中文English
ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 3
Mar.  2019
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Article Contents

Association of APOBEC3B copy number variation with the prognosis of hepatitis B virus infection

DOI: 10.3969/j.issn.1001-5256.2019.03.013
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  • Received Date: 2018-10-08
  • Published Date: 2019-03-20
  • Objective To investigate the difference in the distribution frequency of APOBEC3 B copy number variations ( CNVs) betweenpatients with different outcomes after hepatitis B virus ( HBV) infection and the role of APOBEC3 B CNVs in clinical outcome. MethodsA total of 296 patients with acute self-limiting recovery after HBV infection and 819 patients with different stages of chronic HBV infectionwho visited The First Affiliated Hospital of Anhui Medical University from January 2016 to December 2017 were enrolled as acute self limitingrecovery group and chronic HBV infection group, respectively, and their peripheral blood samples were collected. Among the 819 patientswith chronic HBV injection, 444 had chronic hepatitis B ( CHB) , 252 had liver cirrhosis ( LC) , and 123 had hepatocellular carcinoma ( HCC) . The AccuCopy method was used to measure APOBEC3 B CNVs in peripheral blood, and related clinical data were collected for allpatients. The chi-square test was used for comparison of distribution frequency of APOBEC3 B CNVs between groups. Results For acuteor chronic outcome after chronic HBV infection, the acute self limiting recovery group had a significantly lower proportion of patients with re-duced or deleted APOBEC3 B CNVs than the chronic HBV infection group ( 46. 96% vs 58. 00%, P = 0. 001 1) . For disease progression af-ter chronic HBV infection, the HCC group had the highest proportion of patients with deleted APOBEC3 B CNVs of 22. 76%, followed by theLC group ( 14. 29%) and the CHB group ( 11. 04%) , and there was a significant difference between the three groups ( χ2= 11. 85, P =0. 019) . In the chronic HBV infection group, there was no significant difference in the distribution frequency of APOBEC3 B CNVs betweenthe patients with positive E-antigen and those with negative E-antigen ( χ2= 0. 639, P = 0. 727) . Conclusion APOBEC3 B CNV is asso-ciated with the outcome of chronic HBV infection, and reduced and deleted APOBEC3 B CNV is a genetic susceptibility factor for chronicityand progression of HBV infection.

     

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