|
[1]SU TH,KAO JH,LIU CJ.Molecular mechanism and treatment of viral hepatitis-related liver fibrosis[J].Int J Mol Sci,2014,15(6):10578-10604.
|
|
[2]FRIEDMAN SL.Mechanisms of hepatic fibrogenesis[J].Gastroenterology,2008,134(6):1655-1669.
|
|
[3]BISSEL DM,WANG SS,JARNAQIN WR,et al.Cell-specific expression of transforming growth factor-beta in rat liver.Evidence for autocrine regulation of hepatocyte proliferation[J].J Clin Invest,1995,96(1):447-455.
|
|
[4]GORDON KJ,BLOBE GC.Role of transforming growth factor-βsuperfamily signaling pathways in human disease[J].Biochim Biophys Acta,2008,1782(4):197-228.
|
|
[5]WIERCINSKA E,WICKERT L,DENECKE B,et al.Id1 is a critical mediator in TGF-beta-induced transdifferentiation of rat hepatic stellate cells[J].Hepatology,2006,43(5):1032-1041.
|
|
[6]MUNOZ-FELIX JM,GONZALEZ-NUNEZ M,LOPEZ-NOVOA JM.ALK1-Smad1/5 signaling pathway in fibrosis development:friend or foe?[J].Cytokine Growth Factor Rev,2013,24(6):523-537.
|
|
[7]MUNOZ-FELIX JM,PERRETTA-TEJEDOR N,ELENO N,et al.ALK1 heterozygosity increases extracellular matrix protein expression,proliferation and migration in fibroblasts[J].Biochim Biophys Acta,2014,1843(6):1111-1122.
|
|
[8]UEMURA M,SWENSON ES,GACA MD,et al.Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization[J].Mol Biol Cell,2005,16(9):4214-4224.
|
|
[9]LIU Y,LIU H,MEYER C,et al.Transforming growth factor-β(TGFβ)-mediated connective tissue growth factor(CTGF)expression in hepatic stellate cells requires Stat3 signaling activation[J].J Biol Chem,2013,288(4):30708-30719.
|
|
[10]DING Z,JIN G,LIANG HF,et al.Transforming growth factorβinduces expression of connective tissue growth factor in hepatic progenitor cells through Smad independent signaling[J].Cell Signal,2013,25(10):1981-1992.
|
|
[11]TOMITA K,TERATANI T,SUZUKI T,et al.Free cholesterol accumulation in hepatic stellate cells:mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice[J].Hepatology,2013,59(1):154-169.
|
|
[12]TOMITA K,TERATANI T,SUZUKI T,et al.Acyl-CoA:cholesterol acyltransferase 1 mediates liver fibrosis by regulating free cholesterol accumulation in hepatic stellate cells[J].J Hepatol,2014,61(1):98-106.
|
|
[13]LIU C,CHEN X,YANG L,et al.Transcriptional repression of the transforming growth factorβ(TGFβ)Pseudo receptor BMP and activin membrane-bound inhibitor(BAMBI)by nuclear factor k B(NF-k B)p50 enhances TGFβsignaling in hepatic stellate cells[J].J Biol Chem,2014,289(10):7082-7091.
|
|
[14]JIA D,DUAN F,PENG P,et al.Up-regulation of RACK1by TGFβ1 promotes hepatic fibrosis in mice[J].PLoS One,2013,8(3):e60115.
|
|
[15]LIU M,PENG P,WANG J,et al.RACK1-mediated translation control promotes liver fibrogenesis[J].Biochem Biophys Res Commun,2015,463(3):255-261.
|
|
[16]LI L,WANG JY,YANG CQ,et al.Effect of RhoA on transforming growth factorβ1-induced rat hepatic stellate cell migration[J].Liver Int,2012,32(7):1093-1102.
|
|
[17]CAO S,YAQOOB U,DAS A,et al.Neuropilin-1 promotes cirrhosis of the rodent and human liver by enhancing PDGF/TGF-beta signaling in hepatic stellate cells[J].J Clin Invest,2010,120(7):2379-2394.
|
|
[18]SHAH R,REYES-GORDILLO K,ARELLANES-ROBLEDO J,et al.TGFβ1up-regulates the expression of PDGF-βreceptor mRNA and induces a delayed PI3K-,AKT-,and p70(S6K)-dependent proliferative response in activated hepatic stellate cells[J].Alcohol Clin Exp Res,2013,37(11):1838-1848.
|
|
[19]SONG Y,ZHAN L,YU M,et al.TRPV4 channel inhibits TGFβ1-induced proliferation of hepatic stel ate cel s[J].PLoS One,2014,9(7):e101179.
|
|
[20]FANG L,HUANG C,MENG X,et al.TGFβ1 elevated TRPM7 channel regulates collagen expression in hepatic stellate cells via TGFβ1/Smad pathway[J].Toxicol Appl Pharmacol,2014,280(2):335-344.
|
|
[21]CHIU YS,WEI CC,LIN YJ,et al.Il-20 and IL-20R1 antibodies protect against liver fibrosis[J].Hepatology,2014,60(3):1003-1014.
|
|
[22]SANCHO P,MAINEZ J,CROSAS-MOLIST E,et al.NADPH oxidase NOX4 mediates stellate cell activation and hepatocyte cell death during liver fibrosis development[J].PLoS One,2012,7(9):e45285.
|
|
[23]AOYAMA T,PAIK YH,WATANABE S,et al.Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis:GKT137831 as a novel potential therapeutic agent[J].Hepatology,2012,56(6):2316-2327.
|
|
[24]DOOLEY S,TEN DIJKE P.TGFβin progression of liver disease[J].Cell Tissue Res,2012,347(1):245-256.
|
|
[25]HENDERSON NC,ARNOLD TD,KATAMURA Y,et al.Targeting ofαintegrin identifies a core molecular pathway that regulates fibrosis in several organs[J].Nat Med,2013,19(12):1617-1624.
|
|
[26]DINF N,YU RT,SUBRAMANIAM N,et al.A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response[J].Cell,2013,153(3):601-613.
|
|
[27]HUANG W,LI L,TIAN X,et al.Astragalus and paeoniae radix rubra extract(APE)inhibits hepatic stellate cell activation by modulating transforming growth factor-β/Smad pathway[J].Mol Med Rep,2015,11(4):2569-2577.
|
|
[28]YANG FR,FANG BW,LOU JS.Effects of fufang biejia ruangan pillson hepatic fibrosis in vivo and in vitro[J].Word J Gastrorenterol,2014,19(32):5326-5333.
|
|
[29]van BEUGE MM,PRAKASH J,LACOMBE M,et al.Enhanced effectivity of an ALK5-inhibitor after cell-specific delivery to hepatic stellate cells in mice with liver injury[J].PLoS One,2013,8(2):e56442.
|
|
[30]CALONE I,SOUCHELNYTSKYI S.Inhibition of TGFβsignaling and its implications in anticancer treatments[J].Exp Oncol,2012,34(1):9-16.
|
|
[31]KARKAMPOUNA S,GOUMANS MJ,TEN DIJKE P,et al.Inhibition of TGFβtypeⅠreceptor activity facilitates liver regeneration upon acute CCl4intoxication in mice[J].Arch Toxicol,2016,90(2):347-357.
|
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