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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 2
Feb.  2016
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Article Contents

Current studies of novel drugs against hepatitis B virus in clinical trials

DOI: 10.3969/j.issn.1001-5256.2016.02.038
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  • Received Date: 2015-07-29
  • Published Date: 2016-02-20
  • Chronic hepatitis B( CHB) is one of the major causes of liver cirrhosis and hepatocellular carcinoma. Interferon and nucleos( t)ide analogues can control disease progression. However,they cause very low HBs Ag clearance or seroconversion rates and relapse in most patients after treatment withdrawal. In recent years,the further understanding of the interaction between hepatitis B virus( HBV) and host gives birth to a large number of novel drugs that hold promise for successful cure of CHB. This paper reviews several novel drugs against HBV in phase Ⅰ,Ⅱ,or Ⅲ clinical trials,and points out that these novel drugs against HBV have preliminarily indicated a bright future.

     

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