2016 No. 5

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Editorial

Value of artery resection in pancreatic cancer surgery

Jiang KuiRong, Hu Hao, Miao Yi

2016, 32(5): 826-829. DOI: 10.3969/j.issn.1001-5256.2016.05.001

Abstract(1691)

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Abstract:

Locally advanced pancreatic cancer often invades the surrounding blood vessels. Currently,pancreatectomy combined with venous resection for the treatment of patients with venous involvement is accepted worldwide,but pancreatectomy combined with arterial resection for arterial involvement is still co...

Therapeutic guidelines

Expert consensus on pharmacological prevention of pancreatitis after endoscopic retrograde cholangiopancreatography (2015, Shanghai)

Pancreatic Disease Committee of Chinese Medical Doctor Association, Chinese Society of Digestive Endoscopy, Chinese Medical Association

2016, 32(5): 830-834. DOI: 10.3969/j.issn.1001-5256.2016.05.002

Abstract(255)

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Abstract:

Guideline for diagnosis and treatment of herb-induced liver injury

Branch of Hepatobiliary Diseases, China Association of Chinese Medicine, Branch of Chinese Patent Medicine, China Association of Chinese Medicine

2016, 32(5): 835-843. DOI: 10.3969/j.issn.1001-5256.2016.05.003

Abstract(4418)

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Abstract:

Expert consensus on clinical application of glycyrrhizin preparation in the treatment of liver diseases

Expert Committee on Clinical Application of Glycyrrhizin Preparation in the Treatment of Liver Diseases

2016, 32(5): 844-852. DOI: 10.3969/j.issn.1001-5256.2016.05.004

Abstract(5603)

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Abstract:

The American College of Preventive Medicine position statement on hepatitis C virus infection

Rao HuiYing, Wei Lai

2016, 32(5): 853-856. DOI: 10.3969/j.issn.1001-5256.2016.05.005

Abstract(2428)

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Abstract:

An excerpt of evidence-based clinical practice guidelines for chronic pancreatitis by Japanese Society of Gastroenterology in 2015

Li XiaoQing

2016, 32(5): 857-859. DOI: 10.3969/j.issn.1001-5256.2016.05.006

Abstract(2310)

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Abstract:

Discussions by experts

Clinical features of pancreatic cystic neoplasms and its therapeutic strategy

Zhang JiaLi, Ge ChunLin

2016, 32(5): 860-863. DOI: 10.3969/j.issn.1001-5256.2016.05.007

Abstract(2291)

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Abstract:
The detection rate of pancreatic cystic neoplasms obviously increases with the development of imaging technology. However,it is still difficult to make the differential diagnosis between different types of pancreatic cystic neoplasms. For pancreatic cystic neoplasms,the physical condition of the pat...

Early diagnosis of pancreatic cancer

Liu Xu, Guo XiaoZhong

2016, 32(5): 864-866. DOI: 10.3969/j.issn.1001-5256.2016.05.008

Abstract(2604)

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Abstract:
Pancreatic cancer has a high degree of malignancy and a poor prognosis,and at present,early diagnosis of pancreatic cancer is very difficult. This article reviews the changes in molecular biological characteristics in the development,progression,and metastasis of pancreatic cancer and related mechan...

New thoughts and techniques in pancreatic anastomosis

Feng YeChen, Wang Min, Qin RenYi

2016, 32(5): 867-869. DOI: 10.3969/j.issn.1001-5256.2016.05.009

Abstract(2353)

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Abstract:
The surgical procedures of pancreaticoduodenectomy are always controversial,and digestive tract reconstruction,especially the method of pancreatic anastomosis,has been one of the difficulties. This article introduces the methods of digestive tract reconstruction in pancreaticoduodenectomy at home an...

Chinical experience of laparoscopic spleen-preserving distal pancreatectomy

Wang GuangYi, Jiang Chao

2016, 32(5): 870-872. DOI: 10.3969/j.issn.1001-5256.2016.05.010

Abstract(2567)

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Abstract:

Due to the limitations of laparoscopic surgery,the lack of special instrument,and the particular location,structure,and function of the pancreas,laparoscopic pancreatic surgery develops slowly and is used only for diagnosis. With the innovation of laparoscopic instruments,the increases in operative ...

Original articles_Pancreatic diseases

Efficacy of high-dose hypofractionated radiotherapy in elderly patients with stage Ⅳ pancreatic cancer

Ren Gang, Wang YingJie, Di YuPeng, Chang DongShu, Kang XiaoLi, Zhu FuHai, Wu WeiZhang, Liu Xian, Xia TingYi

2016, 32(5): 873-875. DOI: 10.3969/j.issn.1001-5256.2016.05.011

Abstract(2027)

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Abstract:

Objective To investigate the efficacy and toxic and adverse effects of high- dose hypofractionated radiotherapy in elderly patients with stage Ⅳ pancreatic cancer. Methods The clinical data of the patients with pancreatic cancer and distant metastasis who were admitted to our hospital from September...

Expression and significance of Axin2 in pancreatic cancer cells

Zhang Tao, Chen GuoDong, He GengSheng, He Jun

2016, 32(5): 876-879. DOI: 10.3969/j.issn.1001-5256.2016.05.012

Abstract(2794)

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Abstract:

Objective To investigate the expression of Axin2 in pancreatic cancer cells,and to observe the influence of Axin2 on the proliferation,invasion,and migration of human pancreatic cancer cells( PANC- 1). Methods Quantitative real- time PCR was used to measure the expression of Axin2 in pancreatic canc...

Specific antitumor immune response induced by infusion of Capan-2 pancreatic cancer cells and dendritic cells: an in vitro study

Chen Jiang, Xu WenDa, Li HongYu, Zhao JiaJun, Guo XiaoZhong

2016, 32(5): 880-884. DOI: 10.3969/j.issn.1001-5256.2016.05.013

Abstract(2739)

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Abstract:

Objective To investigate the specific antitumor immune response induced by the infusion of Capan- 2 pancreatic cancer cells and dendritic cells( DC). Methods DC were isolated from the peripheral blood mononuclear cells( PBMC) derived from 6 patients with pancreatic cancer and cultured. The DC obtain...

Original articles_Viral hepatitis

Risk factors for recurrence after drug withdrawal in HBeAg-positive chronic hepatitis B patients completing pharmacotherapy with nucleos(t) ide analogues

Hu BoBin, Jiang JianNing, Fu JiaXin, Wang BaoJian, Wu XiaoLi, Liang Peng, Mo YanYan, Fu YanPing, Du Man, Liu Yu

2016, 32(5): 885-889. DOI: 10.3969/j.issn.1001-5256.2016.05.014

Abstract(2601)

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Abstract:

Objective To investigate the risk factors for recurrence after drug withdrawal in HBeAg- positive chronic hepatitis B( CHB)patients completing the treatment with nucleos( t) ide analogues( NAs). Methods A total of 60 HBeAg- positive CHB patients who visited and were treated in The First Hospital Aff...

Correlation between serum interleukin-1 receptor antagonist and disease severity in patients with HBV-related liver failure

Lai JingLan, Liu YuMing, Lin Chun, Sun Fang, Zhou Rui, Lin Yong, Lin YuanBao

2016, 32(5): 890-893. DOI: 10.3969/j.issn.1001-5256.2016.05.015

Abstract(2343)

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Abstract:

Objective To investigate the correlation between serum interleukin- 1 receptor antagonist( IL- 1Ra) level and disease severity in patients with acute- on- chronic hepatitis B liver failure( HBV- ACLF). Methods A total of 31 patients with HBV- ACLF who visited Fuzhou Infectious Disease Hospital from ...

Effects of hepatitis B virus on the expression of Toll-like receptor 9,interferon regulatory factor-7,and interferon-α in plasmacytoid dendritic cells in the umbilical cord blood of healthy parturients

Peng JianPing, Sun KeWei, Yin SiHan, Wu YuNan

2016, 32(5): 894-898. DOI: 10.3969/j.issn.1001-5256.2016.05.016

Abstract(2349)

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Abstract:

Objective To investigate the effects of hepatitis B virus( HBV) on the expression of Toll- like receptor 9( TLR9),interferon regulatory factor- 7( IRF- 7),and interferonα( IFNα) in plasmacytoid dendritic cells( pDCs) cultured in vitro in the umbilical cord blood of healthy parturients. Methods Hep G...

Original articles_Liver neoplasms

Therapeutic effect of transcatheter arterial chemoembolization combined with thalidomide or sorafenib in treatment of unresectable primary liver cancer: a comparative analysis

Zheng Kang, He MengGuo, Wang ZhiXiang

2016, 32(5): 899-903. DOI: 10.3969/j.issn.1001-5256.2016.05.017

Abstract(2785)

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Abstract:

Objective To investigate the therapeutic effect and adverse effects of transcatheter arterial chemoembolization( TACE) combined with thalidomide or sorafenib in the treatment of unresectable primary liver cancer. Methods A total of 102 patients who underwent TACE combined with thalidomide or sorafen...

Association between single nucleotide polymorphism of microRNA-146a and recurrence after liver cancer surgery

Zhang Hua, He DeHua, Li GuiZhong

2016, 32(5): 904-907. DOI: 10.3969/j.issn.1001-5256.2016.05.018

Abstract(2560)

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Abstract:

Objective To investigate the association between the single nucleotide polymorphism( SNP) of miRNA- 146 a rs2910164 and recurrence after liver cancer surgery. Methods A total of 89 patients with primary liver cancer who underwent radical resection for liver cancer in Maojian Hospital of Dongfeng Med...

Effect of sorafenib combined with thalidomide on angiogenesis in chick chorioallantoic membrane

Guo ZhenYa, Ye JunFeng, Xie QianKun, Wang GuangYi

2016, 32(5): 908-910. DOI: 10.3969/j.issn.1001-5256.2016.05.019

Abstract(2219)

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Abstract:

Objective To investigate the effect of sorafenib and / or thalidomide on angiogenesis in chick chorioallantoic membrane( CAM).Methods White eggs incubated for 7 days were used to establish a CAM model. The model eggs were randomly divided blank control group,sorafenib group,thalidomide group,and sor...

Original articles_Biliary diseases

Preventive measures for bile duct injury and bleeding during laparoscopic cholecystectomy

Huang Wei, Chen Yi

2016, 32(5): 911-913. DOI: 10.3969/j.issn.1001-5256.2016.05.020

Abstract(2072)

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Abstract:
Objective To investigate the surgical methods for the prevention of bile duct injury and bleeding during laparoscopic cholecystectomy( LC). Methods The clinical data of 600 patients who underwent LC from September 2010 to June 2013 were analyzed retrospectively,and with reference to related articles...

Clinical effects of laparoscopy and laparotomy in treatment of gangrenous cholecystitis

Zhou JingSong, Pu DongLi, Du ZiYou

2016, 32(5): 914-917. DOI: 10.3969/j.issn.1001-5256.2016.05.021

Abstract(2343)

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Abstract:
Objective To compare the clinical effects of laparoscopic cholecystectomy( LC) and open cholecystectomy( OC) in the treatment of gangrenous cholecystitis and their influence on inflammatory mediators. Methods A total of 82 patients with gangrenous cholecystitis who underwent surgery in 22 Hospital o...

Risk factors for long-term complications after endoscopic sphincterotomy for benign biliary and pancreatic diseases

Ding ShiHua, Wu DongHai, Guo HaiJian, Liu Jun

2016, 32(5): 918-920. DOI: 10.3969/j.issn.1001-5256.2016.05.022

Abstract(2135)

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Abstract:
Objective To investigate the risk factors for long- term complications after endoscopic sphincterotomy( EST) for benign biliary and pancreatic diseases. Methods The follow- up data of the patients who underwent EST in Department of Gastroenterology,The First Affiliated Hospital of Shenzhen Universit...

Original articles_New technology and therapeutic strategy

Experience in application of pancreaticojejunostomy with double purse-string suture in laparoscopic pancreaticoduodenectomy

Zhang Wei, Wang YingChao, Liu Kai, Liu SongYang, Fu Yu, Liu YaHui

2016, 32(5): 921-924. DOI: 10.3969/j.issn.1001-5256.2016.05.023

Abstract(1775)

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Abstract:
Objective To investigate double purse- string suture as a safe and effective method for pancreaticojejunostomy in laparoscopic pancreaticoduodenectomy. Methods A total of 6 patients who recently underwent laparoscopic pancreaticoduodenectomy in The First Hospital of Jilin University were enrolled. T...

Original articles_Others

Effect of endoscopic injection of cyanoacrylate in treatment of acute esophageal and gastric variceal bleeding in children

Zhang XiaoXing, Li Qian, Yang KaiLong, Han Peng, Zhang YingXu

2016, 32(5): 925-927. DOI: 10.3969/j.issn.1001-5256.2016.05.024

Abstract(314)

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Abstract:

Objective To investigate the effect and safety of endoscopic injection of cyanoacrylate in the treatment of esophageal and gastric variceal bleeding( EGVB) in children. Methods The clinical data of 35 children with acute EGVB who were treated with endoscopic injection of cyanoacrylate in Children's ...

Establishment of a rat model of early-stage liver failure and Th17/Treg imbalance

Li Dong, Lu ZhongHua, Gan JianHe

2016, 32(5): 928-932. DOI: 10.3969/j.issn.1001-5256.2016.05.025

Abstract(2228)

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Abstract:

Objective To investigate the methods for establishing a rat model of early- stage liver failure and the changes in Th17,Treg,and Th17 / Treg after dexamethasone and thymosin interventions. Methods A total of 64 rats were randomly divided into carbon tetrachloride( CCl4) group and endotoxin [lipopoly...

Mechanism of α-naphthyl isothiocyanate inducing cholestatic hepatitis: a preliminary study

Li Hua, Li YiMing, Lu Le

2016, 32(5): 933-937. DOI: 10.3969/j.issn.1001-5256.2016.05.026

Abstract(2898)

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Abstract:

Objective To investigate the mechanism of α- naphthyl isothiocyanate( ANIT) inducing cholestatic hepatitis. Methods A total of 60 healthy male Sprague- Dawley rats were randomly divided into normal control group( N group with 30 rats) and model group( ANIT group with 30 rats),and each group was furt...

Brief reports

Clinical application of three-dimensional reconstruction in preoperative evaluation of hepatectomy

Li LianHai, Wang JianWei, Liu Bin, Xu HuiLing

2016, 32(5): 938-941. DOI: 10.3969/j.issn.1001-5256.2016.05.027

Abstract(1489)

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Abstract:

Case reports

Moxifloxacin-induced thrombocytopenia in treatment of moderately severe acute pancreatitis: a report of one case

Liu MingJiang, Qi WenLei, Zhang RuoYan, Du XiaoHong, Wang GuangYi, Ye JunFeng

2016, 32(5): 942-943. DOI: 10.3969/j.issn.1001-5256.2016.05.028

Abstract(2321)

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Pancreatic tuberculosis misdiagnosed as pancreatic cystadenoma: a report of one case

Liu YanQiu, Chen Jing, Liu Jie

2016, 32(5): 944-945. DOI: 10.3969/j.issn.1001-5256.2016.05.029

Abstract(1505)

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Abstract:

Adenosquamous carcinoma of the pancreas: a report of one case

Ma WenCong, Gu LiTong, Yao HaoChen, Zhang Ping

2016, 32(5): 946-947. DOI: 10.3969/j.issn.1001-5256.2016.05.030

Abstract(1503)

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A case of young female with cryptogenic cirrhosis

Wang JiuHeng, Li GuiYu, Wang YunZhong, Xu ChengJun, Zhao TieJian

2016, 32(5): 948-949. DOI: 10.3969/j.issn.1001-5256.2016.05.031

Abstract(1422)

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Abstract:

Giant hepatic angiomyolipoma: a report of one case and literature review

Guo Pei, Zheng RuiQi, Yu HuiHui, Hu YuLin

2016, 32(5): 950-952. DOI: 10.3969/j.issn.1001-5256.2016.05.032

Abstract(2140)

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A case of chronic hepatitis B virus carriers developing into hepatocellular carcinoma

Liu LiLi, Qi Yue, Wang FengJiao, Hu Yue, Lu: Yang

2016, 32(5): 953-954. DOI: 10.3969/j.issn.1001-5256.2016.05.033

Abstract(1994)

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Abstract:

A case of hepatocellular carcinoma with Lambert-Eaton myasthenic syndrome as the first symptom

Fang XiZhu, Wang QiLong, Zhang Ping

2016, 32(5): 955-956. DOI: 10.3969/j.issn.1001-5256.2016.05.034

Abstract(2222)

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A case of autoimmune hepatitis with positive hepatitis C antibody

Lu: Jing, Xing Feng, Yuan JiLi, Liu ChengHai

2016, 32(5): 957-959. DOI: 10.3969/j.issn.1001-5256.2016.05.035

Abstract(2507)

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Abstract:

One case of primary hepatic amyloidosis

Qiao Yan, Lu ShanShan, Wang HaiBo, You ShaoLi, Xin ShaoJie, Li Jin

2016, 32(5): 960-961. DOI: 10.3969/j.issn.1001-5256.2016.05.036

Abstract(1955)

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Abstract:

Four misdiagnosed cases of cholangiocarcinoma

Yang ZhiGang, Cai YuHan

2016, 32(5): 962-963. DOI: 10.3969/j.issn.1001-5256.2016.05.037

Abstract(2438)

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Reviews

Roles of statins for lipid regulation in the pathogenesis and treatment of acute pancreatitis

Meng XiuNa, Wang Li, Tian Xing, Chen ChengLiang, Jiao Jian

2016, 32(5): 964-967. DOI: 10.3969/j.issn.1001-5256.2016.05.038

Abstract(2310)

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Abstract:

Besides regulating lipid,statins can inhibit inflammatory response,improve the function of endothelial cells,and protect intestinal mucosal barrier. Therefore,it can be used to relieve the clinical symptoms of acute pancreatitis,shorten the course of treatment,and improve the prognosis,and can play ...

Classification and diagnosis of pancreatic cystic neoplasm

Lu: Yan, Zhang XiaoWen

2016, 32(5): 968-971. DOI: 10.3969/j.issn.1001-5256.2016.05.039

Abstract(2218)

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Abstract:
Pancreatic cystic neoplasm is a relatively rare potential neoplasm in clinical practice and has a low- grade malignancy. Pancreatic cystic neoplasm is classified as serous cystic neoplasm,mucinous cystic neoplasm,intraductal papillary mucinous neoplasm,and solid pseudopapillary neoplasm. Due to its ...

Research advances in 125 radioactive seed implantation for treatment of unresectable pancreatic cancer

Tao WeiJie, Shi XiaoJu, Wang GuangYi

2016, 32(5): 972-976. DOI: 10.3969/j.issn.1001-5256.2016.05.040

Abstract(2507)

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Abstract:
In recent years,125 radioactive seed implantation has been greatly developed for the treatment of unresectable pancreatic cancer,and clinical practice shows that it has good therapeutic effects in relieving pain,controlling local tumor progression,and prolonging patients' survival time. This article...

Predictive value of HBs Ag quantification in pegylated interferon therapy for chronic hepatitis B

Zhang HaiYue, Zhou Pei, Gong ZuoJiong

2016, 32(5): 977-980. DOI: 10.3969/j.issn.1001-5256.2016.05.041

Abstract(2943)

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Abstract:
Antiviral therapy is the most important thing in the treatment of chronic hepatitis B( CHB). Pegylated interferon( PEG- IFN)has both antiviral and immunomodulatory effects,and after drug withdrawal,30%- 40% of patients can achieve HBe Ag seroconversion and sustained virologic response. Many studies ...

Renal safety in chronic hepatitis B patients treated with nucleos(t) ide analogues

Ning Ling, Sun Jian, Chen Nan, Hou JinLin

2016, 32(5): 981-985. DOI: 10.3969/j.issn.1001-5256.2016.05.042

Abstract(2641)

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Abstract:
Nucleos( t) ide analogues( NAs) are commonly used as the antiviral treatment in patients with chronic hepatitis B( CHB). The majority of patients need long term medication. Renal injury has been observed in some patients treated with NAs in clinical practice. Therefore,this article reviews the issue...

Research advances in chronic hepatitis B complicated by pulmonary tuberculosis

Liu PingXiang, Cheng ShuQuan

2016, 32(5): 986-991. DOI: 10.3969/j.issn.1001-5256.2016.05.043

Abstract(1582)

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Abstract:
In recent years,increasing attention has been paid to co- infection with hepatitis B virus and mycobacterium tuberculosis,which is characterized by a high incidence,as well as the changes in the progression,prognosis,and treatment outcome of original diseases,toxic or side effects,and even the drug ...

Research advances in innate immunity against hepatitis B virus

Li FengLi, Hua Juan, Lu YinPing, Yang DongLiang

2016, 32(5): 992-996. DOI: 10.3969/j.issn.1001-5256.2016.05.044

Abstract(1558)

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Abstract:
When hepatitis B virus( HBV) invades the human body,innate immunity acts the earliest and plays an important role. When an adult is infected with HBV,HBV can often be eliminated spontaneously. However,if HBV infection occurs right after birth or when the patient is young,the disease tends to become ...

Research advances in chronic hepatitis C complicated by autoimmune hepatitis

Wang HaiQiong, Tang ShanHong, Ceng WeiZheng, Zhang Yong, Mou Dong, Gao Hui

2016, 32(5): 997-1000. DOI: 10.3969/j.issn.1001-5256.2016.05.045

Abstract(1868)

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Abstract:
There are not many studies on chronic hepatitis C complicated by autoimmune hepatitis,and up to now,the clinical diagnosis and treatment of such diseases still face many difficulties. Although related articles put forward some recommendations,there are no standard guidelines for diagnosis and treatm...

Role of bone morphogenetic protein-7/Smads signaling pathway in hepatic fibrosis

Hou Fei, Liu RuiXia, Yin ChengHong

2016, 32(5): 1001-1004. DOI: 10.3969/j.issn.1001-5256.2016.05.046

Abstract(1665)

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Abstract:
Hepatic fibrosis is the process in which the human body repairs the liver tissue damaged due to various reasons. Recent studies have found that bone morphogenetic protein- 7( BMP- 7) and the downstream Smads can antagonize the effect of transforming growth factor- β1,which induces hepatic fibrosis,t...

Research advances in cirrhotic cardiomyopathy

Zhang ShiRong, Chen DongFeng

2016, 32(5): 1005-1008. DOI: 10.3969/j.issn.1001-5256.2016.05.047

Abstract(1627)

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Abstract:
Cirrhotic cardiomyopathy( CCM) refers to the abnormalities in cardiac structure and function in patients with liver cirrhosis. The pathogenesis of CCM involves the apoptosis of cardiomyocytes,impaired β- receptors,and increased levels of cardiodepressant factors such as nitric oxide,carbon monoxide,...

Research advances in the role of autophagy in liver cells and regulation of MAPK pathway

Jiang Na, Ping Jian, Xu LieMing

2016, 32(5): 1009-1012. DOI: 10.3969/j.issn.1001-5256.2016.05.048

Abstract(2094)

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Abstract:
Autophagy is a highly conservative cellular process in eukaryotes that plays an important role in nutrition and energy metabolism in the liver. It can promote the autophagy of hepatocytes and protect the hepatocytes against the adverse external stimulation,but excessive autophagy can cause autophagi...

Role of liver X receptor in process of cholesterol metabolism and its mechanism of action

Chen Yu, Fan XiaoFei, Zheng ZhongQing, Wang BangMao

2016, 32(5): 1013-1017. DOI: 10.3969/j.issn.1001-5256.2016.05.049

Abstract(3100)

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Abstract:
Cholesterol is a component of cell membrane and plays a vital role in maintaining metabolism and normal functions in human body. Liver X receptor( LXR) is a nuclear receptor expressed in abundance in the liver. It influences the process of cholesterol metabolism through regulating the synthesis,tran...

Research advances in association between diseases outside the gallbladder and gallstones

Li Juan, Wei XiaoGuo, Lu QiMing, Zhan Li, Liu PengCheng

2016, 32(5): 1018-1021. DOI: 10.3969/j.issn.1001-5256.2016.05.050

Abstract(1699)

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Abstract:
Gallstones is a common digestive system disease in China and has a complex pathogenesis. It is often considered that it is mediated by many factors in the genetic background,including biliary cholesterol supersaturation,intestinal cholesterol hyperabsorption,abnormal cholesterol nucleation in bile,d...

Research advances in palliative treatment of cholangiocarcinoma

Wang Xing, Li XiangCheng

2016, 32(5): 1022-1025. DOI: 10.3969/j.issn.1001-5256.2016.05.051

Abstract(1844)

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Abstract:
Although radical resection is the only method to cure cholangiocarcinoma,most patients are in the advanced stage at the time of diagnosis and miss the best time for surgery. The palliative treatment focusing on biliary drainage reconstruction can improve patients' quality of life and prolong surviva...

Liver alkaline phosphatase: a marker of cholestasis and bile duct injury

Shen FeiFei, Lu LunGen

2016, 32(5): 1026-1030. DOI: 10.3969/j.issn.1001-5256.2016.05.052

Abstract(1311)

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Abstract:
Studies show that serum alkaline phosphatase( ALP) can be used not only to evaluate cholestasis,but also as a surrogate marker to assess the severity of primary biliary cirrhosis( PBC),primary sclerosing cholangitis( PSC),and several cholestatic liver diseases. This article introduces the mechanisms...