Expression of NEDD9 and its clinical significance in pancreatic cancer

Wu TieLong; Xue LiLi; Dai YuanYuan; Sheng YingYue; Wang WenYuan; Xue YuZheng

doi:10.3969/j.issn.1001-5256.2017.01.028

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Jan. 2017

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Article Navigation > Journal of Clinical Hepatology > 2017 > 33(1): 130-132

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Expression of NEDD9 and its clinical significance in pancreatic cancer

DOI: 10.3969/j.issn.1001-5256.2017.01.028

Department of Gastroenterology, The Third People′s Hospital of Wuxi, Wuxi, Jiangsu 214000, China

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Published Date: 2017-01-20

Abstract

Abstract

Objective To investigate the expression of neural precursor cell- expressed,developmentally down- regulated 9( NEDD9) in pancreatic cancer tissues and adjacent tissues and its association with the progression and prognosis of pancreatic cancer. Methods A total of 98 patients with pancreatic cancer who were treated in The Third People's Hospital of Wuxi from August 2005 to December 2010 were enrolled,and the samples of pancreatic cancer tissues and adjacent tissues were collected. Immunohistochemistry was used to measure the expression of NEDD9 in pancreatic cancer tissues and adjacent tissues. The chi- square test was used for comparison of categorical data between groups. Results The high expression rate of NEDD9 in pancreatic cancer tissues was significantly higher than that in adjacent tissues( 57. 1% vs 41. 8%,χ2= 4. 592,P = 0. 032). The expression of NEDD9 in pancreatic cancer tissues was significantly associated with TNM stage,degree of tumor differentiation,and lymph node metastasis( χ2= 45. 02,20. 41,and 36. 21,all P < 0. 001) and not associated with sex,age,tumor location,or presence or absence of liver metastasis( all P > 0. 05). Conclusion NEDD9 may play a role in the progression and invasion / metastasis of pancreatic cancer and can be used as a prognostic marker and a therapeutic target for pancreatic cancer.
- pancreatic neoplasms,
- NEDD9,
- pathological conditions

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References(13)

References

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Expression of NEDD9 and its clinical significance in pancreatic cancer

DOI: 10.3969/j.issn.1001-5256.2017.01.028