[1]YANG Y, KIM B, PARK YK, et al.Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells[J].Biochim Biophys Acta, 2015, 1850 (1) :187-185.
|
[2]CAO Y, XIA YZ, CHEN J, et al.Anti-fibrosis effects of deoxyschizandrin in human hepatic stellate cells[J].Chin J Clin Pharmacol Ther, 2016, 21 (8) :878-883. (in Chinese) 曹媛, 夏延哲, 陈杰, 等.五味子甲素在人肝星状细胞中的抗纤维化作用[J].中国临床药理学与治疗学, 2016, 21 (8) :878-883.
|
[3]BATALLER R, BRENNER DA.Liver fibrosis[J].J Clin Invest, 2005, 115 (2) :209-218.
|
[4] LUO SZ, LI ZH, XU MY, et al.Reversal of liver fibrosis through AG490 inhibition of the TGFβ1-STAT3 pathway[J].Chin J Hepatol, 2015, 23 (12) :939-943. (in Chinese) 罗声政, 李郑红, 徐铭益, 等.AG490抑制转化生长因子β1-STAT3信号通路逆转肝纤维化的机制研究[J].中华肝脏病杂志, 2015, 23 (12) :939-943.
|
[5]ZHOU XL, YU SP.Role of Wnt signaling pathway in progression of liver cirrhosis[J].J Clin Hepatol, 2015, 31 (9) :1540-1542. (in Chinese) 周雪玲, 余水平.Wnt信号通路对肝硬化进展的影响[J].临床肝胆病杂志, 2015, 31 (9) :1540-1542.
|
[6]REN CZ, HAO LS.Signal transduction involved in activation of hepatic stellate cells[J].J Clin Hepatol, 2015, 31 (3) :452-456. (in Chinese) 任昌镇, 郝礼森.肝星状细胞活化过程中的信号转导[J].临床肝胆病杂志, 2015, 31 (3) :452-456.
|
[7]FABREGAT I, MORENO-CACERES J, SANCHEZ A, et al.TGF-βsignalling and liver disease[J].FEBS J, 2016, 283 (12) :2219-2232.
|
[8] MASSAGUE J.TGFβsignalling in context[J].Nat Rev Mol Cell Biol, 2012, 13 (10) :616-630.
|
[9]HANYU A, ISHIDOU Y, EBISAWA T, et al.The N domain of Smad7 is essential for specific inhibition of transforming growth factor-beta signaling[J].J Cell Biol, 2001, 155 (6) :1017-1027.
|
[10]DOOLEY S, HAMZAVI J, BREIKOPF K, et al.Smad7 prevents activation of hepatic stellate cells and liver fibrosis in rats[J].Gastroenterology, 2003, 125 (1) :178-191.
|
[11]SCHULTZE-MOSGAU S, BLAESE MA, GRABENBAUER G, et al.Smad-3 and Smad-7 expression following anti-transforming growth factor beta 1 (TGFbeta1) -treatment in irradiated rat tissue[J].Radiother Oncol, 2004, 70 (3) :249-259.
|
[12]BALTA C, HERMAN H, BOLDURA OM, et al.Chrysin attenuates liver fibrosis and hepatic stellate cell activation through TGF-β/Smad signaling pathway[J].Chem Biol Interact, 2015, 240:94-101.
|
[13]ARGENTOU N, GERMANIDIS G, HYTIROGLOU P, et al.TGF-βsignaling is activated in patients with chronic HBV infection and repressed by SMAD7 overexpression after successful antiviral treatment[J].Inflamm Res, 2016, 65 (5) :355-365.
|
[14]GEISLER F, STRAZZABOSCO M.Emerging roles of Notch signaling in liver disease[J].Hepatology, 2015, 61 (1) :382-392.
|
[15]CHEN Y, ZHENG S, Qi D, et al.Inhibition of Notch signaling by aγ-secretase inhibitor attenuates hepatic fibrosis in rats[J].PLo SOne, 2012, 7 (10) :e46512.
|
[16]ZHANG X, DU G, XU Y, et al.Inhibition of notch signaling pathway prevents cholestatic liver fibrosis by decreasing the differentiation of hepatic progenitor cells into cholangiocytes[J].Lab Invest, 2016, 96 (3) :350-360.
|
[17]TANRIVERDI G, KAYA-DAGISTANLI F, AYLA S, et al.Resveratrol can prevent CCl 4-induced liver injury by inhibiting Notch signaling pathway[J].Histol Histopathol, 2016, 31 (7) :769-784.
|
[18]CHEN YX, WENG ZH, QI D, et al.Effect of Notch signaling on the activation of hepatic stellate cells[J].Chin J Hepatol, 2012, 20 (9) :677-682. (in Chinese) 陈毅雄, 翁志宏, 祁丹, 等.调控Notch信号对肝星状细胞活化的影响[J].中华肝脏病杂志, 2012, 20 (9) :677-682.
|
[19]ZHANG QD, XU MY, CAI XB, et al.Myofibroblastic transformation of rat hepatic stellate cells:the role of Notch signaling and epithelial-mesenchymal transition regulation[J].Eur Rev Med Pharmacol Sci, 2015, 19 (21) :4130-4138.
|
[20]BANSAL R, BAARLEN JV, STORM G, et al.The interplay of the Notch signaling in hepatic stellate cells and macrophages determines the fate of liver fibrogenesis[J].Sci Rep, 2015, 5:18272.
|
[21]THOMPSON MD, MONGA SP.WNT/beta-catenin signaling in liver health and disease[J].Hepatology, 2007, 45 (5) :1298-1305.
|
[22]CHENG JH, SHE H, HAN YP, et al.Wnt antagonism inhibits hepatic stellate cell activation and liver fibrosis[J].Am J Physiol Gastrointest Liver Physiol, 2008, 294 (1) :g39-g49.
|
[23]LIN X, KONG LN, HUANG C, et al.Hesperetin derivative-7 inhibits PDGF-BB-induced hepatic stellate cell activation and proliferation by targeting Wnt/β-catenin pathway[J].Int Immunopharmacol, 2015, 25 (2) :311-320.
|
[24]MONGA SP.Role of Wnt/β-catenin signaling in liver metabolism and cancer[J].Int J Biochem Cell Biol, 2011, 43 (7) :1021-1029.
|
[25]ZHANG Y, ZHANG H, PENG R, et al.Mechanism research on Artesunate in the treatment of liver fibrosis by inhibiting miR-154/β-catenin in hepatic stellate cell[J].China Med Herald, 2016, 13 (1) :35-38. (in Chinese) 张英, 张洪, 彭锐, 等.青蒿琥酯抑制肝星状细胞microRNA-154/β-catenin治疗肝纤维化的机制研究[J].中国医药导报, 2016, 13 (1) :35-38.
|
[26]MA ZG, LV XD, ZHAN LL, et al.Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway[J].World J Gastroenterol, 2016, 22 (6) :2092-2103.
|
[27]MICHELOTTI GA, XIE G, SWIDERSKA M, et al.Smoothened is a master regulator of adult liver repair[J].J Clin Invest, 2013, 123 (6) :2380-2394.
|
[28]VELCHETI V, GOVINDAN R.Hedgehog signaling pathway and lung cancer[J].J Thorac Oncol, 2007, 2 (1) :7-10.
|
[29]PEREIRA TA, XIE G, CHOI SS, et al.Macrophage-derived Hedgehog ligands promotes fibrogenic and angiogenic responses in human schistosomiasis mansoni[J].Liver Int, 2013, 33 (1) :149-161.
|
[30]XIE G, KARACA G, SWIDERSKA-SYN M, et al.Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice[J].Hepatology, 2013, 58 (5) :1801-1813.
|
[31]CHE L, YUAN YH, JIA J, et al.Activation of sonic hedgehog signaling pathway is an independent potential prognosis predictor in human hepatocellular carcinoma patients[J].Chin J Cancer Res, 2012, 24 (4) :323-331.
|
[32]HOOPER JE, SCOTT MP.Communicating with Hedgehogs[J].Na Rev Mol Cell Biol, 2005, 6 (4) :306-317.
|
[33]LI T, LENG XS, ZHU JY, et al.Suppression of hedgehog signaling regulates hepatic stellate cell activation and collagen secretion[J].Int J Clin Exp Pathol, 2015, 8 (11) :14574-14579.
|
[34]USCHNER FE, RANABHAT G, CHOI SS, et al.Statins activate the canonical hedgehog-signaling and aggravate non-cirrhotic portal hypertension, but inhibit the non-canonical hedgehog signaling and cirrhotic portal hypertension[J].Sci Rep, 2015, 5:14573.
|
[35]YANG JJ, TAO H, LI J.Hedgehog signaling pathway as key player in liver fibrosis:new insights and perspectives[J].Expert Opin T-her Targets, 2014, 18 (9) :1011-1021.
|
[36]YU F, LU Z, CHEN B, et al.Salvianolic acid B-induced microR-NA-152 inhibits liver fibrosis by attenuating DNMT1‐mediated Patched1 methylation[J].J Cell Mol Med, 2015, 19 (11) :2617-2632.
|
[37]EIAGROUDY NN, EINAGA RN, EIRAZEQ RA, et al.Forskolin, a hedgehog signaling inhibitor, attenuates carbon tetrachloride-induced liver fibrosis in rats[J].Br J Pharmacol, 2016, 173 (22) :3248-3260.
|
[38]ZHANG K, JIANG MN, ZHANG CH, et al.Effect of Gan-fukang compound on hepatic expression of integrinα5β1/FAK signal pathway in carbon tetrachloride-induced liver fibrosis in rats[J].J Clin Hepatol, 2012, 15 (2) :104-107. (in Chinese) 张坤, 姜妙娜, 张彩华, 等.肝复康对肝纤维化大鼠肝组织整合素α5β1/FAK信号通路的调节作用[J].实用肝脏病杂志, 2012, 15 (2) :104-107.
|
[39]ELAHARKAWY AM, OAKLEY F, MANN DA.The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis[J].Apoptosis, 2005, 10 (5) :927-939.
|
[40]BI H, MING L, CHENG R, et al.Liver extracellular matrix promotes BM-MSCs hepatic differentiation and reversal of liver fibrosis through activation of integrin pathway[J].J Tissue Eng Regen Med, 2016.[Epub ahead of print]
|
[41]SUGIYAMA A, KANNO K, NISHIMICHI N, et al.Periostin promotes hepatic fibrosis in mice by modulating hepatic stellate cell activation viaαv integrin interaction[J].J Gastroenterol, 2016, 51 (12) :1161-1174.
|