[1] CARSON JP, RAMM GA, ROBINSON MW, et al. Schistosome-induced fibrotic disease:The role of hepatic stellate cells[J]. Trends Parasitol, 2018, 34 (6) :524-540.
|
[2] JUNG YK, YIM HJ. Reversal of liver cirrhosis:current evidenceand expectations[J]. Korean J Intern Med, 2017, 32 (2) :213-228.
|
[3] TSUCHIDA T, FRIEDMAN SL. Mechanisms of hepatic stellatecell activation[J]. Nat Rev Gastroenterol Hepatol, 2017, 14 (7) :397-411.
|
[4] WAKE K.“Sternzellen”in the liver:Perisinusoidal cells withspecial reference to storage of vitamin A[J]. Am J Anat, 1971, 132 (4) :429-462.
|
[5] MEDERACKE I, DAPITO DH, AFFS, et al. High-yield andhigh-purity isolation of hepatic stellate cells from normal andfibrotic mouse livers[J]. Nat Protoc, 2015, 10 (2) :305-315.
|
[6] LEE YA, WALLACE MC, FRIEDMAN SL. Pathobiology of liverfibrosis:A translational success story[J]. Gut, 2015, 64 (5) :830-841.
|
[7] UENO T, SATA M, SAKATA R, et al. Hepatic stellate cellsand intralobular innervation in human liver cirrhosis[J]. HumPathol, 1997, 28 (8) :953-959.
|
[8] HIGASHI T, FRIEDMAN SL, HOSHIDA Y. Hepatic stellate cells askey target in liver fibrosis[J]. Adv Drug Deliv Rev, 2017, 121:27-42.
|
[9] KATZ LH, LIKHTER M, JOGUNOORI W, et al. TGFβsignalingin liver and gastrointestinal cancers[J]. Cancer Lett, 2016, 379 (2) :166-172.
|
[10] LILIANA A, JEFFREY LW. Smads as transcriptional co-mod-ulators[J]. Curr Opin Cell Biol, 2000, 12 (2) :235-243.
|
[11] CHEN J, KATZ LH, MUNOZ NM, et al. Vitamin D deficiencypromotes liver tumor growth in transforming growth factor-be-ta/Smad3-deficient mice through Wnt and Toll-like receptor7 pathway modulation[J]. Sci Rep, 2016, 6:30217.
|
[12] LI XF, CHEN H, YI ZJ, et al. Imidazoline I2 receptor inhibitoridazoxan regulates the progression of hepatic fibrosis via AktNrf2 Smad2/3 signaling pathway[J]. Oncotarget, 2017, 8 (13) :21015-21030.
|
[13] LI HY, JU D, ZHANG DW, et al. Activation of TGF-beta1-CD147 positive feedback loop in hepatic stellate cells pro-motes liver fibrosis[J]. Sci Rep, 2015, 5:16552.
|
[14] CAI X, LI Z, ZHANG Q, et al. CXCL6-EGFR-inducedKupffer cells secrete TGF-beta1 promoting hepatic stellatecell activation via the SMAD2/BRD4/C-MYC/EZH2 pathwayin liver fibrosis[J]. J Cell Mol Med, 2018, 22 (10) :5050-5061.
|
[15] ROSKOSKI R. The role of small molecule platelet-derived growthfactor receptor (PDGFR) inhibitors in the treatment of neoplasticdisorders[J]. Pharmacol Res, 2018, 129:65-83.
|
[16] DING Q, LI Z, LIU B, et al. Propranolol prevents liver cirrhosisby inhibiting hepatic stellate cell activation mediated by thePDGFR/Akt pathway[J]. Hum Pathol, 2018, 76:37-46.
|
[17] KOSTALLARI E, HIRSOVA P, PRASNICKA A, et al. Hepaticstellate cell-derived PDGFR alpha-enriched extracellularvesicles promote liver fibrosis in mice through SHP2[J]. Hep-atology, 2018, 68 (1) :333-348.
|
[18] YANG L, KWON J, POPOV Y, et al. Vascular endothelialgrowth factor promotes fibrosis resolution and repair in mice[J]. Gastroenterology, 2014, 146 (5) :1339-1350. e1.
|
[19] PETROSINO JM, LEASK A, ACCORNERO F. Genetic manipu-lation of CCN2/CTGF unveils cell-specific ECM-remodelingeffects in injured skeletal muscle[J]. FASEB J, 2018.[Epubahead of print]
|
[20] HUANG G, BRIGSTOCK DR. Regulation of hepatic stellatecells by connective tissue growth factor[J]. Front Biosci, 2015, 17:2495-2507.
|
[21] CHEN L, CHEN R, VELAZQUEZ VM, et al. Fibrogenic signa-ling is suppressed in hepatic stellate cells through targeting ofconnective tissue growth factor (CCN2) by cellular or exosom-al microRNA-199a-5p[J]. Am J Pathol, 2016, 186 (11) :2921-2933.
|
[22] HAZRA S, XIONG S, WANG J, et al. Peroxisome proliferator-activated receptor gamma induces a phenotypic switch fromactivated to quiescent hepatic stellate cells[J]. J Biol Chem, 2004, 279 (12) :11392-11401.
|
[23] MORAN-SALVADOR E, TITOS E, RIUS B, et al. Cell-specificPPARgamma deficiency establishes anti-inflammatory and anti-fibrogenic properties for this nuclear receptor in non-parenchy-mal liver cells[J]. J Hepatol, 2013, 59 (5) :1045-1053.
|
[24] IWAISAKO K, HAIMERL M, PAIK YH, et al. Protection from liv-er fibrosis by a peroxisome proliferator-activated receptordelta agonist[J]. Proc Natl Acad Sci U S A, 2012, 109 (21) :e1369-e1376.
|
[25] ZHANG F, LU S, HE J, et al. Ligand activation of PPARγbyligustrazine suppresses pericyte functions of hepatic stellatecells via SMRT-mediated transrepression of HIF-1α[J].Theranostics, 2018, 8 (3) :610-626.
|
[26] RATZIU V, HARRISON SA, FRANCQUE S, et al. Elafibranor, an agonist of the peroxi-some proliferator-activated recep-tor-alpha and-delta, induces resolution of nonalcoholicsteatohepatitis without fibrosis worsening[J]. Gastroenterolo-gy, 2016, 150 (5) :1147-1159. e5.
|
[27] JIANG XP, AI WB, WAN LY, et al. The roles of microRNAfamilies in hepatic fibrosis[J]. Cell Biosci, 2017, 7:34.
|
[28] LI Z, JI L, SU S, et al. Leptin up-regulates microRNA-27a/b-3p level in hepatic stellate cells[J]. Exp Cell Res, 2018, 366 (1) :63-70.
|
[29] HU D, HU Y, XU W, et al. miR-203 inhibits the expression ofcollagen-related genes and the proliferation of hepatic stellat-e cells through a SMAD3-dependent mechanism[J]. MolMed Rep, 2017, 16 (2) :1248-1254.
|
[30] ZOU Y, CAI Y, LU D, et al. MicroRNA-146a-5p attenuatesliver fibrosis by suppressing profibrogenic effects of TGFβ1and lipopolysaccharide[J]. Cell Signal, 2017, 39:1-8.
|
[31] CHEN J, YU Y, LI S. et al. MicroRNA-30a ameliorates he-patic fibrosis by inhibiting Beclin1-mediated autophagy[J].J Cell Mol Med, 2017, 21 (12) :3679-3692.
|
[32] ZHENG J, DONG P, MAO Y, et al. lincRNA-p21 inhibits he-patic stellate cell activation and liver fibrogenesis via p21[J].FEBS J, 2015, 282 (24) :4810-4821.
|
[33] ZHANG K, HAN X, ZHANG Z, et al. The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFβand Notchpathways[J]. Nat Commun, 2017, 8 (1) :144.
|
[34] WANG R, DING Q, YAQOOB U, et al. Exosome adherenceand internalization by hepatic stellate cells triggers sphingosine1-phosphate-dependent migration[J]. J Biol Chem, 2015, 290 (52) :30684-30696.
|
[35] CHARRIER A, CHEN R, CHEN L, et al. Exosomes mediate in-tercellular transfer of pro-fibro-genic connective tissuegrowth factor (CCN2) between hepatic stellate cells, the prin-cipal fibrotic cells in the liver[J]. Surgery, 2014, 156 (3) :548-555.
|
[36] CHEN L, CHARRIER A, ZHOU Y, et al. Epigenetic regulationof connective tissue growth factor by MicroRNA-214 deliveryin exosomes from mouse or human hepatic stellate cells[J].Hepatology, 2014, 59 (3) :1118-1129.
|
[37] CHEN L, BRIGSTOCK DR. Integrins and heparan sulfate pro-teoglycans on hepatic stellate cells (HSC) are novel receptorsfor HSC-derived exosomes[J]. FEBS Lett, 2016, 590 (23) :4263-4274.
|
[38] DEVHARE PB, SASAKI R, SHRIVASTAVA S, et al. Exosome-mediated intercellular communica-tion between hepatitis Cvirus-infected hepatocytes and hepatic stellate cells[J]. JVirol, 2017, 91 (6) :1-14.
|
[39] LEE YS, KIM SY, KO E, et al. Exosomes derived from palmit-ic acid-treated hepatocytes induce fibrotic activation of he-patic stellate cells[J]. Sci Rep, 2017, 7 (1) :3710.
|
[40] SEO W, EUN HS, KIM SY, et al. Exosome-mediated activa-tion of toll-like receptor 3 in stellate cells stimulates interleukin-17 production by gammadelta T cells in liver fibrosis[J].Hepatology, 2016, 64 (2) :616-631.
|