2016 No. 11

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Editorial

Antiviral therapy for chronic hepatitis B: current status and perspectives

Fan Rong, Sun Jian, Hou JinLin

2016, 32(11): 2029-2032. DOI: 10.3969/j.issn.1001-5256.2016.11.001

Abstract(2380)

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Abstract:

Chronic hepatitis B is an important public health issue in China. The drugs used as the antiviral therapy for hepatitis B are mainly interferons and nucleos( t) ide analogues. Although these drugs have realized persistent HBV inhibition in most patients,a large number of patients cannot achieve immu...

Therapeutic guidelines

An excerpt of guideline for the evaluation of cholestatic jaundice in infants: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN) in 2016

Ma LinJie, Chen Gang, Hu ZongQiang

2016, 32(11): 2033-2035. DOI: 10.3969/j.issn.1001-5256.2016.11.002

Abstract(380)

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Abstract:

An excerpt of non-alcoholic fatty liver disease (NAFLD): assessment and management (NICE guidelines in 2016)

Liu Tao, Zhang Li, Fan JianGao, Ji Guang

2016, 32(11): 2036-2038. DOI: 10.3969/j.issn.1001-5256.2016.11.003

Abstract(1968)

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Abstract:

Discussions by experts

Diagnosis and treatment of hepatitis B virus infection complicated by metabolic syndrome

Liu Jing, Shi JunPing

2016, 32(11): 2039-2042. DOI: 10.3969/j.issn.1001-5256.2016.11.004

Abstract(2570)

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Abstract:

With the prevalence of obesity around the world,the incidence rate of hepatitis B virus( HBV) infection complicated by metabolic syndrome( MS) is increasing year by year,and such patients have become a special population in patients with chronic HBV infection. In recent years,the research on the fea...

Advances in research and development of new drugs for antiviral therapy for chronic hepatitis B

Gao YanHang, Liu PeiYan, Gao PuJun

2016, 32(11): 2043-2049. DOI: 10.3969/j.issn.1001-5256.2016.11.005

Abstract(3040)

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Abstract:

Chronic hepatitis B virus( HBV) infection is one of the major disease burdens worldwide. At present,the antiviral therapy for hepatitis B includes interferons and nucleos( t) ide analogues. Current therapeutic regimens based on these drugs cannot significantly increase the proportion of patients wit...

How to evaluate combination therapy using interferon and nucleos(t)ide analogues

Chen Lu, Xie Qing

2016, 32(11): 2050-2053. DOI: 10.3969/j.issn.1001-5256.2016.11.006

Abstract(2617)

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Abstract:

Chronic hepatitis B is still one of the most important chronic diseases in China because of its high relevance to liver cirrhosis and hepatic cell cancer( HCC). Currently,interferon and nucleos( t) ide analogues are two main treatments for chronic hepatitis B,but they have advantages and disadvantag...

New considerations in antiviral therapy for special populations with chronic hepatitis B

Hu XiaoYun, Sun Jian, Peng Jie

2016, 32(11): 2054-2057. DOI: 10.3969/j.issn.1001-5256.2016.11.007

Abstract(2559)

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Abstract:

Increasing attentions have been paid to the antiviral therapy for special populations with chronic hepatitis B( CHB),including patients co- infected with HIV,HDV,or HCV,children and adolescents,pregnant women,patients with chronic kidney diseases,and patients who require chemotherapy or immunosuppre...

Role of liver fibrosis assessment in decision-making and efficacy surveillance for antiviral therapy in patients with chronic hepatitis B

Liang XieEr, Chen YongPeng

2016, 32(11): 2058-2061. DOI: 10.3969/j.issn.1001-5256.2016.11.008

Abstract(2376)

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Abstract:

Liver fibrosis / cirrhosis is the outcome of the progression of chronic hepatitis B and is associated with liver events and long- term prognosis. Effective antiviral therapy can delay or even reverse disease progression. Therefore,assessment of liver fibrosis degree before and during treatment is of...

Research advances in primary biliary cholangitis

Duan WeiJia, Tian QiuJu, You Hong, Jia JiDong

2016, 32(11): 2062-2065. DOI: 10.3969/j.issn.1001-5256.2016.11.009

Abstract(2451)

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Abstract:

Primary biliary cholangitis is a chronic intrahepatic cholestatic liver disease and has increasing incidence and prevalence rates,as is reported in the literature. Examination of specific antibodies including serum anti- mitochondrial antibody subtype M2 and liver histopathological examination help ...

Original articles_Viral hepatitis

Clinical effect of 24-week TDF versus ADV sequential therapy in HBeAg-positive chronic hepatitis B patients with suboptimal response to 48-week pegylated interferon-α-2a treatment

Lu: Ying, Chen XiaoRong

2016, 32(11): 2066-2069. DOI: 10.3969/j.issn.1001-5256.2016.11.010

Abstract(3738)

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Abstract:

Objective To investigate the clinical effect of 24- week tenofovir disoproxil fumarate( TDF) sequential therapy in HBeAg- positive chronic hepatitis B( CHB) patients with suboptimal serological response to 48- week pegylated interferon- α- 2a( Peg- IFN- α- 2a) monotherapy. Methods A total of 21 pati...

Clinical effect of entecavir combined with thymosin in treatment of HBe Ag-positive hepatitis B patients

Huang Ling, Ning HuiMing, Xu YanHua, Tang Qun, Ou Qiang

2016, 32(11): 2070-2074. DOI: 10.3969/j.issn.1001-5256.2016.11.011

Abstract(2090)

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Abstract:

Objective To investigate the clinical effect of entecavir( ETV) combined with thymosin in the treatment of HBe Ag- positive chronic hepatitis B( CHB) patients. Methods A total of 108 HBe Ag- positive CHB patients who were treated in Department of Infectious Diseases in our hospital from March 2012 t...

An analysis of medication rule for HBeAg-positive chronic hepatitis B based on association rule and complex system entropy clustering

Jiao YunTao, Li XiaoKe, Yang XianZhao, Ye YongAn

2016, 32(11): 2075-2079. DOI: 10.3969/j.issn.1001-5256.2016.11.012

Abstract(1888)

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Abstract:
Objective To investigate the features of traditional Chinese medicine( TCM) and prescription rules in the treatment of HBeAg- positive chronic hepatitis B( CHB). Methods A systematic search was performed for the articles on the TCM diagnosis and treatment of HBeAg-positive CHB,the information of TCM...

Impact of nucleos(t)ide analogues on quality of life in patients with chronic hepatitis B

Zhong ChunXiu, Cai ShaoHang, Yin JunHua, Gao YuLin

2016, 32(11): 2080-2083. DOI: 10.3969/j.issn.1001-5256.2016.11.013

Abstract(1993)

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Abstract:

Objective To investigate the impact of treatment with nucleos( t) ide analogues on quality of life( Qo L) in patients with chronic hepatitis B( CHB),as well as proper nursing measures. Methods A total of 102 CHB patients who were treated in Department of Infectious Diseases,Nanfang Hospital,Southern...

Clinical effect of entecavir in treatment of patients with chronic hepatitis B complicated by tuberculosis

Zhu DongLiang, Li DaoBo, Zhao ManZhi, Ma Ke, Song JianXin, Xu Dong

2016, 32(11): 2084-2087. DOI: 10.3969/j.issn.1001-5256.2016.11.014

Abstract(1983)

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Abstract:

Objective To investigate the clinical effect of entecavir in the treatment of patients with chronic hepatitis B( CHB) complicated by tuberculosis during anti- tuberculosis treatment. Methods A retrospective study was performed for the clinical data of 95 patients with CHB complicated by tuberculosis...

Clinical effect of entecavir combined with antituberculosis therapy in patients with tuberculosis complicated by chronic HBV infection

Hong YouZhi, Huang JiShui, Hong WenCong, Jiang TaoYuan

2016, 32(11): 2088-2091. DOI: 10.3969/j.issn.1001-5256.2016.11.015

Abstract(2479)

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Abstract:

Objective To investigate the clinical effect of entecavir combined with antituberculosis therapy in patients with tuberculosis complicated by chronic HBV infection. Methods A total of 108 patients with tuberculosis complicated by chronic HBV infection were divided into entecavir group with 58 patien...

An investigation of clinical features of HBsAg and anti-HBs positive patients with chronic hepatitis B

Song JinYun, Wang JianFang, Wu XuPing, Huang Ling

2016, 32(11): 2092-2095. DOI: 10.3969/j.issn.1001-5256.2016.11.016

Abstract(3544)

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Abstract:
Objective To investigate the phenomenon of coexistence of HBsAg and anti- HBs and its clinical features,as well as related causes. Methods A total of 2260 persons who underwent physical examination in The Second Affiliated Hospital of Southeast University from February 2011 to February 2014 were enr...

Clinical features of patients with acute exacerbation of chronic hepatitis B: an analysis of 74 cases

Ruan JianWen, Gao LiJuan, Su RuKai

2016, 32(11): 2096-2098. DOI: 10.3969/j.issn.1001-5256.2016.11.017

Abstract(2533)

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Abstract:
Objective To investigate the clinical features of patients with acute exacerbation of chronic hepatitis B,and to provide a basis of evidence- based medicine for the diagnosis and treatment of acute exacerbation of chronic hepatitis B. Methods A retrospective analysis was performed for the clinical d...

Correlation between HBsAg,prothrombin time activity,and indocyanine green retention rate at 15 minutes in patients with HBeAg-positive chronic HBV infection

Fan WenHai, Zhao ZhengBin, Chen QingFeng, Zhang LiTing, Wang FeiFei, Wang Qiong, Wang Shan, Wei Xin

2016, 32(11): 2099-2102. DOI: 10.3969/j.issn.1001-5256.2016.11.018

Abstract(2645)

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Abstract:
Objective To investigate the correlation between HBsAg,prothrombin time activity( PTA),and indocyanine green retention rate at 15 minutes( ICG R15) in patients with HBeAg- positive chronic HBV infection. Methods A total of 92 patients with HBeAg- positive chronic HBV infection who were admitted to T...

HBV genotyping of 702 hepatitis B patients in Changchun,China and its clinical significance

Yuan Ye, Yu XueJiao, Lu NianHong, Zhang MingWei

2016, 32(11): 2103-2106. DOI: 10.3969/j.issn.1001-5256.2016.11.019

Abstract(2620)

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Abstract:
Objective To investigate the distribution of HBV genotypes in Changchun,China,as well as the association of genotypes with virus replication level,serum markers,and liver impairment and its clinical significance. Methods A total of 702 patients with HBV infection who visited The First Hospital of Ji...

Effect of hepatitis B virus rtA181T mutation on autophagy of Huh7 hepatoma cells

Shi JingRen, Guo XiangHua, Wang JieLin, Wang ShanShan, Qiao LuXin, Chen DeXi

2016, 32(11): 2107-2111. DOI: 10.3969/j.issn.1001-5256.2016.11.020

Abstract(2123)

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Abstract:
Objective To investigate the effect of reverse transcriptase A181T( rtA181T) mutation in hepatitis B virus( HBV) on autophagy of Huh7 hepatoma cells. Methods Huh7 hepatoma cells were transfected with wild- type( WT) 1. 3mer HBV plasmids( WT group),1. 3mer HBV rt A181 T mutant plasmids( 181 T group),...

Original articles_Liver fibrosis and liver cirrhosis

Effect of transjugular intrahepatic portosystemic shunt combined with splenic artery embolization on hepatic hemodynamics and liver function in patients with liver cirrhosis

Liang XiaoHua, Zhang Feng, Zhu GeYuZheng

2016, 32(11): 2112-2117. DOI: 10.3969/j.issn.1001-5256.2016.11.021

Abstract(2652)

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Abstract:
Objective To investigate the effect of transjugular intrahepatic portosystemic shunt( TIPS) combined with splenic artery embolization( SAE) on hepatic hemodynamics,liver function,and prognosis in patients with liver cirrhosis. Methods A total of 24 patients who underwent TIPS in the Department of Ga...

Value of serum cancer antigen12-5 level in diagnosis of peritoneal effusion in patients with liver cirrhosis

Zhang Hui, Jia Lei, Lu: Dong, Xu YouQing

2016, 32(11): 2118-2120. DOI: 10.3969/j.issn.1001-5256.2016.11.022

Abstract(2194)

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Abstract:
Objective To investigate the value of serum cancer antigen 12- 5( CA12- 5) level in the diagnosis of peritoneal effusion in patients with liver cirrhosis. Methods A total of 142 patients with liver cirrhosis who were hospitalized at Beijing Tiantan hospital from January 2011 to December 2015 and met...

Original articles_Liver neoplasms

Clinical effect of liver cancer resection combined with selective decongestive devascularization in treatment of primary liver cancer complicated by portal hypertension

Zheng GuiLong, Ding HaiHua, Ding ZhiQing, Deng XianRen, Xia JingBo, Li HongXin

2016, 32(11): 2121-2125. DOI: 10.3969/j.issn.1001-5256.2016.11.023

Abstract(2151)

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Abstract:
Objective To investigate the clinical effect of liver cancer resection combined with selective decongestive devascularization in the treatment of primary liver cancer complicated by portal hypertension. Methods A retrospective analysis was performed for the clinical data of 60 patients with primary ...

Influence of Forkhead box Q1 expression on therapeutic effect of transarterial chemoembolization after hepatocellular carcinoma surgery

Zhou YiLong, Chen Yuan, Zhang YiXin, Shao BingFeng, Zhang SuQing, Xu AiBing, He Song, Li YongJun, Tian SiYuan

2016, 32(11): 2126-2129. DOI: 10.3969/j.issn.1001-5256.2016.11.024

Abstract(2120)

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Abstract:
Objective To investigate the expression of Forkhead box Q1( FOXQ1) in the tissue of hepatocellular carcinoma( HCC),its influence on the prognosis of surgical resection combined with transarterial chemoembolization( TACE),and the value of FOXQ1 in evaluating the treatment outcome of HCC. Methods A to...

Original articles_Biliary diseases

Role of reproductive factors in female patients with primary biliary cholangitis

Chen Jing, Guo ZhangCun, Shi YongQuan, Zhou XinMin, He XiaoXia, Chen Yu, Wang Lu, Guo GuanYa, Han ZheYi, Han Ying

2016, 32(11): 2130-2133. DOI: 10.3969/j.issn.1001-5256.2016.11.025

Abstract(2294)

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Abstract:
Objective To investigate the role of productive factors in the development of primary biliary cholangitis( PBC). Methods A total of 273 female patients with a definite diagnosis of PBC who visited Xijing Hospital from October 2013 to August 2015 were enrolled. The patients with autoimmune hepatitis,...

Diagnosis of clonorchiasis during and after biliary tract surgery: a clinical analysis of 15 cases

Qi WenLei, Zhang RuoYan, Chai WenGang, Liu MingJiang, Du XiaoHong, Ye JunFeng

2016, 32(11): 2134-2137. DOI: 10.3969/j.issn.1001-5256.2016.11.026

Abstract(2427)

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Abstract:
Objective To investigate the clinical features of clonorchiasis diagnosed during biliary surgery,and to provide more comprehensive and effective information for the surgical treatment of clonorchiasis. Methods A retrospective analysis was performed for the clinical data of 15 patients who were diagn...

Value of cold laser combined with choledochoscopy in treatment of residual stones after biliary surgery

Jiang ZheLong, Pan Fan, Lu: LiZhi, Jiang Yi

2016, 32(11): 2138-2140. DOI: 10.3969/j.issn.1001-5256.2016.11.027

Abstract(2166)

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Abstract:
Objective To investigate the value of cold laser combined with choledochoscopy in the treatment of residual stones after biliary surgery. Methods A retrospective analysis was performed for the clinical data of 79 patients with residual stones after biliary surgery who were admitted to Fuzhou General...

Application of fast track surgery strategy in perioperative period of primary suture of laparoscopic choledocholithotomy

Liu JinHeng, Wang YanTing, Yi Bin, Gao Yuan, Chen AnPing, Zhang ShengLong

2016, 32(11): 2141-2145. DOI: 10.3969/j.issn.1001-5256.2016.11.028

Abstract(2445)

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Abstract:
Objective To investigate the clinical application value of fast track surgery strategy( EARS) in the perioperative period of primary suture of laparoscopy in the treatment of common bile duct stones. Methods A total of 64 patients with gallstones complicated by common bile duct stones who were hospi...

Original articles_Pancreatic diseases

Effect of angiotensin 1-7 on the TLR4/NF-κB pathway in cerulein-induced pancreatic acinar cells

Wang Yan, Cui LiJian, Xiao HongLi, Wang GuoXing, Yin ChengHong

2016, 32(11): 2146-2150. DOI: 10.3969/j.issn.1001-5256.2016.11.029

Abstract(1832)

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Abstract:
Objective To investigate the effect of angiotensin 1- 7 [Ang( 1- 7) ] on the TLR4 / NF- κB pathway in cerulein- stimulated pancreatic acinar AR42 J cells. Methods AR42 J cells were randomly divided into control group,model group( stimulated with 10 nmol / L cerulein),Ang( 1- 7) group( 10- 7,10- 6,an...

Original articles_Others

Clinical effect of alprostadil combined with entecavir in treatment of HBV-related liver failure complicated by ascites

Ji HuiChun, Zhang ZhenJiang, Zhu Fang, Liu JunQuan, Liu QingDe, Pang Wei

2016, 32(11): 2151-2154. DOI: 10.3969/j.issn.1001-5256.2016.11.030

Abstract(2237)

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Abstract:

Objective To investigate the clinical effect of alprostadil combined with entecavir in the treatment of HBV- related liver failure complicated by ascites. Methods A total of 84 patients with HBV- related liver failure complicated by ascites who were hospitalized and treated in No. 97 Hospital of PLA...

Clinical value of indocyanine green retention rate in condition analysis and prognostic evaluation of patients with HBV-related acute-on-chronic liver failure

Liu JingHua, Liu Na, Liu ChenXi

2016, 32(11): 2155-2158. DOI: 10.3969/j.issn.1001-5256.2016.11.031

Abstract(2289)

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Abstract:

Objective To investigate the clinical value of indocyanine green retention rate at 15 min( ICG R15) in the condition analysis and prognostic evaluation of patients with acute- on- chronic liver failure( ACLF),and to provide a reference index for condition analysis and prognostic evaluation of patien...

Guiding significance of Guideline for diagnosis and treatment of herb-induced liver injury in clinical diagnosis: a retrospective analysis

Zhu Yun, Wang RuiLin, Sun XueYing, Yu SiMiao, Jing Jing, Wang JiaBo, He TingTing, Huang YiXue, Wang LiPing, Sun YongQiang

2016, 32(11): 2159-2162. DOI: 10.3969/j.issn.1001-5256.2016.11.032

Abstract(2248)

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Abstract:

Objective To investigate the clinical guiding significance of Guideline for diagnosis and treatment of herb- induced liver injury in the diagnosis of herb- induced liver injury( HILI). Methods A retrospective analysis was performed for the clinical data of 595 hospitalized patients who were admitted...

Clinical effect of matrine in treatment of rats with nonalcoholic steatohepatitis

Ai ZhengLin, Xie BuShan, Yao ShuKun

2016, 32(11): 2163-2166. DOI: 10.3969/j.issn.1001-5256.2016.11.033

Abstract(2257)

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Abstract:

Objective To investigate the antioxidant effect of matrine and its clinical effect in the treatment of rats with nonalcoholic steatohepatitis( NASH). Methods A total of 30 rats were randomly divided into three groups: control group,NASH group,and matrine group,with 10 in each. A high- fat diet was u...

Case reports

Thrombotic cavernous transformation of the portal vein secondary to hepatitis B cirrhosis treated with warfarin: a case report

Yuan Wei, Zhang YuYi, Zhang ZhengGuo, Zou Ying, Wang JieFei, Qian ZhiPing

2016, 32(11): 2167-2168. DOI: 10.3969/j.issn.1001-5256.2016.11.034

Abstract(1438)

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A case of giant hepatoblastoma

Ma LinJie, Chen Xiao, Zou Long, Liu Hong, Hu ZongQiang, Bai JianHua, Chen Gang

2016, 32(11): 2169-2170. DOI: 10.3969/j.issn.1001-5256.2016.11.035

Abstract(1735)

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A case of ectopic pancreas in the gastric antrum misdiagnosed as hepatic cyst

Hao Qiao, Xue JianFeng, Tian XiangYong, Hu JunLong

2016, 32(11): 2171-2172. DOI: 10.3969/j.issn.1001-5256.2016.11.036

Abstract(1928)

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A case of hepatolenticular degeneration with mental disorder as initial symptomc

Cui YuanYuan, Yang YiLiang, Wang ShaSha, Hua Rui

2016, 32(11): 2173-2174. DOI: 10.3969/j.issn.1001-5256.2016.11.037

Abstract(2019)

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A case of hepatic alveolar echinococcosis

Wang ZhiWei, Li Qiang, Chai Chen

2016, 32(11): 2175-2176. DOI: 10.3969/j.issn.1001-5256.2016.11.038

Abstract(1781)

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A case of gallstones with gallbladder-stomach fistula and biliary ileus

Lin QianHuang, Xu Hui, Tang XiaoLong, Ding Zheng, Tang WenJun, Wu KaiKai, Xun JinLiang

2016, 32(11): 2177-2178. DOI: 10.3969/j.issn.1001-5256.2016.11.039

Abstract(1955)

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Infarct of spleen infarction after laparoscopic spleen-preserving distal pancreatectomy conservation of the splenic arteries and veins: a case report

Zhao Lei, Zhang Ping, Shi XiaoJu, Zang MingCui, Wei Feng, Wang GuangYi

2016, 32(11): 2179-2181. DOI: 10.3969/j.issn.1001-5256.2016.11.040

Abstract(2232)

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Reviews

Research advances in tenofovir in treatment of chronic hepatitis B patients with drug resistance

Yan YueRong, Feng JiHong

2016, 32(11): 2182-2185. DOI: 10.3969/j.issn.1001-5256.2016.11.041

Abstract(1753)

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Abstract:
Currently,tenofovir is the first- line drug for the treatment of chronic hepatitis B. This article reviews the research advances in its therapeutic effects in patients who are resistant to lamivudine and adefovir dipivoxil,respond poorly to entecavir,or have multidrug resistance and introduces the r...

Influence of interaction between endogenous miRNAs and hepatitis B virus in hepatocytes on hepatitis B virus transcription and related mechanisms

Qiu Hua, Sun XueHua, Zhou ZhenHua, Li Man, Zhang Xin, Gao YueQiu

2016, 32(11): 2186-2190. DOI: 10.3969/j.issn.1001-5256.2016.11.042

Abstract(1406)

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Abstract:
MicroRNAs( miRNAs) may be involved in the regulation of gene expression after transcription and play important roles in regulating hepatitis B virus( HBV) transcription and replication. This article summarizes the miRNAs with an anti- HBV effect in hepatocytes and4 regulatory mechanisms,as well as t...

Mechanisms of hyponatremia in patients with decompensated liver cirrhosis treated with terlipressin and related treatment principles

You Jia, Jiang JiaJi

2016, 32(11): 2191-2194. DOI: 10.3969/j.issn.1001-5256.2016.11.043

Abstract(1865)

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Esophagogastric variceal bleeding and hepatorenal syndrome are common complications in patients with decompensated liver cirrhosis and portal hypertension. Terlipressin can lead to the constriction of visceral vessels,reduce portal venous pressure,and increase renal perfusion and is the first- line ...

Regulatory effect of transforming growth factor-β on activation of hepatic stellate cells

Zhao WeiHua, Wang YanHong, Cong Min

2016, 32(11): 2195-2198. DOI: 10.3969/j.issn.1001-5256.2016.11.044

Abstract(1922)

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In the process of liver fibrosis,transforming growth factor β( TGFβ) is considered an important regulatory factor for the activation of hepatic stellate cells( HSCs) and extracellular matrix production. Therefore,the therapeutic strategies targeted at the activation of HSCs and liver fibrosis induce...

Prevention of surgical site infection after liver cancer resection

Xu Feng, Tang Bin, Dai ChaoLiu, Wang Chao, Liu XiaoLin

2016, 32(11): 2199-2202. DOI: 10.3969/j.issn.1001-5256.2016.11.045

Abstract(1759)

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Surgical site infection( SSI) often increases the length of hospital stay,economic burden,and even mortality of patients undergoing liver cancer resection. Targeted preventive measures help to reduce SSI. This article introduces the preventive measures for SSI,including improvement of patients' phys...

Diagnostic value of H19 gene in hepatocellular carcinoma

Wang ShiMei, Wu Xia, Kang Peng, Meng QingYang

2016, 32(11): 2203-2205. DOI: 10.3969/j.issn.1001-5256.2016.11.046

Abstract(2325)

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Abstract:
Recent studies have shown that some long non- coding RNAs( lncRNAs) are expressed abnormally in hepatocellular carcinoma( HCC) tissue,and the expression of H19 gene in lncRNAs in HCC tissue is significantly higher than that in normal tissue. After the knockout of H19 gene,the proliferative and invas...

Expression and role of heat shock protein 70 in hepatocellular carcinoma

He ZeLing, Cao JianBiao, Fan GongRen

2016, 32(11): 2206-2209. DOI: 10.3969/j.issn.1001-5256.2016.11.047

Abstract(2152)

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Abstract:
Heat shock protein 70( HSP70) is expressed differently in hepatocellular carcinoma( HCC) tissues. Since its expression and regulatory mechanism remain unclear,whether HSP70 can help with the early diagnosis,treatment,and prognostic evaluation of HCC has become a hot research topic. This article revi...

Value of ultrasonic elastography in diagnosis of liver diseases

Zhang XiaoTong, Guo LiPing

2016, 32(11): 2210-2213. DOI: 10.3969/j.issn.1001-5256.2016.11.048

Abstract(2291)

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Ultrasonic elastography is a new technique of ultrasonic diagnosis and plays an important role in the diagnosis and monitoring of chronic liver diseases in recent years. This article introduces the principle and classification of ultrasonic elastography,as well as the application value of different ...

Research advances in diagnosis and treatment of liver disease during pregnancy

Luo Huan, Huang WenXiang

2016, 32(11): 2214-2217. DOI: 10.3969/j.issn.1001-5256.2016.11.049

Abstract(2265)

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Liver disease during pregnancy is classified as pregnancy- specific liver disease and non- pregnancy- specific liver disease. The unique physicochemical status during pregnancy increases the burden of liver metabolism. Once liver injury occurs,it tends to be more serious and is closely associated wi...

Research advances in pathogenesis and management of fatigue in patients with primary biliary cirrhosis

Zhao Jian, Cao Jia, Yao DingKang

2016, 32(11): 2218-2221. DOI: 10.3969/j.issn.1001-5256.2016.11.050

Abstract(2628)

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Fatigue is one of the most common symptoms of primary biliary cirrhosis( PBC) and greatly affects patients' quality of life. The pathogenesis of fatigue in PBC remains unknown and there are no effective therapeutic methods. This article reviews the latest advances in the pathogenesis and treatment o...

Role of chymotrypsin C in development and progression of pancreatitis and pancreatic cancer

Liu ZeJie, Song YiLin, Li Hong, Feng YingMing, Su HaiChuan

2016, 32(11): 2222-2225. DOI: 10.3969/j.issn.1001-5256.2016.11.051

Abstract(2393)

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Abstract:
Chymotrypsin C( CTRC) is a trypsinogen synthesized by pancreatic acinar cells and secreted by pancreatic duct cells and belongs to the family of serine chymotrypsin. The main function of CTRC is to regulate the balance between activation and degradation of trypsin and maintain the structural and fun...