2018 No. 4

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Editorial

Current status and perspectives of integrated traditional Chinese and Western medicine therapy for common hepatobiliary and pancreatic diseases

Wang RongBing, Sun FengXia

2018, 34(4): 683-688. DOI: 10.3969/j.issn.1001-5256.2018.04.001

Abstract(2392)

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Abstract:
At present, the diagnosis and treatment with integrated traditional Chinese and Western medicine takes the form of traditional Chinese medicine treatment or the combination of traditional Chinese medicine and Western medicine, with the application of modern diagnostic and therapeutic evaluation meth...

Discussions by experts

The role of traditional Chinese medicine in blocking and reversing hepatic fibrosis:current status, hope, and challenge

Chen Yan, Yang YongPing

2018, 34(4): 689-693. DOI: 10.3969/j.issn.1001-5256.2018.04.002

Abstract(2971)

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Abstract:

Traditional Chinese medicine (TCM) syndrome differentiation-based treatment has certain advantages in blocking and reversing hepatic fibrosis and is the source of candidate drugs for hepatic fibrosis in future.This article overviews the origin and current status of TCM treatment of hepatic fibrosis,...

Traditional Chinese medicine prevention and treatment of liver fibrosis under the new situation of prevention and treatment of viral hepatitis

Chi XiaoLing, Xiao HuanMing

2018, 34(4): 694-697. DOI: 10.3969/j.issn.1001-5256.2018.04.003

Abstract(2698)

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Abstract:

The prevention and treatment of liver fibrosis is an important embodiment of the characteristic advantage of traditional Chinese medicine (TCM) in the prevention and treatment of viral hepatitis.The release of Global Health Sector Strategy on Viral Hepatitis, 2016-2021 and Viral Hepatitis Prevention...

Research advances in integrated traditional Chinese and Western medicine therapy for primary biliary cholangitis

Zhang Wei

2018, 34(4): 698-703. DOI: 10.3969/j.issn.1001-5256.2018.04.004

Abstract(2982)

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Abstract:
This article reviews the etiology and pathogenesis of primary biliary cholangitis (PBC) based on traditional Chinese and Western medicine, integrated traditional Chinese and Western medicine therapies and their clinical effects, and the author's experience in PBC research.The risk of PBC is closely ...

Current status and perspectives of integrated traditional Chinese and Western medicine therapy for chololithiasis

Feng Jian, Cui NaiQiang

2018, 34(4): 704-709. DOI: 10.3969/j.issn.1001-5256.2018.04.005

Abstract(2681)

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Abstract:
Chololithiasis has a high incidence rate, and at present, cholecystectomy has become the standard method for the treatment of gallstones.Traditional Chinese medicine treatment has a long history in the treatment of chololithiasis and has accumulated rich experience.This article summarizes the clinic...

Early traditional Chinese medicine treatment of acute pancreatitis and its mechanism

Yang GuoHong, Zhao WenXia

2018, 34(4): 710-715. DOI: 10.3969/j.issn.1001-5256.2018.04.006

Abstract(2553)

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Abstract:

Traditional Chinese medicine (TCM) plays an important role in the treatment of acute pancreatitis (AP) .This article introduces the clinical effects of TCM treatments including gavage, enema, external application of Chinese medicine, intravenous drip, and acupuncture, and points out that early appli...

Therapeutic guidelines

Chinese expert consensus on treatment of pancreatic cancer by radioactive 125I particle implantation (2017)

Committee of Experts on Radioactive Particle Implantation Technology, Chinese Medical Doctor Association; Particle Treatment Branch, Committee of Minimally Invasive Therapy in Oncology, Chinese Anti-cancer Association

2018, 34(4): 716-723. DOI: 10.3969/j.issn.1001-5256.2018.04.007

Abstract(3201)

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Abstract:

Clinical practice guidelines for the interventional treatment of advanced pancreatic carcinoma (on trial) (2nd edition)

Committee of Interventional Medicine, Cancer Foundation of China

2018, 34(4): 724-736. DOI: 10.3969/j.issn.1001-5256.2018.04.008

Abstract(517)

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Abstract:

An excerpt of update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance

Zhang JingQiao, Li MiaoMiao, Qi XingShun, Ceng QingLei

2018, 34(4): 737-742. DOI: 10.3969/j.issn.1001-5256.2018.04.009

Abstract(468)

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Abstract:

Zhang Hong, Zhang Hao, Liu Li, Jiang JianXin

2018, 34(4): 743-748. DOI: 10.3969/j.issn.1001-5256.2018.04.010

Abstract(2155)

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Abstract:

An excerpt of treatment of chronic hepatitis C virus infection in children. A position paper by the Hepatology Committee of ESPGHAN

Wang Shuai, Han JuQiang, Wen Wei

2018, 34(4): 749-754. DOI: 10.3969/j.issn.1001-5256.2018.04.011

Abstract(221)

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Abstract:

Original articles_Viral hepatitis

Value of serum Golgi protein 73 in assisting the diagnosis of moderate or severe liver injury in patients with chronic hepatitis B

Yao MingJie, Wang LeiJie, Guan GuiWen, Xi JingYuan, Liu ShuHong, Wen XiaJie, Zou Jun, Chen XiangMei, Jia JiDong, Zhao JingMin, Lu FengMin

2018, 34(4): 755-759. DOI: 10.3969/j.issn.1001-5256.2018.04.012

Abstract(3158)

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Abstract:
Objective To investigate the value of Golgi protein 73 (GP73) in the diagnosis of liver inflammatory activity and fibrosis degree in chronic hepatitis B (CHB) patients.Methods Serum samples were collected from 678 patients who underwent liver biopsy in 302 Hospital of PLA from December 2013 to May 2...

Original articles_Liver fibrosis and liver cirrhosis

Value of serum adenosine deaminase in diagnosis of marked liver fibrosis in patients with chronic hepatitis B virus infection

Ke YeFang, Gao GuoSheng, Zhu Zhe, Chen BiCheng

2018, 34(4): 760-763. DOI: 10.3969/j.issn.1001-5256.2018.04.013

Abstract(2646)

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Abstract:
Objective To investigate the value of serum adenosine deaminase (ADA) in the diagnosis of marked liver fibrosis in patients with chronic hepatitis B virus (HBV) infection.Methods A total of 493 patients with chronic HBV infection who underwent liver biopsy in Ningbo No.2 Hospital from May 2011 to Oc...

Value of serum miRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein in predicting fibrosis degree in patients with chronic viral hepatitis

Gao Min, Liu Rong, Zhang Qing

2018, 34(4): 764-769. DOI: 10.3969/j.issn.1001-5256.2018.04.014

Abstract(2581)

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Abstract:
Objective To investigate the clinical value of serum miRNA-122 and Wisteria floribunda agglutinin-positive Mac-2 binding protein (WFA+-M2BP) in predicting fibrosis degree in patients with chronic viral hepatitis.Methods A total of 98 patients with chronic hepatitis B (CHB group) and 104 patients wit...

An investigation of minimal hepatic encephalopathy in patients with hepatitis B cirrhosis

Zhang LiJie, Zhou YingXia, Xing HuiChun, Su Ye, Sun YuMei

2018, 34(4): 770-774. DOI: 10.3969/j.issn.1001-5256.2018.04.015

Abstract(2393)

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Abstract:
Objective To investigate the prevalence of minimal hepatic encephalopathy (MHE) in patients with hepatitis B cirrhosis.Methods A total of 105 patients with hepatitis B cirrhosis who visited Beijing Ditan Hospital, Capital Medical University, from June to December, 2012 were enrolled as cirrhosis gro...

Original articles_Liver neoplasms

Clinical effect and safety of transarterial chemoembolization combined with apatinib in treatment of advanced primary liver cancer

Wu Jian, Yin Fang, Luo GuanHong, Zheng YangYang, Li Hong, Zhu ShaoHua, Zhang Jing, Zhou XinMin

2018, 34(4): 775-778. DOI: 10.3969/j.issn.1001-5256.2018.04.016

Abstract(2898)

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Abstract:
Objective To investigate the clinical effect and safety of transarterial chemoembolization (TACE) combined with apatinib versus TACE alone in the treatment of advanced primary liver cancer (PLC) .Methods A retrospective analysis was performed for the clinical data of 56 patients with PLC who were ad...

Clinical effect of transarterial chemoembolization combined with radiofrequency ablation in treatment of rabbit VX2 liver tumors

Li Hao, Duan XuHua, Han XinWei, Ren JianZhuang, Li FengYao, Kuang DongLin, Li FangZheng

2018, 34(4): 779-783. DOI: 10.3969/j.issn.1001-5256.2018.04.017

Abstract(2274)

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Abstract:
Objective To investigate the clinical effect of transarterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) (TACE + RFA) versus RFA or TACE alone in the treatment of rabbit VX2 hepatic tumors and related pathological changes.Methods The rabbits were sacrificed at 7 days after ...

Effect of lobaplatin on proliferation and apoptosis of hepatocellular carcinoma HepG2 cells and related mechanism of action

Li YingYing, Zhan LiFen, Ceng ZheChao, Xu Shen

2018, 34(4): 784-788. DOI: 10.3969/j.issn.1001-5256.2018.04.018

Abstract(2618)

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Abstract:
Objective To investigate the effect of lobaplatin on the proliferation and apoptosis of hepatocellular carcinoma (HCC) HepG2 cells in vitro and related mechanism of action.Methods HepG2 cells were divided into lobaplatin group (proliferation assay:5 μmol/L, 10 μmol/L, and 15 μmol/L; apoptosis assay:...

Original articles_Biliary diseases

Risk factors for gallstones in Tibetan Plateau

Yang Bo, Hou YongZhi, Wang XiangFei, De Ji, Bin YeJian, Bai Zhen, Mi Ma

2018, 34(4): 789-794. DOI: 10.3969/j.issn.1001-5256.2018.04.019

Abstract(1853)

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Abstract:
Objective To investigate the risk factors for gallstones in Tibetan Plateau.Methods A total of 254 patients who underwent ultrasound examination in a fasting state in Shigatse People's Hospital from April 1 to 15, 2017 were enrolled, and according to the results of ultrasound examination, these pati...

Original articles_Others

Clinical effect of integrated traditional Chinese and Western medicine therapy in patients with hepatitis B virus-related acute-on-chronic liver failure complicated by hepatic encephalopathy

Gong Man, Zhou Chao, Zhang Ning, Sun KeWei, Zhang ZhenGang, Li HanMin, Li XiuHui, Yang HongZhi, Li Qin, Wang Lin, Zhou XiaoZhou, Mao DeWen, Guo JianChun, Zhuo YunHui, Wang XianBo, Deng Xin, Wang JieFei, Cao WuKui, Zhang ShuQin, Zhang MingXiang, Li Yun

2018, 34(4): 795-800. DOI: 10.3969/j.issn.1001-5256.2018.04.020

Abstract(2677)

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Abstract:

Objective To investigate the 8-week mortality rate of patients with hepatitis B virus (HBV) -related acute-on-chronic liver failure (ACLF) complicated by hepatic encephalopathy (HE) treated with integrated traditional Chinese and Western medicine therapy, as well as independent prognostic factors.Me...

Changes in serum levels of interleukin-32 and interleukin-10 and their clinical significance in patients with HBV-related acute-on-chronic liver failure

Gu Jing, Wang Yan, Chen Li, Xu Ying, Gan JianHe

2018, 34(4): 801-805. DOI: 10.3969/j.issn.1001-5256.2018.04.021

Abstract(2713)

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Abstract:

Objective To investigate the changes in the serum levels of interleukin-32 (IL-32) and interleukin-10 (IL-10) and their clinical significance in patients with HBV-related acute-on-chronic liver failure (HBV-ACLF) .Methods A total of 38 HBV-ACLF patients who were hospitalized and treated in The First...

Expression of M30 and CCL20 in serum in patients with HBV-related acute-on-chronic liver failure and their clinical significance

Chen HaiOu, Liu Shi, Lin YiHe

2018, 34(4): 806-809. DOI: 10.3969/j.issn.1001-5256.2018.04.022

Abstract(2374)

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Abstract:

Objective To investigate the serum levels of M30 and CCL20 and their association with short-term (3-month) prognosis in patients with hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF) , as well as their clinical significance.Methods A total of 51 patients with HBV-ACLF who were dia...

Clinical significance of platelet count and its dynamic change in patients with acute-on-chronic liver failure

Xu ShanShan, Wei XinHuan, Lin Wei, Zhang Jing

2018, 34(4): 810-813. DOI: 10.3969/j.issn.1001-5256.2018.04.023

Abstract(2590)

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Abstract:

Objective To investigate the dynamic change of platelets in patients with acute-on-chronic liver failure (ACLF) , the association of platelet count and its change with patients' prognosis, and the cause of thrombocytopenia, since severe thrombocytopenia is often seen in patients with liver failure.M...

Distribution features of TCM syndrome types and syndrome elements of primary biliary cholangitis:a literature review

Zheng YueQi, Chen JianJie, Chen YiYun, Shi Zhen, Xu Li

2018, 34(4): 814-819. DOI: 10.3969/j.issn.1001-5256.2018.04.024

Abstract(2434)

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Abstract:

Objective To investigate the distribution features of traditional Chinese medicine (TCM) syndromes types and syndrome elements of primary biliary cholangitis (PBC) via literature research, and to provide a basis for further research on PBC syndromes and features.Methods CNKI, CBM, CQVIP, Wanfang Dat...

Association between the rapidity of response and progression to cirrhosis in patients with autoimmune hepatitis

Zhang HongXia, Guo LiPing, Zhou Lu, Wang BangMao

2018, 34(4): 820-824. DOI: 10.3969/j.issn.1001-5256.2018.04.025

Abstract(2340)

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Abstract:

Objective To evaluate the association between the rapidity of response and progression to cirrhosis in patients with autoimmune hepatitis (AIH) , and to analyze the influencing factors for the rapidity of response.Methods A retrospective analysis was performed on 61 AIH patients with long-term follo...

A clinical study of pulmonary function changes in patients with nonalcoholic fatty liver disease

Chen ZhiHui, Zhang ShiRong, Sun WenJing, Wen LiangZhi, Liu KaiJun, Guo Yan, Wei YanLing, Wang Bin, Gu XiaoHong, Chen DongFeng

2018, 34(4): 825-828. DOI: 10.3969/j.issn.1001-5256.2018.04.026

Abstract(1639)

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Abstract:

Objective To investigate the pulmonary function changes in patients with nonalcoholic fatty liver disease (NAFLD) and their clinical significance.Methods A total of 275 NAFLD patients who underwent physical examination in Physical Examination Center of Daping Hospital, Army Medical University, from ...

Effect of liver-regulating and spleen-strengthening method on lipid metabolism and expression of microtubule-associated protein light chain 3B in a rat model of nonalcoholic fatty liver disease

Li ZhangXin, Zhou Tao, Niu KeMin, Chen Jing, Wei BeiHai, Wang Jia, Meng SiHong, Li QinNa, Zheng Jiao, Shen QingYan, Chen RuiLin

2018, 34(4): 829-835. DOI: 10.3969/j.issn.1001-5256.2018.04.027

Abstract(2469)

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Abstract:

Objective To investigate the effect of the liver-regulating and spleen-strengthening method on lipid metabolism and expression of microtubule-associated protein light chain 3 B (LC3B) in a rat model of nonalcoholic fatty liver disease (NAFLD) , as well as the mechanism of this method in the treatmen...

Clinical features of patients with hepatic amyloidosis

Yu SiMiao, Wang YaChao, Zhu Yun, Wang LiFu, Du Ning, Sun YongQiang, Xu WenTao, Wang LiPing, Jing Jing, Zhang Fan, Wang RuiLin

2018, 34(4): 836-839. DOI: 10.3969/j.issn.1001-5256.2018.04.028

Abstract(2818)

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Abstract:

Objective To investigate the clinical features of patients with hepatic amyloidosis.Methods A retrospective analysis was performed for the clinical data of 12 patients with hepatic amyloidosis who were hospitalized in Department of Hepatology, 302 Hospital of PLA, from January 2011 to December 2016,...

Case reports

A case of cardiogenic cirrhosis due to long-term hyperthyroidism

Ning XiuJing, He LiLi, Zhou Qi, Xue ShuWen, Ji HuiFan

2018, 34(4): 840-841. DOI: 10.3969/j.issn.1001-5256.2018.04.029

Abstract(2327)

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Abstract:

A case of low-grade mucinous cystic neoplasm of the liver

Wu Bo, Li LiangTao, Xuan ZhiLu, Liu Feng, Han KaiZe, Zhang Wei, Liu YaHui

2018, 34(4): 842-844. DOI: 10.3969/j.issn.1001-5256.2018.04.030

Abstract(2648)

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Abstract:

Acute extensive portal vein thrombosis with pulmonary embolism: a case report

Yan Xin, Song XinYue, Dong HongJing, Yan Qi, Zhao YouYou, Jin JingLan

2018, 34(4): 845-847. DOI: 10.3969/j.issn.1001-5256.2018.04.031

Abstract(2371)

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Abstract:

A case of severe coagulation disorder caused by cefoperazone sodium and sulbactam

Fu Xing, Guo FengChang, Niu JunQi

2018, 34(4): 848-849. DOI: 10.3969/j.issn.1001-5256.2018.04.032

Abstract(2487)

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Abstract:

Upper gastrointestinal hemorrhage caused by splenic artery pseudoaneurysm rupture due to chronic pancreatitis: a case report

Qi WenLei, Zhang JianWei, Ji JingWei, Zhou JianPeng, Wei Feng, Du XiaoHong, Wang GuangYi

2018, 34(4): 850-852. DOI: 10.3969/j.issn.1001-5256.2018.04.033

Abstract(2477)

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Abstract:

Reviews

Current status of the application of direct-acting antiviral agents in treatment of chronic hepatitis C and existing problems

Zhang Xi, Li YongGuo

2018, 34(4): 853-857. DOI: 10.3969/j.issn.1001-5256.2018.04.034

Abstract(2126)

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Abstract:
Chronic hepatitis C can lead to end-stage liver diseases such as liver cirrhosis and hepatocellular carcinoma, and timely antiviral therapy is the key to improving prognosis.The emergence and development of direct-acting antiviral agents (DAAs) have brought great changes to the treatment of chronic ...

Role of the nuclear factor-kappa B signaling pathway on the progress of hepatic fibrosis and the anti-fibrotic mechanism of traditional Chinese medicine

Zhu Hui, Ping Jian, Xu LieMing

2018, 34(4): 858-861. DOI: 10.3969/j.issn.1001-5256.2018.04.035

Abstract(2161)

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Abstract:
Nuclear factor-kappa B (NF-κB) plays an important role in various physiological and pathological processes by regulating gene expression, such as cell survival, growth, proliferation, activation, and apoptosis.In particular, the NF-κB signaling pathway has an important regulatory effect on the progr...

Cellular mechanisms in liver fibrosis regression

Wang Lin, Liu XueEn, Zhuang Hui

2018, 34(4): 862-866. DOI: 10.3969/j.issn.1001-5256.2018.04.036

Abstract(2436)

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Abstract:

With the action of various chronic factors for liver injury, hepatic stellate cells (HSCs) are activated and transformed to myofibroblasts (MFBs) and then migrate to the injured part and secrete a large amount of extracellular matrix (ECM) .Excessive deposition of ECM in the liver causes liver fibro...

Research advances in transarterial chemoembolization combined with sorafenib in treatment of advanced hepatocellular carcinoma

Wu Lei, Wang Su

2018, 34(4): 867-871. DOI: 10.3969/j.issn.1001-5256.2018.04.037

Abstract(1993)

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Abstract:
At present, transarterial chemoembolization (TACE) combined with sorafenib is commonly used for patients with advanced hepatocellular carcinoma (HCC) who have lost the opportunity for surgery, and yet no consensus has been reached on the specific therapeutic paradigm.This article reviews the treatme...

Research advances in molecular imaging of hepatocellular carcinoma

Liu Zhao, Ma WenTing, Zhang PengFei, Li JinKui, Xiao JianXi, Lei JunQiang

2018, 34(4): 872-876. DOI: 10.3969/j.issn.1001-5256.2018.04.038

Abstract(2071)

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Abstract:
Hepatocellular carcinoma (HCC) is one of the malignancies with high mortality, and early diagnosis of this disease will directly affect its treatment regimens and prognosis.At present, molecular imaging is not only the most advanced diagnostic and evaluation method, but also an important research di...

New ideas and methods for the diagnosis and treatment of acute-on-chronic liver failure

Li ShanShan, Duan ZhongPing, Chen Yu

2018, 34(4): 877-882. DOI: 10.3969/j.issn.1001-5256.2018.04.039

Abstract(2241)

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Abstract:
Acute-on-chronic liver failure (ACLF) is commonly seen in China and has a complex pathogenesis, difficult clinical treatment, and poor prognosis.ACLF has become a hot topic in the research on liver diseases in recent years.This article elaborates on the research advances in ACLF in China and foreign...

Research advances in the pathogenesis of drug-induced liver injury

Wang HaiZhen, Li XiuHui

2018, 34(4): 883-887. DOI: 10.3969/j.issn.1001-5256.2018.04.040

Abstract(2199)

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Abstract:
In recent years, the number of drug-induced liver injury (DILI) cases is increasing year by year due to unreasonable drug use in clinical practice, unclear composition of healthcare products and dietary supplements, and a lack of drug safety knowledge, and DILI has become a major cause of liver fail...

Association between periampullary duodenal diverticula and bile duct stones

Ji Sheng, Zhao LiBo, Liu Xu

2018, 34(4): 888-891. DOI: 10.3969/j.issn.1001-5256.2018.04.041

Abstract(1624)

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Abstract:
Endoscopic retrograde cholangiopancreatography helps to improve the diagnostic rate of periampullary duodenal diverticula.The importance of periampullary duodenal diverticula in clinical practice lies in its close association with bile duct stones, and different types of periampullary duodenal diver...

Research advances in clinical diagnosis and treatment of gallbladder internal fistula

Ye Nan, Liu ZhangAn

2018, 34(4): 892-895. DOI: 10.3969/j.issn.1001-5256.2018.04.042

Abstract(1683)

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Abstract:
Gallbladder internal fistula is a rare complication of the biliary system.A lack of specific clinical manifestations of gallbladder internal fistula results in a low preoperative diagnostic rate.Surgery remains the main treatment method for gallbladder internal fistula; however, it may cause injurie...

Advances in the diagnosis and treatment of gallbladder dyskinesia in adults

Liu Bing, Shang PeiZhong

2018, 34(4): 896-899. DOI: 10.3969/j.issn.1001-5256.2018.04.043

Abstract(2084)

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Abstract:
Gallbladder dyskinesia (GD) mainly manifests as recurrent biliary colic, which may greatly affect the patient's work and life, but it is often neglected by clinical physicians due to negative results of ultrasound examination.This article introduces the latest advances in the diagnosis and treatment...

Mechanism of action of curcumin in treatment of pancreatic cancer

Yu ZeYuan, Wang KeShen, Ren YanXian, Luo ZhangJiang, Cao HongTai, Jiao ZuoYi

2018, 34(4): 900-904. DOI: 10.3969/j.issn.1001-5256.2018.04.044

Abstract(2305)

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Abstract:
Curcumin is a polyphenol extracted from the rhizome of Rhizoma Curcumae Longae with anti-inflammatory, antioxidant, and antitumor effects.It can also increase the sensitivity to chemoradiotherapy and protect hepatic and renal function.It is involved in the regulation of various signaling pathways an...