中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 12
Dec.  2017
Turn off MathJax
Article Contents

Research advances in the mechanism of fructose-induced nonalcoholic fatty liver disease

DOI: 10.3969/j.issn.1001-5256.2017.12.044
Research funding:

 

  • Received Date: 2017-07-13
  • Published Date: 2017-12-20
  • In recent years, the incidence rate of nonalcoholic fatty liver disease ( NAFLD) tends to increase in both developed and developing countries, which is associated with an increase in fructose consumption. This article points out that chronic persistent fructose intake can significantly promote de novo lipogenesis ( DNL) in the liver and induce ATP depletion and inhibition of hepatocyte regeneration, which further causes endoplasmic reticulum stress and increased production of reactive oxygen species in the liver and finally leads to the development of NAFLD. It is believed that detailed mechanism of fructose-induced NAFLD and disruption of fructose metabolism in the liver may provide new therapeutic strategies for NAFLD.

     

  • loading
  • [1]WANG H, TENG T, WANG L, et al.Research advances in the pathogenesis of nonalcoholic fatty liver disease[J].J Clin Hepatol, 2017, 33 (4) :769-773. (in Chinese) 王虎, 滕田, 王莉, 等.非酒精性脂肪性肝病发病机制的研究进展[J].临床肝胆病杂志, 2017, 33 (4) :769-773.
    [2]CALDWELL S, ARGO C.The natural history of non-alcoholic fatty liver disease[J].Dig Dis, 2010, 28 (1) :162-168.
    [3]WONG VW, VERGNIOL J, WONG GL, et al.Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease[J].Hepatology, 2010, 51 (2) :454-462.
    [4]YOUNOSSI ZM, KOENIG AB, ABDELATIF D, et al.Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes[J].Hepatology, 2016, 64 (1) :73-84.
    [5]LIM JS, MIETUS-SNYDER M, VALENTE A, et al.The role of fructose in the pathogenesis of NAFLD and the metabolic syndrome[J].Nat Rev Gastroenterol Hepatol, 2010, 7 (5) :251-264.
    [6]BASARANOGLU M, BASARANOGLU G, SABUNCU T, et al.Fructose as a key player in the development of fatty liver disease[J].World J Gastroenterol, 2013, 19 (8) :1166-1172.
    [7]SAKAR Y, NAZARET C, LETTRON P, et al.Positive regulatory control loop between gut leptin and intestinal glut2/glut5 transporters links to hepatic metabolic functions in rodents[J].Plos One, 2009, 4 (11) :e7935.
    [8]LYSSIOTIS CA, CANTLEY LC.Metabolic syndrome:fstands for fructose and fat[J].Nature, 2013, 502 (7470) :181-182.
    [9]WANG Q, LI S, JIANG L, et al.Deficiency in hepatic ATP-citrate lyase affects VLDL-triglyceride mobilization and liver fatty acid composition in mice[J].J Lipid Res, 2010, 51 (9) :2516-2526.
    [10]SOFTIC S, COHEN DE, KAHN CR.Role of dietary fructose and hepatic de novo lipogenesis in fatty liver disease[J].Dig Dis Sci, 2016, 61 (5) :1282-1293.
    [11]HIGUCHI N, KATO M, SHUNDO Y, et al.Liver X receptor in cooperation with SREBP-1c is a major lipid synthesis regulator in nonalcoholic fatty liver disease[J].Hepatol Res, 2008, 38 (11) :1122-1129.
    [12]HORTON JD, BASHMAKOV Y, SHIMOMURA I, et al.Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice[J].Proc Natl Acad Sci U S A, 1998, 95 (11) :5987-5992.
    [13]SOFTIC S, KIRBY M, BERGER NG, et al.Insulin concentration modulates hepatic lipid accumulation in mice in part via transcriptional regulation of fatty acid transport proteins[J].PLo S One, 2012, 7 (6) :e38952.
    [14]HAAS JT, MIAO J, CHANDA D, et al.Hepatic insulin signaling is required for obesity-dependent expression of srebp-1c mrna but not for feeding-dependent expression[J].Cell Metab, 2012, 15 (6) :873-884.
    [15]JURCZAK MJ, LEE AH, JORNAYVAZ FR, et al.Dissociation of inositol-requiring enzyme (ire1 alpha) -mediated c-jun n-terminal kinase activation from hepatic insulin resistance in conditional x-box-binding protein-1 (xbp1) knock-out mice[J].J Biol Chem, 2012, 287 (4) :2558-2567.
    [16]GREGOR MF, YANG L, FABBRINI E, et al.Endoplasmic reticulum stress is reduced in tissues of obese subjects after weight loss[J].Diabetes, 2009, 58 (3) :693-700.
    [17]LEE AH, SCAPA EF, COHEN DE, et al.Regulation of hepatic lipogenesis by the transcription factor XBP1[J].Science, 2008, 320 (5882) :1492-1496.
    [18]NAKAGAWA T, HU H, ZHARIKOV S, et al.A causal role for uric acid in fructose-induced metabolic syndrome[J].Am J Physiol Renal Physiol, 2006, 290 (3) :F625-F631.
    [19]BOESIGER P, BUCHLI R, MEIER D, et al.Changes of liver metabolite concentrations in adults with disorders of fructose metabolism after intravenous fructose by 31P magnetic resonance spectroscopy[J].Pediatr Res, 1994, 36 (4) :436-440.
    [20]SPEICHER T, KHLER UA, CHOUKR A, et al.Fructose protects murine hepatocytes from tumor necrosis factor-induced apoptosis by modulating jnk signaling[J].J Biol Chem, 2012, 287 (3) :1837-1846.
    [21]LANASPA MA, SANCHEZ-LOZADA LG, CHOI YJ, et al.Uric acid induces hepatic steatosis by generation of mitochondrial oxidative stress:potential role in fructose-dependent and-independent fatty liver[J].J Biol Chem, 2012, 287 (48) :40732-40744.
    [22]DAY CP, JAMES OF.Steatohepatitis:a tale of two"hits"?[J].Gastroenterology, 1998, 114 (4) :842-845.
    [23]ALWAHSH SM, GEBHARDT R.Dietary fructose as a risk factor for non-alcoholic fatty liver disease (NAFLD) [J].Arch Toxicol, 2017, 91 (4) :1545-1563.
    [24]KOHLI R, PAN XM, MALLADI P, et al.Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the phosphatidylinositol 3-kinase cell survival pathway[J].J Biol Chem, 2007, 282 (29) :21327-21336.
    [25]HAN ML, GONG ZH.Mechanism of action of gut microbiota in hepatobiliary disease[J].J Clin Hepatol, 2017, 33 (2) :384-388. (in Chinese) 韩美林, 龚振华.肠道菌群在肝胆疾病中的作用机制[J].临床肝胆病杂志, 2017, 33 (2) :384-388.
    [26]WIGG AJ, ROBERTS-THOMSON IC, DYMOCK RB, et al.The role of small intestinal bacterial overgrowth, intestinal permeability, endotoxaemia, and tumour necrosis factor alpha in the pathogenesis of non-alcoholic steatohepatitis[J].Gut, 2001, 48 (2) :206-211.
    [27]SPRUSS A, KANURI G, STAHL C, et al.Metformin protects against the development of fructose-induced steatosis in mice:role of the intestinal barrier function[J].Lab Invest, 2012, 92 (7) :1020-1032.
    [28]MATAK P, ZUMERLE S, MASTROGIANNAKI M, et al.Copper deficiency leads to anemia, duodenal hypoxia, upregulation of HIF-2alpha and altered expression of iron absorption genes in mice[J].PLo S One, 2013, 8 (3) :e59538.
    [29]SONG M, SCHUSCHKE DA, ZHOU Z, et al.High fructose feeding induces copper deficiency in Sprague-Dawley rats:a novel mechanism for obesity related fatty liver[J].J Hepatol, 2012, 56 (2) :433-440.
    [30]SONG M, SCHUSCHKE DA, ZHOU Z, et al.Modest fructose beverage intake causes liver injury and fat accumulation in marginal copper deficient rats[J].Obesity (Silver Spring) , 2013, 21 (8) :1669-1675.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1522) PDF downloads(384) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return