Early diagnosis of hepatocellular carcinoma( HCC) using tumor markers is very important for long- term survival. This article elaborates on the value and high sensitivity and specificity of protein induced by vitamin K absence or antagonist- Ⅱ( PIVKA- Ⅱ) in the early diagnosis,prognostic evaluation,and recurrence prediction of HCC. Its combination with alpha- fetoprotein can significantly increase the early diagnostic rate of HCC. It is pointed out that dynamic measurement of PIVKA- Ⅱ level can assist the correct evaluation of the development,progression,invasion / metastasis,and recurrence of HCC and can be used as an important marker for the prognosis of HCC.
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