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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 4
Apr.  2018
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Research advances in the pathogenesis of drug-induced liver injury

DOI: 10.3969/j.issn.1001-5256.2018.04.040
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  • Published Date: 2018-04-20
  • In recent years, the number of drug-induced liver injury (DILI) cases is increasing year by year due to unreasonable drug use in clinical practice, unclear composition of healthcare products and dietary supplements, and a lack of drug safety knowledge, and DILI has become a major cause of liver failure and liver transplantation.DILI has complex pathogenesis, and medical institutions are paying more and more attention to DILI.Related animal and cell experiments are being conducted all over the world, and advances have been made in metabolic pathways, immune mechanism, mitochondrial abnormality, and genetics of DILI.In-depth research on various pathogeneses and their association helps to reveal the true pathogenesis of DILI.With reference to the articles on the pathogenesis of DILI in China and foreign countries, this article elaborates on the current research status of the pathogenesis of DILI and provides a reference for clinical treatment and basic research.

     

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