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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Issue 6
Jun.  2018
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Article Contents

The association between the intestinal microbiota-lipopolysaccharide-Toll-like receptor 4 axis and hepatocellular carcinoma

DOI: 10.3969/j.issn.1001-5256.2018.06.041
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  • Received Date: 2017-12-11
  • Published Date: 2018-06-20
  • Hepatocellular carcinoma is the major complication of various end-stage chronic liver diseases. Studies have shown that intestinal barrier injury and intestinal flora disturbance are commonly seen in patients with liver diseases, which may cause intestinal bacterial translocation and endotoxemia. Toll-like receptor 4 (TLR4) is a pattern recognition receptor in the liver and can bind to lipopolysaccharide (LPS) , the active ingredient of endotoxin, result in immune inflammatory response via various signal transduction pathways, and finally promote hepatic fibrosis and tumorigenesis. This article reviews the intestinal microbiota-LPS-TLR4 axis and the pathogenesis of hepatocellular carcinoma.

     

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