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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 4
Apr.  2018
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Article Contents

Research advances in integrated traditional Chinese and Western medicine therapy for primary biliary cholangitis

DOI: 10.3969/j.issn.1001-5256.2018.04.004
  • Published Date: 2018-04-20
  • This article reviews the etiology and pathogenesis of primary biliary cholangitis (PBC) based on traditional Chinese and Western medicine, integrated traditional Chinese and Western medicine therapies and their clinical effects, and the author's experience in PBC research.The risk of PBC is closely associated with environmental factors, genetic factors, autoimmunity, and biliary epithelial cell injury.The analysis of etiology based on traditional Chinese medicine (TCM) showed that PBC is associated with " deficiency", " stasis", " depression", " dampness", and " toxin", and the key words of etiology and pathogenesis are damp-heat, blood stasis, stagnation of liver qi, qi stagnation, spleen-qi deficiency, liver-qi deficiency, and liver-kidney yin deficiency.Common TCM syndrome types include damp-heat accumulation, stagnation of liver qi and spleen deficiency, blood stasis obstructing the collaterals, and liver-kidney yin deficiency.Ursodeoxycholic acid is the first-line drug for the treatment of PBC, but 40% of patients have poor response.A combination of traditional Chinese medicine and Western medicine plays an important role in improving quality of life, prolonging survival time, and improving the clinical outcome of patients with PBC.

     

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