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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2017
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Article Contents

Role of histological evaluation of the liver in clinical practice and research on nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2017.12.009
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  • Published Date: 2017-12-20
  • Liver biopsy is currently the gold standard for the diagnosis of nonalcoholic fatty liver disease ( NAFLD) , especially nonalcoholic steatohepatitis ( NASH) . Although liver biopsy has the limitations such as invasiveness, sampling error, and evaluation error, in clinical trials of NAFLD/NASH and related new drugs, it is still used to evaluate the enrollment of patients into a cohort and primary and/or secondary endpoints and cannot be replaced by other methods. The histological evaluation systems of NAFLD/NASH mainly include Brunt system, NASH-CRN scoring system, European SAF/FLIP scoring algorithm, and pediatric NAFLD histological scoring system, and an appropriate histological scoring system should be selected in clinical practice and research.

     

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