中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2016
Turn off MathJax
Article Contents

Research advances in natural drugs for prevention and treatment of nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2016.03.035
Research funding:

 

  • Published Date: 2016-03-20
  • At present,nonalcoholic fatty liver disease( NAFLD) is the most common liver disease,and is often regarded as the manifestation of metabolic syndrome in the liver. There are no specific drugs for this disease at the moment,and the only therapeutic method proved effective is guiding life style to reduce body weight. Insulin resistance,oxidative stress response,inflammatory response,and apoptosis are involved in the pathogenesis of NAFLD. Animal experiments and human studies have proved that various natural drugs have antioxidant,anti- inflammatory,or insulin- sensitizing effects and thus have significant efficacy in the treatment of NAFLD. This article summarizes the research advances in 10 natural drugs commonly used for the prevention and treatment of NAFLD in recent years and treatment of NAFLD in recent years and concludes that more studies are needed to confirm the efficacy of natural drugs in NAFLD patients.

     

  • loading
  • [1]AHMED M.Non-alcoholic fatty liver disease in 2015[J].World J Hepatol,2015,7(11):1450-1459.
    [2]FARRELL GC,WONG VW,CHITTURI S.NAFLD in Asia-as common and important as in the West[J].Nat Rev Gastroenterol Hepatol,2013,10(5):307-318.
    [3]ABD EL-KADER SM,EL-DEN ASHMAWY EM.Non-alcoholic fatty liver disease:the diagnosis and management[J].World J Hepatol,2015,7(6):846-858.
    [4]PAPPACHAN JM,ANTONIO FA,EDAVALATH M,et al.Non-alcoholic fatty liver disease:a diabetologist's perspective[J].Endocrine,2014,45(3):344-353.
    [5]COHEN JC,HORTON JD,HOBBS HH.Human fatty liver disease:old questions and new insights[J].Science,2011,332(6037):1519-1523.
    [6]DAY CP,JAMES OF.Steatohepatitis:a tale of two“hits”?[J].Gastroenterology,1998,114(4):842-845.
    [7]DONGIOVANNI P,ROMEO S,VALENTI L.Hepatocellular carcinoma in nonalcoholic fatty liver:role of environmental and genetic factors[J].World J Gastroenterol,2014,20(36):12945-12955.
    [8]GIBY VG,AJITH TA.Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease[J].World J Hepatol,2014,6(8):570-579.
    [9]FIRENZUOLI F,GORI L.Herbal medicine today:clinical and research issues[J].Evid Based Complement Alternat Med,2007,4(Suppl 1):37-40.
    [10]HEEBLL S,THOMSEN KL,PEDERSEN SB,et al.Effects of resveratrol in experimental and clinical non-alcoholic fatty liver disease[J].World J Hepatol,2014,6(4):188-198.
    [11]HEEBLL S,THOMSEN KL,CLOUSTON A,et al.Effect of resveratrol on experimental non-alcoholic steatohepatitis[J].Pharmacol Res,2015,95-96:34-41.
    [12]CHACHAY VS,MACDONALD GA,MARTIN JH,et al.Resveratrol does not benefit patients with nonalcoholic fatty liver disease[J].Clin Gastroenterol Hepatol,2014,12(12):2092-2103.
    [13]FAGHIHZADEH F,ADIBI P,RAFIEI R,et al.Resveratrol supplementation improves inflammatory biomarkers in patients with nonalcoholic fatty liver disease[J].Nutr Res,2014,34(10):837-843.
    [14]CHANG JJ,HSU MJ,HUANG HP,et al.Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance[J].J Agric Food Chem,2013,61(25):6069-6076.
    [15]VALENTI L,RISO P,MAZZOCCHI A,et al.Dietary anthocyanins as nutritional therapy for nonalcoholic fatty liver disease[J].Oxid Med Cell Longev,2013,2013:145421.
    [16]TANG X,SHEN T,JIANG X,et al.Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency[J].J Agric Food Chem,2015,63(2):552-561.
    [17]ZHANG PW,CHEN FX,LI D,et al.A CONSORT-compliant,randomized,double-blind,placebo-controlled pilot trial of purified anthocyanin in patients with nonalcoholic fatty liver disease[J].Medicine(Baltimore),2015,94(20):e758.
    [18]XIAO J,HO CT,LIONG EC,et al.Epigallocatechin gallate attenuates fibrosis,oxidative stress,and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD,PI3 K/Akt/Fox O1,and NFkappa B pathways[J].Eur J Nutr,2014,53(1):187-199.
    [19]GAN L,MENG ZJ,XIONG RB,et al.Green tea polyphenol epigallocatechin-3-gallate ameliorates insulin resistance in non-alcoholic fatty liver disease mice[J].Acta Pharmacol Sin,2015,36(5):597-605.
    [20]SAKATA R,NAKAMURA T,TORIMURA T,et al.Green tea with high-density catechins improves liver function and fat infiltration in non-alcoholic fatty liver disease(NAFLD)patients:a doubleblind placebo-controlled study[J].Int J Mol Med,2013,32(5):989-994.
    [21]YESIL A,YILMAZ Y.Review article:coffee consumption,the metabolic syndrome and non-alcoholic fatty liver disease[J].Aliment Pharmacol Ther,2013,38(9):1038-1044.
    [22]CHEN S,TEOH NC,CHITTURI S,et al.Coffee and non-alcoholic fatty liver disease:brewing evidence for hepatoprotection?[J].J Gastroenterol Hepatol,2014,29(3):435-441.
    [23]BAMBHA K,WILSON LA,UNALP A,et al.Coffee consumption in NAFLD patients with lower insulin resistance is associated with lower risk of severe fibrosis[J].Liver Int,2014,34(8):1250-1258.
    [24]ZELBER-SAGI S,SALOMONE F,WEBB M,et al.Coffee consumption and nonalcoholic fatty liver onset:a prospective study in the general population[J].Transl Res,2015,165(3):428-436.
    [25]TAKEMURA S,MINAMIYAMA Y,KODAI S,et al.S-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism[J].J Clin Biochem Nutr,2013,53(2):94-101.
    [26]XIAO J,GUO R,FUNG ML,et al.Garlic-derived S-allylmercaptocysteine ameliorates nonalcoholic fatty liver disease in a rat model through inhibition of apoptosis and enhancing autophagy[J].Evid Based Complement Alternat Med,2013,2013:642920.
    [27]LAI YS,CHEN WC,HO CT,et al.Garlic essential oil protects against obesity-triggered nonalcoholic fatty liver disease through modulation of lipid metabolism and oxidative stress[J].J Agric Food Chem,2014,62(25):5897-5906.
    [28]SAHEBKAR A.Potential efficacy of ginger as a natural supplement for nonalcoholic fatty liver disease[J].World J Gastroenterol,2011,17(2):271-272.
    [29]GAO H,GUAN T,LI C,et al.Treatment with ginger ameliorates fructose-induced fatty liver and hypertriglyceridemia in rats:modulation of the hepatic carbohydrate response element-binding protein-mediated pathway[J].Evid Based Complement Alternat Med,2012,2012:570948.
    [30]MONTEIRO J,LESLIE M,MOGHADASIAN MH,et al.The role of n-6 and n-3 polyunsaturated fatty acids in the manifestation of the metabolic syndrome in cardiovascular disease and non-alcoholic fatty liver disease[J].Food Funct,2014,5(3):426-435.
    [31]KIM JK,LEE KS,LEE DK,et al.Omega-3 polyunsaturated fatty acid and ursodeoxycholic acid have an additive effect in attenuating diet-induced nonalcoholic steatohepatitis in mice[J].Exp Mol Med,2014,46:e127.
    [32]CAPANNI M,CALELLA F,BIAGINI MR,et al.Prolonged n-3 polyunsaturated fatty acid supplementation ameliorates hepatic steatosis in patients with non-alcoholic fatty liver disease:a pilot study[J].Aliment Pharmacol Ther,2006,23(8):1143-1151.
    [33]PARKER HM,JOHNSON NA,BURDON CA,et al.Omega-3 supplementation and non-alcoholic fatty liver disease:a systematic review and meta-analysis[J].J Hepatol,2012,56(4):944-951.
    [34]DASARATHY S,DASARATHY J,KHIYAMI A,et al.Double-blind randomized placebo-controlled clinical trial of omega 3 fatty acids for the treatment of diabetic patients with nonalcoholic steatohepatitis[J].J Clin Gastroenterol,2015,49(2):137-144.
    [35]HNCU N,ROMAN G,NITC,et al.Metabolic syndrome-practical approach[J].Rom J Intern Med,2004,42(2):2372-2345.
    [36]SATO K,ARAI H,MIZUNO A,et al.Dietary palatinose and oleic acid ameliorate disorders of glucose and lipid metabolism in Zucker fatty rats[J].J Nutr,2007,137(8):1908-1915.
    [37]NIGAM P,BHATT S,MISRA A,et al.Effect of a 6-month intervention with cooking oils containing a high concentration of monounsaturated fatty acids(olive and canola oils)compared with control oil in male Asian Indians with nonalcoholic fatty liver disease[J].Diabetes Technol Ther,2014,16(4):255-261.
    [38]RANASINGHE P,JAYAWARDANA R,GALAPPATHTHY P,et al.Efficacy and safety of'true'cinnamon(Cinnamomum zeylanicum)as a pharmaceutical agent in diabetes:a systematic review and meta-analysis[J].Diabet Med,2012,29(12):1480-1492.
    [39]ASKARI F,RASHIDKHANI B,HEKMATDOOST A.Cinnamon may have therapeutic benefits on lipid profile,liver enzymes,insulin resistance,and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients[J].Nutr Res,2014,34(2):143-148.
    [40]SURAPANENI KM,JAINU M.Pioglitazone,quercetin and hydroxy citric acid effect on hepatic biomarkers in Non Alcoholic Steatohepatitis[J].Pharmacognosy Res,2014,6(2):153-162.
    [41]PISONERO-VAQUERO S,MARTNEZ-FERRERAS,GARCAMEDIAVILLA MV,et al.Quercetin ameliorates dysregulation of lipid metabolism genes via the PI3K/AKT pathway in a diet-induced mouse model of nonalcoholic fatty liver disease[J].Mol Nutr Food Res,2015,59(5):879-893.
    [42]ISHIKAWA H,TAKAKI A,TSUZAKI R,et al.L-carnitine prevents progression of non-alcoholic steatohepatitis in a mouse model with upregulation of mitochondrial pathway[J].PLo S One,2014,9(7):e100627.
    [43]BAE JC,LEE WY,YOON KH,et al.Improvement of nonalcoholic fatty liver disease with carnitine-orotate complex in type 2 diabetes(CORONA):a randomized controlled trial[J].Diabetes Care,2015,38(7):1245-1252.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1494) PDF downloads(360) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return