2018 No. 6

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Editorial

Research advances in drug-induced liver injury and existing problems in China

Chen ChengWei

2018, 34(6): 1147-1151. DOI: 10.3969/j.issn.1001-5256.2018.06.001

Abstract(2120)

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Abstract:
At present, Drug-induced liver injury (DILI) has become the most common cause of acute liver injury in clinical practice. This article elaborates on the pathogenesis of DILI, new biomarkers, liver tolerance to drug toxicity, adaptability and susceptibility, and testing threshold of alanine aminotran...

Discussions by experts

Current status of epidemiological studies on drug-induced liver injury in China

Shen Tao, Huang Xin, Wang YuYa, Zhuang Hui

2018, 34(6): 1152-1155. DOI: 10.3969/j.issn.1001-5256.2018.06.002

Abstract(2906)

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Abstract:
Drug-induced liver injury (DILI) has been taken more and more seriously by governmental authorities, pharmaceutical companies, clinical physicians, and the general public. An understanding of the incidence, and distribution of DILI and related drugs is helpful for the prevention, clinical diagnosis,...

Differential diagnosis of drug-induced liver injury and autoimmune hepatitis and related therapeutic strategies

Bian ZhaoLian, Shao JianGuo, Ma Xiong

2018, 34(6): 1156-1159. DOI: 10.3969/j.issn.1001-5256.2018.06.003

Abstract(3206)

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Abstract:
Drug-induced liver injury (DILI) and autoimmune hepatitis (AIH) have many similar clinical and histological manifestations, which brings difficulties to clinicians in differential diagnosis. This article elaborates on the association between DILI and AIH and their similarities and differences in cli...

Diagnosis and treatment of drug-induced liver injury

Yu LeCheng, Fan Ye, Chen ChengWei

2018, 34(6): 1160-1165. DOI: 10.3969/j.issn.1001-5256.2018.06.004

Abstract(3069)

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Abstract:
Due to a lack of specific biomarkers, the diagnosis of drug-induced liver injury (DILI) mainly depends on the method of exclusion. The Roussel Uclaf Causality Assessment Method (RUCAM) scale is the most widely used causality assessment scale and is relatively objective, but it is still waiting for f...

Strengthening the scientific research and supervision of drug-induced liver injury based on big data

Mao YiMin

2018, 34(6): 1166-1168. DOI: 10.3969/j.issn.1001-5256.2018.06.005

Abstract(411)

PDF (154KB)(132)

Abstract:
Drug-induced liver injury (DILI) is one of the most important drug-induced diseases and has complex clinical phenotypes, which leads to its unpredictability. The involvement of many types of drugs and complex population heterogeneity pose great challenges to the supervision of scientific research on...

Drug-induced liver injury caused by Chinese herbal medicine cannot be neglected

Chen Jun

2018, 34(6): 1169-1171. DOI: 10.3969/j.issn.1001-5256.2018.06.006

Abstract(2517)

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Abstract:
The hepatotoxicity of Chinese herbal medicine has attracted more and more attention in recent years. The traditional view that Chinese herbs are poisonless and harmless is worth considering. According to related research findings, liver injury due to the abuse of Chinese herbs caused by prescription...

Significance of liver histopathological examination in diagnosis and treatment of drug-induced liver injury

Yang RuiYuan, Zhao XinYan

2018, 34(6): 1172-1175. DOI: 10.3969/j.issn.1001-5256.2018.06.007

Abstract(738)

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Abstract:
The incidence rate of drug-induced liver injury (DILI) tends to increase in recent years, and early accurate diagnosis and evaluation of the degree of liver injury are great challenges in diagnosis and treatment. The pathomorphological features of DILI are determined by the structure and metabolic f...

Guidelines

Consensus on the management of hepatitis B virus infection in women of childbearing age

Chinese Society of Hepatology, Chinese Medical Association

2018, 34(6): 1176-1180. DOI: 10.3969/j.issn.1001-5256.2018.06.008

Abstract(2417)

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Abstract:

An excerpt of diagnosis, staging and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases

Zheng KeXin, Han Bing, Qi XingShun, Guo XiaoZhong

2018, 34(6): 1181-1182. DOI: 10.3969/j.issn.1001-5256.2018.06.009

Abstract(484)

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Abstract:

Recommendations for EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma (2018)

Yu JiongJie, Yan WenTao, Quan Bing, Yang Tian

2018, 34(6): 1183-1186. DOI: 10.3969/j.issn.1001-5256.2018.06.010

Abstract(373)

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Abstract:

Interpretation of EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma (2018)

Ge NingLing, Xue TongChun, Ye ShengLong

2018, 34(6): 1187-1190. DOI: 10.3969/j.issn.1001-5256.2018.06.011

Abstract(2023)

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Abstract:

Recommendations for The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines (2018)

Li QianQian, Zhou XinMiao, Qi XingShun, Li HongYu

2018, 34(6): 1191-1192. DOI: 10.3969/j.issn.1001-5256.2018.06.012

Abstract(2004)

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Abstract:

An excerpt of European evidence-based guidelines on pancreatic cystic neoplasms (2018)

Guan Fu, Hu JuXiang, Wang FuQun, Wang ShengBing

2018, 34(6): 1193-1197. DOI: 10.3969/j.issn.1001-5256.2018.06.013

Abstract(338)

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Abstract:

Original articles_Viral hepatitis

Influencing factors for low response to hepatitis B vaccination in neonates

Wen SiMin, Wang Chong, Pan YuChen, Zhao Dan, Wang Chuan, Kong Fei, Niu JunQi, Jiang Jing

2018, 34(6): 1198-1203. DOI: 10.3969/j.issn.1001-5256.2018.06.014

Abstract(1483)

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Abstract:
Objective To investigate the influencing factors for low response to hepatitis B (Hep B) vaccination in neonates born to HBs Ag-positive mothers. Methods A total of 1152 neonates born to HBs Ag-positive mothers who participated in the project of prevention of mother-to-child transmission of HBV from...

Original articles_Liver fibrosis and liver cirrhosis

Value of gamma-glutamyl transpeptidase-to-platelet ratio in predicting liver fibrosis stage in chronic hepatitis B patients in Guangdong, China

Huang ChunMing, Yang Zhan, Nie YuQiang, Hu ZhongWei, Zhou YongJian, Zhan YuanJing, Guo JiaWei, Yu WeiHua

2018, 34(6): 1204-1208. DOI: 10.3969/j.issn.1001-5256.2018.06.015

Abstract(2533)

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Abstract:
Objective To investigate the value of gamma-glutamyl transpeptidase-to-platelet ratio (GPR) in predicting liver fibrosis stage in chronic hepatitis B (CHB) patients in Guangdong, China. Methods A total of 501 patients who were diagnosed with CHB by liver biopsy in Guangzhou 8 th People's Hospital fr...

Clinical effect of transjugular intrahepatic portosystemic shunt combined with tissue adhesive embolization in treatment of gastroesophageal variceal rebleeding in cirrhotic patients

Chen Min, Zhang Feng, Zhang Ming, Li ZhenLei, He QiBin, Mou ChengCheng, Zhong WenQi, Zhu GeYuZheng

2018, 34(6): 1209-1214. DOI: 10.3969/j.issn.1001-5256.2018.06.016

Abstract(2271)

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Abstract:
Objective To investigate the clinical effect of transjugular intrahepatic portosystemic shunt (TIPS) alone versus TIPS combined with stomach and esophageal variceal embolization (SEVE) in the treatment of gastroesophageal variceal rebleeding in cirrhotic patients.Methods A total of 142 cirrhotic pat...

Effect of fibroblast growth factor 21 on hepatic fibrosis in mice and its mechanism

Wang DaXiu, Han JiWu

2018, 34(6): 1215-1219. DOI: 10.3969/j.issn.1001-5256.2018.06.017

Abstract(2180)

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Abstract:
Objective To investigate the effect of fibroblast growth factor 21 (FGF21) on hepatic fibrosis in mice and the mechanism of its action. Methods Male ICR mice were randomly divided three groups: control group, model group (treated with CCl4) , and treatment group (treated with CCl4+ 1. 0 mg/kg FGF21)...

Original articles_Liver neoplasms

Clinical efficacy of sorafenib in treatment of primary hepatic carcinoma and its effects on serum VEGFR-2 and PLGF levels

Liao WeiRong, Gu Chao, Zhang DaWei

2018, 34(6): 1220-1224. DOI: 10.3969/j.issn.1001-5256.2018.06.018

Abstract(1563)

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Abstract:
Objective To investigate the clinical efficacy of sorafenib in the treatment of primary hepatic carcinoma (PHC) and its effects on serum vascular endothelial growth factor receptor-2 (VEGFR-2) and placental growth factor (PLGF) levels. Methods A total of 110 patients with a confirmed diagnosis of PH...

Original articles_Pancreatic diseases

Evaluation and analysis of the current guidelines for acute pancreatitis using Appraisal of Guidelines for Research and Evaluation Ⅱ

Wang Yu, Rao YouYi, Guo Jun, Yang JianBo, Liu HuaZhu, Zhao XinHua, Pan ShenLiang, Ning Hong

2018, 34(6): 1225-1230. DOI: 10.3969/j.issn.1001-5256.2018.06.019

Abstract(2084)

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Abstract:
Objective To investigate the quality of the guidelines for acute pancreatitis in China and foreign countries using Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument. Methods According to inclusion and exclusion criteria, Wanfang Data, CNKI, VIP, Pub Med, Cochrane, and Else...

Clinical effect and safety of nutritional support after pancreaticoduodenectomy: A Meta-analysis

Zhang BaoHua, Yang Ya, Gong JianPing

2018, 34(6): 1231-1236. DOI: 10.3969/j.issn.1001-5256.2018.06.020

Abstract(1855)

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Abstract:
Objective To investigate the effect of different nutritional support methods (including total parenteral nutrition, early oral nutrition, early enteral nutrition via nasojejunal tube, early enteral nutrition via gastric fistula, and early enteral nutrition via jejunal fistula) on the prognosis of pa...

Original articles_Others

Clinical features of drug-induced liver injury and related risk factors

Lin YunXia, He XiaoBin

2018, 34(6): 1237-1241. DOI: 10.3969/j.issn.1001-5256.2018.06.021

Abstract(2225)

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Abstract:

Objective To investigate the clinical features of drug-induced liver injury (DILI) and related risk factors. Methods A retrospective analysis was performed for the clinical data of 208 patients who were diagnosed with DILI in The Affiliated Hospital of Southwest Medical University from January 2013 ...

Clinical features and prognosis of drug-induced liver injury: An analysis of 95 cases

Yan Rong, Song ZhengJun

2018, 34(6): 1242-1247. DOI: 10.3969/j.issn.1001-5256.2018.06.022

Abstract(2162)

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Abstract:

Objective To analyze and summarize the clinical data of drug-induced liver injury (DILI) , and to investigate the clinical features and prognosis of DILI. Methods A retrospective analysis was performed for the clinical data of 95 patients with DILI who were admitted to The First Affiliated Hospital ...

Expression of programmed death-ligand 1 on peripheral blood T cells and its correlation with liver inflammation grade in patients with type 1 autoimmune hepatitis

Xiong KeGong, Ke KunYu, Kong JinFeng, Liu LiJuan, Chen LiFang, Lin XiaoQin

2018, 34(6): 1248-1252. DOI: 10.3969/j.issn.1001-5256.2018.06.023

Abstract(2282)

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Abstract:

Objective To investigate the expression of programmed death-ligand 1 (PD-L1) on the surface of peripheral blood CD4+and CD8+T cells and its correlation with liver inflammation grade in patients with type 1 autoimmune hepatitis (AIH) . Methods A total of 62 patients with type 1 AIH (43 in the active ...

Clinical features of IgG4-associated sclerosing cholangitis: An analysis of 12 cases

Wang Yan, Pan Jing, Huo Na, Zhang ZhenZhen, Cheng Hao, Wang GuiQiang

2018, 34(6): 1253-1258. DOI: 10.3969/j.issn.1001-5256.2018.06.024

Abstract(2081)

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Abstract:

Objective To investigate the clinical features, steroid response, and recurrence of Ig G4-associated sclerosing cholangitis (Ig G4-SC) , and to shorten the time for clinical diagnosis and reduce recurrence rate. Methods A total of 12 patients with Ig G4-SC who were admitted to Peking University Firs...

A clinical analysis of Uygur patients with acute ischemic cerebral infarction complicated by nonalcoholic fatty liver disease in Urumqi, China

Chen QinQin, Liang CanCan, Yang LiJun, Meng Qing, Ding YongNian

2018, 34(6): 1259-1263. DOI: 10.3969/j.issn.1001-5256.2018.06.025

Abstract(2069)

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Abstract:

Objective To investigate the association between acute ischemic cerebral infarction (AICI) and nonalcoholic fatty liver disease (NAFLD) in Uygur patients in Urumqi, China and possible risk factors. Methods A retrospective analysis was performed for the clinical data of 294 Uygur patients with AICI w...

Establishment of a noninvasive diagnosis equation for nonalcoholic fatty liver disease

Feng Gong, Han HaiJing, Qi Xue, Mi Man, Tian QiuMei, Niu ChunYan

2018, 34(6): 1264-1267. DOI: 10.3969/j.issn.1001-5256.2018.06.026

Abstract(2176)

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Abstract:

Objective To establish a noninvasive diagnosis equation for nonalcoholic fatty liver disease (NAFLD) using related clinical and laboratory markers, and to investigate the value of this equation in the prediction and diagnosis of NAFLD. Methods A total of 127 patients who were diagnosed with NAFLD in...

Influence of bisphenol A on intestinal mucosal barrier in rats with nonalcoholic fatty liver disease

Ding WenJin, Yuan Tao, Shen Feng, Zhou Da, Sun Chao, Fan JianGao, Chen YuanWen

2018, 34(6): 1268-1272. DOI: 10.3969/j.issn.1001-5256.2018.06.027

Abstract(1909)

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Abstract:

Objective To investigate the influence of bisphenol A (BPA) , an environmental endocrine disruptor, on inflammatory response in rats with nonalcoholic fatty liver disease (NAFLD) , as well as its adverse effect on intestinal mucosal barrier. Methods A total of 18 mature male rats were randomly divid...

Antioxidant effect of berberine in a rat model of nonalcoholic steatohepatitis

Jiang Yu, Hu JuLong, Ma JiaLi, Li Ping, Zhou YuLing, Liang XiuXia, Ai ZhengLin, Yao ShuKun

2018, 34(6): 1273-1276. DOI: 10.3969/j.issn.1001-5256.2018.06.028

Abstract(1799)

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Abstract:

Objective To investigate the antioxidant effect of berberine in a rat model of nonalcoholic steatohepatitis (NASH) and an in vitro model of oxidative stress induced by H2 O2. Methods High-fat diet was used to establish a rat model of NASH. After three weeks of treatment with berberine 18 mg/kg/d by ...

Clinical features of sinusoidal obstruction syndrome induced by pyrrolidine alkaloids in China

Guo Yan, Zhang ShiRong, Wen LiangZhi, Liu KaiJun, Hu Lu, Sun WenJing, Wang Bin, Wei YanLing, Chen DongFeng

2018, 34(6): 1277-1281. DOI: 10.3969/j.issn.1001-5256.2018.06.029

Abstract(507)

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Abstract:

Objective To investigate the clinical manifestations, treatment, and prognosis of sinusoidal obstruction syndrome induced by pyrrolidine alkaloids in China. Methods Related databases were searched, and 107 articles on sinusoidal obstruction syndrome published from January 1980 to April 2017 in China...

An analysis of risk factors for early complications after liver transplantation

Jie EnBo, Xuan FengHui, Sun XiaoDong, Sun DaWei, Lu: GuoYue

2018, 34(6): 1282-1288. DOI: 10.3969/j.issn.1001-5256.2018.06.030

Abstract(1786)

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Abstract:

Objective To investigate the risk factors for early complications after liver transplantation and to improve the prognosis. Methods The clinical data of 147 patients who underwent orthotopic liver transplantation in the Hepatic Transplantation Center of The First Hospital of Jilin University from Se...

Case reports

A case of pituitary stalk interruption syndrome with liver cirrhosis

Tian Hua, Xu TianJiao, Zhu Bing, You ShaoLi, Lu: Sa

2018, 34(6): 1289-1291. DOI: 10.3969/j.issn.1001-5256.2018.06.031

Abstract(1975)

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Abstract:

A case of intrahepatic biliary cystadenoma

Cheng PengRui, Su Yang

2018, 34(6): 1292-1293. DOI: 10.3969/j.issn.1001-5256.2018.06.032

Abstract(1805)

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Abstract:

A case of acute drug-induced liver injury caused by norethindrone

Huang DeLiang, Dai Wei

2018, 34(6): 1294-1295. DOI: 10.3969/j.issn.1001-5256.2018.06.033

Abstract(2270)

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Abstract:

An asymptomatic case of Caroli disease

Cao Dan, Xin JieJing, Chen YanPing

2018, 34(6): 1296-1297. DOI: 10.3969/j.issn.1001-5256.2018.06.034

Abstract(2106)

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Abstract:

Conservative treatment of cholecystoduodenal fistula complicated by gallstone ileus: A case report

Wang KeShen, Zhang XiangXiang, Ren YanXian, Ding YongQiang, Wang ShiYao, Jiao ZuoYi

2018, 34(6): 1298-1299. DOI: 10.3969/j.issn.1001-5256.2018.06.035

Abstract(2034)

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Abstract:

Portal hypertension caused by pancreatic tuberculosis: A case report

Mao MiaoMiao, Zhang Duan, Gao Hui, Yang QianQian, Wen XiaoYu, Jin QingLong

2018, 34(6): 1300-1301. DOI: 10.3969/j.issn.1001-5256.2018.06.036

Abstract(1868)

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Abstract:

Reviews

Value of highly sensitive serum virological markers in hepatitis B patients with a low viral load

Gu JiuLian, Liu ShouSheng, Li ChangFei, Xiao JianHan, Xin YongNing, Xuan ShiYing

2018, 34(6): 1302-1307. DOI: 10.3969/j.issn.1001-5256.2018.06.037

Abstract(2198)

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Abstract:
HBV detection plays an important role in the prevention and treatment of hepatitis B. Clinical studies have shown that some patients with undetectable HBV DNA or negative HBs Ag could still progress to liver cirrhosis and hepatocellular carcinoma. Therefore, it is urgent to improve the sensitivity o...

Changes in diagnostic criteria for hepatorenal syndrome and the application of new renal injury indices in cirrhotic patients

Liu QinYu, Li Hai

2018, 34(6): 1308-1312. DOI: 10.3969/j.issn.1001-5256.2018.06.038

Abstract(2040)

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Abstract:
Hepatorenal syndrome is a serious complication of decompensated cirrhosis and has high short-term mortality. There still lacks effective medical treatment at present. Although some drugs are effective, but their effects reported in the literature were different due to a lack of uniform diagnostic cr...

Current status of treatment of primary hepatocellular carcinoma in the elderly population

Huang YongJie, Wu DeQuan, Yuan JunHui

2018, 34(6): 1313-1317. DOI: 10.3969/j.issn.1001-5256.2018.06.039

Abstract(1936)

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Abstract:
With the global aging, the incidence rate of HCC in the elderly population is gradually increasing, and thus it has become a global health issue. With reference to relevant literature, this article analyzes the clinical features of elderly HCC patients and reviews the current status of therapies and...

Research advances in metabolic markers for hepatocellular carcinoma

Sun WenBo, Liu XiangLiang, Li Wei

2018, 34(6): 1318-1324. DOI: 10.3969/j.issn.1001-5256.2018.06.040

Abstract(1694)

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Abstract:
Hepatocellular carcinoma (HCC) has high incidence and mortality rates and poor prognosis and greatly threatens human health.Early identification and diagnosis is an important method for reducing the incidence and mortality rates of HCC. The sensitivities and specificities of commonly used serum tumo...

The association between the intestinal microbiota-lipopolysaccharide-Toll-like receptor 4 axis and hepatocellular carcinoma

Huang Rong, Ni JiaJia, Gao Yi

2018, 34(6): 1325-1328. DOI: 10.3969/j.issn.1001-5256.2018.06.041

Abstract(1576)

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Abstract:
Hepatocellular carcinoma is the major complication of various end-stage chronic liver diseases. Studies have shown that intestinal barrier injury and intestinal flora disturbance are commonly seen in patients with liver diseases, which may cause intestinal bacterial translocation and endotoxemia. To...

Research advances in the role of CCL20/CCR6 in liver cancer and other tumors

Wu Jing, Meng QingHua

2018, 34(6): 1329-1332. DOI: 10.3969/j.issn.1001-5256.2018.06.042

Abstract(1477)

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Abstract:
The role of chemokines/receptors in the pathophysiological activities such as inflammation and tissue injury has been clarified. In recent years, there have been increasing studies on their effect on tumors in the tumor microenvironment. This article reviews research advances in C-C motif chemokine ...

Research advances in Epstein-Barr viral hepatitis

Huang JiangWei, Han FangZheng

2018, 34(6): 1333-1337. DOI: 10.3969/j.issn.1001-5256.2018.06.043

Abstract(3472)

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Abstract:
Epstein-Barr virus hepatitis is liver inflammation caused by Epstein-Barr virus infection, mainly self-limited hepatitis or mild or moderate liver injury. It often has good prognosis, but it may progress to chronic liver disease, severe hepatitis, and even intrahepatic cholangiocarcinoma. The clinic...

Latest clinical advances in autoimmune hepatitis in special populations and special types of autoimmune hepatitis

Li YanQing, Dong HongJing, Liu XiaoWen, Gao YanHang

2018, 34(6): 1338-1342. DOI: 10.3969/j.issn.1001-5256.2018.06.044

Abstract(1320)

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Abstract:
In recent years, the incidence rate of autoimmune hepatitis (AIH) is gradually increasing, which has attracted more and more attention from clinicians. However, there still lacks standardization in the diagnosis and treatment of special types of AIH and AIH in special populations. This article summa...

The role of gut microbiota in the development and progression of nonalcoholic steatohepatitis

Chang Yue, Li Hai

2018, 34(6): 1343-1346. DOI: 10.3969/j.issn.1001-5256.2018.06.045

Abstract(1418)

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Abstract:
Currently, the pathogenesis of nonalcoholic steatohepatitis (NASH) remains unclear, while the theory of " two hits" is insufficient to explain the pathogenesis of NASH in all cases. More and more attention has been paid to the relationship between the change in gut microbiota and the development and...

Association of Th17 cells, regulatory T cells, and their imbalance with nonalcoholic fatty liver disease

Gao WeiHua, Ge KuanXue, Xiang XiaoXing

2018, 34(6): 1347-1350. DOI: 10.3969/j.issn.1001-5256.2018.06.046

Abstract(438)

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Abstract:
Nonalcoholic fatty liver disease (NAFLD) is closely associated with insulin resistance and genetic susceptibility and is one of the chronic liver diseases that threaten human health. Under certain conditions, Th17 cells and regulatory T (Treg) cells can be transformed to each other to maintain immun...

Research progress in prognostic models of acute-on-chronic liver failure

Zhang DongJing, Zhou Bin, Hou JinLin

2018, 34(6): 1351-1356. DOI: 10.3969/j.issn.1001-5256.2018.06.047

Abstract(2471)

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Abstract:
Acute-on-chronic liver failure (ACLF) is characterized by the rapid deterioration of liver function resulting from acute insults in patients with pre-existing liver disease, which is usually correlated with multisystem organ failure. There is still no ideal therapy available for ACLF untill now. An ...

Diagnosis and treatment of vascular complications of acute pancreatitis

Zhu Chang, Zhu YiZhou, Wang Ying, Xu XiaoRong

2018, 34(6): 1357-1360. DOI: 10.3969/j.issn.1001-5256.2018.06.048

Abstract(1823)

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Abstract:
Severe acute pancreatitis is a disease involving multiple organs and systems and can lead to a series of complications. It is reported that a quarter of patients with severe pancreatitis may develop vascular complications, which is the major cause of death. Vascular complications can be divided into...