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2017 No. 11

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Editorial
Primary biliary cholangitis:opportunities and challenges
Wang QiXia, Ma Xiong
2017, 33(11): 2049-2051. DOI: 10.3969/j.issn.1001-5256.2017.11.001
Abstract(432) PDF (154KB)(278)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease mainly involving the interlobular bile ducts and can progress to liver cirrhosis and liver failure.Early diagnosis and management can significantly improve the prognosis of such patients and their quality of life.This article focuses o...
Therapeutic guidelines
Expert consensus on TCM diagnosis and treatment of acute pancreatitis (2017)
Branch of Gastrointestinal Diseases, China Association of Chinese Medicine.
2017, 33(11): 2052-2057. DOI: 10.3969/j.issn.1001-5256.2017.11.002
Abstract(1521) PDF (300KB)(1154)
Abstract:
An excerpt of WHO guidelines for hepatitis B virus vaccine (2017)
Wang HaiYan, Zhang GuoLiang, Yang GuiLin, He Qing
2017, 33(11): 2058-2061. DOI: 10.3969/j.issn.1001-5256.2017.11.003
Abstract(2916) PDF (1478KB)(560)
Abstract:
An interpretation of World Gastroenterology Organisation global guidelines: diagnosis, management, and prevention of hepatitis C (2017 update)
Nie QingHe, Zhao XiTai
2017, 33(11): 2062-2071. DOI: 10.3969/j.issn.1001-5256.2017.11.004
Abstract(460) PDF (337KB)(325)
Abstract:
Updated key points and clinical pathway for NCCN clinical practice guidelines in oncology: hepatobiliary cancers (Version 2.2017)
Yu JiongJie, Wang MingDa, Yang Tian
2017, 33(11): 2072-2082. DOI: 10.3969/j.issn.1001-5256.2017.11.005
Abstract(376) PDF (1303KB)(192)
Abstract:
An excerpt of acute hepatic porphyrias: recommendations for evaluation and long term management of the NCATS Rare Diseases Clinical Research Network
Chen Yang, Li XiaoQing
2017, 33(11): 2083-2086. DOI: 10.3969/j.issn.1001-5256.2017.11.006
Abstract(336) PDF (180KB)(130)
Abstract:
An except of Italian consensus guidelines for the recommendations for screening, monitoring, prevention, prophylaxis and therapy of hepatitis B virus reactivation in patients with haematological malignancies and patients who underwent haematological stem cell transplantation - a position paper(2017)
Li Peng, Xu Hui, Ding HuiGuo
2017, 33(11): 2087-2090. DOI: 10.3969/j.issn.1001-5256.2017.11.007
Abstract(473) PDF (183KB)(174)
Abstract:
An excerpt of Italian consensus guidelines for the management of hepatitis B virus infections in patients with rheumatoid arthritis (2017)
Wu JinLu, Pan WenTing, Chen Ye, Chen YongPing
2017, 33(11): 2091-2094. DOI: 10.3969/j.issn.1001-5256.2017.11.008
Abstract(326) PDF (182KB)(202)
Abstract:
Discussions by experts
Clinical features of primary biliary cholangitis and stratified treatment management
Chen Yu, Han Ying
2017, 33(11): 2095-2100. DOI: 10.3969/j.issn.1001-5256.2017.11.009
Abstract(2601) PDF (1730KB)(671)
Abstract:
Primary biliary cholangitis (PBC) is a disease with relatively strong heterogeneity, and different patients may have great differences in clinical process and phenotypes.Therefore, long-term treatment and follow-up are necessary for accurate risk stratification of these patients.Observation of clini...
Therapeutic strategies for patients with primary biliary cholangitis and suboptimal response to ursodeoxycholic acid
Shi YiWen, You Hong
2017, 33(11): 2101-2104. DOI: 10.3969/j.issn.1001-5256.2017.11.010
Abstract(2725) PDF (1501KB)(542)
Abstract:
In recent years, ursodeoxycholic acid is commonly used for the treatment of primary biliary cholangitis (PBC) ;however, the growing number of PBC patients and the occurrence of suboptimal response and treatment intolerance pose a great challenge to treatment regimens.The approval of the new drug obe...
Advances in genetic research on primary biliary cholangitis
Li YiKang, Ma Xiong, Tang RuQi
2017, 33(11): 2105-2111. DOI: 10.3969/j.issn.1001-5256.2017.11.011
Abstract(2422) PDF (1543KB)(495)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease with strong genetic susceptibility.The genome-wide association studies and immunochip studies conducted in recent years help to reveal the pathogenesis of PBC.The susceptibility genes of PBC are classified into human leukocyte antigen ...
Immunological pathogenesis of primary biliary cholangitis
Zhao ZhiBin, Lian ZheXiong
2017, 33(11): 2112-2116. DOI: 10.3969/j.issn.1001-5256.2017.11.012
Abstract(3013) PDF (1517KB)(744)
Abstract:
Primary biliary cholangitis (PBC) is a chronic cholestatic autoimmune disease caused by the attack of the liver by the immune system and is commonly seen in middle-aged women.The pathological features of this disease include the infiltration of a large number of innate immune cells (NK cells, NK T c...
A study on animal models of primary biliary cholangitis
Hao Juan, Liu ChengHai
2017, 33(11): 2117-2122. DOI: 10.3969/j.issn.1001-5256.2017.11.013
Abstract(2345) PDF (1530KB)(600)
Abstract:
An ideal animal model of primary biliary cholangitis (PBC) plays an important role in the research on physiopathological mechanism and drug research and development.In recent years, great achievements have been made in animal models which can reflect the features of PBC, such as positive serum anti-...
Original articles_Viral hepatitis
Association between liver pathology and clinical features in patients with chronic HBV infection and slightly elevated alanine aminotransferase
Li Wei, Xu KuiHua, Zhao ShouSong
2017, 33(11): 2123-2126. DOI: 10.3969/j.issn.1001-5256.2017.11.014
Abstract(2003) PDF (1581KB)(381)
Abstract:
Objective To investigate the association between liver pathological changes and clinical features in patients with chronic HBV infection and alanine aminotransferase (ALT) 1-2 × upper limits of normal (ULN) .Methods A total of 80 patients with chronic HBV infection and ALT 1-2×ULN who were hospitali...
Dynamic changes in drug-resistant duck hepatitis B virus DNA in single hepatocyte nucleus after hemihepatectomy using a liver regeneration model
Shen GuoJun, Jiang XiaoYun, Huang Jie, Ceng XiaoDong, Mao LongHuo, Fu XiHua
2017, 33(11): 2127-2131. DOI: 10.3969/j.issn.1001-5256.2017.11.015
Abstract(2018) PDF (1592KB)(405)
Abstract:
Objective To investigate the dynamic changes in drug-resistant duck hepatitis B virus (DHBV) DNA in single hepatocyte nucleus after hemihepatectomy using a liver regeneration model.Methods Ducks aged 45 days with chronic DHBV infection were inoculated with mutant DHBV after hemihepatectomy and then ...
Original articles_Liver fibrosis and liver cirrhosis
Effect of thymosin α1 on lymphocyte subsets in patients with decompensated hepatitis B cirrhosis
Tong Jing, Sun ZhangYu, Yang LiBing, Liang YaLin, Kang YanNan
2017, 33(11): 2132-2135. DOI: 10.3969/j.issn.1001-5256.2017.11.016
Abstract(2225) PDF (1511KB)(425)
Abstract:
Objective To investigate the change in peripheral blood lymphocyte subsets after the application of thymosin α1 in patients with decompensated hepatitis B cirrhosis, as well as the effect of thymosin α1 on immune function.Methods A total of 106 patients with decompensated hepatitis B cirrhosis who w...
Value of serum and urinary neutrophil gelatinase-associated lipocalin and cystatin C in diagnosis of liver cirrhosis complicated by acute kidney injury
Xu ZhangHong, Jiang KunRen
2017, 33(11): 2136-2140. DOI: 10.3969/j.issn.1001-5256.2017.11.017
Abstract(2303) PDF (1656KB)(431)
Abstract:
Objective To investigate the value of serum neutrophil gelatinase-associated lipocalin (sNGAL) , urinary neutrophil gelatinase-associated lipocalin (uNGAL) , and serum cystatin C (CysC) in the early diagnosis of acute kidney injury (AKI) in patients with liver cirrhosis.Methods A total of 236 patien...
Clinical effect of modified splenic artery embolization in treatment of hypersplenism and splenic artery steal syndrome due to liver cirrhosis
Lu Hao, Xu XiaoYa, Ye JinDong, Guo Dong, Duan LiuXin, Li ZhangZheng, Liu QuanDa
2017, 33(11): 2141-2146. DOI: 10.3969/j.issn.1001-5256.2017.11.018
Abstract(649) PDF (440KB)(109)
Abstract:

Objective To investigate the clinical effect of modified splenic artery embolization of the splenic artery and branch arteries in the treatment of splenic artery steal syndrome (SASS) and hypersplenism due to liver cirrhosis, since in patients with liver cirrhosis complicated by hypersplenism, the e...
Risk factors for early rebleeding after esophageal variceal ligation in patients with liver cirrhosis
Jin Yan, Wang Xue, Zhang LingJuan, Qiu Ting, Shang BoXin, Lian XiaoYan, Yan ChunYing, Duan TianJiao, Zhang Rong, Liu GuiSheng
2017, 33(11): 2147-2151. DOI: 10.3969/j.issn.1001-5256.2017.11.019
Abstract(2504) PDF (1572KB)(438)
Abstract:
Objective To investigate the risk factors for early rebleeding after esophageal variceal ligation (EVL) in patients with liver cirrhosis.Methods A retrospective analysis was performed for the clinical data of 506 cirrhotic patients with esophageal varices who were admitted to Shaanxi Provincial Peop...
Original articles_Liver neoplasms
Clinical effect of Bielong Ruangan decoction combined with transcatheter arterial chemoembolization in treatment of hepatitis B virus-related primary liver cancer
Wu YuNan, Zhang Dong, Sun KeWei
2017, 33(11): 2152-2157. DOI: 10.3969/j.issn.1001-5256.2017.11.020
Abstract(483) PDF (264KB)(166)
Abstract:
Objective To investigate the clinical effect of Bielong Ruangan decoction combined with transcatheter arterial chemoembolization (TACE) versus TACE alone in the treatment of hepatitis B virus (HBV) -related primary liver cancer.Methods The patients with HBV-related primary liver cancer who were hosp...
Efficacy of laparoscopic microwave ablation in treatment of malignant liver tumors
An DongJun, An Lin, Zhang Cheng, Zhao WeiAn, Han Li
2017, 33(11): 2158-2161. DOI: 10.3969/j.issn.1001-5256.2017.11.021
Abstract(2496) PDF (1596KB)(453)
Abstract:
Objective To investigate the local efficacy and safety of laparoscopic microwave ablation (MWA) in the treatment of malignant liver tumors.Methods A retrospective analysis was performed for the clinical data of 105 patients with malignant liver tumors who were admitted to Xianyang Central Hospital, ...
Value of serum alpha-fetoprotein and protein induced by vitamin K absence or antagonist-Ⅱ in pathological diagnosis of hepatocellular carcinoma
Lu NingNing, Zhang YingHua, Wang HaiYan, Gao WenFeng, Zheng JiaSheng
2017, 33(11): 2162-2165. DOI: 10.3969/j.issn.1001-5256.2017.11.022
Abstract(2230) PDF (1599KB)(380)
Abstract:
Objective To investigate the value of serum alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-Ⅱ) in the pathological diagnosis of hepatocellular carcinoma (HCC) .Methods A retrospective analysis was performed for the clinical data of 134 patients with malignant...
Original articles_Biliary diseases
Clinical experience in choledochoscopy for the treatment of intrahepatic bile duct stones complicated by biliary stricture:a clinical analysis of 230 cases
Zhao GuoPing, Hu JianPing, Wang JiRong
2017, 33(11): 2166-2169. DOI: 10.3969/j.issn.1001-5256.2017.11.023
Abstract(1956) PDF (1845KB)(417)
Abstract:
Objective To investigate the value of choledochoscopy in the treatment of intrahepatic bile duct stones complicated by biliary stricture, treatment methods, and related complications.Methods A retrospective analysis was performed for the clinical data of 230 patients with intrahepatic bile duct ston...
Clinical analysis of laparoscopic combined with choledochoscope via the cystic duct for choledocholithiasis
Liang Gang, Ma FuPing, He MengGuo
2017, 33(11): 2170-2172. DOI: 10.3969/j.issn.1001-5256.2017.11.024
Abstract(2186) PDF (1724KB)(387)
Abstract:
Objective To explore the clinical application of laparoscopic transcystic common bile duct exploration.Methods From Jan2014 to Dec 2015, laparoscopic transcystic common bile duct exploration was performed in 52 cases of cholecystolithiasis.The therapeutic effects of cases were studied.Results Among ...
Original articles_Others
Clinical features of autoimmune liver disease complicated by abdominal lymphadenectasis
Zhang Lu, Liu LiNa
2017, 33(11): 2173-2178. DOI: 10.3969/j.issn.1001-5256.2017.11.025
Abstract(2316) PDF (1537KB)(400)
Abstract:

Objective To investigate the clinical features of autoimmune liver disease (AILD) complicated by abdominal lymphadenectasis (LA) , as well as the clinical significance of LA in AILD.Methods A retrospective analysis was performed for the clinical data of 252 patients who were admitted to The First Af...
Clinical and pathological features of autoimmune hepatitis-primary biliary cholangitis overlap syndrome versus autoimmune hepatitis
Wang TingTing, Lu ChangLi, Fan XiaoLi, Yang Li
2017, 33(11): 2179-2185. DOI: 10.3969/j.issn.1001-5256.2017.11.026
Abstract(2795) PDF (2396KB)(468)
Abstract:

Objective To investigate the clinical and pathological features of autoimmune hepatitis (AIH) -primary biliary cholangitis (PBC) overlap syndrome (AIH-PBC OS) versus AIH, since it is still difficult to diagnose AIH-PBC OS in clinical practice, and to enhance the knowledge of AIH-PBC OS and improve i...
Case reports
Recurrence after Epclusa treatment for compensated genotype 4 hepatitis C cirrhosis:a case report
Kang YanYan, He TingTing, Bai YunFeng, Zhang Ning, Liu Bing, Gong Man
2017, 33(11): 2186-2187. DOI: 10.3969/j.issn.1001-5256.2017.11.027
Abstract(2058) PDF (1494KB)(442)
Abstract:
Small bile duct type primary biliary cholangitis mainly presenting as biliary tract infection:a case report
Zhang XiuJun, Lu JianChun, Xue Yuan, Zheng ShuQin, Shi JianGuo
2017, 33(11): 2188-2189. DOI: 10.3969/j.issn.1001-5256.2017.11.028
Abstract(2007) PDF (1787KB)(504)
Abstract:
Renal tubular acidosis in primary biliary cholangitis:a case report
Dong KaiHui, Wang Yao, Fang YiNa, Kui YiWen, Wen XiaoYu, Jin QingLong
2017, 33(11): 2190-2191. DOI: 10.3969/j.issn.1001-5256.2017.11.029
Abstract(2005) PDF (1477KB)(578)
Abstract:
A case of intrahepatic biliary papillomatosis
Liu Feng, Zhang Qiang, Liu SongYang, Yang Fan, Xuan ZhiLu, Han KaiZe, Liu YaHui
2017, 33(11): 2192-2193. DOI: 10.3969/j.issn.1001-5256.2017.11.030
Abstract(1742) PDF (1812KB)(472)
Abstract:
Systemic lupus erythematosus with acute pancreatitis as the initial presentation:a case report
Ge AnQi, Qin ShaoYou, Han Lin, Zhou ZhangYu
2017, 33(11): 2194-2195. DOI: 10.3969/j.issn.1001-5256.2017.11.031
Abstract(2008) PDF (1483KB)(399)
Abstract:
Reviews
Clinical value of serum HBV RNA
Liu RuiXia, Pan XiuCheng, Geng Jian
2017, 33(11): 2196-2199. DOI: 10.3969/j.issn.1001-5256.2017.11.032
Abstract(2350) PDF (1511KB)(448)
Abstract:
Although there are various indicators for evaluating the effect of anti-HBV therapy, they have low accuracy and sensitivity.New indicators are still needed to guide clinical practice.Recent studies have found that HBV RNA might be a new potential indicator for clinical detection.This article reviews...
Research advances in antiviral drugs and their treatment regimens in chronic hepatitis C
Ceng Qun, Jie ShengHua
2017, 33(11): 2200-2204. DOI: 10.3969/j.issn.1001-5256.2017.11.033
Abstract(2173) PDF (1534KB)(448)
Abstract:
Chronic hepatitis C has become a serious public health issue around the world.In recent years, with the development of pharmacotherapy for hepatitis C, it may be possible to cure hepatitis C.With reference to the epidemic status of hepatitis C and the advantages and side effects of conventional stan...
Influencing factors for the therapeutic effect of direct-acting antiviral agents in hepatitis C
Bian DanDan, Zheng SuJun
2017, 33(11): 2205-2208. DOI: 10.3969/j.issn.1001-5256.2017.11.034
Abstract(1965) PDF (1513KB)(366)
Abstract:
The application of direct-acting antiviral agents significantly increases the rate of sustained virologic response in patients with hepatitis C, but there are still some patients who have no response during treatment or experience recurrence after treatment.Related influencing factors are research h...
Research advances in noninvasive diagnosis of hepatic fibrosis
Yang ErNa, Cao WuKui
2017, 33(11): 2209-2213. DOI: 10.3969/j.issn.1001-5256.2017.11.035
Abstract(2234) PDF (1525KB)(1118)
Abstract:
Hepatic fibrosis is the common pathological basis of various chronic liver diseases.Liver biopsy remains the gold standard for the assessment and diagnosis of liver fibrosis, but its invasiveness and high requirements for operation limit its clinical application.This article introduces the developme...
Application of non-selective β-blockers in patients with liver cirrhosis
Liu XiaoYan, Su HaiBin
2017, 33(11): 2214-2217. DOI: 10.3969/j.issn.1001-5256.2017.11.036
Abstract(2129) PDF (1525KB)(371)
Abstract:
Non-selective β-blockers (NSBBs) can effectively reduce hepatic venous pressure gradient (HVPG) , and are the first-line drugs for primary and secondary prevention of liver cirrhosis complicated by esophagogastric variceal bleeding.In addition, NSBBs can alleviate inflammatory response in patients w...
Pathogenesis of portal hypertensive gastropathy in cirrhotic patients and the application of antacids in treatment
Yang ZongGuo, Zhang JianLiang
2017, 33(11): 2218-2221. DOI: 10.3969/j.issn.1001-5256.2017.11.037
Abstract(1896) PDF (1513KB)(436)
Abstract:
Portal hypertensive gastropathy (PHG) has a high incidence rate in cirrhotic patients, leading to a high risk of upper gastrointestinal bleeding.Gastric mucosal injury is the major pathological change of PHG.There are few studies focusing on the clinical application of antacids in the treatment of P...
Research advances in drug-induced autoimmune hepatitis
Gao XiaoQin, Zhao YongXun, Ren Qian, Zhou YongNing
2017, 33(11): 2222-2225. DOI: 10.3969/j.issn.1001-5256.2017.11.038
Abstract(1739) PDF (1515KB)(470)
Abstract:
Drug-induced autoimmune hepatitis (DIAIH) refers to liver injury mediated by the autoimmune system activated by drugs and accounts for 6%-22% of drug-induced liver injury.At present, the pathogenesis of DIAIH remains unclear, and there are no specific diagnostic criteria, which causes the difficulti...
Research advances in primary biliary cholangitis complicated by osteoporosis
Zhao Jian, Tian Hao, Yao DingKang
2017, 33(11): 2226-2229. DOI: 10.3969/j.issn.1001-5256.2017.11.039
Abstract(1378) PDF (1504KB)(343)
Abstract:
Osteoporosis is a common complication of primary biliary cholangitis (PBC) with a relatively high prevalence rate and a high risk of bone fracture.The pathogenesis of osteoporosis remains unknown.This article reviews the latest advances in the pathogenesis and treatment of osteoporosis in PBC.Studie...
New advances in the treatment of refractory primary biliary cholangitis
Ni Ping, Fan XiaoLi, Wen MaoYao, Yang Li
2017, 33(11): 2230-2234. DOI: 10.3969/j.issn.1001-5256.2017.11.040
Abstract(1873) PDF (1526KB)(436)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune liver disease characterized by small bile duct injury.Ursodeoxycholic acid (UDCA) is often used for the treatment of this disease;however, about 40% of PBC patients do not respond adequately to UDCA and often have poor prognosis.This article summari...
Research advances in the mouse model of primary biliary cholangitis
Zhang JiYu, Fan XingLiang
2017, 33(11): 2235-2238. DOI: 10.3969/j.issn.1001-5256.2017.11.041
Abstract(2010) PDF (1507KB)(492)
Abstract:
Primary biliary cholangitis (PBC) is an autoimmune disease characterized by the destruction of interlobular bile ducts and infiltration of inflammatory factors.An increase in anti-mitochondrial antibody is the major feature of PBC and may eventually lead to intrahepatic cholestasis, liver fibrosis, ...
Research advances in immunoglobulin G4-related sclerosing cholangitis
Li YuHan, Xiang XiaoXing
2017, 33(11): 2239-2242. DOI: 10.3969/j.issn.1001-5256.2017.11.042
Abstract(1531) PDF (1508KB)(359)
Abstract:
Immunoglobulin G4-related sclerosing cholangitis (IgG4-SC) is a new type of secondary sclerosing cholangitis which was discovered recently and has unknown pathogenesis.IgG4-SC is characterized by an increased serum level of immunoglobulin G4 (IgG4) , chronic progressive obstructive jaundice, diffuse...
Research advances in the role of platelets in liver diseases
Lin Yan, Li Xun
2017, 33(11): 2243-2246. DOI: 10.3969/j.issn.1001-5256.2017.11.043
Abstract(2059) PDF (1511KB)(451)
Abstract:
Chronic liver diseases such as liver fibrosis and liver cirrhosis have a complex pathogenesis and are the result of interaction between various cells, cytokines, and matrix in the liver.The traditional viewpoints believe that platelets are mainly involved in hemostasis and coagulation.In recent year...
Research advances in animal models of hepatic alveolar echinococcosis
Zhou QiFeng, Ren Li, Zhang LingQiang, Fan HaiNing
2017, 33(11): 2247-2250. DOI: 10.3969/j.issn.1001-5256.2017.11.044
Abstract(1579) PDF (1521KB)(403)
Abstract:
Hepatic alveolar echinococcosis (HAE) is a serious parasitic disease caused by the infection with the eggs of Echinococcus multilocularis Leuckart.Research on the mechanism of the development and progression of HAE helps to explore new methods for its diagnosis and treatment, and the establishment o...
Research advances in radiotherapy for locally advanced pancreatic cancer
Wang XiHai, Zhao XiangXuan, Lu ZaiMing, Guo QiYong
2017, 33(11): 2251-2255. DOI: 10.3969/j.issn.1001-5256.2017.11.045
Abstract(1407) PDF (1524KB)(396)
Abstract:
Locally advanced pancreatic cancer has a poor prognosis, and conventional radiotherapy alone or combined with chemotherapy has limited effects on local control of locally advanced pancreatic cancer and survival benefit for such patients.Stereotactic radiotherapy and intensity-modulated radiotherapy ...
    

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