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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 5
May  2016
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Article Contents

Liver alkaline phosphatase: a marker of cholestasis and bile duct injury

DOI: 10.3969/j.issn.1001-5256.2016.05.052
  • Published Date: 2016-05-20
  • Studies show that serum alkaline phosphatase( ALP) can be used not only to evaluate cholestasis,but also as a surrogate marker to assess the severity of primary biliary cirrhosis( PBC),primary sclerosing cholangitis( PSC),and several cholestatic liver diseases. This article introduces the mechanisms of action of liver ALP in the healthy population and patients with cholestatic liver disease. In case of cholestasis caused by inflammation,acidic environment and relocation of the bile capillaries cause liver ALP deactivation and an increased accumulation of lipopolysaccharide and thus lead to aggravation and delayed healing. In the treatment of PBC and PSC,promoting the restoration of hepatocyte polarity and the elimination of bile acid through the bile capillaries and using drugs capable of adjusting the p H of bile can achieve a good anti- inflammatory effect. The effect of oral intestinal ALP in the treatment of cholestatic diseases awaits further investigations in laboratories and in clinical practice.

     

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