中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 3
Mar.  2019
Turn off MathJax
Article Contents

Importance of the clinical research on alcoholic hepatitis

DOI: 10.3969/j.issn.1001-5256.2019.03.002
Research funding:

 

  • Published Date: 2019-03-20
  • Alcoholic hepatitis ( AH) is a non-infectious inflammatory injury of the liver and often occurs on the basis of chronic liver dis-ease including fatty liver disease and liver cirrhosis. Acute exacerbation of liver disease due to heavy drinking within a short period of time isa severe manifestation of AH. The prognosis of AH depends on treatment timing and methods, and liver function can quickly recover or rap-idly deteriorate into multiple organ failure. Many clinicians lack the experience in early identification and timely treatment of AH, due to alack of typical clinical manifestations and specific auxiliary examinations, which affects clinical treatment, delays treatment, and exposessome AH patients to the risk of death. Therefore, it is imperative to conduct more clinical studies on AH, summarize real-world data, anddevelop expert consensus.

     

  • loading
  • [1] LI MM, QI XS, SUN MY. Recommendations for ACG clinicalguideline:Alcoholic liver disease (2018) [J]. J Clin Hepatol, 2018, 34 (3) :498-499. (in Chinese) 李苗苗, 祁兴顺, 孙明瑜.《2018年美国胃肠病学院酒精性肝病诊治临床指南》推荐意见[J].临床肝胆病杂志, 2018, 34 (3) :498-499.
    [2] LIU LL, WANG BY. Gastrointestinal microbiota in patients withalcoholic liver diseases[J]. J Pract Hepatol, 2017, 20 (6) :660-662. (in Chinese) 刘露露, 王炳元.肠道微生态与酒精性肝病[J].实用肝脏病杂志, 2017, 20 (6) :660-662.
    [3] YANG AM, INAMINE T, HOCHRATH K, et al. Intestinal fungicontribute to development of alcoholic liver disease[J]. J ClinInvest, 2017, 127 (7) :2829-2841.
    [4] CHEN P, STARKEL P, TURNER JR, et al. Dysbiosisinducedintestinal inflammation activates tumor necrosis factor receptorI and mediates alcoholic liver disease in mice[J]. Hepatolo-gy, 2015, 61 (3) :883-894.
    [5] MCCLAIN C, BARVE S, JOSHI-BARVE S, et al. Dysregulat-ed cytokine metabolism, altered hepatic methionine metabo-lism and proteasome dysfunction in alcoholic liver disease[J].Alcohol Clin Exp Res, 2005, 29 (11 Suppl) :180s-188s.
    [6] XU BB, LI YL, WANG BY. Research advances in risk factorsfor alcoholic liver disease[J]. Chin J Hepatol, 2017, 25 (5) :397-400. (in Chinese) 徐贝贝, 李银玲, 王炳元.酒精性肝病相关危险因素的研究进展[J].中华肝脏病杂志, 2017, 25 (5) :397-400.
    [7] IM GY. Acute alcoholic hepatitis[J]. Clin Liver Dis, 2019, 23 (1) :81-98.
    [8] WANG BY. Severe alcoholic hepatitis:Some current challen-ges and future directions[J]. J Pract Hepatol, 2014, 17 (1) :3-4. (in Chinese) 王炳元.重症酒精性肝炎需要关注的几个问题[J].实用肝脏病杂志, 2014, 17 (1) :3-4.
    [9] MOREAU R, JALAN R, GINES P, et al. Acute-on-chronicliver failure is a distinct syndrome that develops in patients withacute decompensation of cirrhosis[J]. Gastroenterology, 2013, 144 (7) :1426-1437.
    [10] ZHU P, HAN T. An excerpt of medical management of severealcoholic hepatitis:Expert review from the clinical practice up-dates committee of the AGA institute (2017) [J]. J Clin Hepa-tol, 2017, 33 (7) :1246-1248. (in Chinese) 朱萍, 韩涛.《2017年美国胃肠病学会临床实践更新委员会:重症酒精性肝炎的医疗管理》摘译[J].临床肝胆病杂志, 2017, 33 (7) :1246-1248.
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Article Metrics

    Article views (1773) PDF downloads(422) Cited by()
    Proportional views
    Related

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return