Abstract: At present,long- acting interferon combined with ribavirin is still a major therapeutic method for hepatitis C in China,and precision medicine can help cure more patients with hepatitis C. This article briefly introduces the diagnosis and treatment of hepatitis in China and the importance of the str...
Abstract: Prognostic evaluation of patients with primary biliary cirrhosis( PBC) and how to improve the prognosis have attracted much attention. Further therapeutic regimens for PBC patients with poor prognosis has become the direction of clinical and scientific studies. This article summarizes the associatio...
Abstract: At present,endoscopic ultrasound and multi- slice spiral CT portal venography are effective methods to assess the portal vein and collateral circulation. Endoscopic ultrasound can clearly show the blood vessels inside and outside the esophageal wall and in surrounding tissues,as well as the image of...
Abstract: The surgical treatment of hilar cholangiocarcinoma is one of the most challenging routine surgeries in the field of hepatobiliary surgery,and vascular invasion is an important reason for the low rate of radical resection in hilar cholangiocarcinoma. Currently,it is universally acknowledged that rese...
Abstract: At present,traditional imaging techniques for the diagnosis of early- stage pancreatic cancer lack enough sensitivity,and therefore,early diagnosis of pancreatic cancer is still the biggest challenge in precision medicine around the world. Based on a large amount of clinical practice and the develop...
Abstract: Objective To investigate the association of virologic relapse after withdrawal of nucleos( t) ide analogues( NAs) with HBs Ag quantitation and HBV DNA load at withdrawal in patients with chronic hepatitis B( CHB). Methods A total of 205 CHB patients who were treated with NAs in the outpatient servic...
Abstract: Objective To investigate the establishment of a predictive model for early virologic response in previously untreated chronic hepatitis B( CHB) patients treated with telbivudine,since early virologic response can predict the long- term efficacy of nucleotide analogues.Methods A total of 135 CHB pati...
Abstract: Objective To investigate the association between HBsAg clearance and serum level of interleukin- 17( IL- 17) in HBeAg-negative chronic hepatitis B( CHB) patients treated by pegylated interferon( PEG- IFN). Methods A total of 13 HBeAg- negative CHB patients who visited Beijing You An Hospital from Ja...
Abstract: Objective To investigate the effect and safety of bilirubin serum adsorption( BSA) in the treatment of patients with chronic severe hepatitis B. Methods A prospective study was performed for 40 patients with chronic severe hepatitis B[prothrombin activity( PTA)> 25%] who were hospitalized in The ...
Abstract: Objective To investigate the efficacy and safety of low- dose glucocorticoids in the treatment of HBV- related acute- on-chronic liver failure( HBV- ACLF). Methods A total of 118 patients with HBV- ACLF who were treated in Center for Liver Disease Treatment in the Fourth People's Hospital of Panzhih...
Abstract: Objective To investigate the characteristics of familial aggregation and prognosis of chronic hepatitis B( CHB) in Guangzhou,China,where there is a high prevalence of hepatitis B virus( HBV) infection. Methods The CHB patients who were treated in Outpatient Department of Hepatitis in the First Affil...
Abstract: Objective To investigate the independent predictive factors for significant liver histological changes( SLHCs) in patients with HBe Ag- positive high- viral- load chronic hepatitis B virus( HBV) infection and a normal alanine aminotransferase( ALT) level. Methods A retrospective analysis was perform...
Abstract: Objective To investigate the influence of Notch signaling pathway inhibition on interleukin- 22( IL- 22) secreted by CD4~+T cells in patients with hepatitis B,and to elaborate on the role of the Notch- IL- 22 signaling pathway in the pathogenesis of hepatitis B.Methods A total of 45 previously untre...
Abstract: Objective To investigate the correlation between the changes in routine blood test results and antiviral effect in patients with refractory chronic hepatitis C receiving standard treatment. Methods A total of 63 previously untreated patients with refractory chronic hepatitis C who visited Beijing Yo...
Abstract: Objective To investigate the risk genes for predicting the development of chronic hepatitis B( CHB) cirrhosis using gene chip technology. Methods A total of 40 CHB patients who visited Shanghai First People's Hospital from April 2008 to December 2010 were enrolled as a clinical cohort and were divid...
Abstract: Objective To investigate the effect of decoy receptor 3( DcR3) gene on hepatocyte apoptosis,as well as the possible mechanism of action of DcR3 in this process. Methods The human liver cell lines were cultured in vitro,and p EF1α- DcR3 transfection group,p EF1α- IRES transfection group,and negative ...
Abstract: Objective To investigate the risk factors for postoperative pulmonary infection in patients with primary liver cancer through a retrospective analysis,and to provide a reference for appropriate preventive measures in clinical treatment. Methods A total of 286 patients with liver cancer who visited D...
Abstract: Objective To investigate the value of contrast- enhanced ultrasound( CEUS) in the differential diagnosis of single metastatic hepatic carcinoma( MHC) and solitary necrotic nodule of the liver( SNNL). Methods A retrospective analysis was performed for 12 patients with single MHC and 16 patients with ...
Abstract: Objective To investigate the traditional Chinese herbs and core prescriptions commonly used by Professor Qian Ying in the syndrome differentiation- based treatment of primary liver cancer,and to guide clinical medication. Methods A retrospective analysis was performed for the clinical data of the pa...
Abstract: Objective To explore the clinical value of low- and high- frequency ultrasound in the diagnosis of benign lesions of the gallbladder.Methods A retrospective analysis was performed in 110 outpatients with pathologically confirmed benign lesions of the gallbladder in our hospital from January 2015 to ...
Abstract: Objective To investigate the features and methods of clinical diagnosis and treatment of elderly patients with acute calculous cholecystitis. Methods A retrospective analysis was performed for the clinical data of elderly patients who were diagnosed with acute calculous cholecystitis in 451 Hospital...
Abstract: Objective To investigate the recurrence at 1- 3 years after laparoscopic cholecystolithotomy in patients with sand- like and non-sand- like gallstones. Methods A retrospective analysis was performed for the clinical data of 155 patients with gallstones who underwent gallbladder- preserving cholecyst...
Abstract: Objective To investigate the diagnosis,treatment,and outcome of Mirizzi syndrome in patients undergoing laparoscopic cholecystectomy( LC). Methods A retrospective analysis was performed on the clinical data of 32 patients who underwent LC in the 451 Hospital of PLA from December 2006 to December 201...
Abstract: Objective To investigate the value of selective intraoperative cholangiography( IOC) in biliary system surgery. Methods A retrospective analysis was performed on the clinical data and follow- up data of 112 patients who were hospitalized in The First People's Hospital of Pingdingshan and underwent s...
Abstract: Objective To investigate the effect of therapeutic endoscopic retrograde cholangiopancreatography( ERCP) on liver function and treatment outcome in patients with pancreaticobiliary diseases. Methods A total of 397 patients with pancreaticobiliary diseases who underwent ERCP with an electronic duoden...
Abstract: Objective To investigate the value of serum carbohydrate antigen 19- 9( CA19- 9) and carbohydrate antigen 24- 2( CA24-2) in the diagnosis of benign and malignant biliary tract diseases. Methods A total of 214 patients with biliary tract diseases who were hospitalized in Department of Gastroenterolog...
Objective To investigate the influencing factors for the length of hospital stay in patients with drug- induced liver injury( DILI),and to guide clinical practice,reduce the pressure of hospitalization,and reduce the patients' economic burden. Methods The clinical data of the patients with DILI who ...
Objective To investigate the risk factors for hypersensitivity- associated liver injury induced by the combined antiretroviral therapy( c- ART) including nevirapine( NVP) in patients with acquired immunodeficiency syndrome. Methods The clinical data and blood samples of 132 patients who received the...
Objective To investigate the clinical features and risk factors for patients with liver failure complicated by invasive pulmonary aspergillosis( IPA),and to provide a reference for clinical diagnosis and treatment. Methods The clinical data of 477 patients with liver failure who were diagnosed and t...
Objective To analyze the clinical data of patients admitted with an initial diagnosis of digestive diseases who have human immunodeficiency virus( HIV) / acquired immune deficiency syndrome( AIDS),and to guide clinical diagnosis. Methods The clinical data of HIV / AIDS patients who were hospitalized...
Objective To investigate the effect of extracellular signal- regulated kinase 1/2( ERK1/2) pathway inhibitor PD98059 on the proliferation and killing function of γδT cells cultured in vitro. Methods Mononuclear cells were separated from peripheral blood in healthy subjects and placed in RPMI 1640 co...
Abstract: Chronic hepatitis B( CHB) is one of the most important infectious diseases around the world. Currently,interferon and nucleos( t) ide analogues are the main drugs for CHB and have good therapeutic efficacy,but the ultimate goal of eliminating hepatitis B virus( HBV) in human body has not been achiev...
Abstract: With the development and application of the double antigen sandwich method for quantification of hepatitis B core antibody( HBcAb) in recent years,there is increasing knowledge of the ability of HBcAb to reflect the body's anti- viral capability. This article introduces the commonly used measurement...
Abstract: The pre- S/S gene variants of hepatitis B virus( HBV) cause various pathological and clinical outcomes. Occult hepatitis B,fulminant hepatitis or liver failure,HBs Ag- and HBs Ab- positive HBV infection,and primary liver cancer are all associated with HBV pre- S/S gene variants,which are involved in...
Abstract: Portal vein thrombosis( PVT) is a common complication of liver cirrhosis. This article reviews the research advances in liver cirrhosis complicated by PVT in recent years and points out that PVT is induced by the combined effect of various factors. Hemodynamic disorder is an important basis for the ...
Abstract: Recently,more and more studies have shown that the development and progression of primary liver cancer( hereinafter referred to as liver cancer) is closely associated with the metabolism in human body,and metabolic disturbance in human body increases the incidence and mortality of liver cancer. The ...
Abstract: Early identification and diagnosis of hepatocellular carcinoma( HCC) is necessary for improving survival rates of HCC patients.Studies have shown that the abnormal proteins released by tumor cells,i. e.,the autoantibodies stimulated by tumor- associated antigens( TAAs),can be detected before a clini...
Abstract: The relationship between inflammatory response and tumor has gained great attention in recent years. Tumor- associated macrophages( TAMs) play an important role in tumor growth,proliferation,metabolism,and metastasis. Many studies have confirmed that most TAMs have an M2 phenotype and can promote tu...
Abstract: The incidence rate of liver cancer tends to increase in recent years,and the molecular and pathogenic mechanisms of liver cancer should be further investigated to guarantee health. As an important model organism,zebrafish have highly conserved genes and grow fast.The early embryo of zebrafish is tra...
Abstract: Sinusoidal obstruction syndrome( SOS) is a sinusoidal or small venous fibrous occlusive disease. This article reviews the research advances in the etiology,pathogenesis,clinical manifestations,auxiliary examinations,and treatment of SOS,and points out that the pathogenesis of SOS remains unknown and...
Abstract: Differential diagnosis of benign and malignant ascites is of a great value in determining etiology,evaluating prognosis,and determining therapy regimens. There are many diagnostic methods for ascites,but up to now,no method can achieve high sensitivity and specificity and meet the requirements of cl...