2017 No. 5

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Editorial

Improving the diagnosis and treatment of hepatobiliary & pancreatic diseases based on clinical evidence of advantages of integrated traditional Chinese and Western medicine

Liu Ping

2017, 33(5): 805-807. DOI: 10.3969/j.issn.1001-5256.2017.05.001

Abstract(464)

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Abstract:
This issue of Journal of Clinical Hepatology focuses on integrated traditional Chinese and Western medicine and has invited the experts who are engaged in the diagnosis and treatment of hepatobiliary & pancreatic diseases using integrated traditional Chinese and Western medicine.With reference t...

Therapeutic guidelines

An excerpt of The International Liver Transplant Society (ILTS) living donor liver transplant recipient guideline(2016)

Zhou Xia, Yao Hong, Liu HongLing

2017, 33(5): 808-812. DOI: 10.3969/j.issn.1001-5256.2017.05.002

Abstract(376)

PDF (223KB)(183)

Abstract:

An excerpt of American Gastroenterological Association Institute guidelines for the diagnosis and management of acute liver failure（2017）

Chen Jing, Su HaiBin

2017, 33(5): 813-815. DOI: 10.3969/j.issn.1001-5256.2017.05.003

Abstract(2827)

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Abstract:

An excerpt of laparoscopic surgery for pancreatic neoplasms: the European Association for Endoscopic Surgery clinical consensus conference（2017）

Zheng SuLi, Zhang TaiPing

2017, 33(5): 816-819. DOI: 10.3969/j.issn.1001-5256.2017.05.004

Abstract(312)

PDF (196KB)(175)

Abstract:

The Australasian Hepatology Association consensus guidelines for the provision of adherence support to patients with hepatitis C on direct acting antivirals

Rao HuiYing, Wei Lai

2017, 33(5): 820-824. DOI: 10.3969/j.issn.1001-5256.2017.05.005

Abstract(319)

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Abstract:

Discussions by experts

An exploration of therapeutic evaluation of traditional Chinese medicine in treatment of hepatic fibrosis

Xu LieMing

2017, 33(5): 825-828. DOI: 10.3969/j.issn.1001-5256.2017.05.006

Abstract(2904)

PDF (1536KB)(495)

Abstract:
China has become one of the leading counties in the world to treat hepatic fibrosis with Chinese patent drugs.The therapeutic effect of traditional Chinese medicine (TCM) should be evaluated from the aspects of short-term therapeutic effect, long-term therapeutic effect, and effect of relief of symp...

Epidemic features, major causes, and diagnostic evaluation of herb-induced liver injury

Liu ChengHai, Zhu ChunWu

2017, 33(5): 829-832. DOI: 10.3969/j.issn.1001-5256.2017.05.007

Abstract(2676)

PDF (1757KB)(549)

Abstract:
With the wide application of Chinese herbal medicine around the world and the continuous perfection of adverse drug reaction monitoring system, herb-induced liver injury (HILI) has attracted more and more attention, but its actual incidence remains unknown.As is reported in the literature, its const...

Clinical research advances in traditional Chinese medicine in treatment of icteric hepatitis

Guo QiYu, Chen JianNeng, Zheng RuiDan

2017, 33(5): 833-837. DOI: 10.3969/j.issn.1001-5256.2017.05.008

Abstract(2577)

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Abstract:
The pathogenesis of icteric hepatitis is that pathogenic dampness blocks the middle energizer or blood stasis blocks the bile duct, so that the bile is not excreted normally and moves to the skin surface, which makes the skin yellow.Traditional Chinese medicine (TCM) has unique advantages in the pre...

Integrated traditional Chinese and Western medicine therapy for acute and chronic cholecystitis

Zhang JingZhe, Yu Kui

2017, 33(5): 838-842. DOI: 10.3969/j.issn.1001-5256.2017.05.009

Abstract(2757)

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Abstract:
Acute and chronic cholecystitis is often complicated by gallstones.With the rapid development of modern surgery, especially the renovation in surgical concepts, techniques, and methods represented by noninvasive surgery, surgery becomes the most important method for the treatment of such disease.How...

Current status and perspectives of integrated traditional Chinese and Western medicine therapy for pancreatitis

Cui NaiQiang, Cui YunFeng, Zhang ShuKun

2017, 33(5): 843-848. DOI: 10.3969/j.issn.1001-5256.2017.05.010

Abstract(2962)

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Abstract:
Integrated traditional Chinese and Western medicine therapy for pancreatitis has been used since the 1960s.According to the clinical manifestations and traditional Chinese medicine (TCM) syndrome differentiation of pancreatitis, pancreatitis was named “true heart pain with cold limbs caused by splee...

Original articles_Viral hepatitis

Clinical effect of entecavir in treatment of chronic hepatitis B complicated by hepatic steatosis

Wu YanQin, Shen LiJun, Yu JiHong, Sun YuShan

2017, 33(5): 849-852. DOI: 10.3969/j.issn.1001-5256.2017.05.011

Abstract(2888)

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Abstract:

Objective To investigate the effect of antiviral therapy with entecavir in the treatment of chronic hepatitis B (CHB) complicated by hepatic steatosis.Methods A total of 164 HBe Ag-positive CHB patients who visited Bazhou People's Hospital from June 2014 to June2015 were enrolled, and according to t...

Economic burden of inpatients with hepatitis B virus infection-related diseases and its impact on family financial status in Qidong, Jiangsu Province, China

Yao HongYu, Wang YuTing, Tang HongPing, Huang HuiYao, Zhang HongJian, Sha ChunXia, Shi JuFang, Dai Min, Chen TaoYang, Qu ChunFeng

2017, 33(5): 853-859. DOI: 10.3969/j.issn.1001-5256.2017.05.012

Abstract(2626)

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Abstract:

Objective To investigate the economic burden of inpatients with hepatitis B virus (HBV) infection-related diseases (including primary liver cancer, hepatitis B cirrhosis, and chronic hepatitis B) and its impact on family financial status in Qidong, Jiangsu Province, China.Methods Cluster random samp...

Original articles_Liver fibrosis and liver cirrhosis

Risk factors for HBV-related liver cirrhosis complicated by acute upper gastrointestinal bleeding

Yu ZhiRui, Wei GuoXi, Liu QiChang, Jin PeiMin

2017, 33(5): 860-863. DOI: 10.3969/j.issn.1001-5256.2017.05.013

Abstract(1738)

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Abstract:

Objective To investigate the risk factors for HBV-related liver cirrhosis complicated by acute upper gastrointestinal bleeding (AUGIB) .Methods A total of 58 patients with HBV-related liver cirrhosis complicated by AUGIB who were hospitalized in our hospital from January to December, 2011 were enrol...

Original articles_Liver neoplasms

Value of transforming growth factor-β1 in diagnosis of primary liver cancer:a meta-analysis

Mo XiaoLi, Liu Jie, Zhu JiaYu, Chen Chuang, Ou Jie, Mao SuFei

2017, 33(5): 864-868. DOI: 10.3969/j.issn.1001-5256.2017.05.014

Abstract(2654)

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Abstract:

Objective To investigate the value of transforming growth factor-β1 (TGFβ1) in the diagnosis of primary liver cancer using a meta-analysis.Methods Pub Med, EMBASE, Cochrane Library, CBM, CNKI, Wanfang Data, and VIP were searched for articles on TGFβ1 in the diagnosis of primary liver cancer publishe...

Correlation between mRNA expression of heat shock protein in tumor tissue and tumor stage in patients with HBV-related hepatocellular carcinoma

Xu QingNian, Lu YunFei, Tang BoZong, Chen XiaoRong, Yang ZongGuo

2017, 33(5): 869-874. DOI: 10.3969/j.issn.1001-5256.2017.05.015

Abstract(3032)

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Abstract:

Objective To investigate the correlation between mRNA expression of heat shock protein (HSP) and tumor stage in patients with HBV-related hepatocellular carcinoma (HCC) .Methods The GSE14520 data set was downloaded from gene expression omnibus in the website of the National Center of Biotechnology I...

Influence of specific down-regulation of LKB1 expression on invasion and migration of hepatoma cells

Sha Liang, He JianBo, Li KeZhi, Chen Chuang, Huang Shan, Zhao YinNong, Lian Fang, Wu GuoBin

2017, 33(5): 875-879. DOI: 10.3969/j.issn.1001-5256.2017.05.016

Abstract(2588)

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Abstract:

Objective To investigate the influence of specific down-regulation of LKB1 expression on invasion and migration of the hepatoma cell line SK-hep-1.Methods Quantitative real-time PCR (RT-PCR) and Western blot were used to measure the expression of LKB1 in the human hepatoma cell line SK-hep-1 and nor...

Original articles_Biliary diseases

Association between metabolic syndrome and gallstones

Zhou BingBing, Wang XueMei, Zhang Qian, Xu ShiYi, Dan ZhongYan, Lai YaXin, Wang HaoYu

2017, 33(5): 880-882. DOI: 10.3969/j.issn.1001-5256.2017.05.017

Abstract(2730)

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Abstract:

Objective To investigate the association of metabolic syndrome and its components with gallstones and the factors for the development of gallstones.Methods A total of 445 community residents, who were followed up by Department of Endocrinology in The First Affiliated Hospital of China Medical Univer...

Clinical effect of laparoscopic cholecystectomy combined with laparoscopic choledocholithotomy T-tube drainage in treatment of gallbladder and common bile duct stones

Tan ZhanHai, Zhu GuangHui, Chen JianRong, Zhou LianMing, Yang Zhi, Zhang JiFa, Zhang XueLi, Dan YuanZhou

2017, 33(5): 883-887. DOI: 10.3969/j.issn.1001-5256.2017.05.018

Abstract(3412)

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Abstract:

Objectives To investigate the clinical effect of laparoscopic cholecystectomy (LC) combined with laparoscopic choledocholithotomy T-tube drainage (LCHTD) in the treatment of gallbladder and common bile duct stones.Methods A retrospective analysis was performed for 117 patients with gallbladder and c...

Clinical effect of laparoscopic versus open cholecystectomy in treatment of patients with portal hypertension complicated by gallstones

Zhao Bin, Qing XiaoSong, Lai Zhao

2017, 33(5): 888-891. DOI: 10.3969/j.issn.1001-5256.2017.05.019

Abstract(2571)

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Abstract:

Objective To investigate the safety and feasibility of laparoscopic cholecystectomy (LC) in the treatment of portal hypertension complicated by gallstones.Methods A retrospective analysis was performed for the clinical data of 96 patients with portal hypertension complicated by gallstones who underw...

A safety analysis of day-surgery laparoscopic cholecystectomy for elderly patients aged above 65 years with biliary tract diseases

Cao JunNing, Zhao SenFeng, Li XiangJun, Liu Bo

2017, 33(5): 892-895. DOI: 10.3969/j.issn.1001-5256.2017.05.020

Abstract(2679)

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Abstract:

Objective To investigate the safety of day-surgery laparoscopic cholecystectomy (LC/DS) in elderly patients.Methods The clinical data were collected from 4764 patients who underwent LC/DS in PLA General Hospital from November 2009 to July 2015, and a retrospective analysis was performed for the gene...

Association between hematobilia and primary disease after therapeutic endoscopic retrograde cholangiopancreatography

Wang QunRu, Zhang Yong, Mou Dong, Chen BeiJin, Ni Hua, Gao Hui

2017, 33(5): 896-898. DOI: 10.3969/j.issn.1001-5256.2017.05.021

Abstract(2761)

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Abstract:

Objective To investigate the difference in the risk of hematobilia after therapeutic endoscopic retrograde cholangiopancreatography (ERCP) in patients with different primary diseases.Methods A retrospective analysis was performed for the clinical data of 685 patients with pancreaticobiliary diseases...

Protective effect of prostaglandin E1 pretreatment against liver ischemia-reperfusion injury in rats with cholestasis

Xu Feng, Liu XiaoLin, Wang Chao, Dai ChaoLiu

2017, 33(5): 899-904. DOI: 10.3969/j.issn.1001-5256.2017.05.022

Abstract(3053)

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Abstract:

Objective To investigate the protective mechanism of prostaglandin E1 (PGE1) against liver ischemia-reperfusion injury in rats with cholestasis.Methods A total of 36 male Wistar rats were randomly divided into PGE1 group (PGE group) and normal saline group (NS group) .The rats in the PGE group were ...

Clinical effect of Pien Tze Huang in treatment of guinea pigs with cholecystitis induced by lithocholic acid given by gavage

Ren CaiYuan, Ren Feng, Li JunFeng, Ding Mei, Chen Yu, Duan ZhongPing, Zhang HuanHu

2017, 33(5): 905-908. DOI: 10.3969/j.issn.1001-5256.2017.05.023

Abstract(2829)

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Abstract:

Objective To investigate the clinical effect of traditional Chinese medicine Pien Tze Huang in the treatment of guinea pigs with cholecystitis.Methods A total of 80 guinea pigs (40 males and 40 females) were randomly divided into blank control group (10 guinea pigs treated with PBS at the same dose ...

Expression of trophoblast cell-surface antigen 2, phosphorylated extracellular signal-regulated kinase 1/2, and cyclin D1 in gallbladder carcinoma tissue and related clinical significance

Li XinXing, Teng ShiFeng, Xu Kai, Zhang YanYan, Zhang WeiGang, Zhang XianWen, Yao Jun, Yao HouShan, Huang Xin, Hu ZhiQian

2017, 33(5): 909-914. DOI: 10.3969/j.issn.1001-5256.2017.05.024

Abstract(2328)

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Abstract:

Objective To investigate the expression of human trophoblast cell-surface antigen 2 (TROP2) , phosphorylated extracellular signal-regulated kinase 1/2 (p-ERK1/2) , and cyclin D1 in gallbladder carcinoma tissue and their correlation with clinicopathological parameters, as well as their association wi...

Original articles_Pancreatic diseases

Risk factors for recurrence after surgery for biliary pancreatitis

Li RenLi, Zhou Qing

2017, 33(5): 915-918. DOI: 10.3969/j.issn.1001-5256.2017.05.025

Abstract(1855)

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Abstract:

Objective To investigate the risk factors for recurrence after surgery for biliary pancreatitis.Methods A total of 284 patients with biliary pancreatitis who were treated in The Fourth Hospital of PLA from January 2008 to December 2014 were followed up, and the risk factors for postoperative recurre...

A systematic analysis of the application of diagnostic criteria for drug-induced liver injury in China based on the literature

Zhang Dong, Zhang Tao, Wu YuNan, Sun KeWei

2017, 33(5): 919-923. DOI: 10.3969/j.issn.1001-5256.2017.05.026

Abstract(2895)

PDF (1605KB)(549)

Abstract:

Objective To investigate the application of diagnostic criteria for drug-induced liver injury in China.Methods CNKI, VIP, and Wanfang Data were searched for articles published from 1990 to 2015, and the diagnostic criteria in the articles were recorded to investigate the current application of diagn...

Clinical features of different types of drug-induced liver injury and their association with liver histological changes

Xu CengLi, Gao Min, Guo ChunXia, Xing MinDan, Li Jia

2017, 33(5): 924-927. DOI: 10.3969/j.issn.1001-5256.2017.05.027

Abstract(2609)

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Abstract:

Objective To investigate the clinical features of patients with different clinical types of drug-induced liver injury (DILI) , as well as the association between clinical type and pathological type.Methods A total of 289 patients with DILI who were admitted to Tianjin Second People's Hospital from J...

Clinical effect of linagliptin combined with insulin aspart 50 in treatment of hepatogenous diabetes

Yang Shuo, Jiang XiaoDi

2017, 33(5): 928-931. DOI: 10.3969/j.issn.1001-5256.2017.05.028

Abstract(3082)

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Abstract:

Objective To investigate the clinical effect and safety of linagliptin combined with insulin aspart 50 in the treatment of hepatogenous diabetes (HD) .Methods A total of 57 patients with HD who visited The People's Hospital of Liaoning Province from October 2014 to February 2016 were enrolled and ra...

Effect of Huatan Qushi Huoxue prescription on the ADPN/AMPK/ACC signaling pathway in rats with nonalcoholic steatohepatitis

Zhao WenXia, Yan Le, Shao MingYi, Zhang LiHui

2017, 33(5): 932-936. DOI: 10.3969/j.issn.1001-5256.2017.05.029

Abstract(454)

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Abstract:

Objective To investigate the effect of Huatan Qushi Huoxue prescription on the adiponectin (ADPN) /adenosine monophosphate-activated protein kinase (AMPK) /acetyl-Co A carboxylase (ACC) signaling pathway in rats with nonalcoholic steatohepatitis (NASH) .Methods A total of 72 male Sprague-Dawley rats...

Case reports

Misdiagnosis of peritoneal pseudomyxoma as cirrhotic ascites: a report of 2 cases

Shen XiaoXu, Wu YaYun

2017, 33(5): 937-939. DOI: 10.3969/j.issn.1001-5256.2017.05.030

Abstract(2542)

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Abstract:

Hereditary hemorrhagic telangiectasia with liver cirrhosis: a case report

Fu QiLin, Huang Fu, Tang YingHui, Yu Yue, Li FenPing

2017, 33(5): 940-942. DOI: 10.3969/j.issn.1001-5256.2017.05.031

Abstract(2509)

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Abstract:

Liver transplantation for liver failure caused by alcoholic cirrhosis complicated by portal ductopathy: a case report

Wang Yao, Sun Ying, Xu XiJing, Sun XiaoDong, Lu: GuoYue, Wen XiaoYu, Jin QingLong

2017, 33(5): 943-945. DOI: 10.3969/j.issn.1001-5256.2017.05.032

Abstract(2331)

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Abstract:

Caroli disease with nephronophthisis: a case report and literature review

Ou YangYuQing, Lu HaiYing, Xu XiaoYuan

2017, 33(5): 946-948. DOI: 10.3969/j.issn.1001-5256.2017.05.033

Abstract(2256)

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Reviews

Research advances in immune tolerance in chronic hepatitis B virus infection

Wu FengPing, Dang ShuangSuo

2017, 33(5): 949-953. DOI: 10.3969/j.issn.1001-5256.2017.05.034

Abstract(2910)

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Abstract:

Immune tolerance refers to the specific non-response or negative response of T and B lymphocytes to antigens.According to the period of formation, immune tolerance can be classified into central tolerance and peripheral tolerance.Immune tolerance to hepatitis B virus (HBV) after HBV infection is con...

Research advances in signaling pathways involved in the development of hepatic fibrosis

Peng Qin, Zhao ShenJun, Li Wu

2017, 33(5): 954-958. DOI: 10.3969/j.issn.1001-5256.2017.05.035

Abstract(2952)

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Abstract:
Liver fibrosis is a pathological process for the liver to repair various chronic liver injuries and may eventually progress to liver cirrhosis, liver failure, or even liver cancer.Therefore, early intervention and treatment of liver fibrosis is of particular importance.This article summarizes the la...

Evaluation of stent function after transjugular intrahepatic portosystemic shunt using color Doppler and contrast-enhanced ultrasound

Lu ChunYu, Tang ShaoShan

2017, 33(5): 959-962. DOI: 10.3969/j.issn.1001-5256.2017.05.036

Abstract(2736)

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Abstract:
At present, transjugular intrahepatic portosystemic shunt (TIPS) is an effective procedure widely used in the clinical treatment of portal hypertension.The blood stream in the portal vein can be directly shunted into the hepatic vein through the inserted stent, which helps to reduce portal vein pres...

Significance of serological markers in diagnosis of nonalcoholic fatty liver disease

Wan Yan, Chang JianBo, Bai YanXia, Li QianNan, Dai GuangRong

2017, 33(5): 963-968. DOI: 10.3969/j.issn.1001-5256.2017.05.037

Abstract(2778)

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Abstract:
In recent years, the incidence rate of fatty liver tends to increase markedly, and liver biopsy is the gold standard for the diagnosis of fatty liver, but it has some inevitable shortcomings.At present, there lacks a convenient, cheap, and accurate noninvasive diagnostic method for clinical practice...

Complications of radiofrequency ablation for liver cancer in high-risk locations and their prevention

Zhang JunChao, Lin Su, Zhu YueYong

2017, 33(5): 969-973. DOI: 10.3969/j.issn.1001-5256.2017.05.038

Abstract(2751)

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Abstract:
Radiofrequency ablation (RFA) is one of the most important methods for the treatment of liver cancer and has the advantages of small trauma, simple operation, and repeatability.However, for tumors in high-risk locations within 5 mm of the first and second branches of the hepatic portal vein, near th...

Current research status of precancerous dysplastic nodules in hepatocellular carcinoma

Jiao JunZhe, Li JingTao, Yan ShuGuang, Wei HaiLiang, Ju Di, Song YiJun, Chang ZhanJie

2017, 33(5): 974-978. DOI: 10.3969/j.issn.1001-5256.2017.05.039

Abstract(3022)

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Abstract:

Dysplastic nodule (DN) is an important stage for precancerous hepatocellular carcinoma (HCC) lesions progressing to HCC and has a very high risk of canceration.According to the difference in atypia, DN is classified into low-grade DN (LGDN) and high-grade DN (HGDN) .This article summarizes the patho...

Research advances in the identification of clinical biomarkers for liver diseases using metabolomics based on ultra-performance liquid chromatography-mass spectrometry

Zhou Xuan, Lai Yong

2017, 33(5): 979-984. DOI: 10.3969/j.issn.1001-5256.2017.05.040

Abstract(2122)

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Abstract:

The biomarkers currently known for the early diagnosis of liver diseases often have poor sensitivities and specificities, and thus it is very important to find new biomarkers with high sensitivities and specificities for the early diagnosis of liver diseases.The emerging metabolomics technology has ...

Application of statins in prevention and treatment of liver diseases

Liu Lu, Han Tao, Zhou LengXiao

2017, 33(5): 985-989. DOI: 10.3969/j.issn.1001-5256.2017.05.041

Abstract(2005)

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Abstract:

Statins are widely used as important lipid-lowering drugs, and studies have proven the safety of statins in patients with liver diseases.In recent years, there have been more and more studies on the effects of statins in the prevention and treatment of hepatitis C, fatty liver disease, liver cirrhos...

Diagnosis and treatment of hepatic alveolar echinococcosis

Fang Dan, Chen ZheYu

2017, 33(5): 990-993. DOI: 10.3969/j.issn.1001-5256.2017.05.042

Abstract(2391)

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Abstract:

Alveolar echinococcus can be found in various organs of the body, with the liver as the most common organ.This article briefly elaborates on the diagnosis and treatment of hepatic alveolar echinococcosis.The diagnosis of this disease includes epidemic areas, serology, ultrasound, imaging examination...

Research advances in adult hepatic progenitor cells

Li Fei, Ma ZhenZeng, Lu LunGen

2017, 33(5): 994-997. DOI: 10.3969/j.issn.1001-5256.2017.05.043

Abstract(2343)

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Abstract:

The liver has a strong regenerative capacity, and in case of acute injury, the proliferation of mature hepatocytes helps to complete liver regeneration.However, in case of chronic injury, the proliferative capacity of mature hepatocytes is damaged or exhausted, and the activation, proliferation, and...

Novel therapeutic targets for primary biliary cholangitis

Chen RongBin, Wu XueMing, Wu Ying, Yao DingKang

2017, 33(5): 998-1002. DOI: 10.3969/j.issn.1001-5256.2017.05.044

Abstract(2236)

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Abstract:
Primary biliary cholangitis (PBC) is a chronic autoimmune-mediated liver disease manifesting as progressive cholestasis and non-purulent inflammation in small-and medium-sized intrahepatic bile ducts.It finally progresses to liver cirrhosis and liver cancer and greatly threatens patient's life.Studi...