中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2016
Turn off MathJax
Article Contents

Early diagnosis of pancreatic cancer

DOI: 10.3969/j.issn.1001-5256.2016.05.008
  • Received Date: 2016-03-02
  • Published Date: 2016-05-20
  • Pancreatic cancer has a high degree of malignancy and a poor prognosis,and at present,early diagnosis of pancreatic cancer is very difficult. This article reviews the changes in molecular biological characteristics in the development,progression,and metastasis of pancreatic cancer and related mechanisms and determines the potential targets for clinical diagnosis of pancreatic cancer. This article also summarizes the clinical manifestations of pancreatic cancer,high- risk factors,tumor markers,and the role of combined determination and new equipment in early diagnosis,and points out that the application of serological and radiological examinations and identification of new tumor markers are important methods to improve the early diagnosis of pancreatic cancer in clinical practice.

     

  • loading
  • [1]GUO XZ,CUI ZM.Current diagnosis and treatment of pancreatic cancer in China[J].Pancreas,2005,31(1):13-22.
    [2]LI HY,CUI ZM,CHEN J,et al.Pancreatic cancer:diagnosis and treatments[J].Tumour Biol,2015,36(3):1375-1384.
    [3]YACHIDA S,JONES S,BOZIC I,et al.Distant metastasis occurs late during the genetic evolution of pancreatic cancer[J].Nature,2010,467(7319):1114-1117.
    [4]LIOU GY,DPPLER H,NECELA B,et al.Mutant KRAS-induced expression of ICAM-1 in pancreatic acinar cells causes attraction of macrophages to expedite the formation of precancerous lesions[J].Cancer Discov,2015,5(1):52-63.
    [5]REN LN,LI QF,XIAO FJ,et al.Endocrine glands-derived vascular endothelial growth factor protects pancreatic cancer cells from apoptosis via upregulation of the myeloid cell leukemia-1 protein[J].Biochem Biophys Res Commun,2009,386(1):35-39.
    [6]REN L,GUO X,SHAO X,et al.Endocrine gland-derived vascular endothelial growth factor modulates proliferation,apoptosis and migration in pancreatic cancer cells[J].Mol Med Rep,2015,11(6):4279-4284.
    [7]WU CY,YAN J,YANG YF,et al.Overexpression of KAI1 induces autophagy and increases MiaP aC a-2 cell survival through the phosphorylation of extracellular signal-regulated kinases[J].Biochem Biophys Res Commun,2011,404(3):802-808.
    [8]WU CY,GUO XZ,LI HY.Hypoxia and serum deprivation protected MiaP aC a-2 cells from KAI1-induced proliferation inhibition through autophagy pathway activation in solid tumors[J].Clin Transl Oncol,2015,17(3):201-208.
    [9]GUO XZ,FRIESS H,GRABER HU,et al.KAI1 expression is up-regulated in early pancreatic cancer and decreased in the presence of metastases[J].Cancer Res,1996,56(21):4876-4880.
    [10]LIU X,GUO XZ,ZHANG WW,et al.KAI1 inhibits HGF-induced invasion of pancreatic cancer by sphingosine kinase activity[J].Hepatobiliary Pancreat Dis Int,2011,10(2):201-208.
    [11]OUYANG H,GORE J,DEITZ S,et al.microRNA-10b enhances pancreatic cancer cell invasion by suppressing TIP30 expression and promoting EGF and TGF-βactions[J].Oncogene,2014,33(38):4664-4674.
    [12]YAO H,GUO XZ,LI HY,et al.Analysis of 23 misdiagnosed patients with acute pancreatitis[J].Clin Misdiagn Misther,2013,26(2):1-3.(in Chinese)姚辉,郭晓钟,李宏宇,等.急性胰腺炎23例误诊分析[J].临床误诊误治,2013,26(2):1-3.
    [13]LI XS,GUO XZ,REN LN,et al.An analytic study on clinical pathology features of 207 cases of pancreatic adenocarcinoma[J].Pract J Cancer,2010,25(6):638-641.(in Chinese)李晓姝,郭晓钟,任丽楠,等.胰腺癌207例临床病理特征分析[J].实用癌症杂志,2010,25(6):638-641.
    [14]GUO XZ,LI HY,CUI ZM,et al.Review and prospect of the 25-year study of pancreatic carcinoma[J].J Clin Hepatol,2011,27(11):5-8.(in Chinese)郭晓钟,李宏宇,崔忠敏,等.胰腺癌研究25年及展望[J].临床肝胆病杂志,2011,27(11):5-8.
    [15]HUMPHRIS JL,JOHNS AL,SIMPSON SH,et al.Australian Pancreatic Cancer Genome Initiative.Clinical and pathologic features of familial pancreatic cancer[J].Cancer,2014,120(23):3669-3675.
    [16]COTE GA,GORE AJ,McE LYEA SD,et al.A pilot study to develop a diagnostic test for pancreatic ductal adenocarcinoma based on differential expression of select miRNA in plasma and bile[J].Am J Gastroenterol,2014,109(12):1942-1952.
    [17]LIU MP,GUO XZ,XU JH,et al.New tumor-associated antigen SC6 in pancreatic cancer[J].WJG,2005,11(48):7671-7675.
    [18]LI X,GUO X,LI H,et al.Serum carbohydrate antigen 242 expression exerts crucial function in the diagnosis of pancreatic cancer[J].Tumour Biol,2014,35(6):5281-5286.
    [19]WANG D,GUO XZ,LI HY,et al.Prognostic significance of cyclooxygenase-2 protein in pancreatic cancer:a meta-analysis[J].Tumour Biol,2014,35(10):10301-10307.
    [20]O'BRIEN DP,SANDANAYAKE NS,JENKINSON C,et al.Serum CA19-9 is significantly upregulated up to 2 years before diagnosis with pancreatic cancer:implications for early disease detection[J].Clin Cancer Res,2015,21(3):622-631.
    [21]GUO XZ.Discussion of difficult problems of early diagnosis of pancreatic cancer[J].J Clin Hepatol,2014,30(8):734-736.(in Chinese)郭晓钟.胰腺癌早期诊断难点的思考[J].临床肝胆病杂志,2014,30(8):734-736.
    [22]LI H,HU Z,CHEN J,et al.Comparison of ERCP,EUS,and ERCP combined with EUS in diagnosing pancreatic neoplasms:a systematic review and meta-analysis[J].Tumour Biol,2014,35(9):8867-8874.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (2529) PDF downloads(550) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return