中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 11
Nov.  2017

Clinical and pathological features of autoimmune hepatitis-primary biliary cholangitis overlap syndrome versus autoimmune hepatitis

DOI: 10.3969/j.issn.1001-5256.2017.11.026
Research funding:

 

  • Received Date: 2017-05-02
  • Published Date: 2017-11-20
  • Objective To investigate the clinical and pathological features of autoimmune hepatitis (AIH) -primary biliary cholangitis (PBC) overlap syndrome (AIH-PBC OS) versus AIH, since it is still difficult to diagnose AIH-PBC OS in clinical practice, and to enhance the knowledge of AIH-PBC OS and improve its early diagnostic rate.Methods A prospective study was performed for the clinical data, biochemical and immunological markers, autoantibody, and liver pathology of 50 patients with AIH-PBC OS confirmed by liver biopsy who visited West China Hospital, Sichuan University, from January 20, 2015 to November 28, 2016 and 57 patients with AIH alone, in order to compare the features of AIH-PBC OS and AIH.Continuous data such as laboratory markers were expressed as median M (inter-quartile range) and the nonparametric rank sum test was used for comparison of these data between two groups;categorical data including clinical features、histopathological manifestations were expressed as rates and the chi-square test was used for comparison of these data between two groups.Results The AIH-PBC OS group had a significantly lower age of onset than the AIH group (Z=-1.975, P=0.048) , while there was no significant difference in male/female sex ratio between the two groups.The AIH-PBC OS group had a significantly higher proportion of patients with pruritus than the AIH group (22.0% vs 7.0%, χ2=4.960, P=0.026) .Compared with the AIH group, the AIH-PBC OS group had significantly higher levels of alkaline phosphatase (ALP) , gamma-glutamyl transpeptidase (GGT) , and immunoglobulin M (IgM) (Z=-6.250, -4.789, and-5.407, all P<0.001) , a significantly higher positive rate of antimitochondrial antibody (AMA) (χ2=26.811, P<0.001) , and significantly lower serum levels of alanine aminotransferase (ALT) , aspartate aminotransferase, and immunoglobulin G (IgG) (Z=-2.916, -3.381, and-2.285, P=0.004, 0.001, and 0.022) .The AIH-PBC OS group had significantly higher incidence rates of bile duct injury, bile duct loss, granulomatous disease, and cholestasis than the AIH group (χ2=25.612, 15.953, 6.490, and 10.042, P<0.001, <0.001, 0.001, and 0.002) .Conclusion Although AIH-PBC OS has the features of both AIH and PBC, it is not a simple overlap between AIH and PBC.Pruritus, significant increases in the levels of ALP, GGT, and IgM, positive AMA, and inflammatory bile duct disease and cholestasis may have implications for the diagnos of AIH-PBC OS.Since AIH-PBC OS may have milder liver inflammatory injury and autoimmune abnormalities than AIH, the levels of ALT and IgG in Paris criteria can be broadened during the diagnosis of AIH-PBC OS, in order to prevent missed diagnosis and avoid affecting the selection of treatment regimen and patients' prognosis.

     

  • [1]CHAZOUILLERES O, WENDUM D, SERFATY L, et al.Primary biliary cirrhosis-autoimmune hepatitis overlap syndrome:clinical features and response to therapy[J].Hepatology, 1998, 28 (2) :296.
    [2]WOODWARD, NEUBERGER J.Autoimmune overlap syndromes[J].Hepatology, 2001, 33 (4) :994.
    [3]SCHRAMM C, LOHSE AW.Overlap syndromes of cholestatic liver diseases and auto-immune hepatitis[J].Clin Rev Allergy Immunol, 2005, 28 (2) :105-114.
    [4]European Association for the Study of the Liver.EASL clinical practice guidelines:management of cholestatic liver diseases[J].JHepatol, 2009, 51 (2) :237-267.
    [5]BUNCHORNTAVAKUL C, REDDY KR.Diagnosis and management of overlap syndromes[J].Clin Liver Dis, 2015, 19 (1) :81-97.
    [6]KRAWITT EL.Autoimmune hepatitis[J].N Eng I J Med, 2006, 354 (1) :54-66.
    [7]CHEN CW, CHENG J, DOU XG, et al.Consensus on the diagnosis and management of primary biliary cirrhosis (cholangitis) (2015) [J].J Clin Hepatol, 2015, 20 (12) :960-968. (in Chinese) 陈成伟, 成军, 窦晓光, 等.原发性胆汁性肝硬化 (又名原发性胆汁性胆管炎) 诊断和治疗共识 (2015) [J].临床肝胆病杂志, 2015, 20 (12) :960-968.
    [8]BOBERG KM, CHAPMAN RW, HIRSCHFIELD GM, et al.International Autoimmune Hepatitis Group.Overlap syndromes:the international autoimmune hepatitis group (IAIHG) position statement on a controversial issue[J].J Hepatol, 2011, 54 (2) :374-385.
    [9]KUIPER EM, ZONDERVAN PE, van BUUREN HR.Paris criteria are effective in diagnosis of primary biliary cirrhosis and autoimmune hepatitis overlap syndrome[J].Clin Gastroenterol Hepatol, 2010, 8 (6) :530-534.
    [10]POUPON R, CHAZOUILLERES O, CORPECHOT C, et al.Development of autoimmune hepatitis in patients with typical primary biliary cirrhosis[J].Hepatology, 2006, 44 (1) :85.
    [11]SASAKI R, AKIYAMA M, TAKESHITA S, et al.A case of PBC-AIH overlap syndrome who developed AIH 8 years after diagnosis of typical PBC[J].Kanzo, 2009, 50 (50) :445-450.
    [12]MANNS MP, CZAJA A J, GORHAM JD, et al.AASLD Practice Guidelines.Diagnosis and management of autoimmune hepatitis[J].Hepatology, 2010, 51 (6) :2193-2213.
    [13]HENNES EM, ZENIYA M, CZAJA AJ, et al.Simplified criteria for the diagnosis of autoimmune hepatitis[J].Hepatology, 2008, 48 (1) :169.
    [14]CZAJKOWSKI MA, KINGHAM J GC.636 Prevalence and characteristics of overlap syndromes in autoimmune liver disease (AILD) , a twenty-year cohort from a defined community in South Wales[J].J Hepatol, 2006, 44 (Suppl 2) :s236.
    [15]PARK Y, CHO Y, CHO EJ, et al.Retrospective analysis of autoimmune hepatitis-primary biliary cirrhosis overlap syndrome in Korea:characteristics, treatments, and outcomes[J].Clin Mol Hepatol, 2015, 21 (2) :150-157.
    [16]Chinese Society of Hepatology, Chinese Medical Association;Chinese Society of Gastroenterology, Chinese Medical Association;Chinese Society of Infectious Diseases, Chinese Medical Association.Chinese consensus on the diagnosis and management of autoimmune hepatitis (2015) [J].J Clin Hepatol, 2016, 32 (1) :9-22. (in Chinese) 中华医学会肝病学分会, 中华医学会消化病学分会, 中华医学会感染病学分会.自身免疫性肝炎诊断和治疗共识 (2015) [J].临床肝胆病杂志, 2016, 32 (1) :9-22.
    [17]VILLAMIL AG, WELZ G, BANDI JC, et al.556 Overlap syndrome PBC/AIH:prevalence, long term evolution and prognostic factors[J].J Hepatol, 2004, 40 (4) :163.
    [18]OWENDUM C.Long term outcome and response to therapy of primary biliary cirrhosis-autoimmune hepatitis overlap syndrome[J].J Hepatol, 2006, 44 (2) :400-406.
    [19]DEGOTT C, ZAFRANI ES, CALLARD P, et al.Histopathological study of primary biliary cirrhosis and the effect of ursodeoxycholic acid treatment on histology progression[J].Hepatology, 1999, 29 (4) :1007-1012.
    [20]LINDOR KD, GERSHWIN ME, POUPON R, et al.Primary biliary cirrhosis[J].Hepatology, 2009, 50 (1) :291-308.
    [21]HEURGUE A, VITRY F, DIEBOLD MD, et al.Overlap syndrome of primary biliary cirrhosis and autoimmune hepatitis:a retrospective study of 115 cases of autoimmune liver disease[J].Gastroenterol Clin Biol, 2007, 31 (1) :17-25.
    [22]MIAO Q, MA X.Significance of clinical pathology in diagnosis and treatment of autoimmune liver diseases[J].J Clin Hepatol, 2014, 30 (5) :385-389. (in Chinese) 苗琪, 马雄.临床病理学在自身免疫性肝病诊治中的重要性[J].临床肝胆病杂志, 2014, 30 (5) :385-389.
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    4. 郑晖,孙蓉. 药物联合应用对中草药相关肝损伤的影响. 临床肝胆病杂志. 2024(08): 1519-1524 . 本站查看
    5. 李容容,李盟,苟悦,罗琼,吕桦,孙鑫,刘成海. 113例抗肿瘤药物相关肝损伤的临床特点及危险因素分析. 中国药物警戒. 2023(05): 505-510 .
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    12. 孙晓楠,吕萌,程国亭. 药物性肝损伤139例回顾性分析. 中南医学科学杂志. 2022(03): 391-394 .
    13. 李娜. 肺癌患者化疗后药物性肝损伤的临床特点. 中国医药指南. 2022(16): 22-25 .
    14. 劳明珠. 异甘草酸镁治疗抗肿瘤药物引起的急性药物性肝损伤临床效果和安全性. 临床合理用药杂志. 2022(17): 84-87 .
    15. 马万龙,焦运,张旭,丁向春,张平,欧阳花,王梦甜,张乐,徐灵博,杨安宁,姜怡邓. 血清IL-6在人工肝治疗药物性肝损伤预后评估中的价值. 宁夏医科大学学报. 2022(06): 622-629 .
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    18. 汪涛,王学伟,蒋元烨,曹勤,季光. 162例药物性肝损伤患者分析. 肝脏. 2021(03): 243-246 .
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    26. 周力. 中西药所致药物性肝损伤临床及病理特点研究. 临床医药文献电子杂志. 2020(39): 56 .
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    35. 郭立杰,张海丛,叶立红,王超,杜婧,伍彦辉. 中西药所致药物性肝损伤临床及病理特点分析. 临床误诊误治. 2019(08): 28-33 .
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    37. 王建青,叶珺,郜玉峰,杨利琦. 106例药物性肝损伤患者用药回顾性调查. 中国医院药学杂志. 2018(18): 1967-1970 .

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