who were admitted to Huaian No. 1 People's Hospital Affiliated to Nanjing ...

Prognostic factors for transcatheter arterial chemoembolization in patients with hepatocellular carcinoma complicated by portal vein tumor thrombus

Zhang Cheng, Qi XingShun, Bo Ming, Zhao Yan, Wang WeiJuan, Han GuoHong

2016, 32(1): 84-87. DOI: 10.3969/j.issn.1001-5256.2016.01.014

Abstract(2520)

PDF (1631KB)(409)

Abstract:

Objective To investigate the therapeutic effect of transcatheter arterial chemoembolization( TACE) in patients with hepatocellular carcinoma( HCC) complicated by portal vein tumor thrombus,and to identify related prognostic factors. Methods The clinical data of152 HCC patients with portal vein tumor...

Effect of live combined Bacillus subtilis and Enterococcus faecium enteric-coated capsules in treatment of adverse events and complications after transcatheter arterial chemoembolization

Zhao GuangSheng, Ren ZhiZhong, Liu Ying, Zhou Jun, Zhang YueWei, Zhang Ming

2016, 32(1): 88-91. DOI: 10.3969/j.issn.1001-5256.2016.01.015

Abstract(2610)

PDF (1490KB)(446)

Abstract:

Objective To evaluate the effect of live combined Bacillus subtilis and Enterococcus faecium enteric- coated capsules in the prevention and treatment of adverse events and complications after transcatheter arterial chemoembolization( TACE). Methods A total of 239 patients who were diagnosed with hep...

Effect of recombinant human endostatin combined with hepatic artery interventional therapy on progression-free survival of patients with advanced hepatocellular carcinoma

Hao MingZhi, Lin HaiLan, Chen QiZhong, Hu YuBin

2016, 32(1): 92-96. DOI: 10.3969/j.issn.1001-5256.2016.01.016

Abstract(2541)

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Abstract:

Objective To investigate the effect of recombinant human endostatin( Endostar) combined with hepatic artery interventional therapy on the progression- free survival( PFS) of patients with advanced hepatocellular carcinoma( HCC). Methods A total of 86 patients with advanced HCC who were admitted to F...

Clinical effect of systemic chemotherapy combined with transcatheter arterial chemoembolization in treatment of breast cancer with liver metastases

Li LiYe

2016, 32(1): 97-100. DOI: 10.3969/j.issn.1001-5256.2016.01.017

Abstract(2612)

PDF (1482KB)(413)

Abstract:

Objective To investigate the clinical effect of systemic chemotherapy combined with transcatheter arterial chemoembolization( TACE) in the treatment of breast cancer with liver metastases. Methods A total of 86 female breast cancer patients with liver metastases who were treated in the Affiliated Ho...

Diffusion-weighted magnetic resonance imaging for evaluation of micro-angiogenesis in residual tumor after treatment with percutaneous ethanol injection in a rabbit VX2 liver tumor model

Chen Juan, Yin HuaBin, Zhang HuanHuan, Wei ChunXiao, Wang Li, Qian Ting

2016, 32(1): 101-105. DOI: 10.3969/j.issn.1001-5256.2016.01.018

Abstract(2441)

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Abstract:

Objective To investigate the application of diffusion- weighted magnetic resonance imaging( DW- MRI) for the evaluation of the therapeutic effect of percutaneous ethanol injection( PEI) and its effect on micro- angiogenesis in residual tumor in a rabbit VX2 liver tumor model. Methods A total of 26 r...

Original articles_Viral hepatitis

Correlation between platelet indices and liver pathological staging: an analysis of 167 patients with chronic hepatitis B

Chen Nian, Huang WeiE, Su MingHua, Jiang JianNing

2016, 32(1): 106-109. DOI: 10.3969/j.issn.1001-5256.2016.01.019

Abstract(2677)

PDF (1890KB)(501)

Abstract:
Objective To investigate the values of aspartate aminotransferase to platelet ratio index( APRI) and alanine aminotransferase to platelet ratio index( BPRI) for the prediction of pathological changes in liver tissue in patients with chronic hepatitis B( CHB). Methods A total of 167 CHB patients who ...

Clinical analysis of liver injury and hepatitis B virus reactivation after chemotherapy in HBsAg-positive patients with malignant tumors

Wu ShengXi, Xu HongYao, Huang HeCheng, Lin LianXing, Luo HeSan

2016, 32(1): 110-113. DOI: 10.3969/j.issn.1001-5256.2016.01.020

Abstract(2187)

PDF (1488KB)(427)

Abstract:
Objective To investigate the occurrence of liver injury and related risk factors for hepatitis B virus( HBV) reactivation after chemotherapy in HBsAg- positive patients with malignant tumors. Methods A total of 150 HBsAg- positive patients with malignant tumors who received chemotherapy in Shantou C...

Original articles_Liver fibrosis and liver cirrhosis

A comparative analysis of carvedilol and propranolol in hepatic venous pressure gradient reduction in patients with cirrhotic portal hypertension

Li Jing, Sun DongJie, Wang GuangChuan, Feng Hua, Shi YongJun, Zhang ChunQing

2016, 32(1): 114-118. DOI: 10.3969/j.issn.1001-5256.2016.01.021

Abstract(2627)

PDF (2061KB)(442)

Abstract:
Objective To investigate the differences between carvedilol and propranolol in the degree of hepatic venous pressure gradient( HVPG) reduction,response rate,and adverse events in patients with cirrhotic portal hypertension,and to evaluate the efficacy and safety of carvedilol in reducing portal vein...

Original articles_Biliary diseases

Risk factors for hyperamylasemia after endoscopic retrograde cholangiopancreatography

YIERPAN Aishan, Gao Feng

2016, 32(1): 119-122. DOI: 10.3969/j.issn.1001-5256.2016.01.022

Abstract(1906)

PDF (1489KB)(434)

Abstract:
Objective To investigate the risk factors for the development of post- endoscopic retrograde cholangiopancreatography pancreatitis and hyperamylasemia( PEPH) after endoscopic retrograde cholangiopancreatography( ERCP). Methods The clinical data of 233 patients who underwent therapeutic ERCP from Jan...

Original articles_Pancreatic diseases

Efficacy of prostaglandin E1 as adjuvant therapy for mild to moderate acute pancreatitis

Ji Bo, Chen LiYu, Liu YaHui

2016, 32(1): 123-126. DOI: 10.3969/j.issn.1001-5256.2016.01.023

Abstract(2266)

PDF (1485KB)(409)

Abstract:
Objective To observe the clinical effect and efficacy of prostaglandin E1( PGE1),the drug for microcirculation improvement,in the treatment of acute pancreatitis( AP). Methods A total of 80 patients with mild- to- moderate AP who were hospitalized and treated in Second Department of Hepatobiliary an...

Clinical features of recurrent biliary pancreatitis and its predisposing factors

Lu: Kun, Chen Xiang

2016, 32(1): 127-130. DOI: 10.3969/j.issn.1001-5256.2016.01.024

Abstract(2329)

PDF (1480KB)(426)

Abstract:
Objective To investigate the clinical features of recurrent biliary pancreatitis and related predisposing factors. Methods A total of 272 patients with biliary pancreatitis who were admitted and treated in Jiangbei District People's Hospital from January 2008 to December 2014 were enrolled and divid...

Combined determination of serum C-reactive protein,lipase,interleukin-1β,and intercellular adhesion molecule1 in early identification of severity of acute pancreatitis

Jiao ShuHua, Liu PengLiang, Wen YanHui

2016, 32(1): 131-134. DOI: 10.3969/j.issn.1001-5256.2016.01.025

Abstract(2419)

PDF (1498KB)(424)

Abstract:
Objective To evaluate the value of combined determination of various indices in the clinical diagnosis of acute pancreatitis( AP) through dynamic measurements of the levels of peripheral serum C- reactive protein( CRP),lipase( LPS),interleukin- 1β( IL-1β),and intercellular adhesion molecule 1( ICAM-...

Original articles_Others

Logistic regression analysis of prognostic risk factors for hepatic encephalopathy

Cui YanPing, Li QingFang, Li QingYan, Liu ChunHua, Wang WeiHong, Yuan JianGuo, Wang SiKui

2016, 32(1): 135-138. DOI: 10.3969/j.issn.1001-5256.2016.01.026

Abstract(2249)

PDF (1487KB)(420)

Abstract:

Objective To analyze the prognostic risk factors for hepatic encephalopathy( HE),and to explore the risk factors for prognosis.Methods A total of 385 patients with HE who were treated in Liaocheng People's Hospital from January 2006 to June 2014 were enrolled in this study and analyzed retrospective...

Analysis of specific metabolite profiling of minimal hepatic encephalopathy based on metabolomics analytical platforms of GC-TOFMS and UPLC-QTOFMS

Huang GuoChu, Wang Meng, Yang XiaoHui, Yao Fan, Zhong Yu, Yao Chun

2016, 32(1): 139-142. DOI: 10.3969/j.issn.1001-5256.2016.01.027

Abstract(2306)

PDF (1594KB)(449)

Abstract:

Objective To analyze and compare the serum metabolite profiling of healthy volunteers and patients with minimal hepatic encephalopathy( MHE),identify the specific biomarkers of MHE,and explore the method for early diagnosis of MHE. Methods Twenty-nine patients with MHE caused by hepatitis B cirrhosi...

Compatible stability of magnesium isoglycyrrhizinate injection and reduced glutathione for injection

Li XiaoHui, Wen Yu, Jin WenHui, Hong Zhuan, Ceng MeiYan, Chen WeiZhu

2016, 32(1): 143-147. DOI: 10.3969/j.issn.1001-5256.2016.01.028

Abstract(3716)

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Abstract:

Objective To evaluate the compatible stability of magnesium isoglycyrrhizinate( MgIG) injection and reduced glutathione( GSH) for injection at room temperature. Methods High- performance liquid chromatography was applied to measure the changes in the content of MgIG and reduced GSH after MgIG inject...

Changes in serum asymmetric dimethylarginine levels in progression of liver inflammation in an experimental rat model of nonalcoholic fatty liver disease

Ding Jie, Wang Liang, Li Juan, Kong Yin, Zhao Rui, He JingJing, Li GuangMing, Wang JuanXia, Zhang LingYi

2016, 32(1): 148-151. DOI: 10.3969/j.issn.1001-5256.2016.01.029

Abstract(2251)

PDF (1587KB)(413)

Abstract:

Objective To investigate the changes in serum asymmetric dimethylarginine( ADMA) levels in the progression of liver inflammation in a rat model of nonalcoholic fatty liver disease( NAFLD). Methods The rat model of NAFLD was established through high- fat cream by gavage and these rats were considered...

Case reports

TACE combined with sorafenib in treatment of advanced primary hepatocellular carcinoma: a report of one case achieving complete response

Ma JingFan, Chen Gang, Liu Hong

2016, 32(1): 152-154. DOI: 10.3969/j.issn.1001-5256.2016.01.030

Abstract(2089)

PDF (1578KB)(391)

Abstract:

One case of primary hepatic carcinoid tumor with multiple metastases

Lu DongYan, Ye XiaoWei

2016, 32(1): 155-156. DOI: 10.3969/j.issn.1001-5256.2016.01.031

Abstract(2763)

PDF (1673KB)(398)

Abstract:

Surgical resection in treatment of hepatic angiomyolipoma: a report of two cases

Wang Jin, Wang LiMing

2016, 32(1): 157-158. DOI: 10.3969/j.issn.1001-5256.2016.01.032

Abstract(2462)

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Abstract:

Fanconi syndrome with hypophosphatemic osteomalacia induced by low-dose adefovir dipivoxil

Wang ShouQing, Zhao Na, Xin GuiJie

2016, 32(1): 159-160. DOI: 10.3969/j.issn.1001-5256.2016.01.033

Abstract(2212)

PDF (1461KB)(398)

Abstract:

Severe fatty liver induced by glucocorticoids: a report of one case

Liu LiBin, Wang Min, Tian YueLi, Cong Jing, Wang LiYing

2016, 32(1): 161-162. DOI: 10.3969/j.issn.1001-5256.2016.01.034

Abstract(2585)

PDF (1505KB)(406)

Abstract:

Serve acute pancreatitis with chylous ascites: a report of one case

Meng LingYu, Ji Bo, Liu YaHui

2016, 32(1): 163-164. DOI: 10.3969/j.issn.1001-5256.2016.01.035

Abstract(2224)

PDF (1629KB)(467)

Abstract:

Reviews

Research advances in mouse models of hepatitis B virus infection

Wang Jun, Huang YuXiao, Shen Yan, Liang Jiao, Liu XueWu, Li YingHui, Zhao Ya

2016, 32(1): 165-168. DOI: 10.3969/j.issn.1001-5256.2016.01.036

Abstract(3412)

PDF (1545KB)(651)

Abstract:
Hepatitis B virus( HBV) is a great threat to human health,but due to its strong species specificity,there are still no ideal animal models at present to clarify the pathogenesis of HBV infection. At present,the research on HBV infection models mainly concentrates on mice,and great progress has been ...

Research progress in anti-HCV therapeutic regimens without interferon

Li Qiang, Huang YuXian, Chen Liang

2016, 32(1): 169-173. DOI: 10.3969/j.issn.1001-5256.2016.01.037

Abstract(2056)

PDF (1498KB)(401)

Abstract:
There are about 150 million people around the world with chronic hepatitis C virus( HCV) infection currently,of whom 20%will ultimately progress to cirrhosis and eventually die of end- stage liver disease and hepatocellular carcinoma. Interferon( IFN) has long been recognized as the cornerstone of t...

Research advances in traditional Chinese medicine treatment for primary liver cancer

Song HuiXian, Qiao Fei, Shao Ming

2016, 32(1): 174-177. DOI: 10.3969/j.issn.1001-5256.2016.01.038

Abstract(2967)

PDF (1773KB)(478)

Abstract:
Primary liver cancer is a common malignant tumor in the digestive system. Most patients are in the advanced stage when a confirmed diagnosis has been made,and prognosis is often unfavorable. Traditional Chinese medicine( TCM) has unique advantages in the prevention and treatment of primary liver can...

Nutrition support therapy for patients with hepatic encephalopathy

Gan XueMei, Li Wu

2016, 32(1): 178-181. DOI: 10.3969/j.issn.1001-5256.2016.01.039

Abstract(2791)

PDF (1483KB)(525)

Abstract:
Hepatic encephalopathy is one of the most common complications of liver failure and has a high incidence in hospitalized patients.Most patients with hepatic encephalopathy have varying degrees of malnutrition. In recent years,more and more clinical trials have confirmed that the nutritional support ...

Role of hepatic sinusoids in lipopolysaccharide-induced liver injury

Zhao LiLi, Yuan DongYa, Sun FangYun

2016, 32(1): 182-184. DOI: 10.3969/j.issn.1001-5256.2016.01.040

Abstract(2241)

PDF (1476KB)(498)

Abstract:
Endotoxin,which is also called lipopolysaccharide( LPS),is a unique element of Gram- negative bacteria. Liver is the main site for removing bacteria and endotoxin. Meanwhile,it is also the most vulnerable organ. Liver injury initially occurs in the hepatic sinusoids. This article mainly introduces t...

Application of CRISPR/Cas9 system in virus research

Zheng QingFen, Duan ZhongPing, Li JianSheng

2016, 32(1): 185-187. DOI: 10.3969/j.issn.1001-5256.2016.01.041

Abstract(2470)

PDF (1481KB)(459)

Abstract:
To date,the clustered regularly interspaced short palindromic repeat( CRISPR) / Cas9 system has been widely used to edit the genome in many species and cells. The system is the third generation of artificial endonuclease,which can edit DNA by recognizing short DNA sequences. This paper reviews the s...