中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2016
Turn off MathJax
Article Contents

Metabolic syndrome and fatty liver

DOI: 10.3969/j.issn.1001-5256.2016.03.001
  • Received Date: 2016-02-03
  • Published Date: 2016-03-20
  • There is a close relationship of metabolic syndrome( MS) with chronic liver disease,especially fatty liver. There have been many studies on the clinical features,pathogenesis,diagnosis,and treatment of MS with fatty liver,but controversy still exists. This article reviews the latest progress and difficulties in the clinical studies of MS and related fatty liver,alcoholic liver disease,and chronic viral hepatitis,so as to help physicians improve the management of MS and fatty liver.

     

  • loading
  • [1]WANG FS,FAN JG,ZHANG Z,et al.The global burden of liver disease:the major impact of China[J].Hepatology,2014,60(6):2099-2108.
    [2] FAN JG.Epidemiology of alcoholic and nonalcoholic fatty liver disease in China[J].J Gastroenterol Hepatol,2013,28(Suppl 1):11-17.
    [3] RINELLA ME.Nonalcoholic fatty liver disease:a systematic review[J].JAMA,2015,313(22):2263-2273.
    [4]BYRNE CD,TARGHER G.NAFLD:A multisystem disease[J].J Hepatol,2015,62(Suppl 1):s47-s65.
    [5]NASCIMBENI F,PAIS R,BELLENTANI S,et al.From NAFLD in clinical practice to answers from guidelines[J].J Hepatol,2013,59(4):859-871.
    [6]O'SHEA RS,DASARATHY S,Mc CULLOUGH AJ.Alcoholic liver disease.AASLD practice guideline[J].Hepatology,2010,105(1):307-328.
    [7]GU D,REYNOLDS K,WU X,et al.Prevalence of the metabolic syndrome and overweight among adults in China[J].Lancet,2005,365(9468):1398-1405.
    [8]FAN JG,PENG YD.Metabolic syndrome and non-alcoholic fatty liver disease:Asian definitions and Asian studies[J].Hepatobiliary Pancreat Dis Int,2007,6(6):572-578.
    [9]FAN JG,SAIBARA T,CHITTURI S,et al.What are the risk factors and settings for non-alcoholic fatty liver disease in Asia-Pacific?[J].J Gastroenterol Hepatol,2007,22(6):794-800.
    [10] XU C,YU CH,MA H,et al.Prevalence and risk factors for the development of nonalcoholic fatty liver disease in a nonobese Chinese population:the Zhejiang Zhenhai Study[J].Am J Gastroenterol,2013,108(8):1299-1304.
    [11]ALBELDAWI M,AGGARWAL A,MADHWAL S,et al.Cumulative risk of cardiovascular events after orthotopic liver transplantation[J].Liver Transpl,2012,18(3):370-375.
    [12]AGRAWAL S,DARUWALA C.Metabolic syndrome and hepatic resection:improving outcome[J].HPB(Oxford),2011,13(12):846-859.
    [13]FAN JG,CAI XB,LI L,et al.Alcohol consumption and metabolic syndrome among Shanghai adults:a randomized multistage stratified cluster sampling investigation[J].World J Gastroenterol,2008,14(15):2418-2424.
    [14]GUNJI T,MATSUHASHI N,SATO H,et al.Alcohol consumption is inversely correlated with insulin resistance,independent of metabolic syndrome factors and fatty liver diseases[J].J Clin Gastroenterol,2011,45(9):808-813.
    [15]KIM JH,KIM SY,JUNG ES,et al.Carotid intima-media thickness is increased not only in non-alcoholic fatty liver disease patients but also in alcoholic fatty liver patients[J].Digestion,2011,84(2):149-155.
    [16]BUGIANESI E,SALAMONE F,NEGRO F.The interaction of metabolic factors with HCV infection:does it matter?[J].J Hepatol,2012,56(Suppl 1):s56-s65.
    [17]ADINOLFI LE,RESTIVO L,ZAMPINO R,et al.Chronic HCV infection is a risk of atherosclerosis.Role of HCV and HCV-related steatosis[J].Atherosclerosis,2012,221(2):496-502.
    [18]FAN JG,CHITTURI S.Hepatitis B and fatty liver:causal or coincidental?[J].J Gastroenterol Hepatol,2008,23(5):779-782.
    [19]HSU CS,LIU CH,WANG CC,et al.Impact of hepatitis B virus infection on metabolic profiles and modifying factors[J].J Viral Hepat,2012,19(2):e48-e57.
    [20]WONG VW,WONG GL,CHU WC,et al.Hepatitis B virus infection and fatty liver in the general population[J].J Hepatol,2012,56(3):533-540.
    [21]SHI JP,FAN JG,WU R,et al.Prevalence and risk factors of hepatic steatosis and its impact on liver injury in Chinese patients with chronic hepatitis B infection[J].J Gastroenterol Hepatol.2008,23(9):1419-1425.
    [22]PAN Q,ZHANG RN,WANG YQ,et al.Linked polymorphisms of PNPLA3 confer susceptibility to nonalcoholic steatohepatitis and decreased viral load in chronic hepatitis B[J].World J Gastroenterol,2015,21(28):8605-8614.
    [23]DING WJ,WANG MM,WANG GS,et al.Thyroid function is associated with non-alcoholic fatty liver disease in chronic hepatitis B infected subjects[J].J Gastroenterol Hepatol,2015,30(12):1753-1758.
    [24]WANG MM,WANG GS,SHEN F,et al.Hepatic steatosis is highly prevalent in hepatitis B patients and negatively associated with virological factors[J].Dig Dis Sci,2014,59(10):2571-2579.
    [25] JIN X,CHEN YP,YANG YD,et al.Association between hepatic steatosis and entecavir treatment failure in Chinese patients with chronic hepatitis B[J].PLo S One,2012,7(3):e34198.
    [26]HSIANG JC,WONG GL,CHAN HL,et al.Metabolic syndrome delays HBe Ag seroclearance in Chinese patients with hepatitis B[J].Aliment Pharmacol Ther,2014,40(6):716-726.
    [27]ZHANG Z,PAN Q,DUAN XY,et al.Fatty liver reduces hepatitis B virus replication in a genotype B hepatitis B virus transgenic mice model.Fatty liver reduces hepatitis B virus replication in a genotype B hepatitis B virus transgenic mice model[J].J Gastroenterol Hepatol,2012,27(12):1858-1864.
    [28]ZHANG RN,PAN Q,ZHANG Z,et al.Saturated fatty acid inhibits viral replication in chronic HBV infection with nonalcoholic fatty liver disease by TLR4 mediated innate immune response[J].Hepat Mon,2015,15(5):e27909.
    [29]CHU CM,LIN DY,LIAW YF.Clinical and virological characteristics post HBs Ag seroclearance in hepatitis B virus carriers with hepatic steatosis versus those without[J].Dig Dis Sci,2013,58(1):275-281.
    [30]BORENA W,STROHMAIER S,LUKANOVA A,et al.Metabolic risk factors and primary liver cancer in a prospective study of 578,700 adults[J].Int J Cancer,2012,131(1):193-200.
    [31]LIN CW,LIN CC,MO LR,et al.Heavy alcohol consumption increases the incidence of hepatocellular carcinoma in hepatitis B virus-related cirrhosis[J].J Hepatol,2013,58(4):730-735.
    [32]WELZEL TM,GRAUBARD BI,ZEUZEM S,et al.Metabolic syndrome increases the risk of primary liver cancer in the United States:a study in the SEER-Medicare database[J].Hepatology,2011,54(2):463-471.
    [33]Asia-Pacific Working Party for Prevention of Hepatocellular Carcinoma.Prevention of hepatocellular carcinoma in non-viral related liver diseases[J].J Gastroenterol Hepatol,2009,25(4):712-719.
    [34]NOBILI V,CARTER-KENT C,FELDSTEIN AE.The role of lifestyle changes in the management of chronic liver disease[J].BMC Med,2011,9(1):70.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2437) PDF downloads(505) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return