[1]POLLICINO T,CACCIOLA I,SAFFIOTI F,et al.Hepatitis B virus PreS/S gene variants:pathobiology and clinical implications[J].J Hepatol,2014,61(2):408-417.
|
[2]HSU HY,CHANG MH,NI YH,et al.Surface genemutants of hepatitis B virus in infants who develop acute or chronicinfections despite immunoprophylaxis[J].Hepatology,1997,26(3):786-791.
|
[3]ZHANG X,Ding HG.Key role of hepatitis B virus mutation in chronic hepatitis B development to hepatocellular carcinoma[J].World J Hepatol,2015,7(9):1282-1286.
|
[4]HSIEH YH,CHANG YY,SU IJ,et al.Hepatitis B virus pre-S2mutant large surface protein inhibits DNA double-strand break repair and leads to genome instability in hepatocarcinogenesis[J].JPathol,2015,236(3):337-347.
|
[5]COPPOLA N,ONORATO L,MINICHINI C,et al.Clinical significance of hepatitis B surface antigen mutants[J].World J Hepatol,2015,7(27):2729-2739.
|
[6]HOLLINGER FB.Hepatitis B virus genetic diversity and its impact ondiagnostic assays[J].J Viral Hepatitis,2007,14(Suppl 1):11-15.
|
[7]CARMAN WF,ZANETTI AR,KARAYIANNIS P,et al.Vaccine-induced escape mutant of hepatitis B virus[J].Lancet,1990,336(8711):325-329.
|
[8]GERLICH WH,GLEBE D,SCHUTTLER CG.Deficiencies in the standardization and sensitivity of diagnostic tests for hepatitis B virus[J].J Viral Hepatitis,2007,14(Suppl 1):16-21.
|
[9]ROZNOVSKY L,HARRISON TJ,FANG ZL,et al.Unusual hepatitis B surface antigen variation in a child immunised against hepatitis B[J].J Med Virol,2000,61(1):11-14.
|
[10]MELE A,TANCREDI F,ROMANL,et al.Effectiveness of hepatitis B vaccination in babies born to hepatitis B surface antigenpositive mothers in Italy[J].J Infect Dis,2001,184(7):905-908.
|
[11]CHEN WN,OON CJ.Hepatitis B virus surface antigen(HBsA g)mutants in Singapore adults and vaccinated children with high anti-hepatitis B virus antibody levels but negative for HBsA g[J].JClin Microbiol,2000,38(7):2793-2794.
|
[12]HUANG CH,YUAN Q,CHEN PJ,et al.Influence of mutations in hepatitis B virus surfaceprotein on viral antigenicity and phenotype in occult HBVstrains from blood donors[J].J Hepatol,2012,57(4):720-729.
|
[13]HUANG HP,HSU HY,CHEN CL,et al.Pre-S2 deletions of hepatitis B virus and hepatocellular carcinoma in children[J].Pediatr Res,2010,67(1):90-94.
|
[14]ABE K,THUNG SN,WU HC,et al.Pre-S2 deletion mutants of hepatitis B virus could have animportant role in hepatocarcinogenesis in Asian children[J].Cancer Sci,2009,100(12):2249-2254.
|
[15]LIU S,ZHANG H,GU C,et al.Associations between hepatitis Bvirus mutations and the risk of hepatocellular carcinoma:a metaanalysis[J].J Natl Cancer Inst,2009,101(15):1066-1082.
|
[16]YEUNG P,WONG DK,LAI CL,et al.Association of hepatitis Bvirus pre-S deletions with the development of hepatocellular carcinoma in chronic hepatitis B[J].J Infect Dis,2011,203(5):646-654.
|
[17]ZHANG AY,LAI CL,HUANG FY,et al.Evolutionary changes of hepatitis B virus pre-S mutations prior to development of hepatocellular carcinoma[J].PLoS One,2015,10(9):e0139478.
|
[18]QU LS,LIU JX,LIU TT,et al.Association of hepatitis B virus pre-S deletions with the developmentof hepatocellular carcinoma in Qidong,China[J].PLoS One,2014,9(5):e98257.
|
[19]WANG HC,HUANG W,LAI MD,et al.Hepatitis B virus pre-Smutants,endoplasmic reticulum stress and hepatocarcinogenesis[J].Cancer Sci,2006,97(8):683-688.
|
[20]SU IJ,WANG LH,HSIEH WC,et al.The emerging role of hepatitis B virus pre-S2 deletion mutant proteins in HBV tumorigenesis[J].J Biomed Sci,2014,21:98.
|
[21]LIU W,CAO Y,WANG T,et al.The N-glycosylation modification of lhbs(large surface proteins of HBV)effects on endoplasmic reticulum stress,cell proliferation and its secretion[J].Hepat Mon,2013,13(9):e12280.
|
[22]KALININA T,RIU A,FISCHER L,et al.A dominant hepatitis Bvirus population defective in virus secretion because of sevearal S-gene mutations from a patient with fulminant hepatitis[J].Hepatology,2001,34(2):385-394.
|
[23]AI XY.Association between severe hepatitis and mutation in HBVPreS region and effect of traditional Chinese medicine intervention[D].Guangzhou:Guangzhou Univ Chin Med,2013.(in Chinese)艾香英.重型肝炎与HBV PreS区基因突变的关系研究及中医干预的疗效观察[D].广州:广州中医药大学,2013.
|
[24]ANDO K,MORIYAMA T,GUIDOTTI LG,et al.Mechanisms o class I restricted immunopathology.A transgenic mousemodel of fulminant hepatitis[J].J Exp Med,1993,178(5):1541-1554.
|
[25]REN MX,MENG QH.Research progress in mechanism of coexistence of HBsA g and HBsA b in patients with HBV infection[J].J Clin Hepatol,2014,30(4):375-378.(in Chinese)任美欣,孟庆华.HBV感染者HBsA g和抗-HBs双阳性发生机制[J].临床肝胆病杂志,2014,30(4):375-378.
|
[26]YUKIMASA N,OHKUSHI H,FUKASAWA K,et al.Hepatitis Bvirus gene mutations in the sera of three patients with coexisting hepatitis B surface antigen and anti-surface antibody[J].Rinsho Byori,2000,48(2):184-188.
|
[27]LU HY,ZENG Z,XU XY,et al.Mutations in surface and polymerase gene of chronic hepatitis B patients with coexisting HBsA g and anti-HBs[J].World J Gastroenterol,2006,12(26):4219-4223.
|
[28]CHEN Y,QIAN F,YUAN Q,et al.Mutations in hepatitis B virus DNA from patients with coexisting HBsA g and anti-HBs[J].JClin Virol,2011,52(3):198-203.
|
[29]YU DM,LI XH,MOM V,et al.N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape[J].J Hepatol,2014,60(3):515-522.
|