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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 35 Issue 3
Mar.  2019
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Article Contents

Spleen-strengthening and dampness-removing therapy exerts a therapeutic effect on nonalcoholic fatty liver disease by regulating hepatic MTP promoter methylation

DOI: 10.3969/j.issn.1001-5256.2019.03.047
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  • Published Date: 2019-03-20
  • Nonalcoholic fatty liver disease ( NAFLD) is the most common risk factor for diabetes mellitus and cerebrovascular and cardiovascu-lar diseases. The prevalence of NAFLD is increasing rapidly with the improvement in living. Microsome triglyceride transfer protein ( MTP) isa key enzyme for outward transport of liver lipids, and the increase in MTP promoter methylation is an important factor for liver lipid depositionin NAFLD. Traditional Chinese medicine believes that“spleen Qi transfers essence”, and the lipid transport function of MTP may be one of themanifestations of“spleen Qi transfers essence”. Clinical studies have shown that the spleen-strengthening and dampness-removing principleis of great importance in the treatment of NAFLD. By reviewing related articles, this article points out that the spleen-strengthening anddampness-removing therapy can improve NAFLD by regulating MTP promoter methylation, increasing the level of hepatic MTP, promoting theoutflow of liver lipids, and alleviating lipid deposition.

     

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