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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 3
Mar.  2016
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Article Contents

Research advances in paternal- fetal vertical transmission during HBV infection

DOI: 10.3969/j.issn.1001-5256.2016.03.040
  • Published Date: 2016-03-20
  • Hepatitis B virus( HBV) infection is a global public health problem which greatly threatens human health. Paternal- fetal vertical transmission( P- FT) is one of the leading causes of persistent HBV infection,and has a transmission rate similar to that of mother- to- child vertical transmission. In recent years,P- FT has been attracting more and more attention and has become a hot research topic at home and abroad. It has been confirmed that P- FT occurs via sperm,but the mechanism remains unknown. Studies have shown that a high HBV DNA load in serum and semen and positive serum HBe Ag are the major risk factors for the occurrence of P- FT. Random integration of HBV DNA into sperm can affect sperm quality,cause male infertility,and even affect the maternal pregnancy outcome. Currently the most important measure to block P- FT is pre- pregnancy intervention,including antiviral therapy for the father and active immunization for the mother.

     

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