2016 No. 2

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Editorial

Work-up for diagnosis and treatment of liver cirrhosis: convention and development

Tang ChengWei

2016, 32(2): 201-202. DOI: 10.3969/j.issn.1001-5256.2016.02.001

Abstract(463)

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Abstract:

Liver cirrhosis is one of the most important public health issues in China. The etiological treatment for patients with decompensated liver cirrhosis to delay progression has always been the practical and effective classical strategy. High- quality or creative methods for diagnosis and treatment com...

Therapeutic guidelines

Guidelines for the diagnosis and treatment of esophageal and gastric variceal bleeding in cirrhotic portal hypertension

Chinese Society of Hepatology, Chinese Medical Association, Chinese Society of Gastroenterology, Chinese Medical Association, Chinese Society of Endoscopy，Chinese Medical Association

2016, 32(2): 203-219. DOI: 10.3969/j.issn.1001-5256.2016.02.002

Abstract(4587)

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Abstract:

Interpretation of guidelines for the diagnosis and treatment of esophageal and gastric variceal bleeding in cirrhotic portal hypertension

Ding HuiGuo, Xu XiaoYuan, Ling HuEnQiang, Jia JiDong

2016, 32(2): 220-222. DOI: 10.3969/j.issn.1001-5256.2016.02.003

Abstract(2946)

PDF (1499KB)(616)

Abstract:

An excerpt of New 2015 AASLD guidelines for treatment of chronic hepatitis B

Xu Ying, Wang WeiBin, Li ZhanDong, Wu YaoBo, Sun Jian

2016, 32(2): 223-229. DOI: 10.3969/j.issn.1001-5256.2016.02.004

Abstract(360)

PDF (286KB)(573)

Abstract:

Discussions by experts

Retrospects and prospects of transjugular intrahepatic portosystemic shunt in China

Niu Meng, Sun Jun, Xu Ke, Zhong HongShan

2016, 32(2): 230-233. DOI: 10.3969/j.issn.1001-5256.2016.02.005

Abstract(2972)

PDF (1519KB)(489)

Abstract:
In recent years,transjugular intrahepatic portosystemic shunt( TIPS) has been gradually applied and widely accepted in China,and the technical standards,indications,and contraindications of this technique have also been established gradually. The invention of covered stents successfully solved the i...

Advances in transjugular intrahepatic portosystemic shunt and its application in treatment of cirrhotic portal hypertension

Xiao JiangQiang, ZhuGe YuZheng

2016, 32(2): 234-237. DOI: 10.3969/j.issn.1001-5256.2016.02.006

Abstract(2711)

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Abstract:

In recent years,with the development in basic research and clinical application,the success rate of transjugular intrahepatic portosystemic shunt( TIPS) has been increased significantly,and stent restenosis rate and the incidence of postoperative hepatic encephalopathy have been controlled. With ref...

Prevention and treatment of complications after transjugular intrahepatic portosystemic shunt

Xue Hui, Li PeiJie, Li WeiZhi, Su JingWen, Huang Jin

2016, 32(2): 238-241. DOI: 10.3969/j.issn.1001-5256.2016.02.007

Abstract(2956)

PDF (1509KB)(517)

Abstract:
The application of transjugular intrahepatic portosystemic shunt( TIPS) in the treatment of cirrhotic portal hypertension has been widely accepted both at home and abroad. This article focuses on the fatal complications of TIPS( including intraperitoneal bleeding and acute pulmonary embolism),shunt ...

Individualized treatment of liver cirrhosis and esophageal and gastric varices from the perspective of Baveno Ⅳ

Zhang ChunQing, Li Jing

2016, 32(2): 242-244. DOI: 10.3969/j.issn.1001-5256.2016.02.008

Abstract(467)

PDF (1138KB)(350)

Abstract:
The therapeutic methods for portal hypertension have been greatly developed,including surgical operation,endoscopic injection of sclerosing agents,endoscopic variceal ligation,tissue adhesive embolization,and radioactive intervention,and have significantly reduced the fatality of portal hypertension...

Research advances in non-cirrhotic portal hypertension

Zhang BoJing, Han GuoHong, Fan DaiMing

2016, 32(2): 245-249. DOI: 10.3969/j.issn.1001-5256.2016.02.009

Abstract(580)

PDF (239KB)(442)

Abstract:
Although liver cirrhosis is the most common cause of portal hypertension( PH),about 20% of PH cases are caused by non- cirrhotic reasons,which are referred to as non- cirrhotic portal hypertension( NCPH),with a high incidence rate in developing countries.NCPH is a group of heterogeneous hepatic vasc...

Current status and perspectives of surgical treatment of portal hypertension

Yang Zhen

2016, 32(2): 250-253. DOI: 10.3969/j.issn.1001-5256.2016.02.010

Abstract(2365)

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Abstract:
The surgical treatment of portal hypertension once guided the development of modern surgery. In the past 10- 20 years,the non-surgical therapies including drugs to screen and control esophagogastric variceal bleeding,endoscopic variceal ligation,and transjugular intrahepatic portosystemic shunt have...

Original articles_Portal hypertension

Effect of antiviral therapy on prognosis of patients with decompensated hepatitis B cirrhosis undergoing transjugular intrahepatic portosystemic shunt

Lin Jing, Wei Bo, Wu Hao, Tong Huan, Tang ChengWei

2016, 32(2): 254-258. DOI: 10.3969/j.issn.1001-5256.2016.02.011

Abstract(2291)

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Abstract:

Objective To investigate the effect of antiviral therapy on the prognosis of patients with decompensated hepatitis B cirrhosis who underwent transjugular intrahepatic portosystemic shunt( TIPS). Methods The clinical data of 110 patients with decompensated hepatitis B cirrhosis who underwent TIPS to ...

Therapeutic effect and safety of transjugular intrahepatic portosystemic shunt in patients with primary biliary cirrhosis and portal hypertension

Zhang Wei, ZhuGe YuZheng, Zhang Ming, He QiBin, Zhang Feng, Wang Yi, Zou XiaoPing

2016, 32(2): 259-263. DOI: 10.3969/j.issn.1001-5256.2016.02.012

Abstract(363)

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Abstract:

Objective To investigate the short- term effect and safety of transjugular intrahepatic portosystemic shunt( TIPS) in the treatment of decompensated primary biliary cirrhosis( PBC). Methods The clinical data of 26 patients with decompensated PBC who received TIPS in Affiliated Drum Tower Hospital of...

Comparative clinical analysis of three surgical methods in patients with cirrhotic portal hypertension complicated by upper gastrointestinal bleeding

Wen JianSheng, Yue Kun, Wu ZhiQun, Lu HongJuan

2016, 32(2): 264-268. DOI: 10.3969/j.issn.1001-5256.2016.02.013

Abstract(511)

PDF (430KB)(219)

Abstract:

Objective To compare the effects of transjugular intrahepatic portosystemic shunt( TIPS),percutaneous transhepatic variceal embolization( PTVE),and TIPS combined with gastric coronary vein embolization( GCVE) in patients with cirrhotic portal hypertension complicated by upper gastrointestinal bleedi...

Association between serum ascites albumin gradient and esophagogastric variceal bleeding in patients with liver cirrhosis: a Meta-analysis

Zhang Hui, Xu YouQing

2016, 32(2): 269-274. DOI: 10.3969/j.issn.1001-5256.2016.02.014

Abstract(2360)

PDF (1802KB)(445)

Abstract:

Objective To investigate the association between serum ascites albumin gradient( SAAG) and esophagogastric variceal bleeding in patients with liver cirrhosis. Methods The databases Pub Med,Embase,the Cochrane Library,Wanfang Data,VIP,and CNKI were searched to obtain Chinese articles on SAAG and esop...

Clinical manifestations of portal vein thrombosis and related risk factors in patients with liver cirrhosis

Zhou RenHua, Li Peng, Zhang YanTing, Yang Hua, Yang ShaoQi

2016, 32(2): 275-278. DOI: 10.3969/j.issn.1001-5256.2016.02.015

Abstract(2541)

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Abstract:

Objective To investigate the clinical manifestations of portal vein thrombosis( PVT) and related risk factors in patients with liver cirrhosis. Methods A total of 541 patients with liver cirrhosis who were admitted to the General Hospital of Ningxia Medical University from April 2008 to April 2015 w...

Original articles_Viral hepatitis

Effects of nucleos(t) ide analogues on estimated glomerular filtration rate and serum creatinine level in patients with chronic hepatitis B

Xu Yong, Feng JiHong

2016, 32(2): 279-283. DOI: 10.3969/j.issn.1001-5256.2016.02.016

Abstract(469)

PDF (428KB)(108)

Abstract:
Objective To investigate the effects of nucleos( t) ide analogues( NAs) on the estimated glomerular filtration rate( e GFR) and serum creatinine( Scr) in patients with chronic hepatitis B( CHB). Methods A total of 184 patients with CHB who visited and were hospitalized in the Second Affiliated Hospi...

Original articles_Liver fibrosis and liver cirrhosis

Effect of somatostatin combined with pantoprazole in treatment of liver cirrhosis with upper gastrointestinal hemorrhage

Gao ChengGuang, Xie Feng, Feng YaDong

2016, 32(2): 284-287. DOI: 10.3969/j.issn.1001-5256.2016.02.017

Abstract(464)

PDF (213KB)(263)

Abstract:
Objective To investigate the effect of somatostatin( SS) combined with pantoprazole in the treatment of liver cirrhosis with upper gastrointestinal hemorrhage( UGIH). Methods A total of 70 patients with liver cirrhosis and UGIH who were admitted to Jiangyan Hospital of Traditional Chinese Medicine f...

Risk factors for antibiotic prophylaxis failure in patients with liver cirrhosis and upper gastrointestinal bleeding

Li XiaoLou, Chen MingSheng, Gan QiaoRong, Jiang XiaoYan, Chen Li

2016, 32(2): 288-291. DOI: 10.3969/j.issn.1001-5256.2016.02.018

Abstract(2530)

PDF (1516KB)(487)

Abstract:
Objective To investigate the risk factors for antibiotic prophylaxis failure in patients with liver cirrhosis and upper gastrointestinal bleeding. Methods Eighty- two patients with liver cirrhosis and upper gastrointestinal bleeding who were admitted to our hospital from January 2011 to June 2014 we...

Efficacy of entecavir combined with alprostadil in treatment of hepatitis B-related cirrhotic ascites

Li HuiLi, Lu XueFeng, Li Na

2016, 32(2): 292-295. DOI: 10.3969/j.issn.1001-5256.2016.02.019

Abstract(2493)

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Abstract:
Objective To investigate the efficacy of entecavir combined with alprostadil in the treatment of hepatitis B- related cirrhotic ascites. Methods A total of 100 patients with hepatitis B- related cirrhotic ascites who were admitted to Dezhou Hospital of Traditional Chinese Medicine from May 2012 to F...

Clinical features of male patients with alcoholic liver cirrhosis or hepatitis B cirrhosis complicated by abnormal glucose metabolism

Zhang WenJie, Chen QiDan, Wan Yu, Deng Hui

2016, 32(2): 296-300. DOI: 10.3969/j.issn.1001-5256.2016.02.020

Abstract(2296)

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Abstract:
Objective To investigate the clinical features of male patients with alcoholic liver cirrhosis( ALC) or hepatitis B cirrhosis( HBC) complicated by abnormal glucose metabolism. Methods A total of 287 patients with liver cirrhosis who were admitted to Guangzhou Panyu Central Hospital from January 2008...

Short-term efficacy of splenectomy versus partial splenic embolization for liver cirrhosis and hypersplenism: a Meta-analysis

He HaiGuan, Shen YiNan, Pang ShuJie, Yang Tian, Lu JunHua

2016, 32(2): 301-306. DOI: 10.3969/j.issn.1001-5256.2016.02.021

Abstract(2692)

PDF (2689KB)(474)

Abstract:
Objective To systematically evaluate the therapeutic effects of partial splenic embolization( PSE) and splenectomy for liver cirrhosis and hypersplenism. Methods The Medline,Embase,Web of Science,CNKI,Wanfang Data,and VIP were searched to collect the articles on PSE and splenectomy for liver cirrhos...

Effect of adiponectin on hepatic stellate cell contraction induced by endothelin-1 and its mechanism of action

Li Nan, Liu YingDi, Guo MingZhou, Liang Hao

2016, 32(2): 307-311. DOI: 10.3969/j.issn.1001-5256.2016.02.022

Abstract(2373)

PDF (1868KB)(466)

Abstract:
Objective To observe the effect of exogenous adiponectin on hepatic stellate cell( HSC) contraction induced by endothelin- 1( ET- 1),and to investigate the possible mechanism of action of adiponectin in this process. Methods Collagen lattice was applied to observe the effects of adiponectin( 0. 25,0...

Original articles_Liver neoplasms

Accuracy of Fibro Scan for diagnosis of primary liver cancer: a Meta-analysis

Li Mi, Nie QingHe

2016, 32(2): 312-316. DOI: 10.3969/j.issn.1001-5256.2016.02.023

Abstract(2646)

PDF (3892KB)(413)

Abstract:
Objective To investigate the accuracy of liver stiffness( LS) measured by Fibro Scan in the diagnosis of primary liver cancer through a meta- analysis. Methods The databases of Pub Med,Embase,CBM,CMCI,VIP,and CNKI were searched,and a manual search was performed for related journals,to collect the ar...

Effects of two methods for hepatic vascular occlusion in resection of giant hepatic hemangioma

Zhang HuaAn, Zhou XiaoFang

2016, 32(2): 317-319. DOI: 10.3969/j.issn.1001-5256.2016.02.024

Abstract(2846)

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Abstract:
Objective To evaluate the clinical effects of two methods for hepatic vascular occlusion in resection of giant hepatic hemangioma. Methods A total of 20 patients with giant hepatic hemangioma who were hospitalized in Tianmen Hospital of Traditional Chinese Medicine from January 2008 to December 2014...

Original articles_Pancreatic diseases

Effect of continuous blood purification in treatment of patients with severe acute pancreatitis and multiple organ dysfunction syndrome

Zhang Yong, Zeng WeiZheng, Wang YunXia, Weng Min, Zheng ShuMei, Jiang MingDe

2016, 32(2): 320-323. DOI: 10.3969/j.issn.1001-5256.2016.02.025

Abstract(2405)

PDF (1531KB)(442)

Abstract:

Objective To observe the effect of continuous blood purification( CBP) on serum inflammatory mediators in patients with severe acute pancreatitis( SAP) and multiple organ dysfunction syndrome( MODS). Methods Sixty- five SAP patients with MODS who were treated in General Hospital of Chengdu Command A...

Diagnostic value of serum lipase combined with Ranson or BISAP scoring system in assessment of severity of acute pancreatitis

Chen DongLai, Liao ZhenHai, Lin ShunQuan

2016, 32(2): 324-328. DOI: 10.3969/j.issn.1001-5256.2016.02.026

Abstract(2709)

PDF (1562KB)(427)

Abstract:
Objective To investigate the diagnostic value of serum lipase combined with the Ranson or BISAP scoring system in the assessment of severity of acute pancreatitis. Methods A total of 314 patients with acute pancreatitis who were admitted to The Second People' s Hospital of Huidong County from Februa...

Changes in serum levels of M30,M65,and IL-17 and their clinical significance in patients with acute pancreatitis

Hao TingTing, Ma XiaoPeng, Wen YanLi, Dai GuangRong, Feng YiChao, Zhang Li

2016, 32(2): 329-332. DOI: 10.3969/j.issn.1001-5256.2016.02.027

Abstract(2453)

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Abstract:
Objective To investigate the changes in serum levels of M30,M65,and interleukin- 17( IL- 17) and their clinical significance in patients with acute pancreatitis. Methods A total of 126 patients with acute pancreatitis who were admitted to our hospital from December 2009 to December 2013 were selecte...

Effect of Blumgart anastomosis in prevention and treatment of pancreatic fistula after pancreaticoduodenectomy

Pan Chao, Xi PengCheng, Shi ZuoLiang, Bian JianMin, Yang KunXing, Liu ZiJun, Ni ShaoZhong, Yang ShiYong, Shi KaiWang

2016, 32(2): 333-336. DOI: 10.3969/j.issn.1001-5256.2016.02.028

Abstract(2377)

PDF (1573KB)(417)

Abstract:
Objective To investigate the effect of Blumgart anastomosis( BA) on pancreatic fistula( PF) and other complications after pancreaticoduodenectomy. Methods The clinical data of 190 patients who underwent pancreaticoduodenectomy in our hospital from January2005 to December 2011 were analyzed retrospec...

Expression and roles of poly(ADP-ribose) polymerase-1 and caspase-3 in pancreatic cancer and adjacent tissues

Pu Jing, Li Xun, Zhu Jun, Bai ZhongTian, Yan Jun

2016, 32(2): 337-341. DOI: 10.3969/j.issn.1001-5256.2016.02.029

Abstract(537)

PDF (1892KB)(225)

Abstract:
Objective To investigate the protein expression of poly( ADP- ribose) polymerase- 1( PARP- 1) and caspase- 3 in pancreatic cancer and adjacent tissues. Methods A total of 66 cancer tissue samples and 113 samples of adjacent tissues were collected from the patients who underwent surgical treatment wi...

Original articles_Others

Clinical effect of plasma exchange combined with hemofiltration in patients with subacute liver failure induced by antitubercular agents

Hou HuanRong, Shang Jia, Kang Yi, Li YuKui, Ceng YanLi, Ding GangQiang, Mao ZhongShan, Xiao ErHui

2016, 32(2): 342-346. DOI: 10.3969/j.issn.1001-5256.2016.02.030

Abstract(1812)

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Abstract:

Objective To investigate the clinical effect of plasma exchange( PE) combined with hemofiltration( HF) in the treatment of subacute liver failure( SALF) induced by antitubercular agents. Methods A total of 58 patients with SALF induced by antitubercular agents who visited Henan Provincial People's H...

Case reports

Isolated duodenal variceal bleeding caused by liver cirrhosis: a report of one case

Liu LiLi, An Yang, Hu Yue, Hua Rui, Pan Yu, Niu JunQi

2016, 32(2): 347-348. DOI: 10.3969/j.issn.1001-5256.2016.02.031

Abstract(1999)

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Abstract:

Liver cirrhosis complicated by retroperitoneal variceal bleeding: a report of one case

Xiao Xue, Wang Jing, Liu Hui, Yan Yan

2016, 32(2): 349-350. DOI: 10.3969/j.issn.1001-5256.2016.02.032

Abstract(346)

PDF (147KB)(45)

Abstract:

Hepatic angioleiomyoma: a report of one case and literature review

Lai LongXiang, Su Juan, Hao FaTao, Liu ShanShan, Duan LiuXin, Liu QuanDa

2016, 32(2): 351-353. DOI: 10.3969/j.issn.1001-5256.2016.02.033

Abstract(1921)

PDF (1955KB)(449)

Abstract:

Reviews

Treatment and prevention strategies to complications of transjugular intrahepatic portosystemic shunt

Tuo Lin, Tang ShanHong, Zeng WeiZheng, Wu XiaoLing

2016, 32(2): 354-357. DOI: 10.3969/j.issn.1001-5256.2016.02.034

Abstract(1779)

PDF (1523KB)(362)

Abstract:

Transjugular intrahepatic portosystemic shunt( TIPS) can effectively reduce portal hypertension,prevent recurrent esophagogastric variceal bleeding,and relieve intractable ascites. TIPS involves vessel puncture,expansion of puncture tract within the liver parenchyma,and stent implantation,and may ca...

Research advances in portal hypertensive gastropathy

Huang Guan, Dai ShuLong, Yang KunXing, Wang XiaoPing

2016, 32(2): 358-360. DOI: 10.3969/j.issn.1001-5256.2016.02.035

Abstract(2032)

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Abstract:
Portal hypertensive gastropathy( PHG) is a disease caused by cirrhotic( or non- cirrhotic) portal hypertension,with a typical feature of snake- skin appearance of the gastric mucosa under endoscope. Many studies have shown that portal hypertension is a necessary condition for the development and pro...

Research advances in association between regulatory T cells and hepatitis B virus infection

He JunNan, Zhao ShouSong

2016, 32(2): 361-365. DOI: 10.3969/j.issn.1001-5256.2016.02.036

Abstract(1574)

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Abstract:
Regulatory T cells are a subset of T cells,and can inhibit the body's immune response and induce immune tolerance,which has become one of the hot topics in the field of immunological research in recent years. Regulatory T cell dysfunction and the change in the number of regulatory T cells are closel...

Research advances in hepatitis B virus-associated glomerulonephritis

An Shuang, Zhang Rui, Yang WenXuan, Zhou HongJie, Zhang ZeTian, Yang YiLiang, Guo XiaoLin

2016, 32(2): 366-369. DOI: 10.3969/j.issn.1001-5256.2016.02.037

Abstract(1588)

PDF (1520KB)(466)

Abstract:
Hepatitis B virus- associated glomerulonephritis( HBV- GN) is the most common extrahepatic injury induced by chronic hepatitis B virus( HBV) infection,which has been taken seriously by scholars in recent years. This article summarizes the research advances in related risk factors for HBV- GN,pathoge...

Current studies of novel drugs against hepatitis B virus in clinical trials

Li Qiang, Huang YuXian, Chen Liang

2016, 32(2): 370-373. DOI: 10.3969/j.issn.1001-5256.2016.02.038

Abstract(2479)

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Abstract:
Chronic hepatitis B( CHB) is one of the major causes of liver cirrhosis and hepatocellular carcinoma. Interferon and nucleos( t)ide analogues can control disease progression. However,they cause very low HBs Ag clearance or seroconversion rates and relapse in most patients after treatment withdrawal....

Research advances in methods for determination of tumor boundary in hepatectomy

Wang JinWei, Zhang YaMin

2016, 32(2): 374-377. DOI: 10.3969/j.issn.1001-5256.2016.02.039

Abstract(1852)

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Abstract:
With the in- depth understanding of liver physiology,oncology,and anatomy,as well as the development of imaging technology and surgical equipment,hepatectomy has become more precise. Determination of tumor boundary during surgery has a great significance in realizing precise hepatectomy. Various met...

Research advances in non-hormonal therapies for autoimmune hepatitis

Zhong QiHua, Zhou GuiQin, Wang XianBo, Wang XiaoJing, Wang RongBing, Sun FengXia

2016, 32(2): 378-381. DOI: 10.3969/j.issn.1001-5256.2016.02.040

Abstract(2315)

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Abstract:
Autoimmune hepatitis is a chronic progressive inflammatory disease of the liver,which is mediated by the abnormal autoimmune response. Immunosuppressive therapy is the major therapeutic method for this disease,and liver transplantation can be performed for patients in the advanced stage. At present,...

Research advances in the pathogenesis of drug-induced liver injury

Xu Xin, Ji LiSha, Lu LinLin, Chen LiLi, Xin YongNing, Xuan ShiYing

2016, 32(2): 382-385. DOI: 10.3969/j.issn.1001-5256.2016.02.041

Abstract(2205)

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Abstract:
In recent years,with an increasing number of drug types and unreasonable drug use,the incidence and mortality of drug- induced liver injury( DILI) have been increasing. The pathogenesis of DILI is complex,and may involve liver injury caused by the direct effect of drugs,immune- mediated liver injury...

Advances in clinical research on liver disease during pregnancy

Liu MiaoMiao, Jia ShengNan, Zhang Qian, Xiao HeJun, Pan LiuLan

2016, 32(2): 386-389. DOI: 10.3969/j.issn.1001-5256.2016.02.042

Abstract(2108)

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Abstract:
Liver disease during pregnancy is substantially different from common liver diseases,and it is very important to raise the awareness of such disease and improve the diagnostic level. The literature on liver disease during pregnancy published in recent years is reviewed in this article,and the resear...

Role of ADAMTS13 in diagnosis and pathogenesis of liver diseases

Xu ShanShan, Chen YaLi, Zhang Jing

2016, 32(2): 390-392. DOI: 10.3969/j.issn.1001-5256.2016.02.043

Abstract(2449)

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Abstract:
Recent studies have demonstrated that coagulation function and liver microcirculation disturbance are important in the development and progression of liver diseases. ADAMTS13,also known as von Willebrand factor- cleaving protease,is a metalloproteinase produced by hepatic stellate cells,with major f...

Research progress in association between interleukin-23 and liver diseases

Bao SuXia, Zheng JianMing, Shi GuangFeng

2016, 32(2): 393-396. DOI: 10.3969/j.issn.1001-5256.2016.02.044

Abstract(2373)

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Abstract:
Interleukin 23( IL- 23) is a recently discovered cytokine,and growing evidence suggests that IL- 23 plays an important role in the development and progression of autoimmune diseases and inflammatory diseases. In recent years,certain research advances in association between IL- 23 and liver diseases ...

The role of hepatocyte nuclear factor 4 alpha in development and progression of liver diseases

Yang JinLian, Wang Yan

2016, 32(2): 397-403. DOI: 10.3969/j.issn.1001-5256.2016.02.045

Abstract(2888)

PDF (915KB)(547)

Abstract:
Hepatocyte nuclear factor 4 alpha( HNF4α),a member of the nuclear receptor superfamily,has a high expression level in mature hepatocytes. HNF4α can regulate hepatocyte- specific gene expression at a transcriptional level,promote hepatocyte development and differentiation,participate in establishment...

Conference overviews

A summary of 2015 academic conference of Tianjin Society of Integrated Traditional Chinese and Western Medicine for Liver Diseases