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2019 Vol. 35, No. 3

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Editorial
What's new in alcoholic hepatitis
Gao Bin, Vijay H.Shah
2019, 35(3): 465-468. DOI: 10.3969/j.issn.1001-5256.2019.03.001
Abstract(1841) PDF (2061KB)(468)
Abstract:

Alcoholic hepatitis is an important type of alcohol-associated liver disease characterized by acute liver inflammation caused by pro-longed heavy alcohol use. In the present article, the pathogenesis, clinical characteristics, diagnosis, current therapies and future treatmentstrategies of alcoholic ...
Importance of the clinical research on alcoholic hepatitis
Wang BingYuan
2019, 35(3): 469-471. DOI: 10.3969/j.issn.1001-5256.2019.03.002
Abstract(1879) PDF (1957KB)(425)
Abstract:

Alcoholic hepatitis ( AH) is a non-infectious inflammatory injury of the liver and often occurs on the basis of chronic liver dis-ease including fatty liver disease and liver cirrhosis. Acute exacerbation of liver disease due to heavy drinking within a short period of time isa severe manifestation o...
Discussions by experts
Influence of drinking on progression of chronic hepatitis B and outcome of antiviral therapy
Liu Chen, Xing HuiChun, Cheng Jun, Yang Song
2019, 35(3): 472-475. DOI: 10.3969/j.issn.1001-5256.2019.03.003
Abstract(1717) PDF (1979KB)(398)
Abstract:
HBV can interact with alcohol in various ways to cause liver damage. Heavy drinking can accelerate the progression of chronichepatitis B and lead to a poorer prognosis; meanwhile, it can also affect the outcome and compliance in patients receiving antiviral therapy.The epidemiology of drinking in pa...
Clinical diagnosis of alcoholic hepatitis
Zou ZhengSheng
2019, 35(3): 476-477. DOI: 10.3969/j.issn.1001-5256.2019.03.004
Abstract(1602) PDF (1952KB)(409)
Abstract:
Based on the significant differences in definition, clinical features, and prognosis between alcoholic hepatitis ( AH) and severeAH, it is recommended to classify AH into mild and severe AH. As for the disease spectrum of hospitalized patients with alcoholic liver dis-ease, most patients have liver ...
Alcoholic liver disease with nonalcoholic fatty liver disease and obesity
Cao HaiXia, Fan JianGao
2019, 35(3): 478-480. DOI: 10.3969/j.issn.1001-5256.2019.03.005
Abstract(1721) PDF (1964KB)(382)
Abstract:

For a long time, researchers and clinicians have strictly divided fatty liver diseases into alcoholic and non-alcoholic fatty liverdisease. When one was diagnosed as alcoholic liver disease, the effects of non-alcoholic factors, including obesity, diabetes or metabolicsyndrome, on liver diseases hav...
Intestinal microflora and alcoholic liver disease
Li Wei, Xing HuiChun
2019, 35(3): 481-484. DOI: 10.3969/j.issn.1001-5256.2019.03.006
Abstract(1709) PDF (1973KB)(456)
Abstract:

Normal intestinal microflora and microecology are essential for normal physiological functions in human body. Intestinal microfloraimbalance is often observed in patients with alcoholic liver disease and manifests as abnormal number and constituent ratio of intestinal micro-flora, dysfunction of int...
Application status and future prospect of the Gao-Binge model in alcoholic liver disease
Zhou Ke, Wang Hua
2019, 35(3): 485-488. DOI: 10.3969/j.issn.1001-5256.2019.03.007
Abstract(2540) PDF (1982KB)(517)
Abstract:

The pathogenesis of alcoholic liver disease remains unclear, mainly due to the lack of accurate animal models in experiments.Many different animal models have been established to mimic alcoholic liver disease in patients, which have both advantages and disadvanta-ges. Among these models, the Gao-Bin...
Academic contention
Severe alcoholic hepatitis and acute-on-chronic liver failure
Sun FuRong, Wang BingYuan
2019, 35(3): 489-493. DOI: 10.3969/j.issn.1001-5256.2019.03.008
Abstract(1673) PDF (1993KB)(396)
Abstract:

Rapid progression or aggravation of jaundice, coagulation abnormalities and liver-related complications in patients with alcoholichepatitis indicates that they may develop severe alcoholic hepatitis. Some of these patients can progress acute-on-chronic liver failure withacute insults, such as infect...
Therapeutic guidelines
Guidelines for clinical diagnosis and treatment of acute-on-chronic liver failure in traditional Chinese  medicine
China Association of Chinese Medicine
2019, 35(3): 494-503. DOI: 10.3969/j.issn.1001-5256.2019.03.009
Abstract(1994) PDF (2039KB)(536)
Abstract:
Expert consensus of percutaneous transhepatic biliary drainage and stent implantation in treatment of obstructive jaundice(2018 Edition)
The Society of Interventional Therapy, China Anti-Cancer Association
2019, 35(3): 504-508. DOI: 10.3969/j.issn.1001-5256.2019.03.010
Abstract(1037) PDF (233KB)(639)
Abstract:
An excerpt of AGA clinical practice update:Surgical risk assessment and perioperative management in cirrhosis (2018)
Chou Sai, Zhao GuoDong
2019, 35(3): 509-513. DOI: 10.3969/j.issn.1001-5256.2019.03.011
Abstract(264) PDF (227KB)(140)
Abstract:
An excerpt of endoscopic treatment of chronic pancreatitis: European Society of Gastrointestinal Endoscopy (ESGE) guideline - updated 2018
Li JiaSu, Li WanTong, Liu Feng, Li ZhaoShen
2019, 35(3): 514-517. DOI: 10.3969/j.issn.1001-5256.2019.03.012
Abstract(470) PDF (199KB)(233)
Abstract:
Original articles_Viral hepatitis
Association of APOBEC3B copy number variation with the prognosis of hepatitis B virus infection
Xie PengFei, Gao YuFeng, Li Xu
2019, 35(3): 518-521. DOI: 10.3969/j.issn.1001-5256.2019.03.013
Abstract(1518) PDF (1982KB)(300)
Abstract:
Objective To investigate the difference in the distribution frequency of APOBEC3 B copy number variations ( CNVs) betweenpatients with different outcomes after hepatitis B virus ( HBV) infection and the role of APOBEC3 B CNVs in clinical outcome. MethodsA total of 296 patients with acute self-limiti...
Association of blood lipids and albumin-bilirubin index with disease progression in patients with chronic hepatitis B virus infection
Cao WenJun, Wang TongTong, Gao YuFeng, Zou GuiZhou
2019, 35(3): 522-525. DOI: 10.3969/j.issn.1001-5256.2019.03.014
Abstract(1428) PDF (2036KB)(320)
Abstract:
Objective To investigate the value of blood lipid indices and albumin-bilirubin index ( ALBI) in evaluating the progression ofchronic hepatitis B virus ( HBV) infection. Methods A total of 184 patients with chronic HBV infection who visited The Second AffiliatedHospital of Anhui Medical University f...
Clinical effect and safety of sofosbuvir-ledipasvir regimen in treatment of patients with HCV genotype 6a chronic hepatitis C
Li Wei, Kang Yi, Ding GangQiang, Shang Jia, Zhou YuanPing
2019, 35(3): 526-529. DOI: 10.3969/j.issn.1001-5256.2019.03.015
Abstract(1629) PDF (1980KB)(913)
Abstract:
Objective To investigate the clinical effect and safety of sofosbuvir ( SOF) -ledipasvir ( LDV) in the treatment of patients withHCV genotype 6 a chronic hepatitis C ( CHC) . Methods A total of 63 patients with HCV genotype 6 a CHC who visited Department of In-fectious Diseases, Henan Provincial Peo...
Original articles_Liver neoplasms
Value of Barcelona Clinic Liver Cancer staging system versus Hong Kong Liver Cancer staging system in predicting the prognosis of patients with hepatocellular carcinoma
Chen Chuang, Long PeiYun, Chen Jie, Wang Pan, Huang QingYun, Zang YouYa, Deng GuoYu, Lin DongYi, Wang ZongYu
2019, 35(3): 530-534. DOI: 10.3969/j.issn.1001-5256.2019.03.016
Abstract(2095) PDF (2277KB)(338)
Abstract:
Objective To investigate the value of Barcelona Clinic Liver Cancer ( BCLC) staging system versus Hong Kong Liver Cancer ( HKLC) staging system in predicting the prognosis of patients with hepatocellular carcinoma ( HCC) . Methods A retrospective analysiswas performed for the clinical data of 436 pr...
Prognosis and staging system analysis of hepatocellular carcinoma patients with negative serum alpha-fetoprotein
Ye YingJian, Liu Bo, Chen Wei, Li QiongXia
2019, 35(3): 535-541. DOI: 10.3969/j.issn.1001-5256.2019.03.017
Abstract(1995) PDF (2162KB)(332)
Abstract:
Objective To investigate the effect of negative expression of serum alpha-fetoprotein ( AFP) ( < 20 ng/L) on the prognosisand staging of patients with hepatocellular carcinoma ( HCC) , the risk factors for postoperative survival rate of AFP-negative patients, andthe best scoring system for clinic...
Change in serum level of abnormal prothrombin after microwave ablation for hepatocellular carcinoma and its clinical significance
Sun Yu, Zhang HongHai, Yuan ChunWang, Li Cong, Hu CaiXia, Cui ShiChang, Zhang YongHong, Zheng JiaSheng
2019, 35(3): 542-546. DOI: 10.3969/j.issn.1001-5256.2019.03.018
Abstract(1597) PDF (1996KB)(297)
Abstract:
Objective To investigate the changes in serum levels of des-γ-carboxy-prothrombin ( DCP) and alpha-fetoprotein ( AFP) after microwave ablation in patients with hepatocellular carcinoma ( HCC) , to monitor the recurrence of HCC, and to investigate the associa-tion of serum DCP and AFP levels with the...
Expression and clinical significance of protein kinase CK2β in hepatocellular carcinoma
Liang RunWei, Fan ZhengJun, Huang Juan, Sun Tao, Yu ZuQi
2019, 35(3): 547-552. DOI: 10.3969/j.issn.1001-5256.2019.03.019
Abstract(1452) PDF (2299KB)(295)
Abstract:
Objective To investigate the expression and clinical significance of protein kinase CK2β in hepatocellular carcinoma ( HCC) tissue and the association of CK2β expression with patient prognosis. Methods HCC tissue and adjacent tissue samples were collected from127 HCC patients Who were diagnosed in D...
Expression and significance of the ABAT gene in hepatocellular carcinoma:An analysis based on data mining
Zhang YuPeng, Wang Fan, Chen PengFei, Liu Shi, Liu Lan, Chang Ying, Zhao Qiu
2019, 35(3): 553-558. DOI: 10.3969/j.issn.1001-5256.2019.03.020
Abstract(1568) PDF (2502KB)(331)
Abstract:
Objective To investigate the expression and significance of the ABAT gene in hepatocellular carcinoma ( HCC) using relateddatabases. Methods The Oncomine database and GEPIA were used to analyze the expression of ABAT in HCC tissue. GEPIA was used toinvestigate the correlation of ABAT mRNA with the s...
Original articles_Biliary diseases
Clinical effect of percutaneous transhepatic cholangial drainage combined with biliary stent implantation in treatment of high malignant obstructive jaundice and the influencing factors for prognosis
Chen WeiWei, Huang Kun, Liu Rui, Liu ChengLi
2019, 35(3): 559-564. DOI: 10.3969/j.issn.1001-5256.2019.03.021
Abstract(1987) PDF (2185KB)(326)
Abstract:

Objective To investigate the clinical effect of percutaneous transhepatic cholangial drainage ( PTCD) combined with biliarystent implantation in the treatment of high malignant obstructive jaundice ( MOJ) and the risk factors for survival time. Methods A retro-spective analysis was performed for the...
Clinical effect of laparoscopic radical resection in treatment of type Ⅳ hilar cholangiocarcinoma
Xu Jian, Zhang Wei, Wu ZhangKang, Wu Guo, Li JingDong
2019, 35(3): 565-569. DOI: 10.3969/j.issn.1001-5256.2019.03.022
Abstract(1608) PDF (2517KB)(317)
Abstract:

Objective To investigate the feasibility and safety of laparoscopic radical resection in the treatment of type IV hilar cholangio-carcinoma. Methods A retrospective analysis was performed for the clinical data of 4 patients who were admitted to the Affiliated Hospitalof Chuanbei Medical College from...
Effect of Pien Tze Huang on bile excretion and its analgesic effect in experimental animals
Li JunFeng, Ren Feng, Ding Mei, Liu Shuang, Chen ZhiLiang, Chen Yu, Duan ZhongPing
2019, 35(3): 570-573. DOI: 10.3969/j.issn.1001-5256.2019.03.023
Abstract(1844) PDF (2430KB)(299)
Abstract:

Objective To investigate the effect of Pien Tze Huang on bile excretion and its analgesic effect in experimental animals. Meth-ods A total of 30 guinea pigs were randomly divided into Pien Tze Huang group, ursodeoxycholic acid group, and control group. Accordingto body mass, the three groups were tr...
Original articles_Others
Clinical features of liver injury induced by antitumor drugs:An analysis of 56 cases
Zhang HuiJuan, Shi ZuXuan, Zhao LanFang, Gao TianHui, Li Jian
2019, 35(3): 574-578. DOI: 10.3969/j.issn.1001-5256.2019.03.024
Abstract(1812) PDF (2150KB)(352)
Abstract:

Objective To investigate the clinical features of drug-induced liver injury ( DILI) caused by antitumor drugs during the treat-ment of malignant tumors. Methods A retrospective analysis was performed for the clinical data of 56 patients who were diagnosed with ma-lignant tumors in Henan Provincial P...
Drug-induced liver injury in children:An analysis of medication and clinical features
Zhang YanFang, Guo YuMing, Niu Ming, Ge FeiLin, Jing Jing, Zhu Yun, Zhu ShiShu, Han ZiXin, Wang JiaBo, Liu ShiJing, Xiao XiaoHe
2019, 35(3): 579-584. DOI: 10.3969/j.issn.1001-5256.2019.03.025
Abstract(1688) PDF (2679KB)(351)
Abstract:

Objective To investigate the drugs responsible for drug-induced liver injury ( DILI) in children and related risk factors, andto provide a reference for safe drug use in children in clinical practice. Methods A retrospective analysis was performed for the clinical da-ta of 187 children with DILI, ag...
A bioinformatics analysis of the microRNA-mRNA differential expression network for alcoholic hepatitis
Zhang XiuZhi, Li NingNing, Liu XiaoLi, Kang ChunYan, Zhang JinZhong
2019, 35(3): 585-591. DOI: 10.3969/j.issn.1001-5256.2019.03.026
Abstract(401) PDF (577KB)(234)
Abstract:

Objective To establish a microRNA-mRNA differential expression network for alcoholic hepatitis ( AH) , and to investigatenew targets for the diagnosis and treatment of AH. Methods Differentially expressed microRNAs and mRNAs between AH patients and nor-mal controls were screened out. Related softwar...
Effect of human liver-derived stem cells in prevention and treatment of alcoholic fatty liver disease in mice
Bi YanZhen, Zhang QiuSheng, Fan Zeng, Yang YongHong, Zhang XiaoBei, Wang QuanQuan, Wang QuanYi, Wang YiBo, Duan ZhongPing, Chen Yu, Shu ZhenFeng, Si ChuanPing, Hong Feng
2019, 35(3): 592-595. DOI: 10.3969/j.issn.1001-5256.2019.03.027
Abstract(1642) PDF (2315KB)(329)
Abstract:

Objective To investigate the effect of intraperitoneal transplantation of human liver-derived stem cells in the prevention and treatment of alcoholic fatty liver disease in mice. Methods A total of 30 male C57 BL/6 mice were randomly divided into blank control group ( group N) , model control group ...
Clinical effect of intervention with Gandouling tablets in the perioperative period of splenectomy in patients with Wilson's disease accompanied by splenomegaly and hypersplenism
Ma ShouLiang, Yang WenMing, Han Hui, Wang YanXin, Dong Ting, Sheng YuQin
2019, 35(3): 596-599. DOI: 10.3969/j.issn.1001-5256.2019.03.028
Abstract(1635) PDF (1976KB)(283)
Abstract:

Objective To investigate the clinical effect of perioperative Gandouling intervention in patients with Wilson's disease ( WD) complicated by splenomegaly and hypersplenism and the changes in related indices. Methods A total of 60 WD patients with splenomegalyand hypersplenism who were hospitalized i...
Case reports
Hepatitis C virus-associated Waldenstrom macroglobulinemia and cryoglobulinemia: A case report
Yu XiaoYuan, Xin Qi, Liu YingMin, Jin FengYan
2019, 35(3): 600-601. DOI: 10.3969/j.issn.1001-5256.2019.03.029
Abstract(1037) PDF (2429KB)(305)
Abstract:
Primary hepatic follicular dendritic cell sarcoma: A case report
Wang ShouQian, Abudureyimu Tuerhong, Wang ShuPeng, Tang ChaoHui, Wang YingChao
2019, 35(3): 602-604. DOI: 10.3969/j.issn.1001-5256.2019.03.030
Abstract(1279) PDF (2296KB)(297)
Abstract:
Primary hepatic angiosarcoma in the elderly: A case report and literature review
Zhang XueWen, Dai ChaoLiu
2019, 35(3): 605-607. DOI: 10.3969/j.issn.1001-5256.2019.03.031
Abstract(1284) PDF (3042KB)(304)
Abstract:
A case of primary hepatic angiosarcoma with splenic metastasis and rupture
Zhu XiXun, Li ZhiWei, Zheng Yu
2019, 35(3): 608-610. DOI: 10.3969/j.issn.1001-5256.2019.03.032
Abstract(1263) PDF (2397KB)(301)
Abstract:
A case of spontaneous portosystemic shunt with hepatic encephalopathy
Hu WenYan, Rao ChunYan, Liu HuaBao, Wang YaNan
2019, 35(3): 611-612. DOI: 10.3969/j.issn.1001-5256.2019.03.033
Abstract(1507) PDF (2117KB)(313)
Abstract:
Invasive Klebsiella pneumoniae liver abscess syndrome:A report of two cases and literature review
Li Jing, Zhao JieMin, Tang YiQian, Zhao Xin
2019, 35(3): 613-616. DOI: 10.3969/j.issn.1001-5256.2019.03.034
Abstract(1672) PDF (2192KB)(336)
Abstract:
Acute renal failure caused by Viridans streptococci-associated liver abscess:A case report
Zhang ShuZe, Yu ZeYuan, Ren YanXian, Wang KeShen, Yang HanTeng, Jiao ZuoYi
2019, 35(3): 617-618. DOI: 10.3969/j.issn.1001-5256.2019.03.035
Abstract(1828) PDF (2027KB)(319)
Abstract:
Percutaneous transhepatic multi-tube drainage combined with carbapenem antibiotics in treatment of multiple liver abscesses in AIDS:A case report
Yang Yang, Peng FengHui, Jia Feng, Liu YaHui, Ji Bo
2019, 35(3): 619-620. DOI: 10.3969/j.issn.1001-5256.2019.03.036
Abstract(1528) PDF (2058KB)(318)
Abstract:
A case of neuroendocrine tumor of the ampulla of Vater
ABUDUREYIMU Tuerhong, Deng Yu, Wang Kun, Liu Kai, Liu YaHui
2019, 35(3): 621-622. DOI: 10.3969/j.issn.1001-5256.2019.03.037
Abstract(1542) PDF (2164KB)(292)
Abstract:
Three cases of peritoneal mesothelioma
Liu XiaoWen, Zhong YanPing, Liu PeiYan, Gao YanHang
2019, 35(3): 623-626. DOI: 10.3969/j.issn.1001-5256.2019.03.038
Abstract(1417) PDF (3142KB)(315)
Abstract:
Reviews
Research advances in the pathogenesis and diagnosis/treatment of muscle injury after treatment with nucleos (t) ide analogues in patients with chronic hepatitis B
Yuan Ling, Ceng BaiMei, Lin ShiDe
2019, 35(3): 627-630. DOI: 10.3969/j.issn.1001-5256.2019.03.039
Abstract(490) PDF (207KB)(101)
Abstract:
With the wide application of nucleos ( t) ide analogues ( NAs) in antiviral therapy for chronic hepatitis B ( CHB) , the side effectsof NAs after long-term use have attracted more and more attention from clinicians and patients. In recent years, an increasing number ofstudies have reported muscle in...
Research advances in epidemiology, pathogenesis, and diagnosis and treatment of hepatitis D virus infection
Wang Yu, Chen XiaoHua, Zhao ZhiMin, Huang Kai, Liu ChengHai
2019, 35(3): 631-634. DOI: 10.3969/j.issn.1001-5256.2019.03.040
Abstract(1624) PDF (1985KB)(332)
Abstract:
Hepatitis B virus ( HBV) /hepatitis D virus ( HDV) co-infection can accelerate the progression of liver diseases, but due to thelimitations of the detection methods for HDV RNA, the epidemiology of HDV remains unclear. Further studies are needed to investigate thepathogenesis of HBV/HDV co-infection...
Advances in the application of transient elastography in noninvasive diagnosis of liver fibrosis
Luo WenPing, Ma Hong, Wang Yu
2019, 35(3): 635-639. DOI: 10.3969/j.issn.1001-5256.2019.03.041
Abstract(1528) PDF (1997KB)(414)
Abstract:
Liver biopsy is the most sensitive and specific method for the diagnosis and staging of liver fibrosis, but its invasiveness and limi-tations have promoted the wide application of noninvasive evaluation methods for liver fibrosis in clinical practice in recent years. Variousstudies have proved the d...
Mechanism of the activation of hepatic stellate cells:An exploration of new diagnostic markers and therapeutic targets for liver fibrosis
Jiang Na, Ping Jian, Xu LieMing
2019, 35(3): 640-643. DOI: 10.3969/j.issn.1001-5256.2019.03.042
Abstract(1895) PDF (1986KB)(484)
Abstract:
Liver fibrosis has a complex pathogenesis, and at present, the research mainly focuses on hepatic stellate cells ( HSC) . Many stim-ulating factors and regulatory pathways have been found to promote the activation of HSC. This article reviews the recent research findings onseveral major cytokines an...
Role and mechanism of action of adipocytokines in the progression of liver fibrosis
Huo XinMei, Huang HuiFang
2019, 35(3): 644-647. DOI: 10.3969/j.issn.1001-5256.2019.03.043
Abstract(1167) PDF (1983KB)(277)
Abstract:
Liver fibrosis is an essential stage in the development and progression of liver cirrhosis, and uncontrolled liver fibrosis may even-tually lead to liver cirrhosis and/or hepatocellular carcinoma. Liver fibrosis is a dynamic process regulated by many factors. An increasingnumber of evidence has show...
Application of reverse ligation in treatment of gastroesophageal varices
Li HongYan, Tang TongYu
2019, 35(3): 648-650. DOI: 10.3969/j.issn.1001-5256.2019.03.044
Abstract(1148) PDF (1962KB)(305)
Abstract:
As one of the complications of liver cirrhosis, esophageal and gastric varices will seriously threaten patient's life once it rupturesand causes bleeding. At present, endoscopic treatment has become the first-line treatment for this disease. As for gastroesophageal varices, conventional esophageal l...
Risk factors, early screening, and preventing strategy for hepatitis B-related hepatocellular carcinoma
Li Mi, Nie QingHe, Han Man, Ju Di
2019, 35(3): 651-655. DOI: 10.3969/j.issn.1001-5256.2019.03.045
Abstract(1640) PDF (2004KB)(427)
Abstract:
Hepatocellular carcinoma ( HCC) is a leading cause of cancer-related death worldwide and hepatitis B virus ( HBV) infection isone of most important risk factors for HCC. The development of HBV-related HCC involves a complex interaction between host and virus, and related risk factors include HBV vir...
Biological function and regulatory mechanism of epithelial-mesenchymal transition-related long non-coding RNAs in liver cancer
Wang Yuan, Guo Tao, Li JingHua, Zhao JiSen, Zhou YuanLong, Yang JiHong
2019, 35(3): 656-660. DOI: 10.3969/j.issn.1001-5256.2019.03.046
Abstract(1297) PDF (1997KB)(281)
Abstract:
Liver cancer has a high degree of malignancy, and many oncogenes and tumor suppressor genes play an important regulatory rolein the development and progression of liver cancer. Epithelial-mesenchymal transition ( EMT) is a biological process in which epithelialcells transform into mesenchymal cells,...
Spleen-strengthening and dampness-removing therapy exerts a therapeutic effect on nonalcoholic fatty liver disease by regulating hepatic MTP promoter methylation
Liu Tao, Xu QiuLing
2019, 35(3): 661-664. DOI: 10.3969/j.issn.1001-5256.2019.03.047
Abstract(1152) PDF (2025KB)(269)
Abstract:

Nonalcoholic fatty liver disease ( NAFLD) is the most common risk factor for diabetes mellitus and cerebrovascular and cardiovascu-lar diseases. The prevalence of NAFLD is increasing rapidly with the improvement in living. Microsome triglyceride transfer protein ( MTP) isa key enzyme for outward tra...
Role of intestinal dysbacteriosis in the pathogenesis of acute-on-chronic hepatitis B liver failure
Chen MuXing, Wang ShaoYang
2019, 35(3): 665-668. DOI: 10.3969/j.issn.1001-5256.2019.03.048
Abstract(1313) PDF (1985KB)(286)
Abstract:
Acute-on-chronic liver failure is a clinical syndrome with acute exacerbation on the basis of chronic liver disease and cancause severe liver injury and dysfunctions of liver synthesis, detoxification, metabolism, and biotransformation. Intestinal dysbacteriosis is animportant factor for the acceler...
Association between high-mobility group box B1 and hepatic ischemia-reperfusion injury
Gao WeiDong, Feng ZanJie, Peng CiJun, Li Yang, Wu Bo, Geng Xin
2019, 35(3): 669-671. DOI: 10.3969/j.issn.1001-5256.2019.03.049
Abstract(1430) PDF (1968KB)(273)
Abstract:
High-mobility group box B1 ( HMGB1) is a DNA-binding protein widely distributed in eukaryotic cells. When tissue damageoccurs, HMGB1 acts as an endogenous risk signal to activate the body's immune system and mediate aseptic inflammatory response. Currentresearch findings have shown that HMGB1 plays ...
Function and mechanism of action of the PD-1/PD-L1 pathway in liver diseases
Pan SiYu, Wang ZhiXin, ZHOU Ying, Wang Tao, Yin Jie, Wang Qiang, Fan HaiNing
2019, 35(3): 672-676. DOI: 10.3969/j.issn.1001-5256.2019.03.050
Abstract(2217) PDF (2002KB)(590)
Abstract:
Programmed death-1 ( PD-1) is an important immunosuppressive molecule which interacts with its ligand programmed death-ligand 1 ( PD-L1) and plays an important role in central/peripheral immune tolerance, transplantation immunity, tumor immune escape, and autoimmune disease. At present, there is sti...
Clinical and pathological features of primary biliary cholangitis with negative anti-mitochondrial antibody
Liu HongLi, Yang YongFeng
2019, 35(3): 677-680. DOI: 10.3969/j.issn.1001-5256.2019.03.051
Abstract(2294) PDF (1987KB)(354)
Abstract:

Anti-mitochondrial antibody ( AMA) is a typical serum marker for primary biliary cholangitis ( PBC) , and the diagnosis ofAMA-negative PBC may easily be neglected in clinical practice. This article analyzes the differences in epidemiology, clinical and patho-logical features, and treatment outcome b...
Nonsurgical treatment of malignant biliary obstructive diseases
Yin JingYang, Yang Kang
2019, 35(3): 681-685. DOI: 10.3969/j.issn.1001-5256.2019.03.052
Abstract(1449) PDF (1988KB)(288)
Abstract:
Malignant biliary obstructive diseases are caused by various primary or metastatic malignancies of the liver, the biliary tract, andthe pancreas, with major clinical manifestations of obstructive jaundice, liver impairment, and cholangitis. Early diagnosis of such patients isdifficult, and most pati...
Influence of common bile duct stones and juxta-papillary duodenal diverticula on endoscopic retrograde cholangiopancreatography and related coping strategies
Wan QianQian, Jin Jing, Li Jun
2019, 35(3): 686-689. DOI: 10.3969/j.issn.1001-5256.2019.03.053
Abstract(1579) PDF (1984KB)(301)
Abstract:

Juxta-papillary duodenal diverticula ( JPD) may easily cause biliary and pancreatic diseases. JPD changes papillary positionand shape and increases the difficulties in endoscopic retrograde cholangiopancreatography ( ERCP) intubation and stone removal, and itmay also cause a series of complications....
Reconsideration of indications for gallbladder-preserving cholecystolithotomy and preventive measures for postoperative recurrence of gallstones
Li YanFei, Du QianCheng, Zhang MengZhao, Mei XuePeng, Chen YiChong, Zhou Ying, Fan HaiNing
2019, 35(3): 690-695. DOI: 10.3969/j.issn.1001-5256.2019.03.054
Abstract(2120) PDF (2002KB)(336)
Abstract:
Choledochoscopic minimally invasive gallbladder-preserving cholecystolithotomy is a surgical method for preserving the gallblad-der in the treatment of gallstones, and recurrence of gallstones is a hot topic for gallbladder-preserving cholecystolithotomy. The postopera-tive recurrence rate of gallst...
    

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