2016 No. 3

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Editorial

Metabolic syndrome and fatty liver

Fan JianGao, Yan ShiYan

2016, 32(3): 407-410. DOI: 10.3969/j.issn.1001-5256.2016.03.001

Abstract(2563)

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Abstract:
There is a close relationship of metabolic syndrome( MS) with chronic liver disease,especially fatty liver. There have been many studies on the clinical features,pathogenesis,diagnosis,and treatment of MS with fatty liver,but controversy still exists. This article reviews the latest progress and dif...

Therapeutic guidelines

Guideline for the diagnosis and treatment of gallbladder carcinoma(2015 edition)

Biliary Surgery Group of Surgery Branch of Chinese Medical Association

2016, 32(3): 411-419. DOI: 10.3969/j.issn.1001-5256.2016.03.002

Abstract(473)

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Abstract:

An interpretation of recommendations for expert consensus on the diagnosis and treatment of primary sclerosing cholangitis(2015)

Han Ying, Zhu JiangYi

2016, 32(3): 420-422. DOI: 10.3969/j.issn.1001-5256.2016.03.003

Abstract(324)

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Abstract:

Recommendations for APASL Clinical Practice Guidelines: management of hepatitis B (updated in 2015)

Zhu Peng, Tang Yi, Wang YuMing

2016, 32(3): 423-428. DOI: 10.3969/j.issn.1001-5256.2016.03.004

Abstract(346)

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Abstract:

Recommendations for EASL clinical practice guidelines: liver transplantation（2015）

Shi YingHong, Tian MengXin, Fan Jia

2016, 32(3): 429-431. DOI: 10.3969/j.issn.1001-5256.2016.03.005

Abstract(501)

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Abstract:

Discussions by experts

Nonalcoholic fatty liver disease and hepatocellular carcinoma

Li LiangPing

2016, 32(3): 432-436. DOI: 10.3969/j.issn.1001-5256.2016.03.006

Abstract(2571)

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Abstract:
As the etiology of hepatocellular carcinoma( HCC) has been changing,the incidence of HCC related to nonalcoholic fatty liver disease( NAFLD) is gradually increasing in developed countries in Europe and America and some countries in Asia. This article introduces the close association between NAFLD an...

Nonalcoholic fatty liver disease and serum uric acid

Xu BeiBei, Wang BingYuan

2016, 32(3): 437-441. DOI: 10.3969/j.issn.1001-5256.2016.03.007

Abstract(2318)

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Abstract:
Nonalcoholic fatty liver disease( NAFLD) is considered the manifestation of metabolic syndrome( MS) in the liver. Besides glucose and lipid metabolic disorders,the level of serum uric acid( SUA) is also associated with the progression of NAFLD. This article reviews the research achievements in the a...

Role of cell senescence in development and progression of nonalcoholic fatty liver disease

Zhang Jing, Wang BingYuan, Shi JunPing

2016, 32(3): 442-445. DOI: 10.3969/j.issn.1001-5256.2016.03.008

Abstract(2308)

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Abstract:
Nonalcoholic fatty liver disease( NAFLD) is a clinicopathological syndrome characterized by fatty degeneration of hepatocytes due to nonalcoholic reasons. Liver cirrhosis and hepatocellular carcinoma are two important outcomes of NAFLD. Cell senescence is a relatively stable state in which cells dev...

Research advances in susceptibility genes and their role in the pathogenesis of nonalcoholic fatty liver disease

Xuan ShiYing, Yuan Chen, Lu LinLin, Xin YongNing

2016, 32(3): 446-452. DOI: 10.3969/j.issn.1001-5256.2016.03.009

Abstract(2342)

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Abstract:
Currently the incidence of nonalcoholic fatty liver disease( NAFLD) is increasing,and the age of onset is getting younger worldwide,resulting in a heavy economic burden for both individuals and the society. Since NAFLD is closely related to heredity,metabolism,and the environment,genetic factors pla...

Original articles_ Fatty liver and metabolic syndrome

Prevalence of nonalcoholic fatty liver disease and its prognostic factors

Ni ManMan, Zhang YingQiu, Chen YueXiang, Zhang PingPing, Ceng Xin

2016, 32(3): 453-458. DOI: 10.3969/j.issn.1001-5256.2016.03.010

Abstract(2495)

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Abstract:

Objective To investigate the prevalence,natural history,and causes of death of nonalcoholic fatty liver disease( NAFLD),as well as related influencing factors. Methods A total of 833 retired cadres and staff members who underwent physical examination in Shanghai Changzheng Hospital and Shanghai 85 H...

Clinical significance of Fibro Touch,ultrasound,and computed tomography in diagnosis of fatty liver disease: a comparative analysis

Li JingBo, Liu Shu, Wen Bo, Gao Nan, Wang BingYuan

2016, 32(3): 459-462. DOI: 10.3969/j.issn.1001-5256.2016.03.011

Abstract(2794)

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Abstract:

Objective To investigate the clinical significance of image- guided transient elastography Fibro Touch with fat attenuation parameter( FAP) in the diagnosis of fatty liver disease. Methods A total of 1080 persons who underwent physical examination in The First Affiliated Hospital of China Medical Un...

Current status of nonalcoholic fatty liver disease and related risk factors: an analysis of an enterprise in Xi'an

Zhou Juan, Niu ChunYan, Wang Dan, Zhao HongXin, Yan YingLi, Yan Rong

2016, 32(3): 463-466. DOI: 10.3969/j.issn.1001-5256.2016.03.012

Abstract(2204)

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Abstract:

Objective To investigate the current status of nonalcoholic fatty liver disease( NAFLD) in an enterprise in Xi'an,China,and to provide a scientific basis for further studies on NAFLD in Shanxi. Methods A total of 415 employees who underwent health examination in The First Affiliated Hospital of Xi'a...

Original articles_Viral hepatitis

Effects of serum levels of chemokines on sustained virological response in patients with HBeAg-positive chronic hep-atitis B after treatment with pegylated interferon α-2b

Li Yan, Wang Xia, Cheng LiWei, Pan XiuCheng, Dan Ben, Geng Jian, Liu RuiXia, Fu JuanJuan, Li Li

2016, 32(3): 467-471. DOI: 10.3969/j.issn.1001-5256.2016.03.013

Abstract(2226)

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Abstract:
Objective To investigate the changes in serum levels of interferon( IFN)- γ- inducible protein 10( IP- 10),monokine induced by IFN- γ( Mig),and chemokine regulated upon activation,normal T cell expressed and secreted( RANTES) in patients with HBe Ag- positive chronic hepatitis B( CHB) undergoing peg...

Correlation of HBV DNA load with liver pathology,liver function,and serological markers of liver fibrosis in children with chronic hepatitis B

Qin XiaoMei, Fan ChenYing, Li ShuangJie, Peng HuiYun

2016, 32(3): 472-475. DOI: 10.3969/j.issn.1001-5256.2016.03.014

Abstract(2757)

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Abstract:
Objective To investigate the correlation of HBV DNA load with liver pathology,liver function,and serological markers of liver fibrosis in children with chronic hepatitis B( CHB). Methods A total of 79 children with a confirmed diagnosis of CHB who were admitted to Liver Research Center of Children's...

Classification tree model analysis of influencing factors for hepatocyte steatosis in patients with chronic hepatitis B

Wang Peng, Zhang ZhiQiao, Kang KaiFu, Wu GuoBiao

2016, 32(3): 476-479. DOI: 10.3969/j.issn.1001-5256.2016.03.015

Abstract(2063)

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Abstract:
Objective To investigate the influencing factors for hepatocyte steatosis in patients with chronic hepatitis B( CHB) and the high- risk population by classification tree model analysis,and to establish a simple method to assess the risk of hepatocyte steatosis in CHB patients. Methods The clinical d...

Genotypes and resistance loci in patients with chronic hepatitis B achieving virologic breakthrough in treatment with lamivudine combined with adefovir after developing drug resistance in treatment with lamivudine alone

Yang DongQiang, Chen Fang, Kang Yi, Ding GangQiang, Xiao ErHui, Peng Zhen, Shang Jia

2016, 32(3): 480-483. DOI: 10.3969/j.issn.1001-5256.2016.03.016

Abstract(2379)

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Abstract:
Objective To investigate the genotypes and resistance loci in patients with chronic hepatitis B( CHB) achieving virologic breakthrough in the treatment with lamivudine( LAM) combined with adefovir( ADV) after developing drug resistance in the treatment with LAM alone. Methods A total of 89 CHB patie...

Effects of HBV X protein on expression and promoter methylation of p16 tumor suppressor gene

Kang YanHong, Li Wei, Zhan WeiLi, Shang Jia, Yang Lin

2016, 32(3): 484-487. DOI: 10.3969/j.issn.1001-5256.2016.03.017

Abstract(2165)

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Abstract:
Objective To explore the effects of hepatitis B virus X protein( HBx) on the expression and promoter methylation of the p16 tumor suppressor gene,and to investigate the epigenetic role of HBx in the development and progression of hepatitis B virus( HBV)- associated hepatocellular carcinomas( HCC). M...

Original articles_Liver fibrosis and liver cirrhosis

Clinical manifestations and pathological features of congenital hepatic fibrosis: an analysis of 13 patients

Wu Jian, Yin Fang, Xia Lin, Luo GuanHong, Li Hong, Zhu ShaoHua, Zhang Jing, Zheng YangYang, Sun Han, Zhou XinMin

2016, 32(3): 488-490. DOI: 10.3969/j.issn.1001-5256.2016.03.018

Abstract(2423)

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Abstract:
Objective To summarize the clinical manifestations and pathological features of congenital hepatic fibrosis( CHF),and to improve the experience in the diagnosis and treatment of this disease. Methods A total of 13 patients with a confirmed diagnosis of CHF based on histopathological examinations who...

Clinical value of apparent diffusion coefficient in classification of liver fibrosis in chronic liver diseases

Zhang Jing, Zhao Hong, Zhang JiHong, Huang Rui, Lin XiaoRui, Liu RuJun, Li AnLian, Bei JinLing

2016, 32(3): 491-494. DOI: 10.3969/j.issn.1001-5256.2016.03.019

Abstract(2404)

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Abstract:
Objective To investigate the clinical value of apparent diffusion coefficient( ADC) in classification of liver fibrosis in chronic liver diseases. Methods A total of 63 chronic liver disease patients with liver fibrosis who were admitted to The Second People's Hospital of Zhuhai from December 2012 t...

Correlation between serum levels of complement C5a and liver fibrosis markers in patients with obstructive jaundice

Li ZhangZheng, Liu QuanDa, Yu HuiJie, Hu WenWei, Li Xue, Liu MingHao

2016, 32(3): 495-498. DOI: 10.3969/j.issn.1001-5256.2016.03.020

Abstract(340)

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Abstract:
Objective To investigate the change in the serum level of complement C5 a after obstruction removal and its correlation with the serum levels of liver fibrosis markers in patients with obstructive jaundice. Methods A total of 164 patients with obstructive jaundice who underwent endoscopic retrograde...

Relationship of hyponatremia with degree of liver injury and prognosis in patients with decompensated liver cirrhosis

Li Ying, Xu JiZhe, Liang LiNa, Liu LiNa

2016, 32(3): 499-502. DOI: 10.3969/j.issn.1001-5256.2016.03.021

Abstract(2288)

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Abstract:
Objective To investigate the relationship between hyponatremia and degree of liver injury,complications and survival time,and the prognostic value of hyponatremia in patients with decompensated liver cirrhosis. Methods A total of 218 patients who were diagnosed with decompensated liver cirrhosis for...

Antifibrotic mechanism of Fuzheng Huayu prescription by regulation of the differential expression of microRNAs in mouse liver

Wang QingLan, Tao YanYan, Lu: Jing, Liu Ping, Liu ChengHai

2016, 32(3): 503-508. DOI: 10.3969/j.issn.1001-5256.2016.03.022

Abstract(403)

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Abstract:
Objective To identify microRNAs( miRNAs) regulated by Fuzheng Huayu prescription( FZHY) and analyze their biological functions,and to partially reveal the antifibrotic mechanism of FZHY in liver fibrosis. Methods The mouse model of liver fibrosis was developed by subcutaneous injection of CCl4. The ...

Original articles_Liver neoplasms

Tumor features and correlation between lymphocyte count and biochemical parameters in patients with hepatitis B vi-rus- associated primary liver cancer with Yin deficiency

Yang ZhiYun, Du LinLin, He LingLing, Zhao YaLin, Jiang YuYong, Li XiuLan

2016, 32(3): 509-513. DOI: 10.3969/j.issn.1001-5256.2016.03.023

Abstract(2334)

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Abstract:

Objective To investigate the tumor features and the correlation between lymphocyte count and biochemical parameters in patients with hepatitis B virus- associated primary liver cancer( PLC) with yin deficiency. Methods A total of 148 PLC patients who were treated in Beijing Ditan Hospital,Capital Me...

Clinical features of non- B non- C hepatocellular carcinoma and virus-associated hepatocellular carcinoma and re-lated prognostic factors

Huang Yu, Huang Di, Liu Shuo, Weng JieFeng, Zhang Shuai, Zhang Qiang, Mai ZhenHao, Gu WeiLi

2016, 32(3): 514-517. DOI: 10.3969/j.issn.1001-5256.2016.03.024

Abstract(2605)

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Abstract:
Objective To investigate the differences in the clinical features of non- B,non- C hepatocellular carcinoma( NBNC- HCC)and virus- associated hepatocellular carcinoma( BC- HCC) and related prognostic factors. Methods A total of 231 patients with primary liver cancer who underwent partial hepatectomy ...

Clinical effect of precise sequential interventional therapy in patients with unresectable hepatic metastasis after surgery for colorectal cancer

Wang Xin, Zhang Hui, He XiaoJun, Li XinHui, Liu Yang, Zhang HongYi

2016, 32(3): 518-521. DOI: 10.3969/j.issn.1001-5256.2016.03.025

Abstract(2209)

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Abstract:
Objective To investigate the clinical effect of precise sequential interventional therapy in patients with unresectable hepatic metastasis after surgery for colorectal cancer. Methods The clinical data of 63 patients with unresectable hepatic metastasis after surgery for colorectal cancer,who were a...

Original articles_Biliary diseases

Effect of ursodeoxycholic acid on bile secretion after endoscopic nasobiliary drainage in patients with cholestatic liver disease of various causes

Li Lei, Li Bing, Ding HuiGuo

2016, 32(3): 522-525. DOI: 10.3969/j.issn.1001-5256.2016.03.026

Abstract(2219)

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Abstract:

Objective To observe the effect of ursodeoxycholic acid( UDCA) on bile secretion in patients with cholestatic liver disease of various causes. Methods A total of 48 patients who underwent endoscopic nasobiliary drainage( ENBD) in Beijing You'an Hospital Affiliated to Capital Medical University from ...

Effect of laparoscopic cholecystectomy on aminotransferase levels in patients with hyperlipidemia

Liu Yang, Zhang HongYi, Zhao Gang

2016, 32(3): 526-529. DOI: 10.3969/j.issn.1001-5256.2016.03.027

Abstract(2465)

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Abstract:

Objective To investigate the effect of laparoscopic cholecystectomy( LC) on postoperative levels of alanine aminotransferase( ALT) and aspartate aminotransferase( AST) in patients with different types of hyperlipidemia( HLP). Methods A total of 213 HLP patients who underwent LC in Department of Hepa...

Original articles_Pancreatic diseases

Efficacy of incision and drainage versus percutaneous catheter drainage in treatment of severe acute pancreatitis com-plicated by pancreatic abscess

Yang Feng, Xu Jing, Luo XuJuan, Peng Yan

2016, 32(3): 530-532. DOI: 10.3969/j.issn.1001-5256.2016.03.028

Abstract(2398)

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Abstract:
Objective To investigate the clinical features and treatment of severe acute pancreatitis( SAP) complicated by pancreatic abscess( PA). Methods The clinical data of 17 SAP patients with PA who were admitted to Affiliated Hospital of Luzhou Medical College from January 1,2005 to August 25,2015 were a...

Effect and prognosis of peri- pancreatic stepwise minimally invasive treatment in patients with severe acute pancreatitis

Xiong Yong, Wang HeBin, Liu DeQin, Chen JianXun, Liu JianPing, Sun ChangQin

2016, 32(3): 533-536. DOI: 10.3969/j.issn.1001-5256.2016.03.029

Abstract(2135)

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Abstract:
Objective To investigate the clinical effect and prognosis of peri- pancreatic stepwise minimally invasive treatment in patients with severe acute pancreatitis( SAP). Methods The clinical data of 110 patients with SAP who were treated in Panzhihua Central Hospital from January 2013 to December 2014 ...

Therapeutic effect of gemcitabine hydrochloride combined with stereotactic radiotherapy for locally advanced pancre-atic cancer

Ji HongBing, Chen ZhongHua

2016, 32(3): 537-540. DOI: 10.3969/j.issn.1001-5256.2016.03.030

Abstract(2132)

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Abstract:
Objective To investigate the clinical therapeutic effect of gemcitabine hydrochloride combined with stereotactic radiotherapy for locally advanced pancreatic cancer. Methods A total of 122 previously untreated patients with locally advanced pancreatic cancer who were not able to undergo surgical res...

Original articles_Others

Liver injury in children with severe sepsis: a clinical study of 58 patients

Peng HuiYun, Li Miao, Zhou LiFang, Tan XiaoMei, Fan ChenYing, Li ShuangJie

2016, 32(3): 541-544. DOI: 10.3969/j.issn.1001-5256.2016.03.031

Abstract(2050)

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Abstract:

Objective To investigate the clinical characteristics and prognostic value of liver injury in children with severe sepsis. Methods Children with severe sepsis who were admitted to our hospital and had complete clinical data from November 2013 to May 2015 were enrolled as subjects. Clinical character...

Protective effect of magnesium isoglycyrrhizinate in rats with acute liver failure induced by D- galactosamine

Li XiaoPeng, Li Ming, Lei Wan, Zhang LunLi

2016, 32(3): 545-548. DOI: 10.3969/j.issn.1001-5256.2016.03.032

Abstract(1955)

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Abstract:

Objective To investigate the protective effect of magnesium isoglycyrrhizinate( Mg IG) in rats with acute liver failure induced by D- galactosamine( D- Gal N) and related mechanisms. Methods A total of 90 Sprague- Dawley rats were randomly divided into normal group( group A,n = 10),model group( grou...

Case reports

Tang ShanHong, Ceng WeiZheng, Wu XiaoLing, Wang HaiQiong, Chen YiHua, Wang Zhao, Yang JianKun, Zhang Ming, Jiang MingDe

2016, 32(3): 549-551. DOI: 10.3969/j.issn.1001-5256.2016.03.033

Abstract(1367)

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Abstract:

Reviews

Current status of research on nonalcoholic fatty liver disease in China

Hu ZhongJie, Zhang Jing

2016, 32(3): 552-556. DOI: 10.3969/j.issn.1001-5256.2016.03.034

Abstract(2860)

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Abstract:
With the increasing prevalence rate of nonalcoholic fatty liver disease( NAFLD),this disease has been taken more seriously,more and more studies have been carried out in this field,and some important progress has been made. This article introduces the important research findings in the epidemiology,...

Research advances in natural drugs for prevention and treatment of nonalcoholic fatty liver disease

Liu BaoQing, Xu XiuQin, Men SiYe, Yu Wen, Yang ChengCheng, De Ji, Suo LangPingCuo, Chen Jing, Ni MaZhaBa, Dun ZhuCiRen, Wu Wei

2016, 32(3): 557-560. DOI: 10.3969/j.issn.1001-5256.2016.03.035

Abstract(1560)

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Abstract:

At present,nonalcoholic fatty liver disease( NAFLD) is the most common liver disease,and is often regarded as the manifestation of metabolic syndrome in the liver. There are no specific drugs for this disease at the moment,and the only therapeutic method proved effective is guiding life style to red...

Role of dietary intervention in nonalcoholic fatty liver disease

Hong Ze, Chen SiYing, Yang WenJuan, Ding QiLong

2016, 32(3): 561-564. DOI: 10.3969/j.issn.1001-5256.2016.03.036

Abstract(1605)

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Abstract:
Nonalcoholic fatty liver disease( NAFLD) is the most common chronic liver disease. However,at present,there are still no effective therapeutic methods for NAFLD in clinical practice. Lifestyle changes,especially changes in eating habits,play an important role in the treatment of NAFLD. This review s...

Association between nonalcoholic fatty liver disease and malignant transformation of hepatocytes

Gu JuanJuan, Yao Min, Yao DengFu

2016, 32(3): 565-569. DOI: 10.3969/j.issn.1001-5256.2016.03.037

Abstract(1619)

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Abstract:

Nonalcoholic fatty liver disease( NAFLD) is a clinicopathological syndrome characterized by diffuse macrovesicular steatosis and excessive lipid accumulation in the liver due to nonalcoholic reasons and other specific factors for liver injury,including simple fatty liver,nonalcoholic steatohepatitis...

Role of liver immunological inflammation in development and progression of nonalcoholic fatty liver disease

Zhu JuanJuan, Cheng MingLiang, Zhao XueKe

2016, 32(3): 570-573. DOI: 10.3969/j.issn.1001-5256.2016.03.038

Abstract(1693)

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Abstract:

Non- alcoholic fatty liver disease( NAFLD) is a common liver disease in clinical practice and has a complex pathogenesis. At present,the " two- or three- hit" theory is still widely acknowledged as the major pathogenesis of NAFLD. However,in recent years,the role of liver immunological inflammation ...

Role of inflammatory factors in development and progression of alcoholic liver disease

Qiu YuanYuan, Wang WeiHeng, Zhu Liang

2016, 32(3): 574-578. DOI: 10.3969/j.issn.1001-5256.2016.03.039

Abstract(1732)

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Abstract:
Alcohol liver disease( ALD) is the most common disease resulting in liver injury in the world. Inflammatory response is an important reason for liver injury in ALD. After being absorbed into the intestines,alcohol can increase the amount of intestinal endotoxin which enters the bloodstream through e...

Research advances in paternal- fetal vertical transmission during HBV infection

Zhang Kai, Lin ShuMei, Yang XueLiang, Kong Ying, Liu XiaoJing, Zhang Xi, Shi Lei, Chen YunRu, Ye Feng, Li Na

2016, 32(3): 579-583. DOI: 10.3969/j.issn.1001-5256.2016.03.040

Abstract(1873)

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Abstract:
Hepatitis B virus( HBV) infection is a global public health problem which greatly threatens human health. Paternal- fetal vertical transmission( P- FT) is one of the leading causes of persistent HBV infection,and has a transmission rate similar to that of mother- to- child vertical transmission. In ...

Research advances in association between Toll- like receptor 4 and hepatitis B

Fan WenHai, Chen QingFeng

2016, 32(3): 584-587. DOI: 10.3969/j.issn.1001-5256.2016.03.041

Abstract(1512)

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Abstract:

Toll- like receptor 4( TLR4) is an important pattern recognition receptor and plays an important role in the inhibition of hepatitis B virus( HBV) infection. It identifies the HBV- related proteins and produces inflammatory factors,such as tumor necrosis factor- α,interleukin- 6,and interleukin- 12,...

Application of magnetic resonance elastography as a non-invasive technique for diagnosis of liver fibrosis

Yang MingLei, Yao DingKang

2016, 32(3): 588-592. DOI: 10.3969/j.issn.1001-5256.2016.03.042

Abstract(2324)

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Abstract:
At present,liver biopsy is the gold standard for the diagnosis and grading of liver fibrosis,but its limitations have been widely acknowledged. The non- invasive detection methods are needed in clinical practice,and at present,magnetic resonance elastography( MRE)is a hot research topic. This articl...

Research advances in electroencephalographic monitoring of minimal hepatic encephalopathy

An Shuang, Yang WenXuan, Zhang GuoShan, Zhang ZeTian, Zhou HongJie, Yang Kun, Wang ShouQing, Guo XiaoLin

2016, 32(3): 593-596. DOI: 10.3969/j.issn.1001-5256.2016.03.043

Abstract(412)

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Abstract:
Hepatic encephalopathy( HE) is a serious neuropsychological complication in advanced liver disease,and is a major cause of death in patients with liver disease. The paper briefly introduces the advances in application of HE grading,examination methods,and electroencephalography( EEG) in the diagnosi...

Research advances in mesenchymal stem cells from various sources in treatment of liver fibrosis

Wang DongDong, Chen Gang, Hu ZongQiang, Li Li

2016, 32(3): 597-600. DOI: 10.3969/j.issn.1001-5256.2016.03.044

Abstract(2296)

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Abstract:
Mesenchymal stem cells( MSC) are derived from the mesoderm,and exhibit multipotential differentiation. MSC can alleviate liver fibrosis and improve liver function through paracrine cytokines and cell- cell interactions,but their therapeutic mechanism remains unknown. MSC are derived from various tis...

Research advances in application of molecular- targeted therapy for hepatocellular carcinoma

Liang Yuan, Wang ShiMing, Shi ZhenMing

2016, 32(3): 601-604. DOI: 10.3969/j.issn.1001-5256.2016.02.03.045

Abstract(2197)

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Abstract:

Hepatocellular carcinoma( HCC) greatly threatens human health. In clinical treatment,the therapeutic strategies for HCC are attracting more attention. With the research advances in the pathogenesis of HCC and the rapid development of molecular biology techniques,the therapies with molecular- targete...

Research advances in renal replacement therapy for hepatorenal syndrome

Chen Li, Mei Yong, Yang YiBin, Cao MingYan

2016, 32(3): 605-608. DOI: 10.3969/j.issn.1001-5256.2016.03.046

Abstract(2200)

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Abstract:

Hepatorenal syndrome( HRS) is a serious complication of the end- stage liver disease. The overall treatment outcome of HRS is not satisfactory,with a short survival time and a poor prognosis. Currently,renal replacement therapy is one of the main non- transplantation therapeutic methods,but its clin...

Role of UGT1A1 gene polymorphism in the pathogenesis of Gilbert syndrome

Song JinYun, Sun Mei, Li JiaYan, Wang JianFang, Wu XuPing

2016, 32(3): 609-612. DOI: 10.3969/j.issn.1001-5256.2016.03.047

Abstract(2905)

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Abstract:
As a bilirubin metabolic disorder,Gilbert syndrome belongs to the category of congenital non- hemolytic jaundice. Deficiency or decrease in the activity of bilirubin- uridine diphosphate glucuronyltransferase( UGT) is an important reason for the pathogenesis of Gilbert syndrome. UGT1A1,an isoenzyme ...