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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 4
Apr.  2017
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Article Contents

Research advances in insulin-like growth factor 1 receptor and its pathway in diagnosis and treatment of primary liver cancer

DOI: 10.3969/j.issn.1001-5256.2017.04.038
  • Received Date: 2017-01-13
  • Published Date: 2017-04-20
  • The main biological functions of insulin-like growth factor 1 receptor ( IGF-1R) include formation and maintenance of transformed cell phenotype, involvement in cell proliferation and differentiation, and inhibition of cell apoptosis. In addition, IGF-1R regulates cell cycle and works with epidermal growth factor and platelet-derived growth factor to mediate cells to enter S phase from G1 phase. Overexpressed IGF-1R has become one of the target proteins for diagnostic imaging and localization therapy for primary liver cancer. Inhibition of the expression or function of IGF-1R can effectively control the growth and metastasis of tumor cells and enhance their sensitivity to chemotherapy and radiotherapy. This article reviews the role and significance of IGF-1R and its pathway in the diagnosis and treatment of primary liver cancer.

     

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