2017 No. 12

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Editorial

Guidelines for the diagnosis and treatment of nonalcoholic fatty liver disease in children and adults in China and foreign countries:comparison and analysis

Wang Qin, Wei Lai

2017, 33(12): 2265-2269. DOI: 10.3969/j.issn.1001-5256.2017.12.001

Abstract(1750)

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Abstract:
This article makes a comparative analysis of the key recommendations in Guidelines for the diagnosis and management of nonalcoholic fatty liver disease published by American Association for the Study of Liver Diseases in 2017, Clinical practice guidelines for nonalcoholic fatty liver disease jointly...

Guidelines

Expert consensus on TCM diagnosis and treatment of nonalcoholic fatty liver disease (2017)

Branch of Gastrointestinal Diseases, China Association of Chinese Medicine

2017, 33(12): 2270-2274. DOI: 10.3969/j.issn.1001-5256.2017.12.002

Abstract(840)

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Recommendations for the diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases (2017)

Guo ZeQi, Wang QianYi, Qi XingShun, Jia JiDong

2017, 33(12): 2275-2277. DOI: 10.3969/j.issn.1001-5256.2017.12.003

Abstract(2132)

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An excerpt of the Asia-Pacific Working Party on nonalcoholic fatty liver disease guidelines 2017

Liu YingLi, Zhang QiuZan

2017, 33(12): 2278-2282. DOI: 10.3969/j.issn.1001-5256.2017.12.004

Abstract(2375)

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Abstract:

An excerpt of JSGE clinical practice guideline for post-ERCP pancreatitis (2017)

Zhu YiZhou, Wang Ying, Zhu Chang, Xu XiaoRong

2017, 33(12): 2283-2287. DOI: 10.3969/j.issn.1001-5256.2017.12.005

Abstract(353)

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Discussions by experts

Research advances in noninvasive diagnostic methods for nonalcoholic steatohepatitis

Hu MengQi, Xu YouQing, Zhang Tao, Xu HongTuan

2017, 33(12): 2288-2291. DOI: 10.3969/j.issn.1001-5256.2017.12.006

Abstract(2920)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) has become the most common liver disease in the world in terms of incidence rate and is gradually becoming the first cause of liver transplantation in developed countries. The spectrum of this disease includes simple fatty liver, nonalcoholic steatohepatitis...

Clinical trials of investigational new drugs for nonalcoholic steatohepatitis:challenges in design and practice

Mao YiMin

2017, 33(12): 2292-2295. DOI: 10.3969/j.issn.1001-5256.2017.12.007

Abstract(394)

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Abstract:
Research and development of investigational new drugs for nonalcoholic fatty liver disease is now a research hotspot in the field of liver disease. However, there are still great challenges in protocol design and implementation in phase II/III clinical trials. Since there are still controversies ove...

Hepatic fibrosis in nonalcoholic fatty liver disease and its quantitative assessment

Wang Yan, Hou JinLin

2017, 33(12): 2296-2302. DOI: 10.3969/j.issn.1001-5256.2017.12.008

Abstract(2187)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) is becoming a primary etiology underlying the chronic liver injury-related fibrogenesis among general population. Histologic fibrosis has been demonstrated as the most important independent predictor for the major outcomes of NAFLD patients. NAFLD-related fi...

Role of histological evaluation of the liver in clinical practice and research on nonalcoholic fatty liver disease

Jiang LiNa, Zhao JingMin

2017, 33(12): 2303-2306. DOI: 10.3969/j.issn.1001-5256.2017.12.009

Abstract(2572)

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Abstract:
Liver biopsy is currently the gold standard for the diagnosis of nonalcoholic fatty liver disease ( NAFLD) , especially nonalcoholic steatohepatitis ( NASH) . Although liver biopsy has the limitations such as invasiveness, sampling error, and evaluation error, in clinical trials of NAFLD/NASH and re...

Role of imaging techniques in clinical research and practice on nonalcoholic fatty liver disease

Wang Yi

2017, 33(12): 2307-2310. DOI: 10.3969/j.issn.1001-5256.2017.12.010

Abstract(2302)

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Abstract:
Abdominal ultrasound ( US) , computed tomography ( CT) , and magnetic resonance imaging ( MRI) have been used in the clinical diagnosis and management of nonalcoholic fatty liver disease ( NAFLD) . This article elaborates on the advantages and limitations of US, CT, and MRI in the evaluation of NAFL...

Original articles_Viral hepatitis

Influence of combination mode of PEG-IFNα-2a and adefovir dipivoxil on outcome of patients with HBeAg-positive chronic hepatitis B

Wu XiaoLi

2017, 33(12): 2311-2315. DOI: 10.3969/j.issn.1001-5256.2017.12.011

Abstract(494)

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Abstract:
Objective To investigate the influence of the sequence of PEG-IFNα-2 a and adefovir dipivoxil ( ADV) on the clinical outcome of patients with HBe Ag-positive chronic hepatitis B ( CHB) . Methods A total of 86 patients with HBe Ag-positive CHB who were treated in Yucheng People's Hospital from Septem...

Original articles_Liver fibrosis and liver cirrhosis

Clinical effect of Mongolian medicine Qinggan Jiuwei powder in treatment of alcoholic liver fibrosis

Ge HongYan, Zhang ShiHua, Zhao BaiSui, Yu ChuanKe

2017, 33(12): 2316-2320. DOI: 10.3969/j.issn.1001-5256.2017.12.012

Abstract(2347)

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Abstract:
Objective To observe the clinical effect of Mongolian medicine Qinggan Jiuwei powder in the treatment of alcoholic liver fibrosis by observing the improvement in imaging indices. Methods A total of 104 patients with alcoholic liver fibrosis who visited Department of Gastroenterology in Horqin Distri...

Efficacy of endoscopic sclerotherapy with lauromacrogol in treatment of severe esophageal variceal bleeding

Cui MeiLan, Jia YanSheng, Kang HaiYan, Yin ShuYing, Zheng HuanWei

2017, 33(12): 2321-2325. DOI: 10.3969/j.issn.1001-5256.2017.12.013

Abstract(2245)

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Abstract:
Objective To investigate the short-and long-term efficacy of endoscopic sclerotherapy with lauromacrogol in the treatment of cirrhotic patients with severe esophageal variceal bleeding. Methods A retrospective analysis was performed for the clinical data of 160 patients who underwent endoscopic scle...

Original articles_Liver neoplasms

Diagnosis and treatment of subcapsular hemorrhage after liver tumor ablation

Lu NingNing, Sun Bin, Cui XiongWei, Long Jiang, Gao WenFeng, Zheng JiaSheng

2017, 33(12): 2326-2330. DOI: 10.3969/j.issn.1001-5256.2017.12.014

Abstract(3076)

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Abstract:
Objective To investigate the diagnosis and treatment of subcapsular hemorrhage caused by liver tumor ablation. Methods A retrospective analysis was performed for the clinical data of 1596 patients who underwent CT-guided liver tumor microwave/radiofrequency ablation in Beijing You An Hospital, Capit...

Effect of postoperative adjuvant transarterial chemoembolization on postoperative survival of patients with liver cancer and related influencing factors for prognosis

Xing ZhiXiang, Shen ShiQiang, Qin Feng, Yang Qiang, Ye Zi

2017, 33(12): 2331-2336. DOI: 10.3969/j.issn.1001-5256.2017.12.015

Abstract(434)

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Abstract:
Objective To investigate the effect of postoperative adjuvant transarterial chemoembolization ( TACE) on the survival of patients with hepatocellular carcinoma ( HCC) , as well as influencing factors for prognosis. Methods A retrospective analysis was performed for the clinical data of 215 HCC patie...

Effect of Cyber Knife radiosurgery on survival rate of patients with recurrent liver cancer after surgery

Li Huan, Sun Jing, Zhang Tao, Fan YuZe, Sun YingZhe, He WeiPing, Duan XueZhang

2017, 33(12): 2337-2341. DOI: 10.3969/j.issn.1001-5256.2017.12.016

Abstract(2822)

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Objective To investigate the clinical effect of Cyber Knife radiosurgery, a type of stereotactic body radiotherapy, in the treatment of recurrent liver cancer after resection or ablation, as well as the effect of clinical factors on survival rate. Methods A retrospective analysis was performed for t...

Expression of nuclear factor-kappa B p65 in hepatocellular carcinoma and its significance

Xia Geng, Qi Fei, Yang JinHui, Tang YingMei, Shi MengLin, Zhang JunQi

2017, 33(12): 2342-2345. DOI: 10.3969/j.issn.1001-5256.2017.12.017

Abstract(2362)

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Abstract:
Objective To investigate the expression of nuclear factor-kappa B ( NF-κB) p65 in cancer tissue and adjacent tissue using hepatoma tissue microarray, as well as its significance in the development and progression of hepatocellular carcinoma ( HCC) . Methods The hepatoma tissue microarray HLiv H180 S...

Original articles_Pancreatic diseases

Recurrent acute pancreatitis:etiology and selection of treatment regimen

Cao Yu, Ling Jun, Zhang Yong, Ding Bing, Jiang Hui

2017, 33(12): 2346-2349. DOI: 10.3969/j.issn.1001-5256.2017.12.018

Abstract(362)

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Abstract:
Objective To investigate the etiology of recurrent acute pancreatitis ( RAP) and selection of treatment regimen. Methods A retrospective analysis was performed for the clinical data of 284 patients with acute pancreatitis ( AP) who were admitted to The Second People's Hospital of Neijiang from Janua...

Influencing factors for acute pancreatitis in patients with type 2 diabetes complicated by hypertriglyceridemia

Bai YunLei, Dang RunFang

2017, 33(12): 2350-2354. DOI: 10.3969/j.issn.1001-5256.2017.12.019

Abstract(500)

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Abstract:
Objective To investigate the association between hypertriglyceridemia and acute pancreatitis in patients with type 2 diabetes, in order to guide the prevention and treatment of acute pancreatitis in patients with diabetes. Methods A total of 46 patients with type 2 diabetes complicated by acute panc...

Original articles_Others

Epidemiological characteristics of nonalcoholic fatty liver disease with elevated alanine aminotransferase and related risk factors

Ding YuPing, Li Hai, Zhang Wen, Xia ShiHai, Bi Xun

2017, 33(12): 2355-2360. DOI: 10.3969/j.issn.1001-5256.2017.12.020

Abstract(2577)

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Abstract:

Objective To investigate the epidemiological characteristics of nonalcoholic fatty liver disease ( NAFLD) with elevated alanine aminotransferase ( ALT) and related risk factors. Methods A total of 1007 patients with NAFLD who were admitted to The Affiliated Hospital of Logistics University of Chines...

Correlation of liver fat content with serum vitamin A level and insulin resistance in patients with nonalcoholic fatty liver disease

Ding ZhiYong, Bu Le, Lu HongYan, Rao ZhengXuan

2017, 33(12): 2361-2365. DOI: 10.3969/j.issn.1001-5256.2017.12.021

Abstract(545)

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Abstract:

Objective To investigate the correlation of liver fat content ( LFC) with serum vitamin A ( VA) level and insulin resistance ( IR) in patients with nonalcoholic fatty liver disease ( NAFLD) . Methods A total of 200 patients with an initial diagnosis of NAFLD in Shanghai Chongming from February 2016 ...

Performance of transient elastography in diagnosis of nonalcoholic fatty liver disease

Zhuang XiaoFang, Sun Jie, Wang XiaoBo, Wang Yan, Wu QiQi, Wang XiaoZhong

2017, 33(12): 2366-2371. DOI: 10.3969/j.issn.1001-5256.2017.12.022

Abstract(2019)

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Abstract:

Objective To investigate the value of transient elastography ( TE) in the diagnosis of nonalcoholic fatty liver disease ( NAFLD) . Methods A total of 21 patients without fatty liver disease and 92 patients with NAFLD, who visited Traditional Chinese Medicine Hospital of Xinjiang Uygur Autonomous Reg...

Changes in microRNA expression profile in the liver of mice with nonalcoholic fatty liver disease induced by high-fat diet

Mai JingYin, Chen TianYang, Cheng Yang

2017, 33(12): 2372-2375. DOI: 10.3969/j.issn.1001-5256.2017.12.023

Abstract(2381)

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Abstract:

Objective To investigate the effect of miRNA-384 ( miR-384) expression on hepatic steatosis in mice with nonalcoholic fatty liver disease ( NAFLD) induced by high-fat diet ( HFD) . Methods A total of 30 male C57 BL/6 J mice were fed for 7 days to adapt to the environment and then randomly divided in...

An investigation of the prevalence rate of fatty liver disease among people undergoing physical examination in Tangshan, China

Meng YuLin, Zhang HaiYan, Song BaoGuo, Zhou HuiLan, Jin XiuPing, Shi GuoHui

2017, 33(12): 2376-2380. DOI: 10.3969/j.issn.1001-5256.2017.12.024

Abstract(2503)

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Abstract:

Objective To investigate the prevalence rate of fatty liver disease among people undergoing physical examination in Tangshan, China, and to provide a reasonable basis for the prevention and treatment of fatty liver disease. Methods The clinical data of 12 808 individuals who underwent physical exami...

Clinicopathological features of hepatic amyloidosis:an analysis of 8 cases

Liu ShuHong, Zhou GuangDe, Guo ChaoNan, Zhu Li, Zhang Xiao, Zhao JingMin

2017, 33(12): 2381-2383. DOI: 10.3969/j.issn.1001-5256.2017.12.025

Abstract(2289)

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Abstract:

Objective To investigate the clinicopathological features of hepatic amyloidosis. Methods A retrospective analysis was performed for 8 patients with hepatic amyloidosis confirmed by liver biopsy in 302 Hospital of PLA from January 2005 to December 2012. Clinical data, laboratory examination results,...

Effect of retrograde perfusion via the inferior vena cava on renal function in the early stage after liver transplantation

Lian JinFeng, Jiang Yi, Hu HaiZhang, Cai QiuCheng

2017, 33(12): 2384-2388. DOI: 10.3969/j.issn.1001-5256.2017.12.026

Abstract(2110)

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Abstract:

Objective To investigate the effect of retrograde perfusion via the inferior vena cava on renal function in the early stage after liver transplantation. Methods A retrospective analysis was performed for the clinical data of 103 patients with normal serum creatinine and blood urea nitrogen before su...

Case reports

Cirrhotic nodules with focal small hepatocellular carcinoma:a case report

Wang LiMing, Zhang Yang, Zhu Feng

2017, 33(12): 2389-2391. DOI: 10.3969/j.issn.1001-5256.2017.12.027

Abstract(2049)

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Idiopathic portal hypertension:a case report and literature review

Yang Mei, Niu HaiYan, Ding YuPing, Li Hai

2017, 33(12): 2392-2394. DOI: 10.3969/j.issn.1001-5256.2017.12.028

Abstract(1428)

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Experience in clinical treatment of drug-induced liver injury:a case report

Ren Yan, Zheng SuJun

2017, 33(12): 2395-2396. DOI: 10.3969/j.issn.1001-5256.2017.12.029

Abstract(1778)

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Abstract:

Acute liver failure during therapy for primary light-chain amyloidosis:a case report

Xu XiJing, Wang Yao, Sun Ying, Wen XiaoYu, Jin FengYan, Jin QingLong

2017, 33(12): 2397-2399. DOI: 10.3969/j.issn.1001-5256.2017.12.030

Abstract(1489)

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Abstract:

Hepatic metastases from cervical cancer mimicking liver abscess with fever as main clinical symptom:a case report

Yan Xin, Jin JingLan, Dong HongJing, Song XinYue, Zhi YiXiao, Gao PuJun

2017, 33(12): 2400-2402. DOI: 10.3969/j.issn.1001-5256.2017.12.031

Abstract(2013)

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Caroli's syndrome with autosomal dominant polycystic kidney disease:a case report

Chen YangYi, Yuan JiLi, Xing Feng, Liu ChengHai

2017, 33(12): 2403-2404. DOI: 10.3969/j.issn.1001-5256.2017.12.032

Abstract(2224)

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Lupus enteritis misdiagnosed as biliary pancreatitis:a case report

Gao Hui, Bian Jiang, Xin ZhiYing, Zhang MingYuan, Jin QingLong, Wen XiaoYu

2017, 33(12): 2405-2407. DOI: 10.3969/j.issn.1001-5256.2017.12.033

Abstract(2173)

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Acute pancreatitis complicated by splenic vein thrombosis and splenic rupture and bleeding following splenic infarction:a case report

Xie ZhiQin, Tang CaiXi, Chen Xun

2017, 33(12): 2408-2409. DOI: 10.3969/j.issn.1001-5256.2017.12.034

Abstract(2330)

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A case of splenic hamartoma

Wang Jiang, Pan WeiCong, Chen XiaoQian, Zhang Bei, Liu Kai

2017, 33(12): 2410-2411. DOI: 10.3969/j.issn.1001-5256.2017.12.035

Abstract(1924)

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Reviews

Value of microRNAs in diagnosis of chronic hepatitis B-related liver fibrosis

Li PingYing, Yang YongGeng, Lu LunGen, Zhu ZhiYong, Wang YaPing, Ma YingCai

2017, 33(12): 2412-2415. DOI: 10.3969/j.issn.1001-5256.2017.12.036

Abstract(1996)

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It is very important to find suitable serum markers which can accurately identify chronic hepatitis B ( CHB) -related liver fibrosis. This article summarizes the differentially expressed serum microRNAs ( miRNAs) in the process of CHB-related liver fibrosis. The analysis shows that with the developm...

Hot topics in nephropathy with HBV infection

Yang ZhiBin, Chen Qing, Ma ShiWu

2017, 33(12): 2416-2420. DOI: 10.3969/j.issn.1001-5256.2017.12.037

Abstract(1846)

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Abstract:
Patients with abnormal renal function complicated by positive HBV serum markers are commonly seen in clinical practice, with a variety of diseases involved, such as patients with nephropathy complicated by HBV infection ( including acute and chronic HBV infection) and those with chronic HBV infectio...

The role of interleukin-21 in hepatitis B virus infection

Li Yuan, Huang GuYe

2017, 33(12): 2421-2424. DOI: 10.3969/j.issn.1001-5256.2017.12.038

Abstract(1922)

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Abstract:
Interleukin-21 ( IL-21) is a cytokine produced by activated CD4+T cells and can affect the function of various lymphocytes. It should be noted that IL-21-mediated cellular and humoral immune responses play an important role in determining the outcome of viral infection. This article introduces the r...

Research advances in regorafenib in treatment of hepatocellular carcinoma

Chen WeiBo, Cai HuiHua, Yang Yue, Chen XueMin, Jiang Yong, Sun DongLin

2017, 33(12): 2425-2428. DOI: 10.3969/j.issn.1001-5256.2017.12.039

Abstract(2218)

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Abstract:
Hepatocellular carcinoma ( HCC) is the most common malignant liver tumor, and there are limited systemic treatments for patients with advanced HCC. Regorafenib is an oral multi-kinase inhibitor, and phase III clinical trial has shown that regorafenib can significantly extend the median survival of p...

New thoughts on the treatment of common complications of advanced liver cancer by external therapy of traditional Chinese medicine

Pan ShaSha, Zheng HuanTian, Zhan BoLin, Peng LiSheng

2017, 33(12): 2429-2432. DOI: 10.3969/j.issn.1001-5256.2017.12.040

Abstract(2995)

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Abstract:
Cancerous pain, hepatic ascites and intractable hiccups are common complications in patients with advanced liver cancer, but clinical symptomatic treatment cannot achieve satisfactory results. This article reviews the application of external therapy of traditional Chinese medicine in the treatment o...

Advances in the treatment of nonalcoholic fatty liver disease

Feng Gong, Niu ChunYan

2017, 33(12): 2433-2438. DOI: 10.3969/j.issn.1001-5256.2017.12.041

Abstract(2109)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) has become a major liver disease in the world and its prevalence rate continues to increase. As a component of metabolic syndrome, it has become a risk factor for many serious cerebrovascular and cardiovascular diseases.Due to the complex pathogenesis of NAF...

Potential therapeies for nonalcoholic fatty liver disease

Xie Xiao, Lu LunGen

2017, 33(12): 2439-2443. DOI: 10.3969/j.issn.1001-5256.2017.12.042

Abstract(1661)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) is one of the most common chronic liver diseases in the world, and it is associated with obesity, hyperlipidemia, insulin resistance, and type 2 diabetes. Lipid deposition, insulin resistance, and inflammatory response may induce NAFLD, but detailed mechanis...

Application of lipid-regulating drugs in prevention and treatment of nonalcoholic fatty liver disease

Lu BingJie, Chen Xi, Sun MingYu

2017, 33(12): 2444-2448. DOI: 10.3969/j.issn.1001-5256.2017.12.043

Abstract(1640)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) is a clinicopathological syndrome characterized by diffuse macrovesicular steatosis in hepatocytes and is caused by the factors except excessive drinking and other specific factors for liver injury. In particular, lipid metabolism disorder is a significant c...

Research advances in the mechanism of fructose-induced nonalcoholic fatty liver disease

Chen Ye, Wu JinLu, Pan WenTing, Li HaiYing

2017, 33(12): 2449-2452. DOI: 10.3969/j.issn.1001-5256.2017.12.044

Abstract(1608)

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Abstract:
In recent years, the incidence rate of nonalcoholic fatty liver disease ( NAFLD) tends to increase in both developed and developing countries, which is associated with an increase in fructose consumption. This article points out that chronic persistent fructose intake can significantly promote de no...

Research advances in intestinal flora in nonalcoholic fatty liver disease

Liu JiaQi, Zhou ShaoMing

2017, 33(12): 2453-2456. DOI: 10.3969/j.issn.1001-5256.2017.12.045

Abstract(1394)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) is a common chronic liver disease in our country, and its incidence rate is gradually increasing and the age of onset is becoming younger. The pathogenesis of NAFLD remains unclear. Among a variety of pathogenic factors, the change in intestinal flora is clo...

Research advances in animal models based on the pathogenesis and treatment of nonalcoholic fatty liver disease

Chen YanZhen, Chen ChengLiang, Tian Xing, Jiao Jian

2017, 33(12): 2457-2461. DOI: 10.3969/j.issn.1001-5256.2017.12.046

Abstract(1619)

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Abstract:
Nonalcoholic fatty liver disease ( NAFLD) is a continuous disease spectrum characterized by the accumulation of excessive lipid in hepatocytes. Simple hepatic steatosis may progress to NAFLD and even liver fibrosis, liver cirrhosis, and finally hepatocellular carcinoma.Animal models can simulate dif...

Research advances in immune factors for the prognosis of patients with acute-on-chronic liver failure

Gao MengDan, Zhao Yan

2017, 33(12): 2462-2466. DOI: 10.3969/j.issn.1001-5256.2017.12.047

Abstract(1325)

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Abstract:
Acute-on-chronic liver failure ( ACLF) is commonly seen in China, with a complex pathogenesis, difficult clinical treatment, and poor prognosis. Many factors can affect the prognosis of patients with ACLF. This article elaborates on the changes in immune cells and cytokines in ACLF and their influen...